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  1. Article ; Online: Cryptic Diversity of Black Band Disease Cyanobacteria in

    Meyer, Julie L / Gunasekera, Sarath P / Brown, Anya L / Ding, Yousong / Miller, Stephanie / Teplitski, Max / Paul, Valerie J

    Marine drugs

    2023  Volume 21, Issue 2

    Abstract: Black band disease is a globally distributed and easily recognizable coral disease. Despite years of study, the etiology of this coral disease, which impacts dozens of stony coral species, is not completely understood. Although black band disease mats ... ...

    Abstract Black band disease is a globally distributed and easily recognizable coral disease. Despite years of study, the etiology of this coral disease, which impacts dozens of stony coral species, is not completely understood. Although black band disease mats are predominantly composed of the cyanobacterial species
    MeSH term(s) Animals ; Anthozoa/microbiology ; Cyanobacteria/metabolism ; Genomics ; Metagenomics
    Language English
    Publishing date 2023-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21020076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Discovery, Synthesis, and Biological Evaluation of Anaenamides C and D from a New Marine Cyanobacterium,

    Brumley, David A / Gunasekera, Sarath P / Sauvage, Thomas / Dos Santos, Larissa A H / Chen, Qi-Yin / Paul, Valerie J / Luesch, Hendrik

    Journal of natural products

    2022  Volume 85, Issue 3, Page(s) 581–589

    Abstract: Our ongoing efforts to explore the chemical space associated with marine cyanobacteria from coral reefs of Guam have yielded two new members of the anaenamide family of natural products, anaenamides C ( ...

    Abstract Our ongoing efforts to explore the chemical space associated with marine cyanobacteria from coral reefs of Guam have yielded two new members of the anaenamide family of natural products, anaenamides C (
    MeSH term(s) Amides/pharmacology ; Cyanobacteria/chemistry ; HEK293 Cells ; Humans ; NF-E2-Related Factor 2 ; Phylogeny
    Chemical Substances Amides ; NF-E2-Related Factor 2
    Language English
    Publishing date 2022-02-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.1c01073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
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  3. Article ; Online: Cryptic Diversity of Black Band Disease Cyanobacteria in Siderastrea siderea Corals Revealed by Chemical Ecology and Comparative Genome-Resolved Metagenomics

    Meyer, Julie L. / Gunasekera, Sarath P. / Brown, Anya L. / Ding, Yousong / Miller, Stephanie / Teplitski, Max / Paul, Valerie J.

    Mar Drugs. 2023 Jan. 22, v. 21, no. 2

    2023  

    Abstract: Black band disease is a globally distributed and easily recognizable coral disease. Despite years of study, the etiology of this coral disease, which impacts dozens of stony coral species, is not completely understood. Although black band disease mats ... ...

    Abstract Black band disease is a globally distributed and easily recognizable coral disease. Despite years of study, the etiology of this coral disease, which impacts dozens of stony coral species, is not completely understood. Although black band disease mats are predominantly composed of the cyanobacterial species Roseofilum reptotaenium, other filamentous cyanobacterial strains and bacterial heterotrophs are readily detected. Through chemical ecology and metagenomic sequencing, we uncovered cryptic strains of Roseofilum species from Siderastrea siderea corals that differ from those on other corals in the Caribbean and Pacific. Isolation of metabolites from Siderastrea-derived Roseofilum revealed the prevalence of unique forms of looekeyolides, distinct from previously characterized Roseofilum reptotaenium strains. In addition, comparative genomics of Roseofilum strains showed that only Siderastrea-based Roseofilum strains have the genetic capacity to produce lasso peptides, a family of compounds with diverse biological activity. All nine Roseofilum strains examined here shared the genetic capacity to produce looekeyolides and malyngamides, suggesting these compounds support the ecology of this genus. Similar biosynthetic gene clusters are not found in other cyanobacterial genera associated with black band disease, which may suggest that looekeyolides and malyngamides contribute to disease etiology through yet unknown mechanisms.
    Keywords Cyanobacteria ; Scleractinia ; bioactive properties ; biosynthesis ; chemical ecology ; corals ; etiology ; genes ; heterotrophs ; metabolites ; metagenomics ; peptides ; Caribbean
    Language English
    Dates of publication 2023-0122
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21020076
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Anti-Inflammatory Dysidazirine Carboxylic Acid from the Marine Cyanobacterium

