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Article ; Online: The authors reply: Re: Yamamoto R, Sugiura T, Ashida R, Ohgi K, Yamada M, Otsuka S, and Uesaka K. Prognostic value of carbohydrate antigen 19-9 and the surgical margin in extrahepatic Cholangiocarcinoma.

Yamamoto, Ryusei / Sugiura, Teiichi / Ashida, Ryo / Ohgi, Katsuhisa / Yamada, Mihoko / Otsuka, Shimpei / Uesaka, Katsuhiko

Annals of gastroenterological surgery

2023 Volume 7, Issue 3, Page(s) 535–536

Abstract: The specific growth rate of the perioperative carbohydrate antigen 19-9 values was not related to the prognosis of extrahepatic cholangiocarcinoma. ...

Abstract	The specific growth rate of the perioperative carbohydrate antigen 19-9 values was not related to the prognosis of extrahepatic cholangiocarcinoma.
Language	English
Publishing date	2023-02-21
Publishing country	Japan
Document type	Journal Article
ISSN	2475-0328
ISSN (online)	2475-0328
DOI	10.1002/ags3.12667
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Article ; Online: A 62 m K-ion aqueous electrolyte

Seongjae Ko / Yuki Yamada / Atsuo Yamada

Electrochemistry Communications, Vol 116, Iss , Pp 106764- (2020)

2020

Abstract: ... a 61.7 m K-ion aqueous electrolyte composed of KN(SO2F)2 (KFSI) and KSO3CF3 (KOTf). The pioneered ... To achieve higher voltage, even higher alkali-ion molalities are being pursuit up to 55.5 mol kg−1 (m ... beyond-monohydrate realm is unique to K-ion systems, in which [FSI]− anion is stable to hydrolysis. The K-ion ...

Abstract	Concentrated aqueous electrolytes have been widely explored for high-voltage aqueous batteries. To achieve higher voltage, even higher alkali-ion molalities are being pursuit up to 55.5 mol kg−1 (m) that corresponds to monohydrate, but the sacrificially lowered ionic conductivity is problematic. Here we report a 61.7 m K-ion aqueous electrolyte composed of KN(SO2F)2 (KFSI) and KSO3CF3 (KOTf). The pioneered beyond-monohydrate realm is unique to K-ion systems, in which [FSI]− anion is stable to hydrolysis. The K-ion electrolyte has two-order higher ionic conductivity (12 mS cm−1 at 30 °C) than a comparable 55.5 m Li-ion system (0.1 mS cm−1) while exhibiting a 2.7 V potential window on Pt being among the widest in all alkali-ion aqueous electrolytes. This work suggests the superior overall performance of aqueous K-ion batteries over other alkali-ion batteries.
Keywords	Aqueous batteries ; Electrolytes ; Hydrate melts ; Potential window ; Potassium ; Industrial electrochemistry ; TP250-261 ; Chemistry ; QD1-999
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article: [Neuropathology of Disorders Leading to Dementia].

Sakai, Kenji / Yamada, Masahito

Brain and nerve = Shinkei kenkyu no shinpo

2024 Volume 76, Issue 4, Page(s) 333–342

Abstract: Dementia is characterized by acquired cognitive dysfunction caused by various neurological disorders. Many neurological conditions can cause dementia, including neurodegenerative diseases, vascular disorders, infections, inflammation, demyelination, ... ...

Abstract	Dementia is characterized by acquired cognitive dysfunction caused by various neurological disorders. Many neurological conditions can cause dementia, including neurodegenerative diseases, vascular disorders, infections, inflammation, demyelination, intoxication, metabolic disorders, tumors, and head trauma. Despite recent developments in biomarkers and imaging techniques, neuropathological examination is necessary for the final diagnosis. Moreover, approximately 11% of the patients with dementia have dual or triple pathological conditions. The coexistence of neurological diseases makes it difficult for neurologists to diagnose patients accurately. Degenerative diseases are characterized by neuronal loss with gliosis in distinct parts of the brain, the presence of neuronal or glial inclusions, and abnormal protein accumulation. Senile plaques and neurofibrillary tangles are neuropathological hallmarks of Alzheimer's disease. These findings are characterized by the presence of amyloid β protein (Aβ) and phosphorylated tau protein, respectively. Although vascular dementia is common, it may be difficult to identify the relationship between vascular lesions and cognitive impairment. The incidence of sporadic Aβ-type cerebral amyloid angiopathy (CAA) tends to increase with age and causes dementia due to vascular dysfunction and leukoencephalopathy. Furthermore, patients with CAA can develop inflammation. Clinical neurologists should possess a neuropathological perspective for the appropriate diagnosis and management of patients with dementia.
MeSH term(s)	Humans ; Amyloid beta-Peptides ; Alzheimer Disease/pathology ; Cerebral Amyloid Angiopathy/pathology ; Brain/pathology ; Inflammation
Chemical Substances	Amyloid beta-Peptides
Language	Japanese
Publishing date	2024-04-08
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	390389-8
ISSN	1344-8129 ; 1881-6096 ; 0006-8969
ISSN (online)	1344-8129
ISSN	1881-6096 ; 0006-8969
DOI	10.11477/mf.1416202610
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Article: Concanavalin A-peroxidase-diaminobenzidine-periodic acid-m-aminophenol-fast black salt K: a method for the dual staining of neutral complex carbohydrates.

