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Article: [Analysis of medicine paintings of fruit, vegetable and rice sections of Ben Cao Tu Jing].

Peng, Hua-Sheng / Huang, Lu-Qi

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2021 Volume 45, Issue 24, Page(s) 6065–6071

Abstract: Ben Cao Tu Jing is the earliest version of block-printed edition for herbals so far, with 933 ... Sections of Ben Cao Tu Jing, as well as discussed the types of medicine paintings and relevant information ... Jing, which can be divided into four types: broken branch paintings, ground paintings, rootless plant ...

Abstract	Ben Cao Tu Jing is the earliest version of block-printed edition for herbals so far, with 933 medicinal paintings. In this paper, it analyzed the medicine paintings in the Fruit, Vegetable and Rice Sections of Ben Cao Tu Jing, as well as discussed the types of medicine paintings and relevant information when they were drawn. There are a total of 76 paintings in the fruits, vegetables and rice sections of Ben Cao Tu Jing, which can be divided into four types: broken branch paintings, ground paintings, rootless plant paintings and the whole plant with root paintings. The first three paintings were similar to the paintings of Tang and Song, and the paintings of the whole plant with root can be called the type of medicine paintings with Chinese characteristics created by Ben Cao Tu Jing. These four types of paintings had a profound impact on the later illustrations of medicinal materials, such as Lv Chan Yan Ben Cao, Jiu Huang Ben Cao, Ben Cao Pin Hui Jing Yao, Zhi Wen Ben Cao, Zhi Wu Ming Shi Tu Kao. The two types that had the greatest impact on later generations are the broken branch paintings and the whole plant with roots paintings, which had been inherited and developed in contemporary Chinese pharmacy books such as Zhong Yao Cai Pin Zhong Lun Shu and Zhong Hua Ben Cao. The paintings of the fruits, vegetables and rice sections are highly realistic and artistic, not only carrying the role of conveying medicinal knowledge, but also having unique aesthetic value. It can be inferred that the fruits, vegetables and rice sections had the participation of professional painters at least. In addition, through the highly consistent drawing styles of several sets of paintings, it is concluded that the paintings without place names were likely to be drawn uniformly by the editing team, and the local paintings may have been revised and improved by the editing team lately.
MeSH term(s)	China ; Fruit ; Humans ; Medicine ; Medicine, Chinese Traditional ; Oryza ; Paintings ; Vegetables
Language	Chinese
Publishing date	2021-01-26
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20200925.101
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Article: Sheng Jing Decoction Can Promote Spermatogenesis and Increase Sperm Motility of the Oligozoospermia Mouse Model.

Yan, Guang / Tian, Fang / Liu, Peng / Sun, Jianming / Mao, Jianmin / Han, Wenjun / Mo, Ran / Guo, Shishuai / Yu, Quanyao

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 3686494

Abstract: Sheng Jing Decoction (SJD), as a traditional Chinese medicine prescription, is mainly be used ...

Abstract	Sheng Jing Decoction (SJD), as a traditional Chinese medicine prescription, is mainly be used to treat male infertility. However, the pharmacological functions and molecular mechanisms of SJD are poorly understood. In this study, we investigated the functions of SJD on spermatogenesis and sperm motility and explored the potential mechanisms involved. Here, we demonstrated that high, medium, and low doses of SJD are effective in restoring the impairments of the whole body and testicular tissue by cyclophosphamide inducing and to rescue the damage of testicular tissue cells including Sertoli cells and germ cells. SJD can partly restore the decrease in sperm concentration, sperm vitality, sperm motility, and normal sperm morphology rate in oligozoospermic mouse models. Ki67 staining analyses confirm SJD can promote testicular tissue cell proliferation. Real-time RT-PCR analyses also reveal that SJD can upregulate the expression of proliferation-associated gene
Language	English
Publishing date	2021-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/3686494
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Article ; Online: Copula-Based Abrupt Variations Detection in the Relationship of Seasonal Vegetation-Climate in the Jing River Basin, China

Jing Zhao / Shengzhi Huang / Qiang Huang / Hao Wang / Guoyong Leng / Jian Peng / Haixia Dong

Remote Sensing, Vol 11, Iss 13, p

2019 Volume 1628

Abstract: ... the backdrop of a changing environment. The Jing River Basin (JRB), a typical eco-environmentally vulnerable ...