    Gunasekera, Sarath P / Kokkaliari, Sofia / Ratnayake, Ranjala / Sauvage, Thomas / Dos Santos, Larissa A H / Luesch, Hendrik / Paul, Valerie J

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 5

    Abstract: Dysidazirine carboxylic acid (1) was isolated from the lipophilic extract of a collection of the benthic marine cyanobacterium Caldora sp. from reefs near Fort Lauderdale, Florida. The planar structure of this new compound was determined by spectroscopic ...

    Abstract Dysidazirine carboxylic acid (1) was isolated from the lipophilic extract of a collection of the benthic marine cyanobacterium Caldora sp. from reefs near Fort Lauderdale, Florida. The planar structure of this new compound was determined by spectroscopic methods and comparisons between HRMS and NMR data with its reported methyl ester. The absolute configuration of the single chiral center was determined by the conversion of 1 to the methyl ester and the comparison of its specific rotation data with the two known methyl ester isomers, 2 and 3. Molecular sequencing with 16S rDNA indicated that this cyanobacterium differs from Caldora penicillata (Oscillatoriales) and represents a previously undocumented and novel Caldora species. Dysidazirine (2) showed weak cytotoxicity against HCT116 colorectal cancer cells (IC50 9.1 µM), while dysidazirine carboxylic acid (1) was non-cytotoxic. Similar cell viability patterns were observed in RAW264.7 cells with dysidazirine only (2), displaying cytotoxicity at the highest concentration tested (50 µM). The non-cytotoxic dysidazirine carboxylic acid (1) demonstrated anti-inflammatory activity in RAW264.7 cells stimulated with LPS. After 24 h, 1 inhibited the production of NO by almost 50% at 50 µM, without inducing cytotoxicity. Compound 1 rapidly decreased gene expression of the pro-inflammatory gene iNOS after 3 h post-LPS treatment and in a dose-dependent manner (IC50 ~1 µM); the downregulation of iNOS persisted at least until 12 h.
    MeSH term(s) Anti-Inflammatory Agents/pharmacology ; Azirines ; Carboxylic Acids/pharmacology ; Florida ; Humans ; Molecular Structure
    Chemical Substances Anti-Inflammatory Agents ; Azirines ; Carboxylic Acids ; dysidazirine (113507-74-7)
    Language English
    Publishing date 2022-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27051717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  5. Article ; Online: Discovery, Total Synthesis, and SAR of Anaenamides A and B: Anticancer Cyanobacterial Depsipeptides with a Chlorinated Pharmacophore.

    Brumley, David A / Gunasekera, Sarath P / Chen, Qi-Yin / Paul, Valerie J / Luesch, Hendrik

    Organic letters

    2020  Volume 22, Issue 11, Page(s) 4235–4239

    Abstract: New modified depsipeptides and geometric isomers, termed anaenamides A ( ...

    Abstract New modified depsipeptides and geometric isomers, termed anaenamides A (
    MeSH term(s) Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cyanobacteria/chemistry ; Dose-Response Relationship, Drug ; Drug Discovery ; Drug Screening Assays, Antitumor ; HCT116 Cells ; Halogenation ; Humans ; Molecular Structure ; Structure-Activity Relationship
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2020-05-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.0c01281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Chemical and genomic characterization of a potential probiotic treatment for stony coral tissue loss disease.

