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  1. Article: A novel homozygous mutation in

    Zhao, Bei / Tang, Yisi / Chen, Wenjing / Wan, Huiying / Yang, Jiyun / Chen, Xuejun

    Frontiers in physiology

    2023  Volume 13, Page(s) 992190

    Abstract: Aim: ...

    Abstract Aim:
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.992190
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  2. Article: Clinical, neurophysiological evaluation and genetic features of axonal Charcot-Marie-Tooth disease in a Chinese family.

    Cao, Li / Yang, Jie / Zhang, Xiaohuan / Wang, Xu / Chen, Zhangyuwei / Tan, Song / Yang, Jiyun

    Frontiers in neurology

    2024  Volume 14, Page(s) 1337065

    Abstract: Charcot-Marie-Tooth disease (CMT) is a group of inherited peripheral neuropathies related to variants in the mitochondrial transfer RNA ( ...

    Abstract Charcot-Marie-Tooth disease (CMT) is a group of inherited peripheral neuropathies related to variants in the mitochondrial transfer RNA (
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1337065
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  3. Article ; Online: Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery.

    Chen, Jiyun / Chen, Hong / Li, Shanshan / Lin, Xiaofeng / Hu, Rong / Zhang, Kaiming / Liu, Liang

    eLife

    2024  Volume 12

    Abstract: Precursor ribosomal RNA (pre-rRNA) processing is a key step in ribosome biosynthesis and involves numerous RNases. A HEPN (higher eukaryote and prokaryote nucleotide binding) nuclease Las1 and a polynucleotide kinase Grc3 assemble into a tetramerase ... ...

    Abstract Precursor ribosomal RNA (pre-rRNA) processing is a key step in ribosome biosynthesis and involves numerous RNases. A HEPN (higher eukaryote and prokaryote nucleotide binding) nuclease Las1 and a polynucleotide kinase Grc3 assemble into a tetramerase responsible for rRNA maturation. Here, we report the structures of full-length
    MeSH term(s) RNA, Ribosomal ; RNA Precursors ; Ribosomes ; RNA Processing, Post-Transcriptional ; Endonucleases
    Chemical Substances RNA, Ribosomal ; RNA Precursors ; Endonucleases (EC 3.1.-)
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.86847
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  4. Article ; Online: Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery

    Jiyun Chen / Hong Chen / Shanshan Li / Xiaofeng Lin / Rong Hu / Kaiming Zhang / Liang Liu

    eLife, Vol

    2024  Volume 12

    Abstract: Precursor ribosomal RNA (pre-rRNA) processing is a key step in ribosome biosynthesis and involves numerous RNases. A HEPN (higher eukaryote and prokaryote nucleotide binding) nuclease Las1 and a polynucleotide kinase Grc3 assemble into a tetramerase ... ...

    Abstract Precursor ribosomal RNA (pre-rRNA) processing is a key step in ribosome biosynthesis and involves numerous RNases. A HEPN (higher eukaryote and prokaryote nucleotide binding) nuclease Las1 and a polynucleotide kinase Grc3 assemble into a tetramerase responsible for rRNA maturation. Here, we report the structures of full-length Saccharomyces cerevisiae and Cyberlindnera jadinii Las1-Grc3 complexes, and C. jadinii Las1. The Las1-Grc3 structures show that the central coiled-coil domain of Las1 facilitates pre-rRNA binding and cleavage, while the Grc3 C-terminal loop motif directly binds to the HEPN active center of Las1 and regulates pre-rRNA cleavage. Structural comparison between Las1 and Las1-Grc3 complex exhibits that Grc3 binding induces conformational rearrangements of catalytic residues associated with HEPN nuclease activation. Biochemical assays identify that Las1 processes pre-rRNA at the two specific sites (C2 and C2′), which greatly facilitates rRNA maturation. Our structures and specific pre-rRNA cleavage findings provide crucial insights into the mechanism and pathway of pre-rRNA processing in ribosome biosynthesis.
    Keywords HEPN nuclease ; Pre-rRNA processing ; ribosome biosynthesis ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 500
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Characteristics of

    Yang, Jie / Xiao, Gang / Xiao, Ning / Jiang, Zonghan / Jiang, Chao / Li, Yujuan / Chen, Wenxin / Lin, Hongguang / Sun, Zhiliang / Li, Jiyun

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 1

    Abstract: Background: The plasmid-mediated tigecycline resistance gene : Methods: A total of six : Results: Almost all : Conclusions: The presence of similar genetic environments ... ...

    Abstract Background: The plasmid-mediated tigecycline resistance gene
    Methods: A total of six
    Results: Almost all
    Conclusions: The presence of similar genetic environments in
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12010147
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  6. Article ; Online: Electrochemically Exfoliated Graphene Oxide for Simple Fabrication of Cocaine Aptasensors.