Abstract	Understanding the changing relationships between vegetation coverage and precipitation/temperature (P/T) and then exploring their potential drivers are highly necessary for ecosystem management under the backdrop of a changing environment. The Jing River Basin (JRB), a typical eco-environmentally vulnerable region of the Loess Plateau, was chosen to identify abrupt variations of the relationships between seasonal Normalized Difference Vegetation Index (NDVI) and P/T through a copula-based method. By considering the climatic/large-scale atmospheric circulation patterns and human activities, the potential causes of the non-stationarity of the relationship between NDVI and P/T were revealed. Results indicated that (1) the copula-based framework introduced in this study is more reasonable and reliable than the traditional double-mass curves method in detecting change points of vegetation and climate relationships; (2) generally, no significant change points were identified during 1982–2010 at the 95% confidence level, implying the overall stationary relationship still exists, while the relationships between spring NDVI and P/T, autumn NDVI and P have slightly changed; (3) teleconnection factors (including Arctic Oscillation (AO), Pacific Decadal Oscillation (PDO), Niño 3.4, and sunspots) have a more significant influence on the relationship between seasonal NDVI and P/T than local climatic factors (including potential evapotranspiration and soil moisture); (4) negative human activities (expansion of farmland and urban areas) and positive human activities (“Grain For Green” program) were also potential factors affecting the relationship between NDVI and P/T. This study provides a new and reliable insight into detecting the non-stationarity of the relationship between NDVI and P/T, which will be beneficial for further revealing the connection between the atmosphere and ecosystems.
Keywords	copula-based method ; NDVI and precipitation/temperature ; change points ; teleconnection factors ; double cumulative curve method ; Science ; Q
Subject code	333
Language	English
Publishing date	2019-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Copula-Based Abrupt Variations Detection in the Relationship of Seasonal Vegetation-Climate in the Jing River Basin, China

Zhao, Jing / Huang, Shengzhi / Huang, Qiang / Wang, Hao / Leng, Guoyong / Peng, Jian / Dong, Haixia

Remote Sensing. 2019 July 09, v. 11, no. 13

2019

Abstract: ... the backdrop of a changing environment. The Jing River Basin (JRB), a typical eco-environmentally vulnerable ...

Abstract	Understanding the changing relationships between vegetation coverage and precipitation/temperature (P/T) and then exploring their potential drivers are highly necessary for ecosystem management under the backdrop of a changing environment. The Jing River Basin (JRB), a typical eco-environmentally vulnerable region of the Loess Plateau, was chosen to identify abrupt variations of the relationships between seasonal Normalized Difference Vegetation Index (NDVI) and P/T through a copula-based method. By considering the climatic/large-scale atmospheric circulation patterns and human activities, the potential causes of the non-stationarity of the relationship between NDVI and P/T were revealed. Results indicated that (1) the copula-based framework introduced in this study is more reasonable and reliable than the traditional double-mass curves method in detecting change points of vegetation and climate relationships; (2) generally, no significant change points were identified during 1982–2010 at the 95% confidence level, implying the overall stationary relationship still exists, while the relationships between spring NDVI and P/T, autumn NDVI and P have slightly changed; (3) teleconnection factors (including Arctic Oscillation (AO), Pacific Decadal Oscillation (PDO), Niño 3.4, and sunspots) have a more significant influence on the relationship between seasonal NDVI and P/T than local climatic factors (including potential evapotranspiration and soil moisture); (4) negative human activities (expansion of farmland and urban areas) and positive human activities (“Grain For Green” program) were also potential factors affecting the relationship between NDVI and P/T. This study provides a new and reliable insight into detecting the non-stationarity of the relationship between NDVI and P/T, which will be beneficial for further revealing the connection between the atmosphere and ecosystems.
Keywords	agricultural land ; atmospheric circulation ; autumn ; climatic factors ; ecosystem management ; ecosystems ; evapotranspiration ; normalized difference vegetation index ; remote sensing ; soil water ; spring ; temperature ; urban areas ; vegetation ; watersheds ; Arctic region ; China
Language	English
Dates of publication	2019-0709
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2513863-7
ISSN	2072-4292
ISSN	2072-4292
DOI	10.3390/rs11131628
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Sheng Jing Decoction Can Promote Spermatogenesis and Increase Sperm Motility of the Oligozoospermia Mouse Model

