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Book ; Conference proceedings: New perspectives on Mary Elizabeth Braddon

Cox, Jessica

(DQR studies in literature ; 50)

2012

Event/congress	Symposium on Braddon (2006.04.22, Swansea)
Author's details	ed. by Jessica Cox
Series title	DQR studies in literature ; 50
Keywords	Domestic fiction, English/History and criticism ; Sensationalism in literature
Language	English
Size	282 S.
Publisher	Rodopi
Publishing place	Amsterdam u.a.
Document type	Book ; Conference proceedings
ISBN	9789042035799 ; 9789401208543 ; 904203579X ; 9401208549
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Heterologous Expression of Secondary Metabolite Genes in

Shenouda, Mary L / Ambilika, Maria / Skellam, Elizabeth / Cox, Russell J

Journal of fungi (Basel, Switzerland)

2022 Volume 8, Issue 4

Abstract: Trichoderma ... ...

Abstract	Trichoderma reesei
Language	English
Publishing date	2022-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof8040355
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Article ; Online: Heterologous Expression of Secondary Metabolite Genes in Trichoderma reesei for Waste Valorization

Mary L. Shenouda / Maria Ambilika / Elizabeth Skellam / Russell J. Cox

Journal of Fungi, Vol 8, Iss 4, p

2022 Volume 355

Abstract: Trichoderma reesei ( Hypocrea jecorina ) was developed as a microbial cell factory for the heterologous expression of fungal secondary metabolites. This was achieved by inactivation of sorbicillinoid biosynthesis and construction of vectors for the rapid ...

Abstract	Trichoderma reesei ( Hypocrea jecorina ) was developed as a microbial cell factory for the heterologous expression of fungal secondary metabolites. This was achieved by inactivation of sorbicillinoid biosynthesis and construction of vectors for the rapid cloning and expression of heterologous fungal biosynthetic genes. Two types of megasynth(et)ases were used to test the strain and vectors, namely a non-reducing polyketide synthase (nr-PKS, aspks1 ) from Acremonium strictum and a hybrid highly-reducing PKS non-ribosomal peptide synthetase (hr-PKS-NRPS, tenS + tenC ) from Beauveria bassiana . The resulting engineered T. reesei strains were able to produce the expected natural products 3-methylorcinaldehyde and pretenellin A on waste materials including potato, orange, banana and kiwi peels and barley straw. Developing T. reesei as a heterologous host for secondary metabolite production represents a new method for waste valorization by the direct conversion of waste biomass into secondary metabolites.
Keywords	heterologous expression ; PKS-NRPS ; PKS ; waste valorization ; microbial cell factory ; Trichoderma reesei ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Alcohol testing and alcohol involvement among violent deaths by state, 2014-2016.

Greene, Naomi / Tomedi, Laura E / Cox, Mary E / Mello, Elizabeth / Esser, Marissa B

Preventive medicine

2021 Volume 148, Page(s) 106527

Abstract: Blood alcohol concentration (BAC) testing rates vary across states, potentially biasing estimates of alcohol involvement in violent deaths. The National Violent Death Reporting System (NVDRS) collects information on violent deaths, including decedents' ... ...

Abstract	Blood alcohol concentration (BAC) testing rates vary across states, potentially biasing estimates of alcohol involvement in violent deaths. The National Violent Death Reporting System (NVDRS) collects information on violent deaths, including decedents' BACs. This study assessed characteristics of violent deaths by BAC testing status, and the proportion of decedents with a positive BAC or BAC ≥ 0.08 g/dL. NVDRS data from 2014 to 2016 (2014: 18 states; 2015: 27 states; 2016: 32 states) were analyzed to assess BAC testing (tested, not tested, unknown/missing) by state, decedent characteristics, and death investigation system (e.g., state medical examiner, coroners), in 2019. The proportion of violent deaths with a BAC > 0.0 or ≥ 0.08 g/dL was also assessed. Among 95,390 violent death decedents, 57.1% had a BAC test (range: 9.5% in Georgia to 95.8% in Utah), 2.3% were not tested, and 40.6% had an unknown/missing BAC testing status (range: 1.3% in Alaska to 78.0% in Georgia). Decedents who were 21-44 years, American Indian/Alaska Native or Hispanic, died by poisoning, died by undetermined intent, or were investigated by a state medical examiner were most likely to receive BAC testing. Among the violent deaths with a reported BAC, 41.1% had a positive BAC and 27.7% had a BAC ≥ 0.08 g/dL. About 2 in 5 violent deaths were missing data on alcohol testing. Increased testing and reporting of alcohol among violent deaths could inform the development and use of evidence-based prevention strategies (e.g., increasing alcohol taxes, regulating alcohol outlet density) for reducing violent deaths.
MeSH term(s)	Blood Alcohol Content ; Cause of Death ; Georgia ; Homicide ; Humans ; Population Surveillance ; Suicide ; United States/epidemiology ; Utah ; Violence
Chemical Substances	Blood Alcohol Content
Language	English
Publishing date	2021-03-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	184600-0
ISSN	1096-0260 ; 0091-7435
ISSN (online)	1096-0260
ISSN	0091-7435
DOI	10.1016/j.ypmed.2021.106527
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Article ; Online: Characterization of a Long-Acting Site-Specific PEGylated Murine GM-CSF Analog and Analysis of Its Hematopoietic Properties in Normal and Cyclophosphamide-Treated Neutropenic Rats.

