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  1. Book: Critical essays on William Faulkner: the Sutpen family

    Kinney, Arthur F

    (Critical essays on American literature)

    1996  

    Author's details ed. by Arthur F. Kinney
    Series title Critical essays on American literature
    Keywords Families in literature ; Sutpen family (Fictitious characters)
    Language English
    Size XVII, 289, [16] S, Ill., Kt, 25 cm
    Publisher Hall u.a.
    Publishing place New York
    Document type Book
    Note Includes bibliographical references and index ; Literaturangaben
    ISBN 0816173141 ; 9780816173143
    Database Former special subject collection: coastal and deep sea fishing

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  2. Book: Critical essays on William Faulkner: the Sartoris family

    Kinney, Arthur F

    (Critical essays on American literature)

    1985  

    Author's details Arthur F. Kinney [ed.]
    Series title Critical essays on American literature
    Keywords Families in literature ; Sartoris family (Fictitious characters)
    Language English
    Size X,374 S
    Publisher Hall
    Publishing place Boston, Mass
    Document type Book
    ISBN 0816186901 ; 9780816186907
    Database Former special subject collection: coastal and deep sea fishing

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  3. Book: Critical essays on William Faulkner: the Compson family

    Kinney, Arthur F

    (Critical essays on American literature.)

    1982  

    Author's details Arthur F. Kinney
    Series title Critical essays on American literature.
    Keywords Families in literature
    Language English
    Size 433 S
    Publisher Hall
    Publishing place Boston, Mass
    Document type Book
    ISBN 081618464X ; 9780816184644
    Database Former special subject collection: coastal and deep sea fishing

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  4. Article: Knockdown siRNA targeting GPR55 reveals significant differences between the anti-inflammatory actions of KLS-13019 and cannabidiol.

    Brenneman, Douglas E / Kinney, William A / McDonnell, Mark E / Ippolito, Michael J / Ward, Sara Jane

    Research square

    2024  

    Abstract: KLS-13019 was reported previously to reverse paclitaxel-induced mechanical allodynia in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN). Recent studies demonstrated that paclitaxel-induced increases in inflammatory markers (GPR55, ... ...

    Abstract KLS-13019 was reported previously to reverse paclitaxel-induced mechanical allodynia in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN). Recent studies demonstrated that paclitaxel-induced increases in inflammatory markers (GPR55, NLRP3 and IL-1b) of dorsal root ganglion (DRG) cultures were shown to be reversed by KLS-13019 treatment. The mechanism of action for KLS-13019-mediated reversal of paclitaxel-induced neuroinflammation now has been explored using GPR55 siRNA. Pretreatment of DRG cultures with GPR55 siRNA produced a 21% decrease of immunoreactive (IR) area for GPR55 in cell bodies and a 59% decrease in neuritic IR area, as determined by high content imaging. Using a 24-hour reversal treatment paradigm, paclitaxel-induced increases in the inflammatory markers were reversed back to control levels after KLS-3019 treatment. Decreases in these inflammatory markers produced by KLS-13019 were significantly attenuated by GPR55 siRNA co-treatment, with mean IR area responses being attenuated by 56% in neurites and 53% in cell bodies. These data indicate that the percentage decreases in siRNA-mediated attenuation of KLS-13019-related efficacy on the inflammatory markers were similar to the percentage knockdown observed for neuritic GPR55 IR area. Similar studies conducted with cannabidiol (CBD), the parent compound of KLS-13019, produced low efficacy (25%) reversal of all inflammatory markers that were poorly attenuated (29%) by GPR55 siRNA. CBD was shown previously to be ineffective in reversing paclitaxel-induced mechanical allodynia. The present studies indicated significant differences between the anti-inflammatory properties of KLS-13019 and CBD which may play a role in their observed differences in the reversibility of mechanical allodynia in a mouse model of CIPN.
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3982851/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Knockdown siRNA Targeting GPR55 Reveals Significant Differences Between the Anti-inflammatory Actions of KLS-13019 and Cannabidiol.

    Brenneman, Douglas E / Kinney, William A / McDonnell, Mark E / Ippolito, Michael J / Ward, Sara Jane

    Journal of molecular neuroscience : MN

    2024  Volume 74, Issue 2, Page(s) 41

    Abstract: KLS-13019 was reported previously to reverse paclitaxel-induced mechanical allodynia in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN). Recent studies demonstrated that paclitaxel-induced increases in inflammatory markers (GPR55, ... ...

