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Article ; Online: Identification of an Inherent Bioenergetic and Metabolic Phenotype in Late-Onset Alzheimer’s Disease

Kai-Christian Sonntag / Woo-In Ryu / Mariana K. Bormann / Eunjung Koh / Bruce M. Cohen

Biology and Life Sciences Forum, Vol 21, Iss 24, p

2023 Volume 24

Abstract: The pathology of late-onset Alzheimer’s disease (LOAD) is still poorly understood, but it is multifactorial and closely related to changes with aging. We developed a cellular platform for collecting skin fibroblasts or blood cells from LOAD patients and ... ...

Abstract	The pathology of late-onset Alzheimer’s disease (LOAD) is still poorly understood, but it is multifactorial and closely related to changes with aging. We developed a cellular platform for collecting skin fibroblasts or blood cells from LOAD patients and non-demented control individuals, which are then used in an induced pluripotent stem cell (iPSC) paradigm to produce brain cells for determining LOAD pathogenic processes in the context of age, disease, genetic background, cell development, and cell type. This model has provided evidence for an innate inefficient cellular energy management in LOAD that is associated with alterations of cellular transcriptomes and lipid compositions, and interconnected cause-and-effect linkages, such as impaired insulin/IGF-1 signaling, bioenergetic substrate deficiencies, diminished glucose metabolism, and disruption of autophagic flux, among others. In addition, a testing of compounds revealed some restoration of these altered bioenergetic and metabolic processes in LOAD cells. Altogether, our studies have identified an inherent LOAD-associated cellular metabolic phenotype as a potential risk factor for developing neurodegenerative diseases with aging. We propose that our cellular model allows for patient-oriented examination of numerous mechanisms and interactions in LOAD pathogenesis, which can be used as a basis for a personalized medicine approach to predict altered aging and risk of developing dementia, and to test or implement (customized) therapeutic or disease-preventive intervention strategies.
Keywords	autophagy ; bioenergetics ; brain cells ; induced pluripotent stem cells ; insulin/IGF-1 signaling ; late-onset Alzheimer’s disease ; Plant ecology ; QK900-989 ; Animal biochemistry ; QP501-801 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Digital Media Influence on Adolescents' Behavior during the COVID-19 Pandemic: Self-Intravenous Injection of

Koh, Eunjung / Choi, Insu / Choi, Seul-A / Kang, Yeo-Jin / Cho, Hwa-Jin

Children (Basel, Switzerland)

2022 Volume 9, Issue 8

Abstract: During the coronavirus disease 2019 (COVID-19) pandemic, widened physical distance and social deprivation are being replaced with digital media use. The media's social function has tremendously increased following the COVID-19 era and adolescents living ... ...

Abstract	During the coronavirus disease 2019 (COVID-19) pandemic, widened physical distance and social deprivation are being replaced with digital media use. The media's social function has tremendously increased following the COVID-19 era and adolescents living in a media-saturated world are the most vulnerable subjects of all. Social media use can encourage risky behavior in adolescents. Posting videos related to risk behaviors on social media has been linked to jeopardizing not only mental health but also physical safety. Herein, we report a case of a 12-year-old boy who intravenously self-injected
Language	English
Publishing date	2022-07-22
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children9081104
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Article: Rapid progression from trochlear nerve palsy to orbital apex syndrome as an initial presentation of advanced gastric cancer.

Kong, Eunjung / Koh, Sung Ae / Kim, Won Jae

Yeungnam University journal of medicine

2019 Volume 36, Issue 2, Page(s) 159–162

Abstract: The most cases with orbital metastases have been reported in patients with a prior established diagnosis of cancer and widespread systemic involvement. However, ocular symptoms can be developed as an initial presentation of cancer in patients without ... ...