    Lei, Yuting / Ossonon, Benjamin D / Trahan, Pierre-Luc / Chen, Jiyun / Perreault, Jonathan / Tavares, Ana C

    ACS applied materials & interfaces

    2023  Volume 15, Issue 29, Page(s) 35580–35589

    Abstract: Transducers made from graphene-type materials are widely used in sensing applications. However, utilization of graphene oxide obtained from electrochemical exfoliation of graphite (EGO) has remained relatively unexplored. In this study, electrochemical ... ...

    Abstract Transducers made from graphene-type materials are widely used in sensing applications. However, utilization of graphene oxide obtained from electrochemical exfoliation of graphite (EGO) has remained relatively unexplored. In this study, electrochemical cocaine aptasensors based on large-size EGO flakes were investigated. In particular, the influence of the following parameters on the sensor performance was examined: (i) aptamer's terminal group (-NH
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c03777
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  7. Article ; Online: Virulence is one of the mechanisms of vulvovaginal candidiasis recurrence, rather than drug resistance.

    Li, Xinzheng / Chen, Shi / Lyu, Xiangcai / Tian, Jiyun

    Medical mycology

    2022  Volume 60, Issue 11

    Abstract: To explore the mechanism of vulvovaginal candidiasis (VVC) recurrence. A total of 127 strains of Candida albicans (C. albicans) were collected, including 58, 40, and 29 strains from the recurrent vulvovaginal candidiasis (RVVC), VVC, and asymptomatic ... ...

    Abstract To explore the mechanism of vulvovaginal candidiasis (VVC) recurrence. A total of 127 strains of Candida albicans (C. albicans) were collected, including 58, 40, and 29 strains from the recurrent vulvovaginal candidiasis (RVVC), VVC, and asymptomatic carrier (AC), respectively. The strains' virulence such as in vivo hypha formation rate, germ tube formation rate, biofilm formation ability, and sensitivity to five common antifungals were detected. The in vivo hypha formation rates of C. albicans from the RVVC (55.2%) and VVC (40.0%) were significantly higher than that from the AC (0%) (P < .001). The median germ tube formation rate of the RVVC was 88.2%, which was higher than that of the VVC and AC (59.9% and 65.6%), respectively (P < .001). The median absorbance of the biofilm formation test for strains in the RVVC was 0.380, considerably higher than that in the VVC and AC (0.246 and 0.254) (P < .001). The drug sensitivity rate of the strains to 5-fluorocytosine and itraconazole and the ratio of strains sensitive to all the five antifungals in the VVC group were lower than those in the RVVC and AC groups. In conclusion, the virulence of strains from the RVVC is stronger than that of strains from the VVC and AC, the antifungal resistance rate of strains from the RVVC group is lower than that of strains from the VVC group. So, it is suitable to argue that the strains' virulence is one of the mechanisms for the relapse of RVVC, rather than its antifungal resistance.
    MeSH term(s) Animals ; Female ; Candidiasis, Vulvovaginal/veterinary ; Virulence ; Antifungal Agents/pharmacology ; Candida albicans ; Drug Resistance, Fungal
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2022-11-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1421796-x
    ISSN 1460-2709 ; 1369-3786
    ISSN (online) 1460-2709
    ISSN 1369-3786
    DOI 10.1093/mmy/myac087
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    Zs.A 520: Show issues Location:
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  8. Article: LncRNA MACC1-AS1 induces gemcitabine resistance in pancreatic cancer cells through suppressing ferroptosis.

    Zhu, Jiyun / Yu, Zehao / Wang, Xuguang / Zhang, Jinghui / Chen, Yi / Chen, Kaibo / Zhang, Bin / Sun, Jianhong / Jiang, Jianshuai / Zheng, Siming

    Cell death discovery

    2024  Volume 10, Issue 1, Page(s) 101

    Abstract: Pancreatic ductal adenocarcinoma (PDA) mortality is primarily attributed to metastasis and chemotherapy resistance. In this research, the long non-coding RNA MACC1-AS1 was studied, playing a significant role in regulating lipid oxidation processes. This ... ...

