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Book ; Conference proceedings: Molecular biology meets cardiology

Franke, Werner

Special Workshop Heidelberg Heart II ; 9. - 11. September 2011

(Cell & tissue research ; 348,2)

2012

Event/congress	Special Workshop Heidelberg Heart (2, 2011, Heidelberg)
Author's details	guest ed.: Werne W. Franke
Series title	Cell & tissue research ; 348,2
Collection
Language	English
Size	S. 249 - 370 : Ill., graph. Darst.
Publisher	Springer
Publishing place	Heidelberg u.a.
Publishing country	Germany
Document type	Book ; Conference proceedings
Note	Enth. auch: Abstracts
HBZ-ID	HT017246933
Database	Catalogue ZB MED Medicine, Health

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Ub I Zs 94 -348-	verfügbar in Königswinter	Königswinter

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Article ; Online: The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic cell-cell junction system.

Domke, Lisa M / Franke, Werner W

Cell and tissue research

2018 Volume 375, Issue 2, Page(s) 451–482

Abstract: The testes of sexually mature males of six mammalian species (men, bulls, boars, rats, mice, guinea pigs) have been studied using biochemical as well as light and electron microscopical techniques, in particular immunolocalizations. In these tissues, the ...

Abstract	The testes of sexually mature males of six mammalian species (men, bulls, boars, rats, mice, guinea pigs) have been studied using biochemical as well as light and electron microscopical techniques, in particular immunolocalizations. In these tissues, the peritubular walls represent lamellar encasement structures wrapped around the seminiferous tubules as a bandage system of extracellular matrix layers, alternating with monolayers of very flat polyhedral "lamellar smooth muscle cells" (LSMCs), the number of which varies in different species from 1 to 5 or 6. These LSMCs are complete SMCs containing smooth muscle α-actin (SMA), myosin light and heavy chains, α-actinin, tropomyosin, smoothelin, intermediate-sized filament proteins desmin and/or vimentin, filamin, talin, dystrophin, caldesmon, calponin, and protein SM22α, often also cytokeratins 8 and 18. In the monolayers, the LSMCs are connected by adherens junctions (AJs) based on cadherin-11, in some species also with P-cadherin and/or E-cadherin, which are anchored in cytoplasmic plaques containing β-catenin and other armadillo proteins, in some species also striatin family proteins, protein myozap and/or LUMA. The LSMC cytoplasm is rich in myofilament bundles, which in many regions are packed in paracrystalline arrays, as well as in "dense bodies," "focal adhesions," and caveolae. In addition to some AJ-like end-on-end contacts, the LSMCs are laterally connected by numerous vertical AJ-like junctions located in variously sized and variously shaped, overlapping (alter super alterum) lamelliform cell protrusions. Consequently, the LSMCs of the peritubular wall monolayers are SMCs sensu stricto which are laterally connected by a novel architectonic system of arrays of vertical AJs located in overlapping cell protrusions.
MeSH term(s)	Adherens Junctions/metabolism ; Adherens Junctions/ultrastructure ; Animals ; Basement Membrane/metabolism ; Basement Membrane/ultrastructure ; Cell Surface Extensions/metabolism ; Cytoskeleton/metabolism ; Cytoskeleton/ultrastructure ; Extracellular Matrix/metabolism ; Glycoproteins/metabolism ; Humans ; Male ; Mammals/metabolism ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/ultrastructure ; Seminiferous Epithelium/metabolism ; Seminiferous Tubules/cytology ; Seminiferous Tubules/ultrastructure ; Testis/cytology ; Testis/ultrastructure
Chemical Substances	Glycoproteins
Language	English
Publishing date	2018-12-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	125067-x
ISSN	1432-0878 ; 0302-766X
ISSN (online)	1432-0878
ISSN	0302-766X
DOI	10.1007/s00441-018-2968-x
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Article ; Online: Discovering the molecular components of intercellular junctions--a historical view.

Franke, Werner W

Cold Spring Harbor perspectives in biology

2010 Volume 1, Issue 3, Page(s) a003061

Abstract: The organization of metazoa is based on the formation of tissues and on tissue-typical functions and these in turn are based on cell-cell connecting structures. In vertebrates, four major forms of cell junctions have been classified and the molecular ... ...

