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  1. Article ; Online: Differential atrophy along the longitudinal hippocampal axis in Alzheimer's disease for the Alzheimer's Disease Neuroimaging Initiative.

    Morais-Ribeiro, Rafaela / Almeida, Francisco C / Coelho, Ana / Oliveira, Tiago Gil

    The European journal of neuroscience

    2024  

    Abstract: ... hippocampus, the posterior hippocampus negatively correlates with age only in CN subjects (r = -.31 ... a significant increase with age only in CN (r = .25). Overall, in AD, the posterior hippocampus is predominantly ...

    Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder that primarily affects the hippocampus. Since hippocampal studies have highlighted a differential subregional regulation along its longitudinal axis, a more detailed analysis addressing subregional changes along the longitudinal hippocampal axis has the potential to provide new relevant biomarkers. This study included structural brain MRI data of 583 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Cognitively normal (CN) subjects, mild cognitively impaired (MCI) subjects and AD patients were conveniently selected considering the age and sex match between clinical groups. Structural MRI acquisitions were pre-processed and analysed with a new longitudinal axis segmentation method, dividing the hippocampus in three subdivisions (anterior, intermediate, and posterior). When normalizing the volume of hippocampal sub-divisions to total hippocampus, the posterior hippocampus negatively correlates with age only in CN subjects (r = -.31). The longitudinal ratio of hippocampal atrophy (anterior sub-division divided by the posterior one) shows a significant increase with age only in CN (r = .25). Overall, in AD, the posterior hippocampus is predominantly atrophied early on. Consequently, the anterior/posterior hippocampal ratio is an AD differentiating metric at early disease stages with potential for diagnostic and prognostic applications.
    Language English
    Publishing date 2024-04-23
    Publishing country France
    Document type Journal Article
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.16361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2548: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Cardiac conditions.

    Paula Coelho Figueira Freire, Ana / Elkins, Mark R

    Journal of physiotherapy

    2022  

    Language English
    Publishing date 2022-12-14
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2543915-7
    ISSN 1836-9561 ; 1836-9553 ; 0004-9514
    ISSN (online) 1836-9561
    ISSN 1836-9553 ; 0004-9514
    DOI 10.1016/j.jphys.2022.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2001: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Carotenoids Diet: Digestion, Gut Microbiota Modulation, and Inflammatory Diseases.

    Rocha, Helena R / Coelho, Marta C / Gomes, Ana M / Pintado, Manuela E

    Nutrients

    2023  Volume 15, Issue 10

    Abstract: Several epidemiologic studies have found that consuming fruits and vegetables lowers the risk of getting a variety of chronic illnesses, including several types of cancers, cardiovascular diseases (CVDs), and bowel diseases. Although there is still ... ...

    Abstract Several epidemiologic studies have found that consuming fruits and vegetables lowers the risk of getting a variety of chronic illnesses, including several types of cancers, cardiovascular diseases (CVDs), and bowel diseases. Although there is still debate over the bioactive components, various secondary plant metabolites have been linked to these positive health benefits. Many of these features have recently been connected to carotenoids and their metabolites' effects on intracellular signalling cascades, which influence gene expression and protein translation. Carotenoids are the most prevalent lipid-soluble phytochemicals in the human diet, are found in micromolar amounts in human serum, and are very susceptible to multiple oxidation and isomerisation reactions. The gastrointestinal delivery system, digestion processes, stability, and functionality of carotenoids, as well as their impact on the gut microbiota and how carotenoids may be effective modulators of oxidative stress and inflammatory pathways, are still lacking research advances. Although several pathways involved in carotenoids' bioactivity have been identified, future studies should focus on the carotenoids' relationships, related metabolites, and their effects on transcription factors and metabolism.
    MeSH term(s) Humans ; Carotenoids/pharmacology ; Gastrointestinal Microbiome ; Diet ; Vegetables/metabolism ; Digestion
    Chemical Substances Carotenoids (36-88-4)
    Language English
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15102265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular evidence of sporadic Coxiella burnetii excretion in sheep milk, central Portugal.