    Ushijima, Blake / Gunasekera, Sarath P / Meyer, Julie L / Tittl, Jessica / Pitts, Kelly A / Thompson, Sharon / Sneed, Jennifer M / Ding, Yousong / Chen, Manyun / Jay Houk, L / Aeby, Greta S / Häse, Claudia C / Paul, Valerie J

    Communications biology

    2023  Volume 6, Issue 1, Page(s) 248

    Abstract: Considered one of the most devastating coral disease outbreaks in history, stony coral tissue loss disease (SCTLD) is currently spreading throughout Florida's coral reefs and the greater Caribbean. SCTLD affects at least two dozen different coral species ...

    Abstract Considered one of the most devastating coral disease outbreaks in history, stony coral tissue loss disease (SCTLD) is currently spreading throughout Florida's coral reefs and the greater Caribbean. SCTLD affects at least two dozen different coral species and has been implicated in extensive losses of coral cover. Here we show Pseudoalteromonas sp. strain McH1-7 has broad-spectrum antibacterial activity against SCTLD-associated bacterial isolates. Chemical analyses indicated McH1-7 produces at least two potential antibacterials, korormicin and tetrabromopyrrole, while genomic analysis identified the genes potentially encoding an L-amino acid oxidase and multiple antibacterial metalloproteases (pseudoalterins). During laboratory trials, McH1-7 arrested or slowed disease progression on 68.2% of diseased Montastraea cavernosa fragments treated (n = 22), and it prevented disease transmission by 100% (n = 12). McH1-7 is the most chemically characterized coral probiotic that is an effective prophylactic and direct treatment for the destructive SCTLD as well as a potential alternative to antibiotic use.
    MeSH term(s) Animals ; Anthozoa/microbiology ; Coral Reefs ; Genomics ; Caribbean Region
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-04590-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Anti-Inflammatory Dysidazirine Carboxylic Acid from the Marine Cyanobacterium Caldora sp. Collected from the Reefs of Fort Lauderdale, Florida

    Sarath P. Gunasekera / Sofia Kokkaliari / Ranjala Ratnayake / Thomas Sauvage / Larissa A. H. dos Santos / Hendrik Luesch / Valerie J. Paul

    Molecules, Vol 27, Iss 1717, p

    2022  Volume 1717

    Abstract: Dysidazirine carboxylic acid ( 1 ) was isolated from the lipophilic extract of a collection of the benthic marine cyanobacterium Caldora sp. from reefs near Fort Lauderdale, Florida. The planar structure of this new compound was determined by ... ...

    Abstract Dysidazirine carboxylic acid ( 1 ) was isolated from the lipophilic extract of a collection of the benthic marine cyanobacterium Caldora sp. from reefs near Fort Lauderdale, Florida. The planar structure of this new compound was determined by spectroscopic methods and comparisons between HRMS and NMR data with its reported methyl ester. The absolute configuration of the single chiral center was determined by the conversion of 1 to the methyl ester and the comparison of its specific rotation data with the two known methyl ester isomers, 2 and 3 . Molecular sequencing with 16S rDNA indicated that this cyanobacterium differs from Caldora penicillata (Oscillatoriales) and represents a previously undocumented and novel Caldora species. Dysidazirine ( 2 ) showed weak cytotoxicity against HCT116 colorectal cancer cells (IC 50 9.1 µM), while dysidazirine carboxylic acid ( 1 ) was non-cytotoxic. Similar cell viability patterns were observed in RAW264.7 cells with dysidazirine only ( 2 ), displaying cytotoxicity at the highest concentration tested (50 µM). The non-cytotoxic dysidazirine carboxylic acid ( 1 ) demonstrated anti-inflammatory activity in RAW264.7 cells stimulated with LPS. After 24 h, 1 inhibited the production of NO by almost 50% at 50 µM, without inducing cytotoxicity. Compound 1 rapidly decreased gene expression of the pro-inflammatory gene iNOS after 3 h post-LPS treatment and in a dose-dependent manner (IC 50 ~1 µM); the downregulation of iNOS persisted at least until 12 h.
    Keywords marine cyanobacteria ; Caldora ; Oscillatoriales ; marine natural products ; azirine natural product ; cytotoxicity ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Chemical and genomic characterization of a potential probiotic treatment for stony coral tissue loss disease

