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  1. Article ; Online: Alessandro De Gloria

    Francesco Bellotti / Jannicke Baalsrud Hauge / Manuel Gentile / Johan Jeuring / Iza Marfisi Schottman / Manuel Ninaus / Remco Veltkamp / Vanissa Wanick / Riccardo Berta

    International Journal of Serious Games, Vol 10, Iss

    2023  Volume 1

    Abstract: ... by our Editor in Chief and Founder, Prof. Alessandro De Gloria. Alessandro passed away in Genova, Italy ...

    Abstract The editorial of this issue of the International Journal of Serious Games is the last one signed by our Editor in Chief and Founder, Prof. Alessandro De Gloria. Alessandro passed away in Genova, Italy, on March 20th, few days after his 68th birthday. He founded the Serious Games Society and served as its first President, then as Honorary President. He founded also the Games and Learning Alliance Conference, of which he was the first General Chair and Honorary Chair. We mourn a great friend, and a pioneer researcher and creative teacher, with a broad, constructive vision and outstanding team-building skills. The good he made will remain in time.
    Keywords Serious games ; Alessandro De Gloria ; MSc program ; Strategic engineering ; Serious Games Society ; Education ; L ; Electronic computers. Computer science ; QA75.5-76.95 ; Computer software ; QA76.75-76.765
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Serious Games Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book: Multidisciplinary management of prostate cancer

    Gentile, Vincenzo / Panebianco, Valeria / Sciarra, Alessandro

    the role of the prostate cancer unit

    2014  

    Author's details Vincenzo Gentile ; Valeria Panebianco ; Alessandro Sciarra ed
    Keywords Prostate/Cancer ; Prostate/Cancer/Treatment
    Subject code 616.99463
    Language English
    Size X, 152 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018258129
    ISBN 978-3-319-04384-5 ; 9783319043852 ; 3-319-04384-6 ; 3319043854
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2014 A 1943 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Movement disorders and neuropathies: overlaps and mimics in clinical practice.

    Gentile, Francesco / Bertini, Alessandro / Priori, Alberto / Bocci, Tommaso

    Journal of neurology

    2022  Volume 269, Issue 9, Page(s) 4646–4662

    Abstract: Movement disorders as well as peripheral neuropathies are extremely frequent in the general population; therefore, it is not uncommon to encounter patients with both these conditions. Often, the coexistence is coincidental, due to the high incidence of ... ...

    Abstract Movement disorders as well as peripheral neuropathies are extremely frequent in the general population; therefore, it is not uncommon to encounter patients with both these conditions. Often, the coexistence is coincidental, due to the high incidence of common causes of peripheral neuropathy, such as diabetes and other age-related disorders, as well as of Parkinson disease (PD), which has a typical late onset. Nonetheless, there is broad evidence that PD patients may commonly develop a sensory and/or autonomic polyneuropathy, triggered by intrinsic and/or extrinsic mechanisms. Similarly, some peripheral neuropathies may develop some movement disorders in the long run, such as tremor, and rarely dystonia and myoclonus, suggesting that central mechanisms may ensue in the pathogenesis of these diseases. Although rare, several acquired or hereditary causes may be responsible for the combination of movement and peripheral nerve disorders as a unique entity, some of which are potentially treatable, including paraneoplastic, autoimmune and nutritional aetiologies. Finally, genetic causes should be pursued in case of positive family history, young onset or multisystemic involvement, and examined for neuroacanthocytosis, spinocerebellar ataxias, mitochondrial disorders and less common causes of adult-onset cerebellar ataxias and spastic paraparesis. Deep phenotyping in terms of neurological and general examination, as well as laboratory tests, neuroimaging, neurophysiology, and next-generation genetic analysis, may guide the clinician toward the correct diagnosis and management.
    MeSH term(s) Adult ; Dystonia ; Humans ; Parkinson Disease/complications ; Parkinson Disease/diagnosis ; Parkinson Disease/genetics ; Peripheral Nervous System Diseases/diagnosis ; Spinocerebellar Ataxias/genetics ; Tremor
    Language English
    Publishing date 2022-06-03
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-022-11200-0
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  4. Article ; Online: Exploratory pharmacovigilance with machine learning in big patient data: A focused scoping review.

    Kaas-Hansen, Benjamin Skov / Gentile, Simona / Caioli, Alessandro / Andersen, Stig Ejdrup

    Basic & clinical pharmacology & toxicology

    2023  Volume 132, Issue 3, Page(s) 233–241

    Abstract: Background: Machine learning can operationalize the rich and complex data in electronic patient records for exploratory pharmacovigilance endeavours.: Objective: The objective of this review is to identify applications of machine learning and big ... ...