    Pires, Humberto / Santos-Silva, Sérgio / Cruz, Andreia V S / Cardoso, Luís / Lopes, Ana Patrícia / Pereira, Maria A / Nóbrega, Carmen / Mega, Ana Cristina / Santos, Carla / Cruz, Rita / Esteves, Fernando / Vala, Helena / Matos, Ana Cristina / Barradas, Patrícia F / Coelho, Ana Cláudia / Mesquita, João R

    Veterinary research communications

    2024  

    Abstract: Coxiella burnetii is the etiologic agent of Q fever, a worldwide zoonosis. Cattle, sheep and goats are considered the main reservoirs of the disease. Transmission to humans occurs mainly through the inhalation of infectious aerosols from milk, faeces, ... ...

    Abstract Coxiella burnetii is the etiologic agent of Q fever, a worldwide zoonosis. Cattle, sheep and goats are considered the main reservoirs of the disease. Transmission to humans occurs mainly through the inhalation of infectious aerosols from milk, faeces, urine, and birth products from infected ruminants. In this study, a 2-year longitudinal approach was performed to ascertain the excretion of C. burnetii in bulk tank milk samples of sheep from a mountain plateau in central Portugal, with sampling conducted during the years 2015 and 2016. From a total of 156 bulk tank milk samples tested by qPCR, only one showed to be positive for C. burnetii (1.28% [95%CI: 0.03-6.94]), from 2015, the first year of collection. Bidirectional sequencing and phylogenetic analysis of IS1111 transposase partial region confirmed the presence of C. burnetii DNA. The presence of C. burnetii in raw milk samples highlights the necessity for additional research to determine if raw milk is a potential source for human infection. Animal health surveillance and prevention measures against this zoonotic disease should be considered.
    Language English
    Publishing date 2024-04-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 406735-6
    ISSN 1573-7446 ; 0165-7380
    ISSN (online) 1573-7446
    ISSN 0165-7380
    DOI 10.1007/s11259-024-10389-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3453: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Dihydroorotate dehydrogenase inhibitors in SARS-CoV-2 infection.

    Coelho, Ana R / Oliveira, Paulo J

    European journal of clinical investigation

    2020  Volume 50, Issue 10, Page(s) e13366

    MeSH term(s) Antiviral Agents/therapeutic use ; Betacoronavirus ; Biphenyl Compounds/therapeutic use ; COVID-19 ; Coronavirus Infections/drug therapy ; Crotonates/therapeutic use ; Enzyme Inhibitors/therapeutic use ; Humans ; Leflunomide/therapeutic use ; Oxidoreductases Acting on CH-CH Group Donors/antagonists & inhibitors ; Pandemics ; Pneumonia, Viral/drug therapy ; Pyrimidines/biosynthesis ; SARS-CoV-2 ; Toluidines/therapeutic use ; Virus Replication
    Chemical Substances Antiviral Agents ; Biphenyl Compounds ; Crotonates ; Enzyme Inhibitors ; Pyrimidines ; Toluidines ; teriflunomide (1C058IKG3B) ; brequinar (5XL19F49H6) ; Oxidoreductases Acting on CH-CH Group Donors (EC 1.3.-) ; dihydroorotate dehydrogenase (EC 1.3.5.2) ; Leflunomide (G162GK9U4W)
    Keywords covid19
    Language English
    Publishing date 2020-08-16
    Publishing country England
    Document type Editorial
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13366
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 677: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Enrichment of medium-quality colostrum by adding colostrum replacer, combined or not with transition milk in the feeding of dairy calves.

