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  1. Article ; Online: Integrative oncology in cancer care - implementation factors: mixed-methods systematic review.

    Kwong, Ming Hong / Ho, Leonard / Li, Angus S C / Nilsen, Per / Ho, Fai Fai / Zhong, Claire C W / Chung, Vincent C H

    BMJ supportive & palliative care

    2023  

    Abstract: Background: Integrative oncology (IO) appears to be beneficial to patients with cancer, but its implementation remains a challenge. Guided by the Theoretical Domains Framework (TDF) and the Capability-Opportunity-Motivation-Behaviour (COM-B) model, this ...

    Abstract Background: Integrative oncology (IO) appears to be beneficial to patients with cancer, but its implementation remains a challenge. Guided by the Theoretical Domains Framework (TDF) and the Capability-Opportunity-Motivation-Behaviour (COM-B) model, this systematic review identified the barriers to and facilitators of IO implementation in conventional cancer care settings.
    Methods: We searched eight electronic databases from their inception until February 2022 for qualitative, quantitative or mixed-methods empirical studies reporting the implementation outcomes for IO services. Critical appraisal approach was tailored according to study types. The identified implementation barriers and facilitators were mapped onto TDF domains and the COM-B model, and subsequently onto the behavioural change wheel (BCW) for formulating behavioural change interventions.
    Results: We included 28 studies (11 qualitative, 6 quantitative, 9 mixed-methods and 2 Delphi studies) of satisfied methodological quality. The main implementation barriers were the lack of IO knowledge, the absence of funding and healthcare professionals' low level of IO receptiveness. The key implementation facilitators were the dissemination of evidence on IO clinical benefits, the equipping of professionals with IO service delivery skills and the provision of a supportive organisational climate.
    Conclusion: Multifaceted implementation strategies are needed to address the determinants influencing IO service delivery. Based on our BCW-based analysis of the included studies, the key
    Language English
    Publishing date 2023-05-12
    Publishing country England
    Document type Journal Article
    ISSN 2045-4368
    ISSN (online) 2045-4368
    DOI 10.1136/spcare-2022-004150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Consequences of Workplace Ostracism: A Meta-Analytic Review.

    Li, Miaomiao / Xu, Xiaofeng / Kwan, Ho Kwong

    Frontiers in psychology

    2021  Volume 12, Page(s) 641302

    Abstract: Workplace ostracism, which is regarded as "social death," is rampant in organizations and has attracted significant research attention. We extend the understanding of workplace ostracism by conducting a meta-analysis of studies of the relationships ... ...

    Abstract Workplace ostracism, which is regarded as "social death," is rampant in organizations and has attracted significant research attention. We extend the understanding of workplace ostracism by conducting a meta-analysis of studies of the relationships between workplace ostracism and its consequences. We also explore the moderating effects of national culture (i.e., collectivism vs. individualism) and the mediating effects of organization-based self-esteem (OBSE). The results of a meta-analysis of 95 independent samples (
    Language English
    Publishing date 2021-08-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.641302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: UiO66-Derived Catalyst for Low Temperature Catalytic Reduction of NO with NH

    Leung, Ka-Ming / Tsui, Chi-Kin J / Ho, Ching-Kit / Liao, Chang-Zhong / Yau, Hei-Tung / Chan, Kwong-Yu / Li, Chi-Ying V

    ACS omega

    2023  Volume 8, Issue 13, Page(s) 12362–12371

    Abstract: Diesel exhaust emissions are major outdoor air pollutants. Reducing the emission of NOx by diesel commercial vehicles and related machineries is at present a great challenge. In this study, we synthesize a catalyst for low-temperature catalytic reduction ...

    Abstract Diesel exhaust emissions are major outdoor air pollutants. Reducing the emission of NOx by diesel commercial vehicles and related machineries is at present a great challenge. In this study, we synthesize a catalyst for low-temperature catalytic reduction of NO using calcinated UiO-66(Zr) as a host for the doping of cerium, manganese, and titanium by the incipient wetness impregnation, followed by the dispersion of 1.0 wt % platinum. A solid solution of Ce
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c07110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prevalence, Patterns, and Clinical Severity of Long COVID among Chinese Medicine Telemedicine Service Users: Preliminary Results from a Cross-Sectional Study.

    Ho, Fai Fai / Xu, Shanshan / Kwong, Talos Ming Hong / Li, Angus Siu-Cheong / Ha, Eun Hae / Hua, Heyu / Liong, Ching / Leung, Kwan Chi / Leung, Ting Hung / Lin, Zhixiu / Wong, Samuel Yeung-Shan / Pan, Faming / Chung, Vincent Chi Ho

    International journal of environmental research and public health

    2023  Volume 20, Issue 3

    Abstract: Introduction: The emergence and persistence of symptoms after acute COVID-19 is expected to become a major burden on healthcare systems. We assessed the features of the post-COVID-19 Syndrome (Long COVID) burden in a cohort of COVID-19 patients during ... ...

