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  1. Article ; Online: Physical-layer encryption and authentication scheme based on SKGD and 4D hyper-chaos.

    Wang, Danyang / Wang, Hongxiang / Xu, He / Ji, Yuefeng

    Optics express

    2023  Volume 31, Issue 7, Page(s) 11829–11845

    Abstract: In this paper, a scheme to realize encryption and digital identity authentication at the same time is proposed for enhancing the physical-layer security of point-to-point optical links (PPOL). Exploiting identity code encrypted by the key as ... ...

    Abstract In this paper, a scheme to realize encryption and digital identity authentication at the same time is proposed for enhancing the physical-layer security of point-to-point optical links (PPOL). Exploiting identity code encrypted by the key as authentication information effectively resists passive eavesdropping attacks in fingerprint authentication. The proposed scheme theoretically realizes secure key generation and distribution (SKGD) by phase noise estimation of the optical channel and the generation of identity codes with good randomness and unpredictability by the four-dimensional (4D) hyper-chaotic system. The local laser, erbium doped fiber amplifier (EDFA), and public channel provide the entropy source of uniqueness and randomness to extract symmetric key sequences for legitimate partners. The simulation conducted in a quadrature phase shift keying (QPSK) PPOL system over 100km standard single mode fiber verify successfully that 0.95Gbit/s error-free SKGD. The unpredictability and high sensitivity to the initial value and control parameters of the 4D hyper-chaotic system provide a huge space of ~10
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.482317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Decoding the biology and clinical implication of neutrophils in intracranial aneurysm.

    Ji, Hang / Han, Yujing / Danyang Jie / Yue Li / Hailan Yang / Sun, Haogeng / You, Chao / Xiao, Anqi / Liu, Yi

    Annals of clinical and translational neurology

    2024  Volume 11, Issue 4, Page(s) 958–972

    Abstract: Objective: Abundant neutrophils have been identified in both ruptured and unruptured intracranial aneurysm (IA) domes, with their function and clinical implication being poorly characterized.: Materials and methods: We employed single-cell RNA ... ...

    Abstract Objective: Abundant neutrophils have been identified in both ruptured and unruptured intracranial aneurysm (IA) domes, with their function and clinical implication being poorly characterized.
    Materials and methods: We employed single-cell RNA sequencing (scRNA-Seq) datasets of both human and murine model, and external bulk mRNA sequencing datasets to thoroughly explore the features and functional heterogeneous of neutrophils infiltrating the IA dome.
    Results: We found that both unruptured and ruptured IA dome contain a substantial population of neutrophils, characterized by FCGR3B, G0S2, CSF3R, and CXCR2. These cells exhibited heterogeneity in terms of function and differentiation. Despite similar transcriptional activation, neutrophils in IA dome expressed a repertoire of gene programs that mimicked transcriptomic alterations observed from bone marrow to peripheral blood, showing self-similarity. In addition, the recruitment of neutrophils in unruptured IA was primarily mediated by monocytes/macrophages, and once ruptured, both neutrophils, and a specific subset of inflammatory smooth muscle cells (SMCs) were involved in the process. The receiver operator characteristic curve (ROC) analysis indicated that distinct neutrophil subclusters were associated with IA formation and rupture, respectively. By reviewing current studies, we found that neutrophils play a detrimental role to IA wall integrity through secreting specific ligands, ferroptosis driven by ALOX5AP and PTGS2, and the formation of neutrophil extracellular traps (NETs) mediated by PADI4.
    Interpretation: This study delineated the biology and potential clinical implications of neutrophils in IA dome and provided a reliable basis for future researches.
    MeSH term(s) Humans ; Animals ; Mice ; Intracranial Aneurysm/genetics ; Neutrophils ; Gene Expression Profiling ; Transcriptome ; Biology
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2740696-9
    ISSN 2328-9503 ; 2328-9503
    ISSN (online) 2328-9503
    ISSN 2328-9503
    DOI 10.1002/acn3.52014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Modified nucleic acid aptamers: development, characterization, and biological applications.

    Ji, Danyang / Feng, Hengxin / Liew, Shiau Wei / Kwok, Chun Kit

    Trends in biotechnology

    2023  Volume 41, Issue 11, Page(s) 1360–1384

    Abstract: Aptamers are single-stranded oligonucleotides that bind to their targets via specific structural interactions. To improve the properties and performance of aptamers, modified nucleotides are incorporated during or after a selection process such as ... ...