Yamada, K

The Histochemical journal

1978 Volume 10, Issue 5, Page(s) 573–584

Abstract: ... m-aminophenol-Fast Black salt K (PA-AP-FBK) sequence. With the combined method it is possible ...

Abstract	A method has been developed for the dual staining of neutral complex carbohydrates in light microscopy. It combines a concanavalin A-peroxidase-diaminobenzidine (Con A-PO-DAB) method with a period acid-m-aminophenol-Fast Black salt K (PA-AP-FBK) sequence. With the combined method it is possible to stain alpha-D-glycosyl and alpha-D-mannosyl residues brown and 1,2-glycol groups of neutral complex carbohydrates blackish purple. The validity of the method has been confirmed with appropriate histochemical controls and enzyme digestions on test tissues.
MeSH term(s)	3,3'-Diaminobenzidine ; Aminophenols ; Animals ; Carbohydrates/analysis ; Cattle ; Coloring Agents ; Concanavalin A ; Dogs ; Histocytochemistry ; Horseradish Peroxidase ; Humans ; Mice ; Organ Specificity ; Periodic Acid ; Rabbits ; Rats ; Staining and Labeling/methods
Chemical Substances	Aminophenols ; Carbohydrates ; Coloring Agents ; Periodic Acid (10450-60-9) ; Concanavalin A (11028-71-0) ; 3,3'-Diaminobenzidine (2RV4T6KHQI) ; Horseradish Peroxidase (EC 1.11.1.-)
Language	English
Publishing date	1978-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	218207-5
ISSN	1573-6865 ; 0018-2214
ISSN (online)	1573-6865
ISSN	0018-2214
DOI	10.1007/bf01003138
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Zs.A 568: Show issues

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Article ; Online: Photoemission Orbital Tomography Using a Robust Sparse PhaseLift.

Niki, K / Asano, R / Sakanoue, R / Hasegawa, A / Yamada, Y / Hagiwara, M / Mimura, K

The journal of physical chemistry. A

2024 Volume 128, Issue 13, Page(s) 2672–2679

Abstract: Photoemission orbital tomography (POT) from photoelectron momentum maps (PMMs) is a powerful technique that visualizes the shape of the molecular orbitals (MOs) of molecular films. For further utilization of POT, a simple and low-cost method of POT is ... ...

Abstract	Photoemission orbital tomography (POT) from photoelectron momentum maps (PMMs) is a powerful technique that visualizes the shape of the molecular orbitals (MOs) of molecular films. For further utilization of POT, a simple and low-cost method of POT is highly required. Here, we propose a new POT method based on the PhaseLift algorithm (PhaseLift POT). This method utilizes a lifting procedure to convert the PMM, which is a second-order polynomial of MO coefficients, into a first-order polynomial of the lifted MO coefficients and further relaxes the equality constraint for a given PMM. We also established a method to improve the accuracy of phase retrieval from the noisy PMM data by using sparsity for MO coefficients (sparse PhaseLift POT). These methods make it possible to reconstruct the three-dimensional MOs, including phases of the wave function, directly from a single experimental PMM. This method can also precisely determine the adsorption-induced molecular deformations with an accuracy of 0.05 [Å]. Furthermore, the robust sparse PhaseLift POT is robust against unavoidable noise in the experimental PMMs due to the relaxation of the matching condition for a given PMM. Therefore, this will be an innovative tool for POT, especially for analyzing the dynamics of the molecules during the chemical reaction and excitation processes.
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.3c06506
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Article ; Online: Response to Letter to the Editor Concerning "Risk factors for Postoperative Unfavorable Ambulatory Status after Spinal Surgery for Metastatic Spinal Tumor".

