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  1. Article ; Online: Invited Perspective: The Slow Road to Finding Out Whether the "Forever" Chemicals Cause Chronic Disease.

    Steenland, Kyle

    Environmental health perspectives

    2023  Volume 131, Issue 7, Page(s) 71305

    MeSH term(s) Humans ; Chronic Disease
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    DOI 10.1289/EHP13212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1360: Show issues Location:
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  2. Article ; Online: Perfluorooctanoic Acid (PFOA) Exposure and Abnormal Alanine Aminotransferase: Using Clinical Consensus Cutoffs Compared to Statistical Cutoffs for Abnormal Values.

    Ducatman, Alan / Tan, Youran / Nadeau, Brian / Steenland, Kyle

    Toxics

    2023  Volume 11, Issue 5

    Abstract: Background: Per- and polyfluoroalkyl substances (PFASs) including perfluorooctanoic acid (PFOA) are ubiquitous environmental contaminants. Prior analysis in the large "C8 Health Project" population defined abnormal alanine aminotransferase (ALT) with ... ...

    Abstract Background: Per- and polyfluoroalkyl substances (PFASs) including perfluorooctanoic acid (PFOA) are ubiquitous environmental contaminants. Prior analysis in the large "C8 Health Project" population defined abnormal alanine aminotransferase (ALT) with statistically derived cutoffs (>45 IU/L in men, >34 IU/L in women).
    Objective: To explore the degree to which PFOA was associated with modern, clinically predictive ALT biomarker cutoffs in obese and nonobese participants, excluding those with diagnosed liver disease.
    Methods: We reevaluated the relationship of serum PFOA to abnormal ALT using predictive cutoff recommendations including those of the American College of Gastroenterology (ACG). Evaluations modeled lifetime cumulative exposure and measured internal PFOA exposure.
    Results: ACG cutoff values (≥34 IU/L for males, ≥25 IU/L for females) classified 30% of males (3815/12,672) and 21% of females (3359/15,788) above ALT cutoff values. Odds ratios (OR) for above cutoff values were consistently associated with modeled cumulative and measured serum PFOA. Linear trends were highly significant. ORs by quintile showed near monotonic increases. Trends were stronger for the overweight and obese. However, all weight classes were affected.
    Conclusion: Predictive cutoffs increase the OR for abnormal ALT results. Obesity increases ORs, yet association with abnormal ALT pertains to all weight classes. The results are discussed in context of current knowledge about the health implications of PFOA hepatotoxicity.
    Language English
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11050449
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  3. Article ; Online: Excess deaths due to occupation.

    Steenland, Kyle

    Occupational and environmental medicine

    2016  Volume 73, Issue 8, Page(s) 497–498

    Language English
    Publishing date 2016-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1180733-7
    ISSN 1470-7926 ; 1351-0711
    ISSN (online) 1470-7926
    ISSN 1351-0711
    DOI 10.1136/oemed-2016-103743
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    In stock of ZB MED Cologne/Königswinter

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  4. Book: Topics in environmental epidemiology

    Steenland, Kyle

    1997  

    Author's details ed. by Kyle Steenland
    Keywords Environmental Exposure / adverse effects ; Epidemiologic Factors ; Epidemiologic Methods ; Environmental Pollutants / adverse effects ; Umweltkrankheit ; Epidemiologie
    Subject Krankheitsverbreitung ; Umweltbedingte Krankheit
    Language English
    Size XII, 363 S. : graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT008008367
    ISBN 0-19-509564-2 ; 978-0-19-509564-7
    Database Catalogue ZB MED Medicine, Health

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    1997 A 8969 order for loan Magazin

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  5. Article: PFAS and cancer, a scoping review of the epidemiologic evidence

    Steenland, Kyle / Winquist, Andrea

    Environmental research. 2021 Mar., v. 194

    2021  

    Abstract: The number of studies addressing per- and polyfluoroalkyl substances (PFAS) and cancer is increasing. Many communities have had water contaminated by PFAS, and cancer is one of the important community concerns related to PFAS exposure.We critically ... ...