Cox, George N / Lee, Ji I / Rosendahl, Mary S / Chlipala, Elizabeth A / Doherty, Daniel H

The protein journal

2020 Volume 39, Issue 2, Page(s) 160–173

Abstract: Previously we reported that site-specific modification of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) A3C analog with polyethylene glycol (PEG) dramatically improved the pharmacokinetic properties of the protein in rats. However, ... ...

Abstract	Previously we reported that site-specific modification of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) A3C analog with polyethylene glycol (PEG) dramatically improved the pharmacokinetic properties of the protein in rats. However, we could not evaluate the hematological properties of the PEG-A3C protein in rats because human GM-CSF is inactive in rodents. To study the biological effects of PEGylated GM-CSF analogs in rodents we created a homologous site-specific PEGylated murine (mu) GM-CSF (T3C) protein. muGM-CSF and the T3C protein were expressed in Escherichia coli and purified by column chromatography. The purified T3C protein was covalently modified with a linear 20 kDa- or a branched 40 kDa-maleimide-PEG, and the monoPEGylated proteins purified by column chromatography. muGM-CSF, T3C and the two PEG-T3C proteins had comparable in vitro biological activities, as measured by stimulation of proliferation of the murine FDC-P1 cell line. The PEG-T3C proteins had 10- to 25-fold longer circulating half-lives than muGM-CSF and stimulated greater and longer lasting increases in neutrophils and white blood cells than muGM-CSF following a single intravenous or subcutaneous administration to rats. Treatment of rats made neutropenic with cyclophosphamide with the PEG-T3C proteins shortened the time for recovery of neutrophils to normal levels from 9 or 10 days to 5 or 6 days, whereas muGM-CSF showed no benefit versus vehicle solution. Acceleration of neutrophil recovery in cyclophosphamide-treated rats required a minimum of three PEG-T3C treatments over five days. The PEG-T3C proteins should prove useful for evaluating the potential therapeutic benefits of GM-CSF and long-acting GM-CSF proteins in rodent disease models.
MeSH term(s)	Animals ; Cell Line ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Granulocyte Colony-Stimulating Factor/pharmacokinetics ; Half-Life ; Hematopoiesis/drug effects ; Male ; Neutropenia/drug therapy ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/pharmacokinetics
Chemical Substances	Recombinant Proteins ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Polyethylene Glycols (3WJQ0SDW1A) ; pegylated granulocyte colony-stimulating factor (I4QL0KKG3K)
Language	English
Publishing date	2020-03-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2143071-8
ISSN	1875-8355 ; 1572-3887
ISSN (online)	1875-8355
ISSN	1572-3887
DOI	10.1007/s10930-020-09894-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Transcriptional profiles of pulmonary artery endothelial cells in pulmonary hypertension.

Singh, Navneet / Eickhoff, Carsten / Garcia-Agundez, Augusto / Bertone, Paul / Paudel, Sunita S / Tambe, Dhananjay T / Litzky, Leslie A / Cox-Flaherty, Katherine / Klinger, James R / Monaghan, Sean F / Mullin, Christopher J / Pereira, Mandy / Walsh, Thomas / Whittenhall, Mary / Stevens, Troy / Harrington, Elizabeth O / Ventetuolo, Corey E

Scientific reports

2023 Volume 13, Issue 1, Page(s) 22534

Abstract: Pulmonary arterial hypertension (PAH) is characterized by endothelial cell (EC) dysfunction. There are no data from living patients to inform whether differential gene expression of pulmonary artery ECs (PAECs) can discern disease subtypes, progression ... ...