    Abstract Introduction: The emergence and persistence of symptoms after acute COVID-19 is expected to become a major burden on healthcare systems. We assessed the features of the post-COVID-19 Syndrome (Long COVID) burden in a cohort of COVID-19 patients during the fifth major wave in Hong Kong.
    Methods: A cross-sectional study of 135 patients with confirmed COVID-19 from Feb to Apr 2022 who utilized traditional Chinese medicine telemedicine services was conducted. The COVID-19 Yorkshire Rehabilitation Scale was administered using an online survey 12 weeks after the COVID-19 infection. Prevalence of symptom severity and functional impairments were assessed to identify burdens and patterns. The correlation between symptom severity, functional impairments, patient characteristics, and overall health was evaluated.
    Results: The mean age was 46.8 years, with 46 (34.1%) males. Symptoms, functional impairments, and overall health worsened significantly when compared to the status prior to the infection. More than 50% reported the following sequelae 12 weeks after the acute infection: breathlessness, laryngeal or airway complications, fatigue, weakness, sleep, cognition, and anxiety. The presence of a single symptom or functional impairment significantly correlated with at least seven other problems positively, except for pain. Severity tended to be higher among vulnerable groups, including those who were chronic disease patients, older, less well educated, female, or had incomplete COVID-19 vaccinations.
    Conclusions: Long COVID is a significant healthcare burden among telemedicine users in Hong Kong, with complex needs for symptom and functional impairment management. Designing relevant health and rehabilitation services tailored to the needs of these patients is warranted.
    MeSH term(s) Male ; Humans ; Female ; Middle Aged ; Post-Acute COVID-19 Syndrome ; COVID-19/epidemiology ; Cross-Sectional Studies ; Prevalence ; Medicine, Chinese Traditional ; Telemedicine
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20031827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Paradoxical Effects of Performance Pressure on Employees' In-Role Behaviors: An Approach/Avoidance Model.

    Xu, Xiaofeng / Wang, Yihui / Li, Miaomiao / Kwan, Ho Kwong

    Frontiers in psychology

    2021  Volume 12, Page(s) 744404

    Abstract: Performance pressure acts as a double-edged sword for employees. Based on an approach/avoidance framework, we theorize that performance pressure produces both positive and negative effects on employees' in-role ... ...

    Abstract Performance pressure acts as a double-edged sword for employees. Based on an approach/avoidance framework, we theorize that performance pressure produces both positive and negative effects on employees' in-role behaviors
    Language English
    Publishing date 2021-10-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.744404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Differential Responses of Retinal Neurons and Glia Revealed via Proteomic Analysis on Primary and Secondary Retinal Ganglion Cell Degeneration.

    Kwong, Jacky M K / Caprioli, Joseph / Lee, Joanne C Y / Song, Yifan / Yu, Feng-Juan / Bian, Jingfang / Sze, Ying-Hon / Li, King-Kit / Do, Chi-Wai / To, Chi-Ho / Lam, Thomas Chuen

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: To explore the temporal profile of retinal proteomes specific to primary and secondary retinal ganglion cell (RGC) loss. Unilateral partial optic nerve transection (pONT) was performed on the temporal side of the rat optic nerve. Temporal and nasal ... ...

    Abstract To explore the temporal profile of retinal proteomes specific to primary and secondary retinal ganglion cell (RGC) loss. Unilateral partial optic nerve transection (pONT) was performed on the temporal side of the rat optic nerve. Temporal and nasal retinal samples were collected at 1, 4 and 8 weeks after pONT (n = 4 each) for non-biased profiling with a high-resolution hybrid quadrupole time-of-flight mass spectrometry running on label-free SWATH
    Language English
    Publishing date 2023-07-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Characterization of emergent toxigenic M1

    Li, Ho Kwong / Zhi, Xiangyun / Vieira, Ana / Whitwell, Harry J / Schricker, Amelia / Jauneikaite, Elita / Li, Hanqi / Yosef, Ahmed / Andrew, Ivan / Game, Laurence / Turner, Claire E / Lamagni, Theresa / Coelho, Juliana / Sriskandan, Shiranee

    Microbial genomics

    2023  Volume 9, Issue 4

    Abstract: Streptococcus ... ...

    Abstract Streptococcus pyogenes
    MeSH term(s) Streptococcus pyogenes/genetics ; Phylogeny ; Proteomics ; Antigens, Bacterial/genetics ; England
    Chemical Substances Antigens, Bacterial
    Language English
    Publishing date 2023-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.000994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Characterization of the RofA regulon in the pandemic M1

    Zhi, Xiangyun / Vieira, Ana / Huse, Kristin K / Martel, Paulo J / Lobkowicz, Ludmila / Li, Ho Kwong / Croucher, Nick / Andrew, Ivan / Game, Laurence / Sriskandan, Shiranee

    Microbial genomics

    2023  Volume 9, Issue 12

    Abstract: The standalone regulator RofA is a positive regulator of the pilus locus ... ...

