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  1. Article ; Online: Particulate Matter Induced Adverse Effects on Eye Development in Zebrafish (

    Priyadarshana, Dalawalla G Charith E / Cheon, Jayeon / Lee, Yoonsung / Cha, Seon-Heui

    Toxics

    2024  Volume 12, Issue 1

    Abstract: Particulate matter (PM) can cause human diseases, particularly respiratory diseases. Since eyes are directly exposed to the air, they might be directly adversely affected by PM. Therefore, we determined the toxicity caused to eye development by PM using ... ...

    Abstract Particulate matter (PM) can cause human diseases, particularly respiratory diseases. Since eyes are directly exposed to the air, they might be directly adversely affected by PM. Therefore, we determined the toxicity caused to eye development by PM using zebrafish (
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics12010059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: 5-Bromoprotocatechualdehyde Combats against Palmitate Toxicity by Inhibiting Parkin Degradation and Reducing ROS-Induced Mitochondrial Damage in Pancreatic β-Cells.

    Cha, Seon-Heui / Zhang, Chunying / Heo, Soo-Jin / Jun, Hee-Sook

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 2

    Abstract: Pancreatic β-cell loss is critical in diabetes pathogenesis. Up to now, no effective treatment has become available for β-cell loss. A polyphenol recently isolated ... ...

    Abstract Pancreatic β-cell loss is critical in diabetes pathogenesis. Up to now, no effective treatment has become available for β-cell loss. A polyphenol recently isolated from
    Language English
    Publishing date 2021-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10020264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Combination of PD98059 and TGF-β1 Efficiently Differentiates Human Urine-Derived Stem Cells into Smooth Muscle Cells

    Yongha Hwang / Seon-Heui Cha / Donghee Kim / Hee-Sook Jun

    International Journal of Molecular Sciences, Vol 22, Iss 10532, p

    2021  Volume 10532

    Abstract: Pluripotent adult stem cells have potential applications in cell therapy and tissue engineering. Urine-derived stem cells (UDSCs) differentiate into various cell types. Here, we attempted to differentiate human UDSCs (hUDSCs) into smooth muscle cells ( ... ...

    Abstract Pluripotent adult stem cells have potential applications in cell therapy and tissue engineering. Urine-derived stem cells (UDSCs) differentiate into various cell types. Here, we attempted to differentiate human UDSCs (hUDSCs) into smooth muscle cells (SMCs) using transforming growth factor-beta 1 (TGF-β1) and/or PD98059, an extracellular signal-regulated kinase (ERK) inhibitor. Both quantitative polymerase chain reaction (qPCR) and Western blot analysis showed that the expression of messenger ribonucleic acid (mRNA) and proteins for alpha-smooth muscle actin (α-SMA), calponin (CNN1), and smooth muscle myosin heavy chain (SM-MHC), which are specific markers for SMCs, increased on day 9 after differentiation and again on day 14. The differentiated cells from human UDSCs (hUDSCs) with a combination of TGF-β1 and PD98059 showed the highest expression of SMC marker proteins. Immunocytochemical staining performed to assess the molecular expression revealed CNN and α-SMA colocalizing in the cytoplasm. The cells that differentiated from hUDSCs with a combination of TGF-β1 and PD98059 showed the strongest expression for CNN1, α-SMA, and SM-MHC. Functional testing of the differentiated cells revealed a stronger contractile capacity for the cells differentiated with a combination of PD98059 and TGF-β1 than those differentiated with a single factor. These results suggest the combination of PD98059 and TGF-β1 to be a more effective differentiation method and that differentiated SMCs could be used for restoring the functions of the sphincter muscle or bladder.
    Keywords urine-derived stem cell ; diabetes ; differentiation of insulin producing cell ; pluripotent adult stem cells ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610 ; 571
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: In Silico Virtual Screening of Marine Aldehyde Derivatives from Seaweeds against SARS-CoV-2

    Nalae Kang / Seong-Yeong Heo / Seon-Heui Cha / Ginnae Ahn / Soo-Jin Heo

    Marine Drugs, Vol 20, Iss 399, p

    2022  Volume 399

    Abstract: Coronavirus disease 2019, caused by the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global pandemic that poses an unprecedented threat to the global economy and human health. Several potent inhibitors targeting ...