Abstract	The most cases with orbital metastases have been reported in patients with a prior established diagnosis of cancer and widespread systemic involvement. However, ocular symptoms can be developed as an initial presentation of cancer in patients without cancer history. We report a case of rapid progression from trochlear nerve palsy to orbital apex syndrome as an initial presentation of advanced gastric cancer.
Language	English
Publishing date	2019-02-15
Publishing country	Korea (South)
Document type	Case Reports
ISSN	2384-0293
ISSN	2384-0293
DOI	10.12701/yujm.2019.00129
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Article ; Online: Rapid progression from trochlear nerve palsy to orbital apex syndrome as an initial presentation of advanced gastric cancer

Eunjung Kong / Sung Ae Koh / Won Jae Kim

Yeungnam University Journal of Medicine, Vol 36, Iss 2, Pp 159-

2019 Volume 162

Abstract	The most cases with orbital metastases have been reported in patients with a prior established diagnosis of cancer and widespread systemic involvement. However, ocular symptoms can be developed as an initial presentation of cancer in patients without cancer history. We report a case of rapid progression from trochlear nerve palsy to orbital apex syndrome as an initial presentation of advanced gastric cancer.
Keywords	Diplopia ; Metastasis ; Optic neuropathy ; Stomach neoplasms ; Trochlear nerve palsy ; Medicine (General) ; R5-920
Language	English
Publishing date	2019-05-01T00:00:00Z
Publisher	Yeungnam University College of Medicine
Document type	Article ; Online
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Article: A questionnaire survey on the diagnosis and treatment of Fabry nephropathy in clinical practice.

Choi, Soo Jeong / Kim, Su Hyun / Lee, Min Sung / Park, Samel / Cho, Eunjung / Han, Seung Seok / Koh, Eun Sil / Chung, Byung Ha / Jeong, Kyung Hwan / Bae, EunHui / Lee, Eun Young / Kwon, Young Joo

Kidney research and clinical practice

2023 Volume 42, Issue 5, Page(s) 628–638

Abstract: Background: Fabry nephropathy is characterized by a deficiency of lysosomal alpha-galactosidase A, which results in proteinuria and kidney disease. The ineffectiveness of enzyme replacement therapy (ERT) for severe kidney failure highlights the need for ...

Abstract	Background: Fabry nephropathy is characterized by a deficiency of lysosomal alpha-galactosidase A, which results in proteinuria and kidney disease. The ineffectiveness of enzyme replacement therapy (ERT) for severe kidney failure highlights the need for early detection and meaningful markers. However, because the diagnosis and treatment of Fabry disease can vary according to the expertise of physicians, we evaluated the opinions of Korean specialists. Methods: A questionnaire regarding the management of Fabry nephropathy was emailed to healthcare providers with the experience or ability to treat individuals with Fabry nephropathy. Results: Of the 70 experts who responded to the survey, 43 were nephrologists, and 64.3% of the respondents reported having treated patients with Fabry disease. Pediatricians are treating primarily patients with classic types of the disease, while nephrologists and cardiologists are treating more patients with variant types. Only 40.7% of non-nephrologists agreed that a kidney biopsy was required at the time of diagnosis, compared with 81.4% of nephrologists. Thirty-eight of 70 respondents (54.3%) reported measuring globotriaosylsphingosine (lyso-Gb3) as a biomarker. The most common period to measure lyso-Gb3 was at the time of diagnosis, followed by after ERT, before ERT, and at screening. For the stage at which ERT should begin, microalbuminuria and proteinuria were chosen by 51.8% and 28.6% of respondents, respectively. Conclusion: Nephrologists are more likely to treat variant Fabry disease rather than classic cases, and they agree that ERT should be initiated early in Fabry nephropathy, using lyso-Gb3 as a biomarker.
Language	English
Publishing date	2023-06-15
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2656420-8
ISSN	2211-9132
ISSN	2211-9132
DOI	10.23876/j.krcp.22.235
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Article ; Online: Association of Knowledge About Dementia with Two Dimensional Attitudes Among a Community Population in South Korea.