Abstract	The organization of metazoa is based on the formation of tissues and on tissue-typical functions and these in turn are based on cell-cell connecting structures. In vertebrates, four major forms of cell junctions have been classified and the molecular composition of which has been elucidated in the past three decades: Desmosomes, which connect epithelial and some other cell types, and the almost ubiquitous adherens junctions are based on closely cis-packed glycoproteins, cadherins, which are associated head-to-head with those of the hemi-junction domain of an adjacent cell, whereas their cytoplasmic regions assemble sizable plaques of special proteins anchoring cytoskeletal filaments. In contrast, the tight junctions (TJs) and gap junctions (GJs) are formed by tetraspan proteins (claudins and occludins, or connexins) arranged head-to-head as TJ seal bands or as paracrystalline connexin channels, allowing intercellular exchange of small molecules. The by and large parallel discoveries of the junction protein families are reported.
MeSH term(s)	Adherens Junctions/metabolism ; Animals ; Biology/history ; Cadherins/metabolism ; Cell Communication ; Claudins/chemistry ; Connexins/chemistry ; Desmosomes/metabolism ; Gap Junctions/metabolism ; History, 20th Century ; History, 21st Century ; Humans ; Membrane Proteins/chemistry ; Models, Biological ; Occludin ; Tight Junctions/metabolism
Chemical Substances	Cadherins ; Claudins ; Connexins ; Membrane Proteins ; OCLN protein, human ; Occludin
Language	English
Publishing date	2010-01-12
Publishing country	United States
Document type	Historical Article ; Journal Article ; Review
ISSN	1943-0264
ISSN (online)	1943-0264
DOI	10.1101/cshperspect.a003061
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature.

Franke, Werner W / Domke, Lisa M / Dörflinger, Yvette / Zimbelmann, Ralf

Cell and tissue research

2019 Volume 379, Issue 1, Page(s) 75–92

Abstract: In the molecular biological and ultrastructural studies of the peritubular wall cells encasing the seminiferous tubules of mammalian testes, we found it necessary to characterize the outermost cell layer bordering on the interstitial space in detail. For ...

Abstract	In the molecular biological and ultrastructural studies of the peritubular wall cells encasing the seminiferous tubules of mammalian testes, we found it necessary to characterize the outermost cell layer bordering on the interstitial space in detail. For half a century, the extremely thin cells of this monolayer have in the literature been regarded as part of a lymphatic endothelium, in particular in rodents. However, our double-label immunofluorescence microscopical results have shown that in all six mammalian species examined, including three rodent ones (rat, mouse, guinea pig), this classification is not correct: the very attenuated cells of this monolayer are not of lymphatic endothelial nature as they do not contain established endothelial marker molecules. In particular, they do not contain claudin-5-positive tight junctions, VE-cadherin-positive adherens junctions, "lymph vessel endothelium hyaluronan receptor 1" (LYVE-1), podoplanin, protein myozap and "von Willebrand Factor" (vWF). By contrast and as controls, all these established marker molecules for the lymphatic endothelial cell type are found in the endothelia of the lymph and-partly also-blood vessels located nearby in the interstitial space. Thus, our results provide evidence that the monolayer cells covering the peritubular wall do not contain endothelial marker molecules and hence are not endothelial cells. We discuss possible methodological reasons for the maintenance of this incorrect cell type classification in the literature and emphasize the value of molecular analyses using multiple cell type-specific markers, also with respect to physiology and medical sciences.
MeSH term(s)	Animals ; Biomarkers/analysis ; Endothelial Cells/cytology ; Humans ; Immunohistochemistry ; Intercellular Junctions/ultrastructure ; Male ; Mammals/anatomy & histology ; Seminiferous Tubules/ultrastructure ; Testis/anatomy & histology ; Testis/ultrastructure
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-11-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	125067-x
ISSN	1432-0878 ; 0302-766X
ISSN (online)	1432-0878
ISSN	0302-766X
DOI	10.1007/s00441-019-03116-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Phenotype-Genotype Correlation Applying a Cocktail Approach and an Exome Chip Analysis Reveals Further Variants Contributing to Variation of Drug Metabolism.