    Abstract Coronavirus disease 2019, caused by the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global pandemic that poses an unprecedented threat to the global economy and human health. Several potent inhibitors targeting SARS-CoV-2 have been published; however, most of them have failed in clinical trials. This study aimed to assess the therapeutic compounds among aldehyde derivatives from seaweeds as potential SARS-CoV-2 inhibitors using a computer simulation protocol. The absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) properties of the compounds were analyzed using a machine learning algorithm, and the docking simulation of these compounds to the 3C-like protease (Protein Data Bank (PDB) ID: 6LU7) was analyzed using a molecular docking protocol based on the CHARMm algorithm. These compounds exhibited good drug-like properties following the Lipinski and Veber rules. Among the marine aldehyde derivatives, 4-hydroxybenzaldehyde, 3-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, and 5-bromoprotocatechualdehyde were predicted to have good absorption and solubility levels and non-hepatotoxicity in the ADME/Tox prediction. 3-hydroxybenzaldehyde and 3,4-dihydroxybenzaldehyde were predicted to be non-toxic in TOPKAT prediction. In addition, 3,4-dihydroxybenzaldehyde was predicted to exhibit interactions with the 3C-like protease, with binding energies of −71.9725 kcal/mol. The computational analyses indicated that 3,4-dihydroxybenzaldehyde could be regarded as potential a SARS-CoV-2 inhibitor.
    Keywords SARS-CoV-2 ; Coronavirus disease 2019 ; seaweed ; aldehyde derivatives ; in silico ; virtual screening ; Biology (General) ; QH301-705.5
    Subject code 540
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Antioxidant, Antiviral, and Anti-Inflammatory Activities of Lutein-Enriched Extract of

    Kim, Eun-A / Kang, Nalae / Heo, Seong-Young / Oh, Jae-Young / Lee, Seung-Hong / Cha, Seon-Heui / Kim, Won-Keun / Heo, Soo-Jin

    Marine drugs

    2023  Volume 21, Issue 7

    Abstract: Microalgae are proposed to have powerful applications for human health in the pharmaceutical and food industries. ...

    Abstract Microalgae are proposed to have powerful applications for human health in the pharmaceutical and food industries.
    MeSH term(s) Animals ; Mice ; Humans ; Antioxidants/pharmacology ; Lutein/pharmacology ; Lutein/metabolism ; Zebrafish/metabolism ; Lipopolysaccharides/pharmacology ; Antiviral Agents/pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Anti-Inflammatory Agents/pharmacology ; NF-kappa B/metabolism ; RAW 264.7 Cells ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/metabolism
    Chemical Substances Antioxidants ; Lutein (X72A60C9MT) ; Lipopolysaccharides ; Antiviral Agents ; Plant Extracts ; Anti-Inflammatory Agents ; NF-kappa B ; Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase Type II (EC 1.14.13.39)
    Language English
    Publishing date 2023-06-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21070369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Combination of PD98059 and TGF-β1 Efficiently Differentiates Human Urine-Derived Stem Cells into Smooth Muscle Cells.

    Hwang, Yongha / Cha, Seon-Heui / Kim, Donghee / Jun, Hee-Sook

    International journal of molecular sciences

    2021  Volume 22, Issue 19

    Abstract: Pluripotent adult stem cells have potential applications in cell therapy and tissue engineering. Urine-derived stem cells (UDSCs) differentiate into various cell types. Here, we attempted to differentiate human UDSCs (hUDSCs) into smooth muscle cells ( ... ...