Yamada, Kentaro / Yoshii, Toshitaka / Toba, Mikayo / Fushimi, Kiyohide

Spine

2024

Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	752024-4
ISSN	1528-1159 ; 0362-2436
ISSN (online)	1528-1159
ISSN	0362-2436
DOI	10.1097/BRS.0000000000004947
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Zs.A 1305: Show issues

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Article ; Online: Estimated number of spine surgeries and related deaths in Japan from 2014 to 2020.

Nagata, Kosei / Chang, Chang / Nishizawa, Mitsuhiro / Yamada, Koji

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

2024

Abstract: ... number of surgeries was counted using K codes, a procedure classification unique to Japan, and classified ...

Abstract	Background: The total number of spine surgeries per year and their related deaths in Japan has not been adequately estimated in the literature. Methods: We retrospectively reviewed the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) between April 2014 to March 2021, which covers 99.9 % of health insurance claim receipts by general practitioners. The annual number of surgeries was counted using K codes, a procedure classification unique to Japan, and classified into the following six categories; percutaneous vertebroplasty, endoscopic surgery, open discectomy, laminoplasty/laminectomy, instrumentation surgery, and others. The data distribution was also summarized by sex and age. Additionally, by reviewing DPC database-related papers for evaluation of the mortality rate after spine surgery in Japan, the number of spine surgery-related deaths was calculated. Results: The NDB showed that the number of spine surgeries analyzed in this study increased from 170,081 in 2014 to 193,903 in 2019, with a slight decrease in 2020. The ratio of instrumentation surgery increased from 33.0 % in 2014 to 37.9 % in 2020. The rate of patients aged 75 or older increased 31.6 % to 39.6 %. Combining these findings with DPC data showing a mortality rate of 0.1 % to 0.4 % revealed that the estimated number of deaths related to spine surgery in Japan ranged from 200 to 800 per year. Conclusions: Approximately 200,000 spine surgeries and 200 to 800 spine surgery-related inpatient deaths were estimated to have occurred in Japan around 2020.
Language	English
Publishing date	2024-01-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1314243-4
ISSN	1436-2023 ; 0949-2658
ISSN (online)	1436-2023
ISSN	0949-2658
DOI	10.1016/j.jos.2023.12.006
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Zs.A 4484: Show issues

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Article ; Online: Risk of severe COVID-19 in unvaccinated patients during the period from wild-type to Omicron variant: real-world evidence from Japan.

Tomioka, Kimiko / Uno, Kenji / Yamada, Masahiro

Environmental health and preventive medicine

2024 Volume 29, Page(s) 10

Abstract: Background: Many studies have reported that the Omicron variant is less pathogenic than the Delta variant and the wild-type. Epidemiological evidence regarding the risk of severe COVID-19 from the wild-type to the Omicron variant has been lacking.: ... ...

Abstract	Background: Many studies have reported that the Omicron variant is less pathogenic than the Delta variant and the wild-type. Epidemiological evidence regarding the risk of severe COVID-19 from the wild-type to the Omicron variant has been lacking. Methods: Study participants were COVID-19 patients aged 18 and older without previous COVID-19 infection who were notified to the Nara Prefecture Chuwa Public Health Center from January 2020 to March 2023, during the periods from the wild-type to the Omicron variant. The outcome variable was severe COVID-19 (i.e., ICU admission or COVID-19-related death). The explanatory variable was SARS-CoV-2 variant type or the number of COVID-19 vaccinations. Covariates included gender, age, risk factors for aggravation, and the number of general hospital beds per population. The generalized estimating equations of negative binomial regression models were used to estimate the adjusted incidence proportion (AIP) with 95% confidence interval (CI) for severe COVID-19. Results: Among 77,044 patients included in the analysis, 14,556 (18.9%) were unvaccinated and 520 (0.7%) developed severe COVID-19. Among unvaccinated patients, the risk of severe COVID-19 increased in the Alpha/Delta variants and decreased in the Omicron variant compared to the wild-type (AIP [95% CI] was 1.55 [1.06-2.27] in Alpha/Delta and 0.25 [0.15-0.40] in Omicron), but differed by age. Especially in patients aged ≥80, there was no significant difference in the risk of severe COVID-19 between the wild-type and the Omicron variant (AIP [95% CI] = 0.59 [0.27-1.29]). Regarding the preventive effect of vaccines, among all study participants, the number of vaccinations was significantly associated with the prevention of severe COVID-19, regardless of variant type. After stratified analyses by age, patients aged ≥80 remained a significant association for all variant types. On the other hand, the number of vaccinations had no association in Omicron BA.5 of patients aged 18-64. Conclusions: Patients aged ≥80 had less reduction in risk of severe COVID-19 during the Omicron variant period, and a greater preventive effect of vaccines against severe COVID-19, compared to younger people. Our findings suggest that booster vaccination is effective and necessary for older people, especially aged ≥80.
MeSH term(s)	Humans ; Aged ; SARS-CoV-2/genetics ; COVID-19/epidemiology ; Japan/epidemiology ; Vaccines
Chemical Substances	Vaccines
Language	English
Publishing date	2024-03-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2018758-0
ISSN	1347-4715 ; 1342-078X
ISSN (online)	1347-4715
ISSN	1342-078X
DOI	10.1265/ehpm.23-00274
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Zs.A 5232: Show issues