    Abstract The number of studies addressing per- and polyfluoroalkyl substances (PFAS) and cancer is increasing. Many communities have had water contaminated by PFAS, and cancer is one of the important community concerns related to PFAS exposure.We critically reviewed the evidence relating to PFAS and cancer from an epidemiologic standpoint to highlight directions for future research that would be the most likely to meaningfully increase knowledge.We conducted a search in PubMed for studies of cancer and PFAS (through 9/20/2020). We identified epidemiologic studies that provided a quantitative estimate for some measure of the association between PFAS and cancer. Here, we review that literature, including several aspects of epidemiologic study design that impact the usefulness of study results.We identified 16 cohort (or case-cohort) studies, 10 case-control studies (4 nested within cohorts and 6 non-nested), 1 cross sectional study and 1 ecologic study. The cancer sites with the most evidence of an association with PFAS are testicular and kidney cancer. There are also some suggestions in a few studies of an association with prostate cancer, but the data are inconsistent.Each study's design has strengths and limitations. Weaknesses in study design and methods can, in some cases, lead to questionable associations, but in other cases can make it more difficult to detect true associations, if they are present. Overall, the evidence for an association between cancer and PFAS remains sparse. A variety of studies with different strengths and weaknesses can be helpful to clarify associations between PFAS and cancer. Long term follow-up of large-sized cohorts with large exposure contrasts are most likely to be informative.
    Keywords cross-sectional studies ; ecological studies ; experimental design ; kidney neoplasms ; prostatic neoplasms ; research ; testes
    Language English
    Dates of publication 2021-03
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2020.110690
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
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  6. Book: Case studies in occupational epidemiology

    Steenland, Kyle

    1993  

    Author's details ed. by Kyle Steenland
    Keywords Epidemiologic Methods / problems ; Occupational Diseases / epidemiology / problems
    Language English
    Size VIII, 208 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Pr
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT004950504
    ISBN 0-19-506831-9 ; 978-0-19-506831-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1993 A 2916 order for loan Magazin

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  7. Article ; Online: PFAS and cancer, a scoping review of the epidemiologic evidence.

    Steenland, Kyle / Winquist, Andrea

    Environmental research

    2020  Volume 194, Page(s) 110690

    Abstract: Background: The number of studies addressing per- and polyfluoroalkyl substances (PFAS) and cancer is increasing. Many communities have had water contaminated by PFAS, and cancer is one of the important community concerns related to PFAS exposure.: ... ...

    Abstract Background: The number of studies addressing per- and polyfluoroalkyl substances (PFAS) and cancer is increasing. Many communities have had water contaminated by PFAS, and cancer is one of the important community concerns related to PFAS exposure.
    Objectives: We critically reviewed the evidence relating to PFAS and cancer from an epidemiologic standpoint to highlight directions for future research that would be the most likely to meaningfully increase knowledge.
    Methods: We conducted a search in PubMed for studies of cancer and PFAS (through 9/20/2020). We identified epidemiologic studies that provided a quantitative estimate for some measure of the association between PFAS and cancer. Here, we review that literature, including several aspects of epidemiologic study design that impact the usefulness of study results.
    Results: We identified 16 cohort (or case-cohort) studies, 10 case-control studies (4 nested within cohorts and 6 non-nested), 1 cross sectional study and 1 ecologic study. The cancer sites with the most evidence of an association with PFAS are testicular and kidney cancer. There are also some suggestions in a few studies of an association with prostate cancer, but the data are inconsistent.
    Discussion: Each study's design has strengths and limitations. Weaknesses in study design and methods can, in some cases, lead to questionable associations, but in other cases can make it more difficult to detect true associations, if they are present. Overall, the evidence for an association between cancer and PFAS remains sparse. A variety of studies with different strengths and weaknesses can be helpful to clarify associations between PFAS and cancer. Long term follow-up of large-sized cohorts with large exposure contrasts are most likely to be informative.
    MeSH term(s) Alkanesulfonic Acids ; Case-Control Studies ; Cross-Sectional Studies ; Environmental Pollutants ; Fluorocarbons/analysis ; Humans ; Kidney Neoplasms ; Male ; Water
    Chemical Substances Alkanesulfonic Acids ; Environmental Pollutants ; Fluorocarbons ; Water (059QF0KO0R)
    Language English
    Publishing date 2020-12-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2020.110690
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Chronic renal disease among lead-exposed workers.

    Steenland, Kyle / Barry, Vaughn

    Occupational and environmental medicine

    2020  Volume 77, Issue 6, Page(s) 415–417

    Abstract: Background: Very high exposure to inorganic lead causes serious kidney damage. We have studied workers with occupational exposure and data on blood lead.: Methods: We extended follow-up for 7 more years, for a previously studied cohort of 58 307 male ...