    Abstract Background: Machine learning can operationalize the rich and complex data in electronic patient records for exploratory pharmacovigilance endeavours.
    Objective: The objective of this review is to identify applications of machine learning and big patient data in exploratory pharmacovigilance.
    Methods: We searched PubMed and Embase and included original articles with an exploratory pharmacovigilance purpose, focusing on medicinal interventions and reporting the use of machine learning in electronic patient records with ≥1000 patients collected after market entry.
    Findings: Of 2557 studies screened, seven were included. Those covered six countries and were published between 2015 and 2021. The most prominent machine learning methods were random forests, logistic regressions, and support vector machines. Two studies used artificial neural networks or naive Bayes classifiers. One study used formal concept analysis for association mining, and another used temporal difference learning. Five studies compared several methods against each other. The numbers of patients in most data sets were in the order of thousands; two studies used what can more reasonably be considered big data with >1 000 000 patients records.
    Conclusion: Despite years of great aspirations for combining machine learning and clinical data for exploratory pharmacovigilance, only few studies still seem to deliver somewhat on these expectations.
    MeSH term(s) Humans ; Pharmacovigilance ; Bayes Theorem ; Machine Learning ; Big Data ; Electronic Health Records
    Language English
    Publishing date 2023-01-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2134679-3
    ISSN 1742-7843 ; 1742-7835
    ISSN (online) 1742-7843
    ISSN 1742-7835
    DOI 10.1111/bcpt.13828
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  5. Article: Deep brain stimulation for autism spectrum disorder.

    Marini, Stefano / D'Agostino, Lucia / Ciamarra, Carla / Gentile, Alessandro

    World journal of psychiatry

    2023  Volume 13, Issue 5, Page(s) 174–181

    Abstract: Deep brain stimulation (DBS) is a medical treatment that aims to obtain therapeutic effects by applying chronic electrical impulses in specific brain structures and neurological circuits. Over the years, DBS has been studied for the treatment of many ... ...

    Abstract Deep brain stimulation (DBS) is a medical treatment that aims to obtain therapeutic effects by applying chronic electrical impulses in specific brain structures and neurological circuits. Over the years, DBS has been studied for the treatment of many psychiatric disorders. Scientific research on the use of DBS in people with autism has focused this interest mainly on treatment-resistant obsessive-compulsive disorder, drug-resistant epilepsy, self-injurious behaviors (SIB), and aggressive behaviors toward the self. Autism spectrum disorder (ASD) includes a group of developmental disabilities characterized by patterns of delay and deviance in the development of social, communicative, and cognitive skills and the presence of repetitive and stereotyped behaviors as well as restricted interests. People with autism often have numerous medical and psychiatric comorbidities that worsen the quality of life of patients and their caregivers. Obsessive-compulsive symptoms can be found in up to 81.3% of people with autism. They are often severe, refractory to treatment, and particularly difficult to treat. SIB has a high prevalence in severely retarded individuals and is often associated with autism. Drug treatment of both autism and SIB presents a therapeutic challenge. To describe the current state of the art regarding the efficacy of DBS in people with ASD, a literature search was conducted for relevant studies using the PubMed database. Thirteen studies have been considered in this paper. Up to date, DBS has been used for the stimulation of the nucleus accumbens, globus pallidus internus, anterior limb of the internal capsule, ventral anterior limb of the internal capsule, basolateral amygdala, ventral capsule and ventral striatum, medial forebrain bundle, and posterior hypothalamus. In the total sample of 16 patients, 4 were adolescents, and 12 were adults. All patients had symptoms resistant to multiple drug therapy. Many patients taken into consideration by the studies showed clinical improvements as evidenced by the scores of the psychopathological scales used. In some cases, clinical improvements have varied over time, which may require further investigation. Among the new therapeutic perspectives, DBS could be a valid option. However, further, and more in-depth research is needed in this field.
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2220-3206
    ISSN 2220-3206
    DOI 10.5498/wjp.v13.i5.174
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  6. Article: A Rare Case of Duodenal Metastasis from Lobular Breast Cancer: From Diagnosis to Surgery.

    Barbieri, Erika / Caraceni, Giulia / Gentile, Damiano / Gavazzi, Francesca / Zerbi, Alessandro / Tinterri, Corrado

    Case reports in oncology

    2023  Volume 16, Issue 1, Page(s) 391–396

    Abstract: Gastrointestinal tract breast cancer (BC) metastases represent a rare event and generally originate from the lobular subtype. Duodenal involvement was rarely described in previous case series. Abdominal symptoms are extremely unspecific and misleading. ... ...