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Article ; Online: Enhanced social motivation in briefly isolated male rats.

Toyoshima, Michimasa / Yamada, Kazuo

IBRO neuroscience reports

2023 Volume 15, Page(s) 203–208

Abstract: Loneliness and anxiety are associated with psychiatric disorders in humans. Although brief social isolation in adult rats and mice has been proposed as a rodent model of loneliness, its socioemotional characteristics are not well known. In this study, we ...

Abstract	Loneliness and anxiety are associated with psychiatric disorders in humans. Although brief social isolation in adult rats and mice has been proposed as a rodent model of loneliness, its socioemotional characteristics are not well known. In this study, we evaluated the social and emotional behaviors of adult male rats subjected to brief social isolation. Isolated rats frequently showed sniffing behavior toward empty cylinders where conspecifics had previously existed, as well as conspecifics themselves. Furthermore, social motivation correlated with anxiety levels, as indicated by the elevated plus-maze test performance in isolated but not in non-isolated rats. These results suggest that high social motivation is associated with anxiety in briefly isolated rats.
Language	English
Publishing date	2023-09-11
Publishing country	Netherlands
Document type	Journal Article
ISSN	2667-2421
ISSN (online)	2667-2421
DOI	10.1016/j.ibneur.2023.08.2195
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Article ; Online: A simulation study on model-informed precision dosing of amikacin for achieving target area under the concentration-time curve.

Yamada, Tomoyuki / Oda, Kazutaka / Nishihara, Masami / Neo, Masashi

British journal of clinical pharmacology

2024 Volume 90, Issue 4, Page(s) 1173–1182

Abstract: Aims: Amikacin requires therapeutic drug monitoring for optimum efficacy; however, the optimal model-informed precision dosing strategy for the area under the concentration-time curve (AUC) of amikacin is uncertain. This simulation study aimed to ... ...

Abstract	Aims: Amikacin requires therapeutic drug monitoring for optimum efficacy; however, the optimal model-informed precision dosing strategy for the area under the concentration-time curve (AUC) of amikacin is uncertain. This simulation study aimed to determine the efficient blood sampling points using the Bayesian forecasting approach for early achievement of the target AUC range for amikacin in critically ill patients. Methods: We generated a virtual population of 3000 individuals using 2 validated population pharmacokinetic models identified using a systematic literature search. AUC for each blood sampling point was evaluated using the probability of achieving a ratio of estimated/reference AUC at steady state in the 0.8-1.2 range. Results: On day 1, the 1-point samplings for population pharmacokinetic models showed a priori probabilities of 26.3 and 45.6%, which increased to 47.3 and 94.4% at 23 and 15 h, respectively. Using 2-point sampling at the peak (3 and 4 h) and trough (24 h) on day 1, these probabilities further increased to 72.3 and 99.5%, respectively. These probabilities were comparable on days 2 and 3, regardless of 3 and 6 sampling points or estimated glomerular filtration rate. These results indicated the higher predictive accuracy of 2-point sampling than 1-point sampling on day 1 for amikacin AUC estimation. Moreover, 2-point sampling was a more reasonable approach than rich sampling. Conclusions: This study contributes to the development of an efficient model-informed precision dosing strategy for early targeting of amikacin AUC in critically ill patients.
MeSH term(s)	Humans ; Amikacin/pharmacokinetics ; Amikacin/therapeutic use ; Bayes Theorem ; Critical Illness/therapy ; Computer Simulation ; Time Factors ; Area Under Curve ; Anti-Bacterial Agents
Chemical Substances	Amikacin (84319SGC3C) ; Anti-Bacterial Agents
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.16002
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