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  1. Article ; Online: Accurate Scaling Functions of the Scaled Schrödinger Equation. II. Variational Examination of the Correct Scaling Functions with the Free Complement Theory Applied to the Helium Atom.

    Nakatsuji, Hiroshi / Nakashima, Hiroyuki

    Journal of chemical theory and computation

    2024  

    Abstract: In a previous paper [ ...

    Abstract In a previous paper [
    Language English
    Publishing date 2024-04-29
    Publishing country United States
    Document type Journal Article
    ISSN 1549-9626
    ISSN (online) 1549-9626
    DOI 10.1021/acs.jctc.4c00263
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  2. Article ; Online: Potential Energy Curves of the Low-Lying Five

    Nakashima, Hiroyuki / Nakatsuji, Hiroshi

    Journal of chemical theory and computation

    2023  Volume 19, Issue 19, Page(s) 6733–6744

    Abstract: The potential energy curves (PECs) of the low-lying ... ...

    Abstract The potential energy curves (PECs) of the low-lying five
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ISSN 1549-9626
    ISSN (online) 1549-9626
    DOI 10.1021/acs.jctc.3c00645
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  3. Article ; Online: Role of NT5DC2 in tyrosine hydroxylase phosphorylation based on the analysis of NT5DC2-binding proteins.

    Yamaguchi, Hisateru / Hara, Satoshi / Ichinose, Hiroshi / Nagasaki, Hiroshi / Nakashima, Akira

    Biochemical and biophysical research communications

    2024  Volume 703, Page(s) 149698

    Abstract: The gene encoding 5'-nucleotidase domain-containing protein 2 (NT5DC2) has been associated with neuropsychiatric disorders related to the abnormality of dopamine activity in the brain. However, its physiological functions remain unclear. In this study, ... ...

    Abstract The gene encoding 5'-nucleotidase domain-containing protein 2 (NT5DC2) has been associated with neuropsychiatric disorders related to the abnormality of dopamine activity in the brain. However, its physiological functions remain unclear. In this study, we analyzed the features of NT5DC2 that influence its binding with tyrosine hydroxylase (TH) and its effects on dihydroxyphenylalanine (DOPA) synthesis, using NT5DC2 overexpressed in PC12D cells by the pCMV vector. Western blot analysis revealed that the purified NT5DC2-DYKDDDDK-tag (NT5DC2-tag) protein can bind with the phosphorylated form of recombinant human TH type 1 (rhTH1), apart from the endogenous TH in PC12D cells. Proteomic analysis by mass spectrometry revealed that the purified NT5DC2-tag protein has the potential to bind to 41 proteins with multiple phosphorylation sites in PC12D cells (NT5DC2 binding proteins: positive, 391 sites/41 proteins; and negative, 85 sites/27 proteins). Overexpression of NT5DC2 in PC12D cells decreased DOPA levels in the medium. When the lysate of PC12D cells overexpressing NT5DC2 was incubated at 37 °C, the phosphorylated form of endogenous TH in PC12D cells decreased. This decrease was also detected when phosphorylated rhTH1 was incubated with purified NT5DC2-tag. Overall, our results suggest that NT5DC2 regulates DOPA synthesis by promoting the dephosphorylation of TH, similar to a phosphatase. Therefore, our study provides useful information for understanding various disorders associated with abnormalities in dopamine levels in the brain.
    MeSH term(s) Humans ; Tyrosine 3-Monooxygenase/genetics ; Tyrosine 3-Monooxygenase/metabolism ; Phosphorylation ; Mixed Function Oxygenases/metabolism ; Dopamine ; Carrier Proteins/metabolism ; Proteomics ; Dihydroxyphenylalanine/metabolism
    Chemical Substances Tyrosine 3-Monooxygenase (EC 1.14.16.2) ; Mixed Function Oxygenases (EC 1.-) ; Dopamine (VTD58H1Z2X) ; Carrier Proteins ; Dihydroxyphenylalanine (63-84-3)
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2024.149698
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    Zs.A 116: Show issues Location:
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  4. Article ; Online: Potential curves of the lower nine states of Li

    Nakatsuji, Hiroshi / Nakashima, Hiroyuki

    The Journal of chemical physics

    2022  Volume 157, Issue 9, Page(s) 94109

    Abstract: The free-complement (FC) theory proposed for solving the Schrödinger equation of atoms and molecules highly accurately was applied to the calculations of the potential curves of the lower nine states of the ... ...