Lee, Seunghoon / Jeong, Hyunsuk / Koh, Im-Seok / Suh, Jeewon / Cho, HyunSung / Kim, YongBok / Cho, EunJung / Chang, Jhin Goo / Hong, Minha / Lee, Su Young

Journal of Alzheimer's disease : JAD

2023 Volume 92, Issue 2, Page(s) 565–572

Abstract: Background: Providing correct information about dementia and people living with dementia and improving the attitude toward the disease have important implications in overcoming prejudice and negative perceptions and strengthening the social support ... ...

Abstract	Background: Providing correct information about dementia and people living with dementia and improving the attitude toward the disease have important implications in overcoming prejudice and negative perceptions and strengthening the social support system. However, studies are limited about which aspects of dementia knowledge affect attitudes toward it and the influence of such knowledge on particular aspects of such attitudes. Objective: This study examined which part of dementia knowledge affects attitudes toward dementia and, furthermore, the influence of such knowledge on two aspects of attitudes in the general population. Methods: A population-based cross-sectional survey of 1,200 participants aged 20 years or older was adopted. A landline and wireless telephone survey was conducted from October 12 to October 22, 2021. The survey data included self-report questions about dementia knowledge, dementia attitudes, demographics, and family information. Multiple linear regression analysis was performed. Results: Dementia knowledge was positively associated with global dementia attitudes. In terms of the relationship between the two dimensions of dementia attitudes and knowledge, the latter displayed a significant positive association with accepting attitudes (β= 0.121, p < 0.001) but not with affective attitudes (β= 0.064, p = 0.084). Among dementia knowledge, dementia symptom/diagnosis and policy categories were positively associated with accepting attitudes (β= 0.198, p = 0.006; β= 0.357, p < 0.001). Conclusion: Our study suggests that people with more dementia knowledge have more accepting attitudes toward dementia. It may be effective to continue education on dementia to improve the public accepting attitudes. However, to improve negative emotional attitudes toward dementia, various approaches beyond education may be needed.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Attitude ; Educational Status ; Surveys and Questionnaires ; Dementia/epidemiology ; Health Knowledge, Attitudes, Practice
Language	English
Publishing date	2023-02-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-220736
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Article ; Online: Population-based evaluation of disparities in stomach cancer by nativity among Asian and Hispanic populations in California, 2011-2015.

Lee, Eunjung / Tsai, Kai-Ya / Zhang, Juanjuan / Hwang, Amie E / Deapen, Dennis / Koh, Jennifer J / Kawaguchi, Eric S / Buxbaum, James / Ahn, Sang Hoon / Liu, Lihua

Cancer

2023 Volume 130, Issue 7, Page(s) 1092–1100

Abstract: Background: Stomach cancer incidence presents significant racial/ethnic disparities among racial/ethnic minority groups in the United States, particularly among Asian and Hispanic immigrant populations. However, population-based evaluation of ... ...

Abstract	Background: Stomach cancer incidence presents significant racial/ethnic disparities among racial/ethnic minority groups in the United States, particularly among Asian and Hispanic immigrant populations. However, population-based evaluation of disparities by nativity has been scarce because of the lack of nativity-specific population denominators, especially for disaggregated Asian subgroups. Population-based stomach cancer incidence and tumor characteristics by detailed race/ethnicity and nativity were examined. Methods: Annual age-adjusted incidence rates were calculated by race/ethnicity, sex, and nativity and tumor characteristics, such as stage and anatomic subsite, were evaluated using the 2011-2015 California Cancer Registry data. For Hispanic and Asian populations, nativity-specific population counts were estimated using the US Census and the American Community Survey Public Use Microdata Sample data. Results: During 2011-2015 in California, 14,198 patients were diagnosed with stomach cancer. Annual age-adjusted incidence rates were higher among foreign-born individuals than their US-born counterparts. The difference was modest among Hispanics (∼1.3-fold) but larger (∼2- to 3-fold) among Chinese, Japanese, and Korean Americans. The highest incidence was observed for foreign-born Korean and Japanese Americans (33 and 33 per 100,000 for men; 15 and 12 per 100,000 for women, respectively). The proportion of localized stage disease was highest among foreign-born Korean Americans (44%); a similar proportion was observed among US-born Korean Americans, although numbers were limited. For other Asians and Hispanics, the localized stage proportion was generally lower among foreign-born than US-born individuals and lowest among foreign-born Japanese Americans (23%). Conclusions: Nativity-specific investigation with disaggregated racial/ethnic groups identified substantial stomach cancer disparities among foreign-born immigrant populations.
MeSH term(s)	Male ; Humans ; Female ; United States/epidemiology ; Asian ; Ethnicity ; Stomach Neoplasms/epidemiology ; Minority Groups ; Hispanic or Latino ; California/epidemiology
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.35141
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Article ; Online: A questionnaire survey on the diagnosis and treatment of Fabry nephropathy in clinical practice