    Abstract Background: Very high exposure to inorganic lead causes serious kidney damage. We have studied workers with occupational exposure and data on blood lead.
    Methods: We extended follow-up for 7 more years, for a previously studied cohort of 58 307 male workers who were part of a surveillance programme in 11 different states. Mortality was assessed using the National Death Index, and end-stage renal disease (ESRD) incidence was assessed using the US Renal Data System. We conducted internal analyses via Cox regression adjusting for age, calendar time and race.
    Results: The cohort was followed for a median of 18 years and had 524 cases of ESRD and 6527 deaths. Average maximum blood lead was 26 µg/dL; the mean year of first blood lead test was 1997. No trends by lead level were seen overall or when restricting to those with 15+ years follow-up. Among non-Caucasians with >15 years of follow-up, there was a positive but inconsistent trend (Rate ratios (RRs) 1.00, 2.10, 1.33, 2.20 and 2.76 for maximum blood lead categories of <20 µg/dL, 20-29 µg/dL, 30 to <40 µg/dL, 40 to ≤50 µg/dL and >50 µg/dL, respectively (p for linear trend 0.26). Those with >15 years of follow-up and birth year <1941 showed a positive trend with increased blood lead (RRs 1.00, 1.14, 1.18, 1.46, 1.66, p trend=0.26).
    Conclusions: We found no association between higher lead exposure and ESRD. There were positive but not statistically significant trends of increased risk for non-Caucasians with >15 years of follow-up and for older men with >15 years of follow-up.
    MeSH term(s) Adolescent ; Adult ; Aged ; Follow-Up Studies ; Humans ; Lead/adverse effects ; Lead/blood ; Male ; Middle Aged ; National Institute for Occupational Safety and Health, U.S. ; Occupational Diseases/chemically induced ; Occupational Diseases/epidemiology ; Occupational Exposure/adverse effects ; Occupational Exposure/analysis ; Renal Insufficiency, Chronic/chemically induced ; Renal Insufficiency, Chronic/epidemiology ; United States/epidemiology ; Young Adult
    Chemical Substances Lead (2P299V784P)
    Language English
    Publishing date 2020-03-22
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1180733-7
    ISSN 1470-7926 ; 1351-0711
    ISSN (online) 1470-7926
    ISSN 1351-0711
    DOI 10.1136/oemed-2019-106363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effect modification by maximum temperature of the association between PM

    Steenland, Kyle / Vu, Bryan / Scovronick, Noah

    Journal of exposure science & environmental epidemiology

    2021  Volume 32, Issue 4, Page(s) 590–595

    Abstract: Background: The health effects of fine particulate matter (PM: Objective: To investigate temperature's effect on PM: Methods: Time-series regressions relating PM: Results: The average PM: Significance: Results strengthen the evidence that ... ...

    Abstract Background: The health effects of fine particulate matter (PM
    Objective: To investigate temperature's effect on PM
    Methods: Time-series regressions relating PM
    Results: The average PM
    Significance: Results strengthen the evidence that air pollution may be more dangerous when temperatures are higher.
    Impact: Our data contribute to a growing body of literature which indicates that the damaging effects of PM
    MeSH term(s) Air Pollutants/adverse effects ; Air Pollutants/analysis ; Air Pollution/adverse effects ; Air Pollution/analysis ; Cardiovascular Diseases ; Emergency Service, Hospital ; Humans ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Peru/epidemiology ; Temperature
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2021-10-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2218551-3
    ISSN 1559-064X ; 1559-0631
    ISSN (online) 1559-064X
    ISSN 1559-0631
    DOI 10.1038/s41370-021-00393-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Marginal structural models to control for time-varying confounding in occupational and environmental epidemiology.

    Steenland, Kyle

    Occupational and environmental medicine

    2013  Volume 70, Issue 9, Page(s) 601–602

    MeSH term(s) Asthma, Occupational/epidemiology ; Asthma, Occupational/etiology ; Female ; Humans ; Male ; Occupational Exposure/adverse effects ; Occupations
    Language English
    Publishing date 2013-09
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 1180733-7
    ISSN 1470-7926 ; 1351-0711
    ISSN (online) 1470-7926
    ISSN 1351-0711
    DOI 10.1136/oemed-2013-101629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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