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  1. Article: Ligand and Linkage Isomers of Bis(ethylthiocarbamato) Copper Complexes with Cyclic C

    Bajaj, Kritika / Andres, Sarah A / Hofsommer, Dillon T / Michael, Okolocha Chekwube / Mashuta, Mark S / Bates, Paula J / Buchanan, Robert M / Grapperhaus, Craig A

    European journal of inorganic chemistry

    2023  Volume 26, Issue 34

    Abstract: A series of isomeric bis(alkylthiocarbamate) copper complexes have been synthesized, characterized, and evaluated for antiproliferation activity. The complexes were derived from ligand isomers with 3-methylpentyl ( ... ...

    Abstract A series of isomeric bis(alkylthiocarbamate) copper complexes have been synthesized, characterized, and evaluated for antiproliferation activity. The complexes were derived from ligand isomers with 3-methylpentyl (H
    Language English
    Publishing date 2023-09-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1475009-0
    ISSN 1099-0682 ; 1434-1948
    ISSN (online) 1099-0682
    ISSN 1434-1948
    DOI 10.1002/ejic.202300447
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  2. Article: Optimization of Tumor Targeting Gold Nanoparticles for Glioblastoma Applications.

    Allen, Nicholas C / Chauhan, Rajat / Bates, Paula J / O'Toole, Martin G

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 21

    Abstract: Glioblastoma brain tumors represent an aggressive form of gliomas that is hallmarked by being extremely invasive and aggressive due to intra and inter-tumoral heterogeneity. This complex tumor microenvironment makes even the newer advancements in ... ...

    Abstract Glioblastoma brain tumors represent an aggressive form of gliomas that is hallmarked by being extremely invasive and aggressive due to intra and inter-tumoral heterogeneity. This complex tumor microenvironment makes even the newer advancements in glioblastoma treatment less effective long term. In developing newer treatment technologies against glioblastoma, one should tailor the treatment to the tumor microenvironment, thus allowing for a more robust and sustained anti-glioblastoma effect. Here, we present a novel gold nanoparticle therapy explicitly designed for bioactivity against glioblastoma representing U87MG cell lines. We employ standard conjugation techniques to create oligonucleotide-coated gold nanoparticles exhibiting strong anti-glioblastoma behavior and optimize their design to maximize bioactivity against glioblastoma. Resulting nanotherapies are therapy specific and show upwards of 75% inhibition in metabolic and proliferative activity with stark effects on cellular morphology. Ultimately, these gold nanotherapies are a good base for designing more multi-targeted approaches to fighting against glioblastoma.
    Language English
    Publishing date 2022-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12213869
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  3. Article: The Impact of PEGylation on Cellular Uptake and In Vivo Biodistribution of Gold Nanoparticle MRI Contrast Agents.

    El-Baz, Nagwa / Nunn, Betty M / Bates, Paula J / O'Toole, Martin G

    Bioengineering (Basel, Switzerland)

    2022  Volume 9, Issue 12

    Abstract: Gold nanoparticles (GNPs) have immense potential in biomedicine, but understanding their interactions with serum proteins is crucial as it could change their biological profile due to the formation of a protein corona, which could then affect their ... ...

    Abstract Gold nanoparticles (GNPs) have immense potential in biomedicine, but understanding their interactions with serum proteins is crucial as it could change their biological profile due to the formation of a protein corona, which could then affect their ultimate biodistribution in the body. Grafting GNPs with polyethylene glycol (PEG) is a widely used practice in research in order to decrease opsonization of the particles by serum proteins and to decrease particle uptake by the mononuclear phagocyte system. We investigated the impact of PEGylation on the formation of protein coronae and the subsequent uptake by macrophages and MDA-MB-231 cancer cells. Furthermore, we investigated the in vivo biodistribution in xenograft tumor-bearing mice using a library of 4 and 10 nm GNPs conjugated with a gadolinium chelate as MRI contrast agent, cancer-targeting aptamer AS1411 (or CRO control oligonucleotide), and with or without PEG molecules of different molecular weight (Mw: 1, 2, and 5 kDa). In vitro results showed that PEG failed to decrease the adsorption of proteins; moreover, the cellular uptake by macrophage cells was contingent on the different configurations of the aptamers and the length of the PEG chain. In vivo biodistribution studies showed that PEG increased the uptake by tumor cells for some GNPs, albeit it did not decrease the uptake of GNPs by macrophage-rich organs.
    Language English
    Publishing date 2022-12-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering9120766
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  4. Article ; Online: Optimization of Tumor Targeting Gold Nanoparticles for Glioblastoma Applications