Abstract	Pulmonary arterial hypertension (PAH) is characterized by endothelial cell (EC) dysfunction. There are no data from living patients to inform whether differential gene expression of pulmonary artery ECs (PAECs) can discern disease subtypes, progression and pathogenesis. We aimed to further validate our previously described method to propagate ECs from right heart catheter (RHC) balloon tips and to perform additional PAEC phenotyping. We performed bulk RNA sequencing of PAECs from RHC balloons. Using unsupervised dimensionality reduction and clustering we compared transcriptional signatures from PAH to controls and other forms of pulmonary hypertension. Select PAEC samples underwent single cell and population growth characterization and anoikis quantification. Fifty-four specimens were analyzed from 49 subjects. The transcriptome appeared stable over limited passages. Six genes involved in sex steroid signaling, metabolism, and oncogenesis were significantly upregulated in PAH subjects as compared to controls. Genes regulating BMP and Wnt signaling, oxidative stress and cellular metabolism were differentially expressed in PAH subjects. Changes in gene expression tracked with clinical events in PAH subjects with serial samples over time. Functional assays demonstrated enhanced replication competency and anoikis resistance. Our findings recapitulate fundamental biological processes of PAH and provide new evidence of a cancer-like phenotype in ECs from the central vasculature of PAH patients. This "cell biopsy" method may provide insight into patient and lung EC heterogeneity to advance precision medicine approaches in PAH.
MeSH term(s)	Humans ; Hypertension, Pulmonary/pathology ; Pulmonary Artery/pathology ; Endothelial Cells/metabolism ; Pulmonary Arterial Hypertension/pathology ; Familial Primary Pulmonary Hypertension/metabolism ; Vascular Diseases/pathology ; Wnt Signaling Pathway/genetics
Language	English
Publishing date	2023-12-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-48077-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Risk vs benefit in diabetes pharmacotherapy: a rational approach to choosing pharmacotherapy in type 2 diabetes.

Cox, Mary Elizabeth / Feinglos, Mark N

Current diabetes reports

2013 Volume 13, Issue 3, Page(s) 319–328

Abstract: Type 2 diabetes now affects more than 1 in 10 US adults and is a leading cause of morbidity, mortality, and healthcare expense. There are increasing numbers of available pharmacotherapies, with established agents as well as newer drugs developed from ... ...

Abstract	Type 2 diabetes now affects more than 1 in 10 US adults and is a leading cause of morbidity, mortality, and healthcare expense. There are increasing numbers of available pharmacotherapies, with established agents as well as newer drugs developed from hormones in the incretin pathway, among others. New data are accumulating continuously with respect to potential benefits of both long-standing and new agents, as well as risks identified through post-marketing surveillance. Here we review the commonly prescribed pharmacotherapy options with attention to recently published information and provide a rational approach to choice of therapy.
MeSH term(s)	Animals ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Glucagon-Like Peptide-1 Receptor ; Humans ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/therapeutic use ; Life Style ; Receptors, Glucagon/agonists ; Receptors, Glucagon/metabolism ; Risk Factors
Chemical Substances	Dipeptidyl-Peptidase IV Inhibitors ; GLP1R protein, human ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; Receptors, Glucagon
Language	English
Publishing date	2013-03-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2065167-3
ISSN	1539-0829 ; 1534-4827
ISSN (online)	1539-0829
ISSN	1534-4827
DOI	10.1007/s11892-013-0374-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pharmacologic Treatment of Perinatal Depression.

Kimmel, Mary C / Cox, Elizabeth / Schiller, Crystal / Gettes, Edith / Meltzer-Brody, Samantha

Obstetrics and gynecology clinics of North America

2018 Volume 45, Issue 3, Page(s) 419–440

Abstract: This review provides information about medications used to treat perinatal depression, including guidance around when to use certain medications and when to consult a mental health provider. For each group of medications, including selective serotonin ... ...

Abstract	This review provides information about medications used to treat perinatal depression, including guidance around when to use certain medications and when to consult a mental health provider. For each group of medications, including selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, mirtazapine, bupropion, lithium, atypical antipsychotics, and lamotrigine, the risks and benefits of treatment during pregnancy and lactation are reviewed, and unique qualities of each medication. A treatment algorithm is included and a description of the Food and Drug Administration's approach to providing information about medications. The article also discusses hormone therapies and future directions for new pharmacologic treatments.
MeSH term(s)	Antidepressive Agents/adverse effects ; Antidepressive Agents/therapeutic use ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Clinical Decision-Making ; Contraindications ; Depression/drug therapy ; Female ; Humans ; Practice Patterns, Physicians'/statistics & numerical data ; Pregnancy ; Pregnancy Complications/drug therapy ; Pregnancy Complications/psychology ; Pregnant Women/psychology ; Prenatal Exposure Delayed Effects/prevention & control ; Psychotherapy ; Risk Assessment
Chemical Substances	Antidepressive Agents ; Antipsychotic Agents
Language	English
Publishing date	2018-08-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1004315-9
ISSN	1558-0474 ; 0889-8545
ISSN (online)	1558-0474
ISSN	0889-8545
DOI	10.1016/j.ogc.2018.04.007
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Article ; Online: A protocol for the Heart Matters stepped wedge cluster randomised trial: The effectiveness of heart attack education in regions at highest-risk.