    Abstract Pancreatic ductal adenocarcinoma (PDA) mortality is primarily attributed to metastasis and chemotherapy resistance. In this research, the long non-coding RNA MACC1-AS1 was studied, playing a significant role in regulating lipid oxidation processes. This regulation could further lead to the inhibition of ferroptosis induced by chemotherapeutic drugs, making it a contributing factor to gemcitabine resistance in PDA. In both gemcitabine-resistant PDA patients and mouse models, the elevated expression level of MACC1-AS1 in the tumors was noted. Additionally, overexpression of MACC1-AS1 in pancreatic cancer cells was found to enhance tolerance to gemcitabine and suppress ferroptosis. Proteomic analysis of drug-resistant pancreatic cells revealed that overexpressed MACC1-AS1 inhibited the ubiquitination degradation of residues in the protein kinase STK33 by MDM4. Furthermore, its accumulation in the cytoplasm activated STK33, further activating the ferroptosis-suppressing proteins GPX4, thereby counteracting gemcitabine-induced cellular oxidative damage. These findings suggested that the long non-coding RNA MACC1-AS1 could play a significant role in the ability of pancreatic cancer cells to evade iron-mediated ferroptosis induced by gemcitabine. This discovery holds promise for developing clinical therapeutic strategies to combat chemotherapy resistance in pancreatic cancer.
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-024-01866-y
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  9. Article ; Online: A Space Expander of Laparoscopic Rectal Cancer Surgery for Overweight or Obese Patients.

    Chen, Guofeng / Lu, Yu / Zhu, Jiyun / Huang, Yi / Chen, Jian / Chen, Kaibo

    Surgical innovation

    2023  Volume 30, Issue 5, Page(s) 664–667

    Abstract: Background/need: Laparoscopic rectal cancer surgery (LRCS) has become a preferred approach for its minimal invasion and fast postoperative recovery. But it is challenging for the tumors of the middle and lower rectum, especially for overweight or obese ... ...

    Abstract Background/need: Laparoscopic rectal cancer surgery (LRCS) has become a preferred approach for its minimal invasion and fast postoperative recovery. But it is challenging for the tumors of the middle and lower rectum, especially for overweight or obese patients.
    Methodology: We present a space expander of laparoscopic rectal cancer surgery, which is a simple tool to widen the perirectal space, as to facilitate the procedure of total mesorectal excision (TME) during the rectal cancer surgery. It has several advantages of lower demand for an assistant, less risk of surgical complications and good feasibility.
    Device description: It is designed as a cylindrical shape, and it is the first invented device to help surgeons safely perform accurate TME on overweight or obese patients during LRCS. With this method, we are able to dissect the rectal wall circumferentially in a safe and quick way.
    Preliminary results: Our previous pig experiments indicated that the learning curve for this technique was as short as 10 minutes.
    Current status: Further clinical trials will be conducted on its efficacy and safety in the future.
    MeSH term(s) Humans ; Animals ; Swine ; Overweight/complications ; Overweight/surgery ; Rectal Neoplasms/surgery ; Rectum/surgery ; Laparoscopy/methods ; Obesity/surgery ; Obesity/complications ; Treatment Outcome ; Postoperative Complications/etiology
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2182571-3
    ISSN 1553-3514 ; 1553-3506
    ISSN (online) 1553-3514
    ISSN 1553-3506
    DOI 10.1177/15533506231157793
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    Zs.A 4269: Show issues Location:
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  10. Article: Diagnosis of Alzheimer's disease by feature weighted-LSTM: a preliminary study of temporal features in brain resting-state fMRI.

    Li, Jiyun / Song, Binbin / Qian, Chen

    Journal of integrative neuroscience

    2022  Volume 21, Issue 2, Page(s) 56

    Abstract: The long short-term memory network (LSTM) is widely used in time series data processing as a temporal recursive network. The resting-state functional magnetic resonance data shows that not only are there temporal variations in the resting state, but ... ...

    Abstract The long short-term memory network (LSTM) is widely used in time series data processing as a temporal recursive network. The resting-state functional magnetic resonance data shows that not only are there temporal variations in the resting state, but there are also interactions between brain regions. To integrate the temporal and spatial characteristics of brain regions, this paper proposes a model called feature weighted-LSTM (FW-LSTM). The feature weight is defined by spatial characteristics calculating the frequency of connectivity of each brain region and further integrated into the LSTM. Thus, it can comprehensively model both temporal and spatial changes in rs-fMRI brain regions. The FW-LSTM model on the Alzheimer's disease neuroimaging initiative (ADNI) dataset is used to extract the time-varying characteristics of 90 brain regions for Alzheimer's disease (AD) classification. The model performances are 77.80%, 76.41%, and 78.81% in accuracy, sensitivity, and specificity. It outperformed the one-dimensional convolutional neural networks (1D-CNN) model and LSTM model, which only used temporal features of brain regions.
    MeSH term(s) Alzheimer Disease/pathology ; Brain ; Humans ; Magnetic Resonance Imaging/methods ; Neural Networks, Computer ; Neuroimaging
    Language English
    Publishing date 2022-03-31
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2136427-8
    ISSN 0219-6352
    ISSN 0219-6352
    DOI 10.31083/j.jin2102056
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    Zs.A 6117: Show issues Location:
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