    Abstract The free-complement (FC) theory proposed for solving the Schrödinger equation of atoms and molecules highly accurately was applied to the calculations of the potential curves of the lower nine states of the Li
    Language English
    Publishing date 2022-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0101315
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  5. Book ; Online ; E-Book: IgG4-related kidney disease

    Saito, Takao / Stone, John H. / Nakashima, Hiroshi / Saeki, Takako / Kawano, Mitsuhiro

    2016  

    Author's details Takao Saito, John H. Stone, Hitoshi Nakashima, Takako Saeki, Mitsuhiro Kawano editors
    Keywords Kidney Diseases ; Immunoglobulin G
    Language English
    Size 1 Online-Ressource (xi, 311 Seiten), Illustrationen
    Publisher Springer
    Publishing place Tokyo
    Publishing country Japan
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019363130
    ISBN 978-4-431-55687-9 ; 9784431556862 ; 4-431-55687-7 ; 4431556869
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online: Using a Minimal Parameter Set for Early Diagnosis of Hemophagocytic Lymphohistiocytosis in Non-European Children.

    Nakashima, Yu / Koga, Hiroshi

    The American journal of case reports

    2022  Volume 23, Page(s) e934037

    Abstract: BACKGROUND Children with hemophagocytic lymphohistiocytosis require rapid diagnosis for timely treatment. However, diagnostic delays may arise in settings with limited clinical resources. To address this issue, a simplified rule for diagnosing ... ...

    Abstract BACKGROUND Children with hemophagocytic lymphohistiocytosis require rapid diagnosis for timely treatment. However, diagnostic delays may arise in settings with limited clinical resources. To address this issue, a simplified rule for diagnosing hemophagocytic lymphohistiocytosis has recently been proposed. We retrospectively applied this diagnostic rule in 2 infants to evaluate its generalizability to non-European children. CASE REPORT We present 2 cases of hemophagocytic lymphohistiocytosis, involving an Asian neonate with secondary hemophagocytic lymphohistiocytosis subsequent to echovirus infection and an African infant with familial hemophagocytic lymphohistiocytosis caused by PRF1 mutation. Limitations on time and clinical resources prevented tissue biopsy and measurement of natural killer cell activity in either case at our center. The Asian case did not meet HLH-2004 criteria, but both cases met a rapid diagnostic rule on admission to our center. Both cases were transported to a tertiary center and diagnosed with hemophagocytic lymphohistiocytosis based on HLH-2004 criteria. Although treatment suppressed disease activity, the Asian neonate died of multiple-organ failure at age 6 months. The African infant remains in remission after allogenic cord blood stem cell transplantation. CONCLUSIONS A simplified diagnostic rule for hemophagocytic lymphohistiocytosis may be useful for early diagnosis of hemophagocytic lymphohistiocytosis in Asian and African children, especially in resource-limited clinical settings. Further investigation is required to elucidate whether early diagnosis with a simplified diagnostic rule improves treatment outcomes for children with hemophagocytic lymphohistiocytosis.
    MeSH term(s) Early Diagnosis ; Humans ; Infant ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; Mutation ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2022-01-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.934037
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  7. Article ; Online: Clinical Evaluation of Computer-Aided Colorectal Neoplasia Detection Using a Novel Endoscopic Artificial Intelligence: A Single-Center Randomized Controlled Trial.

    Nakashima, Hirotaka / Kitazawa, Naoko / Fukuyama, Chika / Kawachi, Hiroshi / Kawahira, Hiroshi / Momma, Kumiko / Sakaki, Nobuhiro

    Digestion

    2023  Volume 104, Issue 3, Page(s) 193–201

    Abstract: Introduction: Computer-aided diagnostic systems are emerging in the field of gastrointestinal endoscopy. In this study, we assessed the clinical performance of the computer-aided detection (CADe) of colonic adenomas using a new endoscopic artificial ... ...