Soo Jeong Choi / Su Hyun Kim / Min Sung Lee / Samel Park / Eunjung Cho / Seung Seok Han / Eun Sil Koh / Byung Ha Chung / Kyung Hwan Jeong / Eun Hui Bae / Eun Young Lee / Young Joo Kwon

Kidney Research and Clinical Practice, Vol 42, Iss 5, Pp 628-

2023 Volume 638

Abstract: Background Fabry nephropathy is characterized by a deficiency of lysosomal alpha-galactosidase A, which results in proteinuria and kidney disease. The ineffectiveness of enzyme replacement therapy (ERT) for severe kidney failure highlights the need for ... ...

Abstract	Background Fabry nephropathy is characterized by a deficiency of lysosomal alpha-galactosidase A, which results in proteinuria and kidney disease. The ineffectiveness of enzyme replacement therapy (ERT) for severe kidney failure highlights the need for early detection and meaningful markers. However, because the diagnosis and treatment of Fabry disease can vary according to the expertise of physicians, we evaluated the opinions of Korean specialists. Methods A questionnaire regarding the management of Fabry nephropathy was emailed to healthcare providers with the experience or ability to treat individuals with Fabry nephropathy. Results Of the 70 experts who responded to the survey, 43 were nephrologists, and 64.3% of the respondents reported having treated patients with Fabry disease. Pediatricians are treating primarily patients with classic types of the disease, while nephrologists and cardiologists are treating more patients with variant types. Only 40.7% of non-nephrologists agreed that a kidney biopsy was required at the time of diagnosis, compared with 81.4% of nephrologists. Thirty-eight of 70 respondents (54.3%) reported measuring globotriaosylsphingosine (lyso-Gb3) as a biomarker. The most common period to measure lyso-Gb3 was at the time of diagnosis, followed by after ERT, before ERT, and at screening. For the stage at which ERT should begin, microalbuminuria and proteinuria were chosen by 51.8% and 28.6% of respondents, respectively. Conclusion Nephrologists are more likely to treat variant Fabry disease rather than classic cases, and they agree that ERT should be initiated early in Fabry nephropathy, using lyso-Gb3 as a biomarker.
Keywords	biopsy ; chronic renal insufficiency ; fabry disease ; kidney diseases ; surveys and questionnaire ; therapeutics ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951
Subject code	610
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	The Korean Society of Nephrology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ultrasonography-Based Radiomics of Screening-Detected Ductal Carcinoma In Situ According to Visibility on Mammography.

Koh, Jieun / Lee, Eunjung / Han, Kyunghwa / Lee, Young Han / Kwak, Jin Young / Yoon, Jung Hyun / Moon, Hee Jung

Ultrasound quarterly

2020 Volume 37, Issue 1, Page(s) 23–27

Abstract: Abstract: Ductal carcinoma in situ (DCIS) has different prognostic factors according to the detection modality. The purpose of this study was to compare parameters from a radiomic analysis of ultrasonography (US) images for DCIS detected on screening ... ...