    Abstract Aptamers are single-stranded oligonucleotides that bind to their targets via specific structural interactions. To improve the properties and performance of aptamers, modified nucleotides are incorporated during or after a selection process such as systematic evolution of ligands by exponential enrichment (SELEX). We summarize the latest modified nucleotides and strategies used in modified (mod)-SELEX and post-SELEX to develop modified aptamers, highlight the methods used to characterize aptamer-target interactions, and present recent progress in modified aptamers that recognize different targets. We discuss the challenges and perspectives in further advancing the methodologies and toolsets to accelerate the discovery of modified aptamers, improve the throughput of aptamer-target characterization, and expand the functional diversity and complexity of modified aptamers.
    Language English
    Publishing date 2023-06-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 47474-5
    ISSN 1879-3096 ; 0167-7799
    ISSN (online) 1879-3096
    ISSN 0167-7799
    DOI 10.1016/j.tibtech.2023.05.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2750: Show issues Location:
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  4. Article: Rare and Common Variants in

    Liu, Xiaolu / Yang, Qiong / Tang, Lu / He, Ji / Tian, Danyang / Wang, Baojun / Xie, Lihong / Li, Changbao / Fan, Dongsheng

    Frontiers in neurology

    2022  Volume 13, Page(s) 827165

    Abstract: Here, we screened ... ...

    Abstract Here, we screened the
    Language English
    Publishing date 2022-05-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.827165
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  5. Article ; Online: Thiadiazole-Derived Covalent Organic Framework Macroscopic Ultralight Aerogel.

    Ji, Haifeng / Li, Mengke / Yan, Gaojie / Qiao, Danyang / Dong, Beibei / Feng, Yi / Qu, Xiongwei / Shi, Jingjing / Zhang, Xiaojie

    ACS applied materials & interfaces

    2023  Volume 15, Issue 30, Page(s) 36738–36747

    Abstract: Shaping covalent organic frameworks (COFs) into macroscopic objects for practical application remains a huge challenge. Herein, a new thiadiazole-derived COF macroscopic ultralight aerogel (NNS-VCOF) was prepared through acid-catalyzed aldol condensation ...

    Abstract Shaping covalent organic frameworks (COFs) into macroscopic objects for practical application remains a huge challenge. Herein, a new thiadiazole-derived COF macroscopic ultralight aerogel (NNS-VCOF) was prepared through acid-catalyzed aldol condensation between 2,5-dimethyl-1,3,4-thiadiazole and a tritopic aromatic aldehyde derivative. NNS-VCOF aerogel shows extremely low density (
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c08351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Hypoglycemic Effect of Exopolysaccharide from

    Qi, Yuan / Wang, Danyang / Fang, Li / Liu, Xiaoting / Liu, Chunlei / Zhao, Fanrui / Wu, Dan / Wang, Xiyan / Wang, Ji / Min, Weihong

    Foods (Basel, Switzerland)

    2022  Volume 11, Issue 22

    Abstract: Two doses (300 mg/kg bw and 600 mg/kg bw) of ... ...

    Abstract Two doses (300 mg/kg bw and 600 mg/kg bw) of the
    Language English
    Publishing date 2022-11-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods11223571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Modified nucleic acid aptamers: development, characterization, and biological application

    Ji, Danyang / Feng, Hengxin / Liew, Shiau Wei / Kwok, Chun Kit

    Trends in Biotechnology.

    2023  

    Abstract: Aptamers are single-stranded oligonucleotides that recognize their target of interest via specific structural interactions. To improve the properties and performance of aptamers, modified nucleotides are introduced during or after selection processes ... ...