    Blake Ushijima / Sarath P. Gunasekera / Julie L. Meyer / Jessica Tittl / Kelly A. Pitts / Sharon Thompson / Jennifer M. Sneed / Yousong Ding / Manyun Chen / L. Jay Houk / Greta S. Aeby / Claudia C. Häse / Valerie J. Paul

    Communications Biology, Vol 6, Iss 1, Pp 1-

    2023  Volume 13

    Abstract: A multidisciplinary approach identifies broad-spectrum antibacterial activity of Pseudoalteromonas sp. strain McH1-7 against stony coral tissue loss disease, which is threatening Caribbean coral reefs. ...

    Abstract A multidisciplinary approach identifies broad-spectrum antibacterial activity of Pseudoalteromonas sp. strain McH1-7 against stony coral tissue loss disease, which is threatening Caribbean coral reefs.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Discovery, Total Synthesis, and SAR of Anaenamides A and B: Anticancer Cyanobacterial Depsipeptides with a Chlorinated Pharmacophore

    Brumley, David A / Gunasekera, Sarath P / Chen, Qi-Yin / Paul, Valerie J / Luesch, Hendrik

    Organic letters. 2020 May 16, v. 22, no. 11

    2020  

    Abstract: New modified depsipeptides and geometric isomers, termed anaenamides A (1a) and B (1b), along with the presumptive biosynthetic intermediate, anaenoic acid (2), were discovered from a marine cyanobacterium from Guam. Structures were confirmed by total ... ...

    Abstract New modified depsipeptides and geometric isomers, termed anaenamides A (1a) and B (1b), along with the presumptive biosynthetic intermediate, anaenoic acid (2), were discovered from a marine cyanobacterium from Guam. Structures were confirmed by total synthesis. The alkylsalicylic acid fragment and the C-terminal α-chlorinated α,β-unsaturated ester are novelties in cyanobacterial natural products. Cancer cell viability assays indicated that the C-terminal unit serves as the pharmacophore and that the double-bond geometry impacts the cytotoxicity.
    Keywords biosynthesis ; cell viability ; cytotoxicity ; depsipeptides ; geometry ; neoplasm cells ; pharmacology ; Guam
    Language English
    Dates of publication 2020-0516
    Size p. 4235-4239.
    Publishing place American Chemical Society
    Document type Article
    Note NAL-AP-2-clean
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.0c01281
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Eudesmacarbonate, a Eudesmane-Type Sesquiterpene from a Marine Filamentous Cyanobacterial Mat (Oscillatoriales) in the Florida Keys.

    Lydon, Christina A / Mathivathanan, Logesh / Sanchez, Juanita / Dos Santos, Larissa A H / Sauvage, Thomas / Gunasekera, Sarath P / Paul, Valerie J / Berry, John P

    Journal of natural products

    2020  Volume 83, Issue 6, Page(s) 2030–2035

    Abstract: A new, cyclic carbonate eudesmane-type sesquiterpene, eudesmacarbonate ( ...

    Abstract A new, cyclic carbonate eudesmane-type sesquiterpene, eudesmacarbonate (
    MeSH term(s) Animals ; Behavior, Animal/drug effects ; Cyanobacteria/chemistry ; Embryo, Nonmammalian ; Florida ; Larva ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Neurotoxicity Syndromes/psychology ; Neurotoxins/toxicity ; Sesquiterpenes/pharmacology ; Sesquiterpenes, Eudesmane/toxicity ; X-Ray Diffraction ; Zebrafish
    Chemical Substances Neurotoxins ; Sesquiterpenes ; Sesquiterpenes, Eudesmane ; eudesmane (473-11-0)
    Language English
    Publishing date 2020-05-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.0c00203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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