    Silva, Ana Paula / Cezar, Amanda M / de Toledo, Ariany F / Coelho, Marina G / Tomaluski, Cristiane R / Virgínio Júnior, Gercino F / Bittar, Carla M M

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5533

    Abstract: Fifty Holstein calves were allocated in randomized blocks and distributed in a 2 × 2 factorial arrangement; (A) two sources of Ig: (1) Control: bovine colostrum (25% Brix); (2) Enriched colostrum: mid-quality bovine colostrum (20% Brix) enriched with ... ...

    Abstract Fifty Holstein calves were allocated in randomized blocks and distributed in a 2 × 2 factorial arrangement; (A) two sources of Ig: (1) Control: bovine colostrum (25% Brix); (2) Enriched colostrum: mid-quality bovine colostrum (20% Brix) enriched with colostrum replacer to 25% Brix; and (B) two transition feeding diets: (1) Whole milk (WM): supply of 4 L/day of whole milk for 3 days after the colostrum feeding; and (2) Formulated transition milk (FTM): supply 4 L/day of whole milk enriched with 70 g/L of colostrum replacer for 3 days after the colostrum feeding. Blood samples were collected at 0, 24, 48, and 72 h of age to determine total serum protein (TSP), glucose, non-esterified fatty acids (NEFA), erythrocyte and leukocyte concentrations. IgG was measured at 48 h. During the preweaning period, calves received 6 L/day of whole milk. Blood samples were collected weekly to determine TSP, glucose, and lactate. The colostrum protocols were equally efficient for transfer of passive immunity with IgG concentration at 48 h ≥ 49.6 g/L. Colostrum or transition feeding program did not influence the erythrocyte and leukocyte concentrations. The TSP concentration measured until 72 h was higher for calves fed maternal colostrum. Calves fed milk in the transition period had higher glucose concentrations. Calves receiving bovine colostrum and FTM had higher glucose concentrations in the preweaning period, while the enriched colostrum decreased plasma lactate concentrations. In summary, enrichment of mid-quality colostrum is an alternative in situations of a shortage of high-quality colostrum; however, feeding 4 L/day of FTM only for 3 days after colostrum feeding does not show additional benefits.
    MeSH term(s) Animals ; Cattle ; Female ; Pregnancy ; Milk ; Colostrum ; Glucose ; Lactic Acid ; Immunoglobulin G
    Chemical Substances Glucose (IY9XDZ35W2) ; Lactic Acid (33X04XA5AT) ; Immunoglobulin G
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55757-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Conference proceedings: NRF2 as a therapeutic target in early and intermediate AMD

    Falcão, Ana Sofia / Pedro, M. / Miguel, V. / Coelho, R. / Tenreiro, S. / Seabra, M.

    2023  , Page(s) 23amd09

    Event/congress 8th International Symposium on Age-related Macular Degeneration: Understanding pathogenetic mechanism – towards clinical translation; Baden-Baden; German Society of Ophthalmology; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-09-07
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23amd09
    Database German Medical Science

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  9. Article: Morphologic and Genetic Analysis of

    Lopes, Carolina / Santos-Silva, Sérgio / Nunes, Carolina / Mendes, Susana / Costa, Catarina / Brazio, Erica / Coutinho, Teresa / Rodrigues, Filipa Teixeira / Mesquita, João R / Coelho, Ana Cláudia / Cardoso, Luís / Lopes, Ana Patrícia

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 5

    Abstract: The long-eared owl ( ...

    Abstract The long-eared owl (
    Language English
    Publishing date 2023-05-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12050717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Epileptic seizure or parasomnia? From knowledge to recognition. Sleep-related hypermotor epilepsy.

    Cristóvão Ferreira, Ana / Moniz Dionísio, Joana / Ferreira, Rosário / Coelho, Joana

    Anales de pediatria

    2024  

    Language English
    Publishing date 2024-04-12
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2830901-7
    ISSN 2341-2879 ; 2341-2879
    ISSN (online) 2341-2879
    ISSN 2341-2879
    DOI 10.1016/j.anpede.2023.12.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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