    Abstract Pluripotent adult stem cells have potential applications in cell therapy and tissue engineering. Urine-derived stem cells (UDSCs) differentiate into various cell types. Here, we attempted to differentiate human UDSCs (hUDSCs) into smooth muscle cells (SMCs) using transforming growth factor-beta 1 (TGF-β1) and/or PD98059, an extracellular signal-regulated kinase (ERK) inhibitor. Both quantitative polymerase chain reaction (qPCR) and Western blot analysis showed that the expression of messenger ribonucleic acid (mRNA) and proteins for alpha-smooth muscle actin (α-SMA), calponin (CNN1), and smooth muscle myosin heavy chain (SM-MHC), which are specific markers for SMCs, increased on day 9 after differentiation and again on day 14. The differentiated cells from human UDSCs (hUDSCs) with a combination of TGF-β1 and PD98059 showed the highest expression of SMC marker proteins. Immunocytochemical staining performed to assess the molecular expression revealed CNN and α-SMA colocalizing in the cytoplasm. The cells that differentiated from hUDSCs with a combination of TGF-β1 and PD98059 showed the strongest expression for CNN1, α-SMA, and SM-MHC. Functional testing of the differentiated cells revealed a stronger contractile capacity for the cells differentiated with a combination of PD98059 and TGF-β1 than those differentiated with a single factor. These results suggest the combination of PD98059 and TGF-β1 to be a more effective differentiation method and that differentiated SMCs could be used for restoring the functions of the sphincter muscle or bladder.
    MeSH term(s) Adult ; Cell Differentiation/drug effects ; Female ; Flavonoids/pharmacology ; Humans ; Male ; Middle Aged ; Muscle Cells/cytology ; Muscle Cells/metabolism ; Stem Cells/cytology ; Stem Cells/metabolism ; Transforming Growth Factor beta1/pharmacology ; Urine/cytology
    Chemical Substances Flavonoids ; TGFB1 protein, human ; Transforming Growth Factor beta1 ; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one (SJE1IO5E3I)
    Language English
    Publishing date 2021-09-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms221910532
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: In Silico Virtual Screening of Marine Aldehyde Derivatives from Seaweeds against SARS-CoV-2.

    Kang, Nalae / Heo, Seong-Yeong / Cha, Seon-Heui / Ahn, Ginnae / Heo, Soo-Jin

    Marine drugs

    2022  Volume 20, Issue 6

    Abstract: Coronavirus disease 2019, caused by the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global pandemic that poses an unprecedented threat to the global economy and human health. Several potent inhibitors targeting ...

    Abstract Coronavirus disease 2019, caused by the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global pandemic that poses an unprecedented threat to the global economy and human health. Several potent inhibitors targeting SARS-CoV-2 have been published; however, most of them have failed in clinical trials. This study aimed to assess the therapeutic compounds among aldehyde derivatives from seaweeds as potential SARS-CoV-2 inhibitors using a computer simulation protocol. The absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) properties of the compounds were analyzed using a machine learning algorithm, and the docking simulation of these compounds to the 3C-like protease (Protein Data Bank (PDB) ID: 6LU7) was analyzed using a molecular docking protocol based on the CHARMm algorithm. These compounds exhibited good drug-like properties following the Lipinski and Veber rules. Among the marine aldehyde derivatives, 4-hydroxybenzaldehyde, 3-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, and 5-bromoprotocatechualdehyde were predicted to have good absorption and solubility levels and non-hepatotoxicity in the ADME/Tox prediction. 3-hydroxybenzaldehyde and 3,4-dihydroxybenzaldehyde were predicted to be non-toxic in TOPKAT prediction. In addition, 3,4-dihydroxybenzaldehyde was predicted to exhibit interactions with the 3C-like protease, with binding energies of -71.9725 kcal/mol. The computational analyses indicated that 3,4-dihydroxybenzaldehyde could be regarded as potential a SARS-CoV-2 inhibitor.
    MeSH term(s) Aldehydes/pharmacology ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; COVID-19/drug therapy ; Computer Simulation ; Coronavirus 3C Proteases ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protease Inhibitors/pharmacology ; SARS-CoV-2 ; Seaweed/metabolism ; Viral Nonstructural Proteins/chemistry
    Chemical Substances Aldehydes ; Antiviral Agents ; Protease Inhibitors ; Viral Nonstructural Proteins ; Coronavirus 3C Proteases (EC 3.4.22.28)
    Language English
    Publishing date 2022-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20060399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: In Silico Virtual Screening of Marine Aldehyde Derivatives from Seaweeds against SARS-CoV-2

    Kang, Nalae / Heo, Seong-Yeong / Cha, Seon-Heui / Ahn, Ginnae / Heo, Soo-Jin

    Marine drugs. 2022 June 16, v. 20, no. 6

    2022  

    Abstract: Coronavirus disease 2019, caused by the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global pandemic that poses an unprecedented threat to the global economy and human health. Several potent inhibitors targeting ...