    Nicholas C. Allen / Rajat Chauhan / Paula J. Bates / Martin G. O’Toole

    Nanomaterials, Vol 12, Iss 3869, p

    2022  Volume 3869

    Abstract: Glioblastoma brain tumors represent an aggressive form of gliomas that is hallmarked by being extremely invasive and aggressive due to intra and inter-tumoral heterogeneity. This complex tumor microenvironment makes even the newer advancements in ... ...

    Abstract Glioblastoma brain tumors represent an aggressive form of gliomas that is hallmarked by being extremely invasive and aggressive due to intra and inter-tumoral heterogeneity. This complex tumor microenvironment makes even the newer advancements in glioblastoma treatment less effective long term. In developing newer treatment technologies against glioblastoma, one should tailor the treatment to the tumor microenvironment, thus allowing for a more robust and sustained anti-glioblastoma effect. Here, we present a novel gold nanoparticle therapy explicitly designed for bioactivity against glioblastoma representing U87MG cell lines. We employ standard conjugation techniques to create oligonucleotide-coated gold nanoparticles exhibiting strong anti-glioblastoma behavior and optimize their design to maximize bioactivity against glioblastoma. Resulting nanotherapies are therapy specific and show upwards of 75% inhibition in metabolic and proliferative activity with stark effects on cellular morphology. Ultimately, these gold nanotherapies are a good base for designing more multi-targeted approaches to fighting against glioblastoma.
    Keywords glioblastoma ; gold nanoparticles ; AS1411 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Characterizing Oligonucleotide Uptake in Cultured Cells: A Case Study Using AS1411 Aptamer.

    Reyes-Reyes, Elsa M / Bates, Paula J

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 2036, Page(s) 173–186

    Abstract: Oligonucleotides can be designed or evolved to bind to specific DNA, RNA, protein, or small molecule targets and thereby alter the biological function of the target. The therapeutic potential of oligonucleotides targeted to intracellular molecules will ... ...

    Abstract Oligonucleotides can be designed or evolved to bind to specific DNA, RNA, protein, or small molecule targets and thereby alter the biological function of the target. The therapeutic potential of oligonucleotides targeted to intracellular molecules will depend largely on their ability to be taken up by the cells of interest, as well as their subsequent subcellular distribution. Here we describe methods to characterize the extent and mechanism of cellular uptake of AS1411, an aptamer oligonucleotide that has progressed to human clinical trials and which is also widely used by researchers as a cancer-targeting ligand.
    MeSH term(s) Aptamers, Nucleotide/administration & dosage ; Aptamers, Nucleotide/chemistry ; Aptamers, Nucleotide/metabolism ; Biological Transport ; Cell Line ; Cell Line, Tumor ; Cells, Cultured ; Endocytosis ; Flow Cytometry ; Humans ; Microscopy, Confocal ; Oligodeoxyribonucleotides/administration & dosage ; Oligodeoxyribonucleotides/chemistry ; Oligodeoxyribonucleotides/metabolism ; Pinocytosis
    Chemical Substances AGRO 100 ; Aptamers, Nucleotide ; Oligodeoxyribonucleotides
    Language English
    Publishing date 2019-08-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9670-4_10
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  6. Article ; Online: Physical structure of constitutional isomers influences antiproliferation activity of thiosemicarbazone-alkylthiocarbamate copper complexes.

    Bajaj, Kritika / Andres, Sarah A / Hofsommer, Dillon T / Greene, Aidan F / Hietsoi, Oleksandr / Mashuta, Mark S / Weis, Theresa / Beverly, Levi J / Bates, Paula J / Buchanan, Robert M / Grapperhaus, Craig A

    Journal of inorganic biochemistry

    2023  Volume 246, Page(s) 112288

    Abstract: A series of hybrid thiosemicarbazone-alkylthiocarbamate copper complexes with similar electronic environments but distinct physical structures have been prepared, characterized, and evaluated for antiproliferation activity. The complexes include the ... ...