    Abstract Gastrointestinal tract breast cancer (BC) metastases represent a rare event and generally originate from the lobular subtype. Duodenal involvement was rarely described in previous case series. Abdominal symptoms are extremely unspecific and misleading. Diagnosis is challenging, and it consists of a few mandatory steps from radiological examinations to histological and immunohistochemical analyses. Here, we presented the clinical case of a 54-year-old postmenopausal woman who was hospitalized for vomiting and jaundice, presenting increased level of liver enzymes and minimal main bile duct and choledocus dilatation at abdominal ultrasonography. She underwent breast-conserving surgery and axillary lymph node dissection for stage IIIB lobular BC, 5 years before. Metastatic infiltration of the duodenal bulb originating from lobular BC was proven histologically, through fine-needle aspiration during endoscopic ultrasonography. Treatment was established after multidisciplinary team evaluation, based on the clinical status and prognosis of the patient. Pancreaticoduodenectomy was performed, and final histological examination confirmed the secondary localization of lobular BC, infiltrating the duodenal and gastric wall, pancreas parenchyma, and surrounding tissues. No metastatic lymph nodes were found. After surgery, the patient underwent first line of adjuvant systemic treatment with fulvestrant and ribociclib. After a follow-up of 21 months, the patient was in good clinical condition, without signs of locoregional or distant recurrence. This report stressed on the importance of a tailored therapeutic approach. Although systemic therapy generally represents the preferred option, surgery should not be excluded if an oncological radical resection can be performed achieving acceptable locoregional disease control.
    Language English
    Publishing date 2023-05-31
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000530603
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  7. Article ; Online: Focus on the Use of Resveratrol in Bladder Cancer.

    Zucchi, Alessandro / Claps, Francesco / Pastore, Antonio Luigi / Perotti, Alessandro / Biagini, Andrea / Sallicandro, Luana / Gentile, Rosaria / Caglioti, Concetta / Palazzetti, Federico / Fioretti, Bernard

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: Bladder cancer is the most common tumor of the urinary system, with a high incidence in the male population. Surgery and intravesical instillations can eradicate it, although recurrences are very common, with possible progression. For this reason, ... ...

    Abstract Bladder cancer is the most common tumor of the urinary system, with a high incidence in the male population. Surgery and intravesical instillations can eradicate it, although recurrences are very common, with possible progression. For this reason, adjuvant therapy should be considered in all patients. Resveratrol displays a biphasic dose response both in vitro and in vivo (intravesical application) with an antiproliferative effect at high concentrations and antiangiogenic action in vivo (intraperitoneal application) at a low concentration, suggesting a potential role for it in clinical management as an adjuvant to conventional therapy. In this review, we examine the standard therapeutical approach to bladder cancer and the preclinical studies that have investigated resveratrol in xenotransplantation models of bladder cancer. Molecular signals are also discussed, with a particular focus on the STAT3 pathway and angiogenic growth factor modulation.
    MeSH term(s) Humans ; Male ; Resveratrol/therapeutic use ; Urinary Bladder Neoplasms/pathology ; Administration, Intravesical ; Combined Modality Therapy
    Chemical Substances Resveratrol (Q369O8926L)
    Language English
    Publishing date 2023-02-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24054562
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  8. Article: Case Report: Infectious prophylaxis in hematological malignancies.

    Passucci, Mauro / Masucci, Chiara / Paoletti, Francesca / Ielo, Claudia / Costa, Alessandro / Carmosino, Ida / Scalzulli, Emilia / Martelli, Maurizio / Gentile, Giuseppe / Breccia, Massimo

    Frontiers in oncology

    2023  Volume 13, Page(s) 1163175

    Abstract: Patients with hematological malignancies and past serological evidence of hepatitis B are at risk for HBV reactivation. In myeloproliferative neoplasms, continuous treatment with the JAK 1/2 inhibitor ruxolitinib confers a moderate risk of reactivation ( ... ...

    Abstract Patients with hematological malignancies and past serological evidence of hepatitis B are at risk for HBV reactivation. In myeloproliferative neoplasms, continuous treatment with the JAK 1/2 inhibitor ruxolitinib confers a moderate risk of reactivation (1-10%); nevertheless, no prospective randomized data are available to strongly recommend HBV prophylaxis in these patients. Here, we report a case of primary myelofibrosis and past serological evidence of HBV infection, treated with ruxolitinib and concomitant lamivudine, developing HBV reactivation due to premature withdrawal of prophylaxis. This case underlines the potential need for persistent HBV prophylaxis in the setting of ruxolitinib treatment.
    Language English
    Publishing date 2023-05-01
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1163175
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  9. Article ; Online: The evolution in the surgical management of Peyronie's disease.