Guang Yan / Fang Tian / Peng Liu / Jianming Sun / Jianmin Mao / Wenjun Han / Ran Mo / Shishuai Guo / Quanyao Yu

Evidence-Based Complementary and Alternative Medicine, Vol

2021 Volume 2021

Abstract: Sheng Jing Decoction (SJD), as a traditional Chinese medicine prescription, is mainly be used ...

Abstract	Sheng Jing Decoction (SJD), as a traditional Chinese medicine prescription, is mainly be used to treat male infertility. However, the pharmacological functions and molecular mechanisms of SJD are poorly understood. In this study, we investigated the functions of SJD on spermatogenesis and sperm motility and explored the potential mechanisms involved. Here, we demonstrated that high, medium, and low doses of SJD are effective in restoring the impairments of the whole body and testicular tissue by cyclophosphamide inducing and to rescue the damage of testicular tissue cells including Sertoli cells and germ cells. SJD can partly restore the decrease in sperm concentration, sperm vitality, sperm motility, and normal sperm morphology rate in oligozoospermic mouse models. Ki67 staining analyses confirm SJD can promote testicular tissue cell proliferation. Real-time RT-PCR analyses also reveal that SJD can upregulate the expression of proliferation-associated gene Lin28a and differentiation-associated genes Kit, Sohlh2, and Stra8. SJD can also reduce the impairment of mitochondrial membrane potential (MMP) and sperm plasma membrane integrity by cyclophosphamide inducing. Our results reveal that SJD is effective in improving both sperm quantity and quality by increasing the sperm concentration, sperm vitality, sperm motility, and normal sperm morphology rate. SJD can promote spermatogenesis by upregulating the expression of the proliferation-associated gene Lin28a and the differentiation-associated genes (Kit, Sohlh2, and Stra8). SJD can sustain MMP and sperm plasma membrane integrity to increase sperm motility.
Keywords	Other systems of medicine ; RZ201-999
Subject code	572
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: JFNE-A isolated from Jing-Fang n-butanol extract attenuates lipopolysaccharide-induced acute lung injury by inhibiting oxidative stress and the NF-κB signaling pathway via promotion of autophagy.

Rao, Zhili / Zeng, Jiuseng / Li, Xiangyu / Peng, Lixia / Wang, Baojun / Luan, Fei / Zeng, Nan

Phytomedicine : international journal of phytotherapy and phytopharmacology

2021 Volume 96, Page(s) 153891

Abstract: Background: Jing-Fang powder consists of Jingjie (Nepeta tenuifolia Benth, (Lamiaceae)). and ... that the Jing-Fang powder n-butanol extract (JFNE) has anti-acute lung injury (ALI) and anti-inflammatory ...