    Abstract A series of hybrid thiosemicarbazone-alkylthiocarbamate copper complexes with similar electronic environments but distinct physical structures have been prepared, characterized, and evaluated for antiproliferation activity. The complexes include the constitutional isomers (1-phenylpropane-1-imine-(O-ethylthiocarbamato)-2-one-(N-methylthiosemicarbazonato))copper(II) (CuL
    MeSH term(s) Copper/chemistry ; Propane ; Electron Spin Resonance Spectroscopy ; Thiosemicarbazones/pharmacology ; Thiosemicarbazones/chemistry ; Imines ; Coordination Complexes/pharmacology ; Coordination Complexes/chemistry ; Crystallography, X-Ray ; Ligands
    Chemical Substances Copper (789U1901C5) ; Propane (T75W9911L6) ; Thiosemicarbazones ; Imines ; Coordination Complexes ; Ligands
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 162843-4
    ISSN 1873-3344 ; 0162-0134
    ISSN (online) 1873-3344
    ISSN 0162-0134
    DOI 10.1016/j.jinorgbio.2023.112288
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1730: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  7. Article: A Cross-Sectional Investigation of Preadolescent Cardiometabolic Health: Associations with Fitness, Physical Activity, Sedentary Behavior, Nutrition, and Sleep.

    Castro, Nicholas / Zieff, Gabriel / Bates, Lauren C / Pagan Lassalle, Patricia / Higgins, Simon / Faulkner, James / Lark, Sally / Skidmore, Paula / Hamlin, Michael J / Signal, T Leigh / Williams, Michelle A / Stoner, Lee

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 2

    Abstract: Background: Cardiometabolic disease (CMD) risk often begins early in life. Healthy lifestyle behaviors can mitigate risk, but the optimal combination of behaviors has not been determined. This cross-sectional study simultaneously examined the ... ...

    Abstract Background: Cardiometabolic disease (CMD) risk often begins early in life. Healthy lifestyle behaviors can mitigate risk, but the optimal combination of behaviors has not been determined. This cross-sectional study simultaneously examined the associations between lifestyle factors (fitness, activity behaviors, and dietary patterns) and CMD risk in preadolescent children.
    Methods: 1480 New Zealand children aged 8-10 years were recruited. Participants included 316 preadolescents (50% female, age: 9.5 ± 1.1 years, BMI: 17.9 ± 3.3 kg/m
    Results: Only CRF (β = -0.45,
    Conclusion: The findings indicate that increasing CRF and decreasing sedentary behavior may be important public health targets in preadolescent children.
    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10020336
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  8. Article ; Online: Comparison of Acoustofluidic and Static Systems for Ultrasound-Mediated Molecular Delivery to T Lymphocytes.

    Centner, Connor S / Moore, John T / Baxter, Mary E / Yaddanapudi, Kavitha / Bates, Paula J / Kopechek, Jonathan A

    Ultrasound in medicine & biology

    2022  Volume 49, Issue 1, Page(s) 90–105

    Abstract: Continuous-flow acoustofluidic technologies can potentially improve processing of T lymphocytes for cell therapies by addressing the limitations with viral and non-viral delivery methods. The objective of this study was to assess the intracellular ... ...

    Abstract Continuous-flow acoustofluidic technologies can potentially improve processing of T lymphocytes for cell therapies by addressing the limitations with viral and non-viral delivery methods. The objective of this study was to assess the intracellular delivery efficiency with acoustofluidic treatment compared with that of static ultrasound treatment. Optimization of parameters in acoustofluidic and static configurations was performed by assessing intracellular delivery of a fluorescent compound (calcein) in viable human Jurkat T lymphocytes. Ultrasound pressure and the concentration of cationic phospholipid-coated microbubbles influenced calcein delivery in both systems. In the static system, a treatment time of 45 s increased molecular delivery compared with 0-30 s (p < 0.01). Refined parameters were used to assess molecular delivery of small and large compounds (0.6-kDa calcein and 150-kDa fluorescein isothiocyanate-dextran, respectively) after ultrasound treatment with the acoustofluidic or static systems. Molecular delivery was similar with refined parameters for acoustofluidic treatment and static treatment (p > 0.05), even though acoustofluidic treatment had lower microbubble concentration (24 μg/mL vs. 94 μg/mL) and shorter treatment time (∼2-3 s vs. 45 s). This study indicates that the acoustofluidic system can significantly enhance intracellular molecular delivery, which could potentially enable acoustofluidic cell transfection during continuous flow processing for manufacture of cell therapies or other applications.
    MeSH term(s) Humans ; T-Lymphocytes ; Microbubbles ; Transfection ; Ultrasonography ; Drug Delivery Systems/methods
    Chemical Substances fluorexon (V0YM2B16TS)
    Language English
    Publishing date 2022-10-12
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2022.08.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 963: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Investigations of Bis(alkylthiocarbamato)copper Linkage Isomers.