Böhm, Ruwen / Bruckmueller, Henrike / Oswald, Stefan / Hübenthal, Matthias / Kaehler, Meike / Ehmke, Lena / Höcker, Jan / Siegmund, Werner / Franke, Andre / Cascorbi, Ingolf

Clinical pharmacology and therapeutics

2024

Abstract: Although great progress has been made in the fine-tuning of diplotypes, there is still a need to further improve the predictability of individual phenotypes of pharmacogenetically relevant enzymes. The aim of this study was to analyze the additional ... ...

Abstract	Although great progress has been made in the fine-tuning of diplotypes, there is still a need to further improve the predictability of individual phenotypes of pharmacogenetically relevant enzymes. The aim of this study was to analyze the additional contribution of sex and variants identified by exome chip analysis to the metabolic ratio of five probe drugs. A cocktail study applying dextromethorphan, losartan, omeprazole, midazolam, and caffeine was conducted on 200 healthy volunteers. CYP2D6, 2C9, 2C19, 3A4/5, and 1A2 genotypes were analyzed and correlated with metabolic ratios. In addition, an exome chip analysis was performed. These SNPs correlating with metabolic ratios were confirmed by individual genotyping. The contribution of various factors to metabolic ratios was assessed by multiple regression analysis. Genotypically predicted phenotypes defined by CPIC discriminated very well the log metabolic ratios with the exception of caffeine. There were minor sex differences in the activity of CYP2C9, 2C19, 1A2, and CYP3A4/5. For dextromethorphan (CYP2D6), IP6K2 (rs61740999) and TCF20 (rs5758651) affected metabolic ratios, but only IP6K2 remained significant after multiple regression analysis. For losartan (CYP2C9), FBXW12 (rs17080138), ZNF703 (rs79707182), and SLC17A4 (rs11754288) together with CYP diplotypes, and sex explained 50% of interindividual variability. For omeprazole (CYP2C19), no significant influence of CYP2C:TG haplotypes was observed, but CYP2C19 rs12777823 improved the predictability. The comprehensive genetic analysis and inclusion of sex in a multiple regression model significantly improved the explanation of variability of metabolic ratios, resulting in further improvement of algorithms for the prediction of individual phenotypes of drug-metabolizing enzymes.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1002/cpt.3270
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Article: The cell–cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions—a novel architectonic cell–cell junction system

Domke, Lisa M / Werner W. Franke

Cell and tissue research. 2019 Feb., v. 375, no. 2

2019

Abstract	The testes of sexually mature males of six mammalian species (men, bulls, boars, rats, mice, guinea pigs) have been studied using biochemical as well as light and electron microscopical techniques, in particular immunolocalizations. In these tissues, the peritubular walls represent lamellar encasement structures wrapped around the seminiferous tubules as a bandage system of extracellular matrix layers, alternating with monolayers of very flat polyhedral “lamellar smooth muscle cells” (LSMCs), the number of which varies in different species from 1 to 5 or 6. These LSMCs are complete SMCs containing smooth muscle α-actin (SMA), myosin light and heavy chains, α-actinin, tropomyosin, smoothelin, intermediate-sized filament proteins desmin and/or vimentin, filamin, talin, dystrophin, caldesmon, calponin, and protein SM22α, often also cytokeratins 8 and 18. In the monolayers, the LSMCs are connected by adherens junctions (AJs) based on cadherin-11, in some species also with P-cadherin and/or E-cadherin, which are anchored in cytoplasmic plaques containing β-catenin and other armadillo proteins, in some species also striatin family proteins, protein myozap and/or LUMA. The LSMC cytoplasm is rich in myofilament bundles, which in many regions are packed in paracrystalline arrays, as well as in “dense bodies,” “focal adhesions,” and caveolae. In addition to some AJ-like end-on-end contacts, the LSMCs are laterally connected by numerous vertical AJ-like junctions located in variously sized and variously shaped, overlapping (alter super alterum) lamelliform cell protrusions. Consequently, the LSMCs of the peritubular wall monolayers are SMCs sensu stricto which are laterally connected by a novel architectonic system of arrays of vertical AJs located in overlapping cell protrusions.
Keywords	actin ; adherens junctions ; beta catenin ; boars ; bulls ; cadherins ; cytoplasm ; desmin ; dystrophin ; extracellular matrix ; filamin ; focal adhesions ; guinea pigs ; men ; mice ; myocytes ; myosin ; rats ; seminiferous tubules ; sexual maturity ; smooth muscle ; talin ; tropomyosins ; vimentin
Language	English
Dates of publication	2019-02
Size	p. 451-482.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	125067-x
ISSN	1432-0878 ; 0302-766X
ISSN (online)	1432-0878
ISSN	0302-766X
DOI	10.1007/s00441-018-2968-x
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