    Abstract Aptamers are single-stranded oligonucleotides that recognize their target of interest via specific structural interactions. To improve the properties and performance of aptamers, modified nucleotides are introduced during or after selection processes referred to as the systematic evolution of ligands by exponential enrichment (SELEX). Herein, we summarize the latest modified nucleotides and strategies used in modified (mod)-SELEX and post-SELEX to develop modified aptamers, highlight the approaches commonly used to characterize modified aptamer-target interactions, and present recent progress in modified aptamers recognizing different targets. We discuss the challenges and perspectives to further advance the methodologies and toolsets capable of speeding up the discovery of modified aptamers, improving the throughput of aptamer-target characterization, and expanding the functional diversity and complexity of modified aptamers.
    Keywords biotechnology ; functional diversity ; nucleic acids ; oligonucleotides ; systematic evolution of ligands by exponential enrichment ; modified nucleotides ; aptamer ; mod-SELEX ; post-SELEX modification ; nucleic acid ; biological application
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 47474-5
    ISSN 1879-3096 ; 0167-7799
    ISSN (online) 1879-3096
    ISSN 0167-7799
    DOI 10.1016/j.tibtech.2023.05.005
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2750: Show issues Location:
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  8. Article ; Online: Selective targeting of parallel G-quadruplex structure using L-RNA aptamer.

    Ji, Danyang / Yuan, Jia-Hao / Chen, Shuo-Bin / Tan, Jia-Heng / Kwok, Chun Kit

    Nucleic acids research

    2023  Volume 51, Issue 21, Page(s) 11439–11452

    Abstract: G-quadruplexes (G4) are special nucleic acid structures with diverse conformational polymorphisms. Selective targeting of G-quadruplex conformations and regulating their biological functions provide promising therapeutic intervention. Despite the large ... ...

    Abstract G-quadruplexes (G4) are special nucleic acid structures with diverse conformational polymorphisms. Selective targeting of G-quadruplex conformations and regulating their biological functions provide promising therapeutic intervention. Despite the large repertoire of G4-binding tools, only a limited number of them can specifically target a particular G4 conformation. Here, we introduce a novel method, G4-SELEX-Seq and report the development of the first L-RNA aptamer, L-Apt12-6, with high binding selectivity to parallel G4 over other nucleic acid structures. Using parallel dG4 c-kit 1 as an example, we demonstrate the strong binding affinity between L-Apt12-6 and c-kit 1 dG4 in vitro and in cells, and notably report the applications of L-Apt12-6 in controlling DNA replication and gene expression. Our results suggest that L-Apt12-6 is a valuable tool for targeting parallel G-quadruplex conformation and regulating G4-mediated biological processes. Furthermore, G4-SELEX-Seq can be used as a general platform for G4-targeting L-RNA aptamers selection and should be applicable to other nucleic acid structures.
    MeSH term(s) G-Quadruplexes ; Aptamers, Nucleotide/chemistry ; Nucleic Acids
    Chemical Substances Aptamers, Nucleotide ; Nucleic Acids
    Language English
    Publishing date 2023-10-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkad900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1067: Show issues Location:
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  9. Article ; Online: Novel L-RNA Aptamer Controls

    Zhao, Haizhou / Wong, Hei Yuen / Ji, Danyang / Lyu, Kaixin / Kwok, Chun Kit

    ACS applied materials & interfaces

    2022  Volume 14, Issue 27, Page(s) 30582–30594

    Abstract: Guanine quadruplex (G4) structure is a four-stranded nucleic acid secondary structure motif with unique chemical properties and important biological roles. Amyloid precursor protein (APP) is an Alzheimer's disease (AD)-related gene, and recently, we ... ...

    Abstract Guanine quadruplex (G4) structure is a four-stranded nucleic acid secondary structure motif with unique chemical properties and important biological roles. Amyloid precursor protein (APP) is an Alzheimer's disease (AD)-related gene, and recently, we reported the formation of RNA G4 (rG4) at the 3'UTR of
    MeSH term(s) 3' Untranslated Regions ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Aptamers, Nucleotide/chemistry ; G-Quadruplexes ; Gene Expression
    Chemical Substances 3' Untranslated Regions ; Amyloid beta-Protein Precursor ; Aptamers, Nucleotide
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c06390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Influence of Outer Membrane Protein on Ampicillin Resistance of

    Meng, Xiangyu / Huang, Danyang / Zhou, Qing / Ji, Fan / Tan, Xin / Wang, Jianli / Wang, Xiaoyuan

    The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

    2023  Volume 2023, Page(s) 8079091

    Abstract: The antibiotic resistance of the food-borne ... ...

    Abstract The antibiotic resistance of the food-borne pathogen
    Language English
    Publishing date 2023-01-13
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 1057056-1
    ISSN 1712-9532 ; 1180-2332
    ISSN 1712-9532 ; 1180-2332
    DOI 10.1155/2023/8079091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3099: Show issues Location:
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