Resuscitation plus

2023 Volume 15, Page(s) 100431

Abstract: Aim: To describe the Heart Matters (HM) trial which aims to evaluate the effectiveness of a community heart attack education intervention in high-risk areas in Victoria, Australia. These local government areas (LGAs) have high rates of acute coronary ... ...

Abstract	Aim: To describe the Heart Matters (HM) trial which aims to evaluate the effectiveness of a community heart attack education intervention in high-risk areas in Victoria, Australia. These local government areas (LGAs) have high rates of acute coronary syndrome (ACS), out-of-hospital cardiac arrest (OHCA), cardiovascular risk factors, and low rates of emergency medical service (EMS) use for ACS. Methods: The trial follows a stepped-wedge cluster randomised design, with eight clusters (high-risk LGAs) randomly assigned to transition from control to intervention every four months. Two pairs of LGAs will transition simultaneously due to their proximity. The intervention consists of a heart attack education program delivered by trained HM Coordinators, with additional support from opportunistic media and a geo-targeted social media campaign. The primary outcome measure is the proportion of residents from the eight LGAs who present to emergency departments by EMS during an ACS event. Secondary outcomes include prehospital delay time, rates of OHCA and heart attack awareness. The primary and secondary outcomes will be analysed at the patient/participant level using mixed-effects logistic regression models. A detailed program evaluation is also being conducted. The trial was registered on August 9, 2021 (NCT04995900). Results: The intervention was implemented between February 2022 and March 2023, and outcome data will be collected from administrative databases, registries, and surveys. Primary trial data is expected to be locked for analysis by October 31st 2023, with a follow-up planned until March 31st 2024. Conclusion: The results from this trial will provide high-level evidence the effectiveness of a community education intervention targeting regions at highest-risk of ACS and low EMS use.
Language	English
Publishing date	2023-07-25
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-5204
ISSN (online)	2666-5204
DOI	10.1016/j.resplu.2023.100431
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Article ; Online: Team-Based Coaching Intervention to Improve Contrast-Associated Acute Kidney Injury: A Cluster-Randomized Trial.

Clinical journal of the American Society of Nephrology : CJASN

2023 Volume 18, Issue 3, Page(s) 315–326

Abstract: Background: Up to 14% of patients in the United States undergoing cardiac catheterization each year experience AKI. Consistent use of risk minimization preventive strategies may improve outcomes. We hypothesized that team-based coaching in a Virtual ... ...

Abstract	Background: Up to 14% of patients in the United States undergoing cardiac catheterization each year experience AKI. Consistent use of risk minimization preventive strategies may improve outcomes. We hypothesized that team-based coaching in a Virtual Learning Collaborative (Collaborative) would reduce postprocedural AKI compared with Technical Assistance (Assistance), both with and without Automated Surveillance Reporting (Surveillance). Methods: The IMPROVE AKI trial was a 2×2 factorial cluster-randomized trial across 20 Veterans Affairs medical centers (VAMCs). Participating VAMCs received Assistance, Assistance with Surveillance, Collaborative, or Collaborative with Surveillance for 18 months to implement AKI prevention strategies. The Assistance and Collaborative approaches promoted hydration and limited NPO and contrast dye dosing. We fit logistic regression models for AKI with site-level random effects accounting for the clustering of patients within medical centers with a prespecified interest in exploring differences across the four intervention arms. Results: Among VAMCs' 4517 patients, 510 experienced AKI (235 AKI events among 1314 patients with preexisting CKD). AKI events in each intervention cluster were 110 (13%) in Assistance, 122 (11%) in Assistance with Surveillance, 190 (13%) in Collaborative, and 88 (8%) in Collaborative with Surveillance. Compared with sites receiving Assistance alone, case-mix-adjusted differences in AKI event proportions were -3% (95% confidence interval [CI], -4 to -3) for Assistance with Surveillance, -3% (95% CI, -3 to -2) for Collaborative, and -5% (95% CI, -6 to -5) for Collaborative with Surveillance. The Collaborative with Surveillance intervention cluster had a substantial 46% reduction in AKI compared with Assistance alone (adjusted odds ratio=0.54; 0.40-0.74). Conclusions: This implementation trial estimates that the combination of Collaborative with Surveillance reduced the odds of AKI by 46% at VAMCs and is suggestive of a reduction among patients with CKD. Clinical trial registry name and registration number: IMPROVE AKI Cluster-Randomized Trial (IMPROVE-AKI), NCT03556293.
MeSH term(s)	Humans ; United States ; Mentoring ; Contrast Media/adverse effects ; United States Department of Veterans Affairs ; Renal Insufficiency, Chronic/chemically induced ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/prevention & control
Chemical Substances	Contrast Media
Language	English
Publishing date	2023-02-08
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.0000000000000067
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