    Abstract Introduction: Computer-aided diagnostic systems are emerging in the field of gastrointestinal endoscopy. In this study, we assessed the clinical performance of the computer-aided detection (CADe) of colonic adenomas using a new endoscopic artificial intelligence system.
    Methods: This was a single-center prospective randomized study including 415 participants allocated into the CADe group (n = 207) and control group (n = 208). All endoscopic examinations were performed by experienced endoscopists. The performance of the CADe was assessed based on the adenoma detection rate (ADR). Additionally, we compared the adenoma miss rate for the rectosigmoid colon (AMRrs) between the groups.
    Results: The basic demographic and procedural characteristics of the CADe and control groups were as follows: mean age, 54.9 and 55.9 years; male sex, 73.9% and 69.7% of participants; and mean withdrawal time, 411.8 and 399.0 s, respectively. The ADR was 59.4% in the CADe group and 47.6% in the control group (p = 0.018). The AMRrs was 11.9% in the CADe group and 26.0% in the control group (p = 0.037).
    Conclusion: The colonoscopy with the CADe system yielded an 11.8% higher ADR than that performed by experienced endoscopists alone. Moreover, there was no need to extend the examination time or request the assistance of additional medical staff to achieve this improved effectiveness. We believe that the novel CADe system can lead to considerable advances in colorectal cancer diagnosis.
    MeSH term(s) Humans ; Male ; Middle Aged ; Artificial Intelligence ; Colonic Polyps/diagnostic imaging ; Prospective Studies ; Colonoscopy ; Colonic Neoplasms ; Adenoma/diagnostic imaging ; Computers ; Colorectal Neoplasms/diagnostic imaging
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1712-7
    ISSN 1421-9867 ; 0012-2823
    ISSN (online) 1421-9867
    ISSN 0012-2823
    DOI 10.1159/000528085
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 572: Show issues Location:
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  8. Article ; Online: Myocardial Late Iodine Enhancement Using Photon-Counting Computed Tomography in Patients With Hypertrophic Cardiomyopathy.

    Nishihara, Takahiro / Miyoshi, Toru / Akagi, Noriaki / Nakashima, Mitsutaka / Nakamura, Kazufumi / Ito, Hiroshi

    Circulation reports

    2023  Volume 5, Issue 6, Page(s) 269–270

    Language English
    Publishing date 2023-05-18
    Publishing country Japan
    Document type Journal Article
    ISSN 2434-0790
    ISSN (online) 2434-0790
    DOI 10.1253/circrep.CR-23-0034
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  9. Article ; Online: Corrigendum to "G9a is involved in the regulation of cranial bone formation through activation of Runx2 function during development" [Bone 137 (2020) 115332].

    Ideno, Hisashi / Nakashima, Kazuhisa / Komatsu, Koichiro / Araki, Ryoko / Abe, Masumi / Arai, Yoshinori / Kimura, Hiroshi / Shinkai, Yoichi / Tachibana, Makoto / Nifuji, Akira

    Bone

    2024  Volume 180, Page(s) 117000

    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2023.117000
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    Zs.MO 332: Show issues

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  10. Article ; Online: Accurate scaling functions of the scaled Schrödinger equation.

    Nakatsuji, Hiroshi / Nakashima, Hiroyuki / Kurokawa, Yusaku I

    The Journal of chemical physics

    2022  Volume 156, Issue 1, Page(s) 14113

    Abstract: The scaling function g of the scaled Schrödinger equation (SSE) is generalized to obtain accurate solutions of the Schrödinger equation (SE) with the free complement (FC) theory. The electron-nuclear and electron-electron scaling functions, ... ...

    Abstract The scaling function g of the scaled Schrödinger equation (SSE) is generalized to obtain accurate solutions of the Schrödinger equation (SE) with the free complement (FC) theory. The electron-nuclear and electron-electron scaling functions, g
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0077495
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    In stock of ZB MED Bonn / Germany

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