    Abstract Coronavirus disease 2019, caused by the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global pandemic that poses an unprecedented threat to the global economy and human health. Several potent inhibitors targeting SARS-CoV-2 have been published; however, most of them have failed in clinical trials. This study aimed to assess the therapeutic compounds among aldehyde derivatives from seaweeds as potential SARS-CoV-2 inhibitors using a computer simulation protocol. The absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) properties of the compounds were analyzed using a machine learning algorithm, and the docking simulation of these compounds to the 3C-like protease (Protein Data Bank (PDB) ID: 6LU7) was analyzed using a molecular docking protocol based on the CHARMm algorithm. These compounds exhibited good drug-like properties following the Lipinski and Veber rules. Among the marine aldehyde derivatives, 4-hydroxybenzaldehyde, 3-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, and 5-bromoprotocatechualdehyde were predicted to have good absorption and solubility levels and non-hepatotoxicity in the ADME/Tox prediction. 3-hydroxybenzaldehyde and 3,4-dihydroxybenzaldehyde were predicted to be non-toxic in TOPKAT prediction. In addition, 3,4-dihydroxybenzaldehyde was predicted to exhibit interactions with the 3C-like protease, with binding energies of −71.9725 kcal/mol. The computational analyses indicated that 3,4-dihydroxybenzaldehyde could be regarded as potential a SARS-CoV-2 inhibitor.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; absorption ; algorithms ; computer simulation ; databases ; excretion ; human health ; hydroxybenzaldehyde ; metabolism ; pandemic ; prediction ; proteinases ; solubility ; therapeutics ; toxicity
    Language English
    Dates of publication 2022-0616
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20060399
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Protective Effect of

    Wang, Lei / Oh, Jae-Young / Yang, Hye-Won / Hyun, Jimin / Ahn, Ginnae / Fu, Xiaoting / Xu, Jiachao / Gao, Xin / Cha, Seon-Heui / Jeon, You-Jin

    Polymers

    2023  Volume 15, Issue 8

    Abstract: Our previous studies have evaluated the bioactivities of a fucoidan isolated ... ...

    Abstract Our previous studies have evaluated the bioactivities of a fucoidan isolated from
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15081912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Diphlorethohydroxycarmalol Attenuates Palmitate-Induced Hepatic Lipogenesis and Inflammation.

    Cha, Seon-Heui / Hwang, Yongha / Heo, Soo-Jin / Jun, Hee-Sook

    Marine drugs

    2020  Volume 18, Issue 9

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease, encompassing a range of conditions caused by lipid deposition within liver cells, and is also associated with obesity and metabolic diseases. Here, we investigated the ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease, encompassing a range of conditions caused by lipid deposition within liver cells, and is also associated with obesity and metabolic diseases. Here, we investigated the protective effects of diphlorethohydroxycarmalol (DPHC), which is a polyphenol isolated from an edible seaweed,
    MeSH term(s) Hep G2 Cells ; Heterocyclic Compounds, 3-Ring/isolation & purification ; Heterocyclic Compounds, 3-Ring/pharmacology ; Humans ; Inflammation/pathology ; Inflammation/prevention & control ; Lipogenesis/drug effects ; Liver/drug effects ; Liver/physiopathology ; Non-alcoholic Fatty Liver Disease/prevention & control ; Palmitates/toxicity ; Phaeophyceae/chemistry
    Chemical Substances Heterocyclic Compounds, 3-Ring ; Palmitates ; diphlorethohydroxycarmalol
    Language English
    Publishing date 2020-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md18090475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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