    Abstract The standalone regulator RofA is a positive regulator of the pilus locus in
    MeSH term(s) Streptococcus pyogenes/genetics ; Streptococcus pyogenes/metabolism ; Regulon/genetics ; Bacterial Proteins/metabolism ; Pandemics ; United Kingdom
    Chemical Substances Bacterial Proteins
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.001159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: ENOX2 inhibition enhances infiltration of effector memory T-cell and mediates response to chemotherapy in immune-quiescent nasopharyngeal carcinoma.

    Kam, Ngar-Woon / Laczka, Olivier / Li, Xiang / Wilkinson, John / Hung, Desmond / Lai, Syrus Pak Hei / Wu, Ka Chun / Tsao, Sai Wa / Dai, Wei / Che, Chi Ming / Lee, Victor Ho-Fun / Kwong, Dora Lai-Wan

    Journal of advanced research

    2023  Volume 56, Page(s) 69–86

    Abstract: Introduction: The immunosuppressive tumor microenvironment is a major barrier for chemotherapy. Different chemosensitization approaches to reinstate immunological surveillance for cancers that are immune quiescent at the outset, have thus been devised. ... ...

    Abstract Introduction: The immunosuppressive tumor microenvironment is a major barrier for chemotherapy. Different chemosensitization approaches to reinstate immunological surveillance for cancers that are immune quiescent at the outset, have thus been devised. Cancer-specific ENOX2 expression is correlated with abnormal cell growth and has been proposed as a cellular target for anti-cancer activity. However, the potential effects of ENOX2 on the interaction between immune system and tumor cells remain elusive.
    Objectives: To understand the mechanisms by which tumor-intrinsic ENOX2-mediated alterations in anti-tumor activity of T-cells and response to chemotherapy.
    Methods: In situ multiplexed immunohistochemistry with single cell and bulk RNA sequencing data from nasopharyngeal carcinoma (NPC) human tissues were used to define tumor phenotypes. Two NPC cell lines, with distinct ENOX2 expression, were used in a co-culture platform to study tumor-immune interactions between cancer cells/spheroids and T-cells. The effect of cisplatin treatment with ENOX2 inhibition by idronoxil (IDX) were tested in vitro and in vivo. Multi-parametric flow cytometry was used to characterize T-cell infiltrates in an NPC tumor humanized mouse model treated with combined treatment.
    Results: NPC predominantly displayed an immune-excluded profile. This "cold-phenotype" was shown to exhibit higher ENOX2 expression and was associate with poorer progression-free survival (PFS). The therapeutic combination of IDX with cisplatin was effective in promoting CD8
    Conclusion: Tumor-intrinsic ENOX2 expression is associated with tumor phenotype and PFS in NPC. Targeting ENOX2 with IDX and cisplatin impose qualitative control of T-cell response by preferentially increasing immune cells infiltration, Tem differentiation and tumor suppression. We suggest that ENOX2 inhibition may be a promising therapeutic strategy to enhance the effects of chemotherapy.
    MeSH term(s) Humans ; Animals ; Mice ; Nasopharyngeal Carcinoma/drug therapy ; Nasopharyngeal Carcinoma/genetics ; Nasopharyngeal Carcinoma/metabolism ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Memory T Cells ; Cell Line, Tumor ; Nasopharyngeal Neoplasms/drug therapy ; Nasopharyngeal Neoplasms/genetics ; Nasopharyngeal Neoplasms/metabolism ; Tumor Microenvironment
    Chemical Substances Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2023-04-13
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2541849-X
    ISSN 2090-1224 ; 2090-1224
    ISSN (online) 2090-1224
    ISSN 2090-1224
    DOI 10.1016/j.jare.2023.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Emerging Invasive Group A Streptococcus M1

    Zhi, Xiangyun / Li, Ho Kwong / Li, Hanqi / Loboda, Zuzanna / Charles, Samson / Vieira, Ana / Huse, Kristin / Jauneikaite, Elita / Reeves, Lucy / Mok, Kai Yi / Coelho, Juliana / Lamagni, Theresa / Sriskandan, Shiranee

    Emerging infectious diseases

    2023  Volume 29, Issue 5, Page(s) 1007–1010

    Abstract: Increasing reports of invasive Streptococcus pyogenes infections mandate surveillance for toxigenic lineage ... ...

    Abstract Increasing reports of invasive Streptococcus pyogenes infections mandate surveillance for toxigenic lineage M1
    MeSH term(s) Humans ; Streptococcus pyogenes/genetics ; Scarlet Fever/epidemiology ; Alleles ; England/epidemiology ; Streptococcal Infections/diagnosis ; Streptococcal Infections/epidemiology ; Polymerase Chain Reaction ; Antigens, Bacterial/genetics ; Bacterial Outer Membrane Proteins/genetics
    Chemical Substances Antigens, Bacterial ; Bacterial Outer Membrane Proteins
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2905.221887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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