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Book: Dörfer im Emsland

Franke, Werner

erhaltenswerte ländliche Siedlungsstrukturen in Niedersachsen

(Siedlungsstrukturen in Niedersachsen)

1988

Author's details	Werner Franke
Series title	Siedlungsstrukturen in Niedersachsen
Keywords	Landkreis Emsland ; Siedlung ; Planung
Subject	Plan ; Besiedelung ; Besiedlung ; Siedlungsstätte ; Siedlungsgebiet ; Siedlungen
Size	124 S. : zahlr. Ill., graph. Darst., Kt.
Publisher	Emsländ. Heimatbund
Publishing place	Sögel
Document type	Book
HBZ-ID	HT003758086
ISBN	3-88077-123-5 ; 978-3-88077-123-9
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

Shelf mark	Loan status	Location
918/1109	available for loan (reading room)	Freihandmagazin (U1)

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Article: Shoichiro Tsukita (1953-2005) - a cell biologist who will live with us forever.

Franke, Werner W

Journal of cell science

2006 Volume 119, Issue Pt 6, Page(s) 977–978

MeSH term(s)	Cell Biology/history ; History, 20th Century ; History, 21st Century ; Humans
Language	English
Publishing date	2006-03-15
Publishing country	England
Document type	Biography ; Historical Article ; Journal Article ; Portraits
ZDB-ID	2993-2
ISSN	1477-9137 ; 0021-9533
ISSN (online)	1477-9137
ISSN	0021-9533
DOI	10.1242/jcs.02929
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Zs.MG 14: Show issues

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Article: Enzymatisch isolierte Cellulose-Fibrillen der Valonia-Zellwand

Franke, Werner W / Heinz Falk

Zeitschrift für Naturforschung. 2014 June 2, v. 23, no. 2

2014

Abstract: Cellulose microfibrils from the cell wall of the green alga Valonia macrophysa were isolated by enzymatical digestion of the wall matrix and examined in the electron microscope using the negative staining technique. The smallest fibrils obtained after ... ...

Abstract	Cellulose microfibrils from the cell wall of the green alga Valonia macrophysa were isolated by enzymatical digestion of the wall matrix and examined in the electron microscope using the negative staining technique. The smallest fibrils obtained after prolonged treatment were found to be flat ribbons with a width about 10—20 nm and a height of 3 to 4 nm. This result is discussed in relation to Frey- Wyssling's concept of an “elementary fibril“ with a cross-section of 3.5 × 3.5 nm. Some alternation of unstained areas along the fibrils was observed. This was interpreted as artificially induced rather than relating to the structure and the arrangement of the cellulose chain molecules.
Keywords	Valonia ; cellulose ; cellulose microfibrils ; digestion ; enzymatic hydrolysis ; staining
Language	English
Dates of publication	2014-0602
Size	p. 272-274.
Publishing place	Verlag der Zeitschrift für Naturforschung
Document type	Article
ZDB-ID	124635-5
ISSN	0340-5087 ; 0044-3174 ; 0932-0776 ; 0341-0447 ; 0341-0420
ISSN	0340-5087 ; 0044-3174 ; 0932-0776 ; 0341-0447 ; 0341-0420
DOI	10.1515/znb-1968-0226
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Article: Shoichiro Tsukita 1953-2005.

Franke, Werner W

Nature cell biology

2006 Volume 8, Issue 4, Page(s) 302

MeSH term(s)	Cell Biology/history ; Cell Membrane/physiology ; Cell Membrane/ultrastructure ; History, 20th Century ; History, 21st Century ; Molecular Biology/history
Language	English
Publishing date	2006-04
Publishing country	England
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	1474722-4
ISSN	1476-4679 ; 1465-7392
ISSN (online)	1476-4679
ISSN	1465-7392
DOI	10.1038/ncb0406-302
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