    Bajaj, Kritika / Andres, Sarah A / Hofsommer, Dillon T / Galib, Mirza / Mashuta, Mark S / Bennett, Brian / Narayanan, Badri / Buchanan, Robert M / Bates, Paula J / Grapperhaus, Craig A

    Inorganic chemistry

    2022  Volume 61, Issue 20, Page(s) 7715–7719

    Abstract: Linkage isomers are coordination compounds with the same composition but different donor atoms, resulting in distinct physical and electronic structures. A pair of linkage isomers, ...

    Abstract Linkage isomers are coordination compounds with the same composition but different donor atoms, resulting in distinct physical and electronic structures. A pair of linkage isomers,
    MeSH term(s) Copper/chemistry ; Copper/pharmacology ; Isomerism
    Chemical Substances Copper (789U1901C5)
    Language English
    Publishing date 2022-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.2c00371
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  10. Article ; Online: Delivery of thymoquinone to cancer cells with as1411-conjugated nanodroplets.

    Murphy, Emily M / Centner, Connor S / Bates, Paula J / Malik, Mohammad T / Kopechek, Jonathan A

    PloS one

    2020  Volume 15, Issue 5, Page(s) e0233466

    Abstract: Systemic delivery of conventional chemotherapies can cause negative systemic toxicity, including reduced immunity and damage to organs such as the heart and kidneys-limiting the maximum dose that can be administered. Targeted therapies appear to address ... ...

    Abstract Systemic delivery of conventional chemotherapies can cause negative systemic toxicity, including reduced immunity and damage to organs such as the heart and kidneys-limiting the maximum dose that can be administered. Targeted therapies appear to address this problem by having a specific target while mitigating off-target effects. Biocompatible perfluorocarbon-based nanodroplet emulsions encapsulated by a phospholipid shell are in development for delivery of molecular compounds and hold promise as vehicles for targeted delivery of chemotherapeutics to tumors. When ultrasound is applied, perfluorocarbon will undergo a phase change-ultimately inducing transient perforation of the cell membrane when in close proximity, which is more commonly known as "sonoporation." Sonoporation allows enhanced intracellular delivery of molecular compounds and will reseal to encapsulate the molecular compound intracellularly. In this study, we investigated delivery of thymoquinone (TQ), a natural hydrophobic phytochemical compound with bioactivity in cancer cells. In addition, we conjugated a G-quadruplex aptamer, 'AS1411', to TQ-loaded nanodroplets and explored their effects on multiple human cancer cell lines. AS1411 binds nucleolin, which is over-expressed on the surface of cancer cells, and in addition to its tumor-targeting properties AS1411 has also been shown to induce anti-cancer effects. Thymoquinone was loaded onto AS1411-conjugated nanodroplet emulsion to assess activity against cancer cells. Confocal microscopy indicated uptake of AS1411-conjugated nanodroplets by cancer cells. Furthermore, AS1411-conjugated nanoemulsions loaded with TQ significantly enhanced cytotoxicity in cancer cells compared to free compound. These results demonstrate that AS1411 can be conjugated onto nanodroplet emulsions for targeted delivery to human cancer cells. This novel formulation offers significant potential for targeted delivery of hydrophobic chemotherapeutics to tumors for cancer treatment.
    MeSH term(s) Aptamers, Nucleotide ; Benzoquinones/administration & dosage ; Cell Line, Tumor ; Drug Delivery Systems ; Humans ; Nanoparticles/administration & dosage ; Oligodeoxyribonucleotides/administration & dosage
    Chemical Substances AGRO 100 ; Aptamers, Nucleotide ; Benzoquinones ; Oligodeoxyribonucleotides ; thymoquinone (O60IE26NUF)
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0233466
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