Abstract	Background: Jing-Fang powder consists of Jingjie (Nepeta tenuifolia Benth, (Lamiaceae)). and Fangfeng (Saposhnikovia divaricata (Turcz.) Schischk, (Apiaceae)) Previous studies have revealed that the Jing-Fang powder n-butanol extract (JFNE) has anti-acute lung injury (ALI) and anti-inflammatory properties; however, the active ingredient and mechanism remain unknown. Purpose: In the present study, we investigated the anti-inflammatory effect of a bioactive fraction obtained from JFNE(JFNE-A) on lipopolysaccharide (LPS)-induced ALI in mice and explored the underlying mechanism. Study design: The anti-acute lung injury effect and mechanism of JFNE-A was investigated by prophylactic administration of JFNE-A in mice with LPS-induced acute lung injury. Methods: The expression levels of myeloperoxidase(MPO) in lung tissues of mice and interleukin(IL)-6, tumor necrosis factor(TNF)-α, IL-1β, IL-5, interferon (IFN)-γ, monocyte chemotactic protein (MCP)-1, macrophage colony stimulating factor (M-CSF), macrophage inflammatory protein (MIP)-1α, and MIP-1β in bronchi alveolar lavage fluid (BALF) were detected by reagent kit and the histological changes were examined by hematoxylin and eosin (H & E) for general histopathological conditions under a light microscope. In addition, the ultrastructure of the cells in lung tissues were observed and photographed under a transmission electron microscope. The expression levels of protein were detected via Western blotting and the mRNA expression of relative genes were determined of via reverse transcriptase polymerase chain reaction (RT-PCR). What's more, we also further clarified the potential targets of JFNE-A through network pharmacology analysis, which could be utilized in ALI treatment. Results: Our results showed that pretreatment with JFNE-A for 7 days significantly reduced the lung pathological injury score, alleviated pulmonary edema, and decreased the lung tissue MPO level. Mechanistically, JFNE-A dramatically downregulated the protein levels of IL-6, TNF-α, IL-1β, M-CSF, and IFN-γ in BALF and mRNA expression levels of IL-6, TNF-α, IL-1β, and IFN-γ in lung tissues. JFNE-A also significantly lowered the protein levels of iNOS and phosphorylated NF-κB (p65) and mRNA expression levels of iNOS, Rela, CHUK, and NF-κB1, and also elevated the protein expression levels of Nrf2, HO-1, and SOD1 and the mRNA expression levels of Nrf2, Hmox1, and Keap-1 in the lungs. Moreover, JFNE-A significantly decreased the protein expression of p62 and increased the ratio of LC3II/LC3I. It also upregulated the mRNA expression levels of Atg5 and Beclin-1, whereas it reduced the mRNA expression level of SQSTM1 and increased autophagosome structures. Conclusion: Overall, treatment with JFNE-A ameliorated LPS-induced ALI in mice by suppressing the NF-κB signaling pathways and promoting Nrf2 signaling pathways by accelerating autophagy.
MeSH term(s)	1-Butanol ; Acute Lung Injury/chemically induced ; Acute Lung Injury/drug therapy ; Autophagy ; Butanols ; Humans ; Lipopolysaccharides ; Lung/metabolism ; NF-kappa B/metabolism ; Network Pharmacology ; Oxidative Stress ; Plant Extracts/pharmacology ; Signal Transduction
Chemical Substances	Butanols ; Lipopolysaccharides ; NF-kappa B ; Plant Extracts ; 1-Butanol (8PJ61P6TS3)
Language	English
Publishing date	2021-12-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2021.153891
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Article ; Online: The characteristics of abnormal wintertime pollution events in the Jing-Jin-Ji region and its relationships with meteorological factors.

Zhu, Wenhui / Xu, Xiangde / Zheng, Jun / Yan, Peng / Wang, Yinjun / Cai, Wenyue

The Science of the total environment

2018 Volume 626, Page(s) 887–898

Abstract: ... events were still encountered in the Beijing-Tianjin-Hebei (Jing-Jin-Ji) region during the winter 2016 ... dynamical and thermal structures, and PBL height over the Jing-Jin-Ji region in history and recent years ...

Abstract	Despite the implementation of strict air pollution control measures in recent years, severe haze events were still encountered in the Beijing-Tianjin-Hebei (Jing-Jin-Ji) region during the winter 2016. In this work, seasonal differences in correlations between air pollution and geographic terrain, atmospheric dynamical and thermal structures, and PBL height over the Jing-Jin-Ji region in history and recent years were investigated and a comprehensive model of atmospheric factors affecting winter air pollution formation was proposed. We found that the distribution of PM
MeSH term(s)	Air Pollutants/analysis ; Air Pollution/statistics & numerical data ; Beijing ; Environmental Monitoring ; Meteorological Concepts ; Particulate Matter/analysis ; Seasons
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2018-02-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2018.01.083
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Article: Attribution analysis of climatic and multiple anthropogenic causes of runoff change in the Loess Plateau—A case‐study of the Jing River Basin

Gao, Xuerui / Yan, Chengsheng / Wang, Yubao / Zhao, Xining / Zhao, Yong / Sun, Miao / Peng, Shouzhang

Land degradation & development. 2020 Aug. 15, v. 31, no. 13

2020

Abstract: Over the past five decades, under the joint influence of climate change and human activity, river runoff in most areas of Loess Plateau showed a significant declining trend, which poses a great threat to ecological security and land degradation and soil ... ...