    Colombo, Fulvio / Franceschelli, Alessandro / Gentile, Giorgio / Droghetti, Matteo / Fiorillo, Alessandro / Palmisano, Franco

    Urologia

    2021  Volume 88, Issue 2, Page(s) 79–89

    Abstract: Peyronie's disease (PD) is due to a fibrotic alteration of the tunica albuginea of the penis. It is responsible of penile pain, angulation, and possible erectile dysfunction (ED). Despite almost three centuries have passed since the first description of ... ...

    Abstract Peyronie's disease (PD) is due to a fibrotic alteration of the tunica albuginea of the penis. It is responsible of penile pain, angulation, and possible erectile dysfunction (ED). Despite almost three centuries have passed since the first description of the disease, etiology still remains uncertain. This fact has led to the lack of a truly effective medical therapy and to date the surgical treatment, although not yet standardized, is the only one that offers acceptable outcomes in terms of function and overall patient's satisfaction. Since the beginning of the surgical experience in this field, two different currents of thought have developed: the first, involved the proposal of a number of different plication techniques, applied on the healthy side of the penis, opposite to the sick side, with the sole purpose of correcting the curvature; on the other side, efforts have focused on treating the "focus" of the disease, thus developing the so called "plaque surgery." If with the passing of the decades neither of the two "philosophical" currents has prevailed, this probably depends on the fact that is still not clear which is the lesser of evils: the frequent onset of ED which may follows the plaque surgery or rather the penis shortening that inevitably occurs if any technique of plication has been applied. Our contribution aims to offer an historical retrospective of the surgical treatment of this disease as well as to discuss the latest international guidelines on this topic. The reader will also find some notes about our personal experience in this field.
    MeSH term(s) Humans ; Male ; Penile Induration/surgery ; Urologic Surgical Procedures, Male/methods ; Urologic Surgical Procedures, Male/trends
    Language English
    Publishing date 2021-03-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 204043-8
    ISSN 1724-6075 ; 0376-0057 ; 0391-5603
    ISSN (online) 1724-6075
    ISSN 0376-0057 ; 0391-5603
    DOI 10.1177/03915603211005326
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  10. Article ; Online: Comparison of pharmacokinetic properties of alteplase and tenecteplase. The future of thrombolysis in acute ischemic stroke.

    Marè, Alessandro / Lorenzut, Simone / Janes, Francesco / Gentile, Carolina / Marinig, Roberto / Tereshko, Yan / Gigli, Gian Luigi / Valente, Mariarosaria / Merlino, Giovanni

    Expert opinion on drug metabolism & toxicology

    2024  Volume 20, Issue 1-2, Page(s) 25–36

    Abstract: Introduction: The drug most frequently used for thrombolysis in cases of acute ischemic stroke (AIS) is alteplase. However, there is moderate-to-high-quality evidence that tenecteplase has similar or higher efficacy and safety. With improved ... ...

    Abstract Introduction: The drug most frequently used for thrombolysis in cases of acute ischemic stroke (AIS) is alteplase. However, there is moderate-to-high-quality evidence that tenecteplase has similar or higher efficacy and safety. With improved pharmacokinetic properties over alteplase, tenecteplase could be a significant advantage in treating AIS.
    Areas covered: After conducting an extensive search on Scopus and PubMed, this manuscript reviews and compares the pharmacokinetic properties of alteplase and tenecteplase. Additionally, it provides information on pharmacodynamics, clinical efficacy, safety, tolerability, and drug-drug interactions.
    Expert opinion: The pharmacokinetic profile of alteplase and tenecteplase is derived from studies in patients with acute myocardial infarction. Thanks to its pharmacokinetic properties, tenecteplase is the drug closest to being the ideal fibrinolytic for AIS. Its longer half-life enables a single-bolus administration, which is particularly useful in emergencies. Tenecteplase has proven to have a good efficacy and safety profile in randomized clinical trials. Although we are awaiting the results of the ongoing phase 3 randomized clinical trials, we believe that tenecteplase has the potential to revolutionize the treatment of AIS through thrombolysis.
    MeSH term(s) Humans ; Fibrinolytic Agents/pharmacokinetics ; Fibrinolytic Agents/therapeutic use ; Ischemic Stroke/drug therapy ; Tenecteplase/pharmacokinetics ; Tenecteplase/therapeutic use ; Thrombolytic Therapy ; Tissue Plasminogen Activator/pharmacokinetics ; Tissue Plasminogen Activator/therapeutic use ; Treatment Outcome
    Chemical Substances Fibrinolytic Agents ; Tenecteplase (WGD229O42W) ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1080/17425255.2024.2311168
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