Abstract	Abstract: Ductal carcinoma in situ (DCIS) has different prognostic factors according to the detection modality. The purpose of this study was to compare parameters from a radiomic analysis of ultrasonography (US) images for DCIS detected on screening mammography (MMG) and US and detected on screening US only. A total of 154 surgically confirmed DCIS visible on US were included. Regions of interest were drawn onto US images of DCIS, and texture analysis was performed. Lesions were classified into those detected by both US and MMG (the US-MMG group) and those detected by US only (the US group). Analysis parameters were compared between the US-MMG group and the US group. Ninety-six lesions were included in the US-MMG group and 58 lesions in the US group. Energy, entropy, maximum, mean absolute deviation, range, SD, and variance were significantly higher in the US-MMG group than the US group. Kurtosis, skewness, and uniformity were significantly lower in the US-MMG group than the US group. Among the 22 gray-level cooccurrence matrix parameters, 18, 21, 22, 20, and 21 parameters were significantly different between the 2 groups in 0, 45, 90, and 135 degrees and the average value. Among the 11 gray-level run-length matrix parameters, 6, 6, 7, 7, and 6 parameters were significantly different in 0, 45, 90, and 135 degrees and the average value. Inverse variance and gray-level nonuniformity were the most different features between the 2 groups. Screening-detected DCIS showed different radiomic features according to the detection modality.
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Carcinoma, Intraductal, Noninfiltrating/diagnostic imaging ; Early Detection of Cancer ; Female ; Humans ; Mammography ; Ultrasonography ; Ultrasonography, Mammary
Language	English
Publishing date	2020-11-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	645107-x
ISSN	1536-0253 ; 0894-8771
ISSN (online)	1536-0253
ISSN	0894-8771
DOI	10.1097/RUQ.0000000000000538
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Article ; Online: Three-dimensional radiomics of triple-negative breast cancer: Prediction of systemic recurrence.

Koh, Jieun / Lee, Eunjung / Han, Kyunghwa / Kim, Sujeong / Kim, Dong-Kyu / Kwak, Jin Young / Yoon, Jung Hyun / Moon, Hee Jung

Scientific reports

2020 Volume 10, Issue 1, Page(s) 2976

Abstract: This paper evaluated 3-dimensional radiomics features of breast magnetic resonance imaging (MRI) as prognostic factors for predicting systemic recurrence in triple-negative breast cancer (TNBC) and validated the results with a different MRI scanner. The ... ...

Abstract	This paper evaluated 3-dimensional radiomics features of breast magnetic resonance imaging (MRI) as prognostic factors for predicting systemic recurrence in triple-negative breast cancer (TNBC) and validated the results with a different MRI scanner. The Rad score was generated from 3-dimensional radiomic features of MRI for 231 TNBCs (training set (GE scanner), n = 182; validation set (Philips scanner), n = 49). The Clinical and Rad models to predict systemic recurrence were built up and the models were externally validated. In the training set, the Rad score was significantly higher in the group with systemic recurrence (median, -8.430) than the group without (median, -9.873, P < 0.001). The C-index of the Rad model to predict systemic recurrence in the training set was 0.97, which was significantly higher than in the Clinical model (0.879; P = 0.009). When the models were externally validated, the C-index of the Rad model was 0.848, lower than the 0.939 of the Clinical model, although the difference was not statistically significant (P = 0.100). The Rad model for predicting systemic recurrence in TNBC showed a significantly higher C-index than the Clinical model. However, external validation with a different MRI scanner did not show the Rad model to be superior over the Clinical model.
MeSH term(s)	Adult ; Breast/diagnostic imaging ; Breast/pathology ; Breast/surgery ; Chemotherapy, Adjuvant/statistics & numerical data ; Female ; Humans ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Mastectomy ; Middle Aged ; Neoadjuvant Therapy/methods ; Neoadjuvant Therapy/statistics & numerical data ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/prevention & control ; Nomograms ; Treatment Outcome ; Triple Negative Breast Neoplasms/diagnosis ; Triple Negative Breast Neoplasms/epidemiology ; Triple Negative Breast Neoplasms/pathology ; Triple Negative Breast Neoplasms/therapy
Language	English
Publishing date	2020-02-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-59923-2
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