Abstract	Over the past five decades, under the joint influence of climate change and human activity, river runoff in most areas of Loess Plateau showed a significant declining trend, which poses a great threat to ecological security and land degradation and soil erosion control. To identify the key factors controlling this decline and quantify the contribution rates of the multiple factors, a runoff simulation was established based on the Soil Water Assessment Tool (SWAT), and the influence of climatic and anthropogenic factors on runoff change was calculated by comparing the results of the simulation based on different modeling scenarios. First, the impact of climatic factors on runoff change was gradually decreasing over time, and the anthropogenic factors’ impact was increasing based on the runoff observations. Second, the SWAT model proved to be reliable and acceptable for both the calibration and the validation periods, with R ² and Nash–Sutcliffe efficiency values both above .8. Third, the influence of climatic factors decreases from 85.70% to 42.43% but that of anthropogenic factors increases from 14.3% to 57.57% in different subperiods. Among the anthropogenic factors, the influence of the direct factor (water withdrawal) is growing the fastest, and the influence of indirect factors is increasing continuously. Therefore, future ecological management and water‐related planning in Loess Plateau should consider the importance of human activity and the relationship between humans and the Earth. Finally, a range of comprehensive countermeasures are proposed to assist with sustainable watershed management in the Loess Plateau.
Keywords	Soil and Water Assessment Tool model ; climate change ; erosion control ; humans ; land degradation ; loess ; rivers ; runoff ; soil erosion ; soil water ; watershed management ; watersheds ; China
Language	English
Dates of publication	2020-0815
Size	p. 1622-1640.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	1319202-4
ISSN	1085-3278
ISSN	1085-3278
DOI	10.1002/ldr.3557
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Aerosol–cloud interaction in the atmospheric chemistry model GRAPES_Meso5.1/CUACE and its impacts on mesoscale numerical weather prediction under haze pollution conditions in Jing–Jin–Ji in China

W. Zhang / H. Wang / X. Zhang / L. Huang / Y. Peng / Z. Liu / H. Che

Atmospheric Chemistry and Physics, Vol 22, Pp 15207-

2022 Volume 15221

Abstract: ... aerosol and stratus cloud over the Jing–Jin–Ji region in China to investigate the impact of ACI ...

Abstract	The representation of aerosol–cloud interaction (ACI) and its impacts in the current climate or weather model remains a challenge, especially for severely polluted regions with high aerosol concentration, which is even more important and worthy of study. Here, ACI is first implemented in the atmospheric chemistry model GRAPES_Meso5.1/CUACE by allowing for real-time aerosol activation in the Thompson cloud microphysics scheme. Two experiments are conducted focusing on a haze pollution case with coexisting high aerosol and stratus cloud over the Jing–Jin–Ji region in China to investigate the impact of ACI on the mesoscale numerical weather prediction (NWP). Study results show that ACI increases cloud droplet number concentration, water mixing ratio, liquid water path (CLWP), and optical thickness (COT), as a result improving the underestimated CLWP and COT (reducing the mean bias by 21 % and 37 %, respectively) over a certain subarea by the model without ACI. A cooling in temperature in the daytime below 950 hPa occurs due to ACI, which can reduce the mean bias of 2 m temperature in the daytime by up to 14 % ( ∼ 0.6 ∘ C) in the subarea with the greatest change in CLWP and COT. The 24 h cumulative precipitation in this subarea corresponding to moderate-rainfall events increases, which can reduce the mean bias by 18 %, depending on the enhanced melting of the snow by more cloud droplets. In other areas or periods with a slight change in CLWP and COT, the impact of ACI on NWP is not significant, suggesting the inhomogeneity of ACI. This study demonstrates the critical role of ACI in the current NWP model over the severely polluted region and the complexity of the ACI effect.
Keywords	Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	551
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: JFNE-A isolated from Jing-Fang n-butanol extract attenuates lipopolysaccharide-induced acute lung injury by inhibiting oxidative stress and the NF-κB signaling pathway via promotion of autophagy

Rao, Zhili / Zeng, Jiuseng / Li, Xiangyu / Peng, Lixia / Wang, Baojun / Luan, Fei / Zeng, Nan

Phytomedicine. 2022 Feb., v. 96

2022

Abstract: Jing-Fang powder consists of Jingjie (Nepeta tenuifolia Benth, (Lamiaceae)). and Fangfeng ... Saposhnikovia divaricata (Turcz.) Schischk, (Apiaceae)) Previous studies have revealed that the Jing-Fang powder ...

Abstract	Jing-Fang powder consists of Jingjie (Nepeta tenuifolia Benth, (Lamiaceae)). and Fangfeng (Saposhnikovia divaricata (Turcz.) Schischk, (Apiaceae)) Previous studies have revealed that the Jing-Fang powder n-butanol extract (JFNE) has anti-acute lung injury (ALI) and anti-inflammatory properties; however, the active ingredient and mechanism remain unknown.In the present study, we investigated the anti-inflammatory effect of a bioactive fraction obtained from JFNE(JFNE-A) on lipopolysaccharide (LPS)-induced ALI in mice and explored the underlying mechanism.The anti-acute lung injury effect and mechanism of JFNE-A was investigated by prophylactic administration of JFNE-A in mice with LPS-induced acute lung injury.The expression levels of myeloperoxidase(MPO) in lung tissues of mice and interleukin(IL)-6, tumor necrosis factor(TNF)-α, IL-1β, IL-5, interferon (IFN)-γ, monocyte chemotactic protein (MCP)-1, macrophage colony stimulating factor (M-CSF), macrophage inflammatory protein (MIP)-1α, and MIP-1β in bronchi alveolar lavage fluid (BALF) were detected by reagent kit and the histological changes were examined by hematoxylin and eosin (H & E) for general histopathological conditions under a light microscope. In addition, the ultrastructure of the cells in lung tissues were observed and photographed under a transmission electron microscope. The expression levels of protein were detected via Western blotting and the mRNA expression of relative genes were determined of via reverse transcriptase polymerase chain reaction (RT-PCR). What's more, we also further clarified the potential targets of JFNE-A through network pharmacology analysis, which could be utilized in ALI treatment.Our results showed that pretreatment with JFNE-A for 7 days significantly reduced the lung pathological injury score, alleviated pulmonary edema, and decreased the lung tissue MPO level. Mechanistically, JFNE-A dramatically downregulated the protein levels of IL-6, TNF-α, IL-1β, M-CSF, and IFN-γ in BALF and mRNA expression levels of IL-6, TNF-α, IL-1β, and IFN-γ in lung tissues. JFNE-A also significantly lowered the protein levels of iNOS and phosphorylated NF-κB (p65) and mRNA expression levels of iNOS, Rela, CHUK, and NF-κB1, and also elevated the protein expression levels of Nrf2, HO-1, and SOD1 and the mRNA expression levels of Nrf2, Hmox1, and Keap-1 in the lungs. Moreover, JFNE-A significantly decreased the protein expression of p62 and increased the ratio of LC3II/LC3I. It also upregulated the mRNA expression levels of Atg5 and Beclin-1, whereas it reduced the mRNA expression level of SQSTM1 and increased autophagosome structures.Overall, treatment with JFNE-A ameliorated LPS-induced ALI in mice by suppressing the NF-κB signaling pathways and promoting Nrf2 signaling pathways by accelerating autophagy.
Keywords	Nepeta ; Saposhnikovia divaricata ; active ingredients ; anti-inflammatory activity ; autophagosomes ; autophagy ; butanol ; chemotaxis ; edema ; eosin ; gene expression ; histology ; histopathology ; interleukin-5 ; interleukin-6 ; light microscopes ; lipopolysaccharides ; macrophages ; monocytes ; myeloperoxidase ; oxidative stress ; protein synthesis ; reverse transcriptase polymerase chain reaction ; transmission electron microscopes ; ultrastructure
Language	English
Dates of publication	2022-02
Publishing place	Elsevier GmbH
Document type	Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2021.153891
Database	NAL-Catalogue (AGRICOLA)

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