    Abstract KLS-13019 was reported previously to reverse paclitaxel-induced mechanical allodynia in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN). Recent studies demonstrated that paclitaxel-induced increases in inflammatory markers (GPR55, NLRP3, and IL-1β) of dorsal root ganglion (DRG) cultures were shown to be reversed by KLS-13019 treatment. The mechanism of action for KLS-13019-mediated reversal of paclitaxel-induced neuroinflammation now has been explored using GPR55 siRNA. Pre-treatment of DRG cultures with GPR55 siRNA produced a 21% decrease of immunoreactive (IR) area for GPR55 in cell bodies and a 59% decrease in neuritic IR area, as determined by high-content imaging. Using a 24-h reversal treatment paradigm, paclitaxel-induced increases in the inflammatory markers were reversed back to control levels after KLS-3019 treatment. Decreases in these inflammatory markers produced by KLS-13019 were significantly attenuated by GPR55 siRNA co-treatment, with mean IR area responses being attenuated by 56% in neurites and 53% in cell bodies. These data indicate that the percentage decreases in siRNA-mediated attenuation of KLS-13019-related efficacy on the inflammatory markers were similar to the percentage knockdown observed for neuritic GPR55 IR area. Similar studies conducted with cannabidiol (CBD), the parent compound of KLS-13019, produced low efficacy (25%) reversal of all inflammatory markers that were poorly attenuated (29%) by GPR55 siRNA. CBD was shown previously to be ineffective in reversing paclitaxel-induced mechanical allodynia. The present studies indicated significant differences between the anti-inflammatory properties of KLS-13019 and CBD which may play a role in their observed differences in the reversibility of mechanical allodynia in a mouse model of CIPN.
    MeSH term(s) Animals ; Mice ; RNA, Small Interfering/genetics ; Cannabidiol/pharmacology ; Cannabidiol/therapeutic use ; Hyperalgesia/drug therapy ; Anti-Inflammatory Agents ; Disease Models, Animal ; Paclitaxel/toxicity ; Receptors, Cannabinoid/genetics
    Chemical Substances RNA, Small Interfering ; Cannabidiol (19GBJ60SN5) ; Anti-Inflammatory Agents ; Paclitaxel (P88XT4IS4D) ; GPR55 protein, mouse ; Receptors, Cannabinoid
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1043392-2
    ISSN 1559-1166 ; 0895-8696
    ISSN (online) 1559-1166
    ISSN 0895-8696
    DOI 10.1007/s12031-024-02217-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Assessing the Clinical Utility of SNP Microarray for Prader-Willi Syndrome due to Uniparental Disomy.

    Santoro, Stephanie L / Hashimoto, Sayaka / McKinney, Aimee / Mihalic Mosher, Theresa / Pyatt, Robert / Reshmi, Shalini C / Astbury, Caroline / Hickey, Scott E

    Cytogenetic and genome research

    2017  Volume 152, Issue 2, Page(s) 105–109

    Abstract: Maternal uniparental disomy (UPD) 15 is one of the molecular causes of Prader-Willi syndrome (PWS ...

    Abstract Maternal uniparental disomy (UPD) 15 is one of the molecular causes of Prader-Willi syndrome (PWS), a multisystem disorder which presents with neonatal hypotonia and feeding difficulty. Current diagnostic algorithms differ regarding the use of SNP microarray to detect PWS. We retrospectively examined the frequency with which SNP microarray could identify regions of homozygosity (ROH) in patients with PWS. We determined that 7/12 (58%) patients with previously confirmed PWS by methylation analysis and microsatellite-positive UPD studies had ROH (>10 Mb) by SNP microarray. Additional assessment of 5,000 clinical microarrays, performed from 2013 to present, determined that only a single case of ROH for chromosome 15 was not caused by an imprinting disorder or identity by descent. We observed that ROH for chromosome 15 is rarely incidental and strongly associated with hypotonic infants having features of PWS. Although UPD microsatellite studies remain essential to definitively establish the presence of UPD, SNP microarray has important utility in the timely diagnostic algorithm for PWS.
    MeSH term(s) Chromosomes, Human, Pair 15/genetics ; DNA Methylation/genetics ; Humans ; Oligonucleotide Array Sequence Analysis/methods ; Polymorphism, Single Nucleotide/genetics ; Prader-Willi Syndrome/diagnosis ; Prader-Willi Syndrome/genetics ; Uniparental Disomy/diagnosis
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2087824-2
    ISSN 1424-859X ; 1424-8581
    ISSN (online) 1424-859X
    ISSN 1424-8581
    DOI 10.1159/000478921
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 512: Show issues Location:
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  7. Article: Efficient Syntheses of KLS-13019 Using Palladium Mediated Cross Couplings.

    Kinney, William A / McDonnell, Mark E / Freeman, Stanley / Simons, Nick / Han, Chao / Yang, Lanyi

    Tetrahedron letters

    2023  Volume 117

    Abstract: KLS-13019 is a structural analogue of cannabidiol, that shows improved bioavailability and potency in both preventing and reversing paclitaxel-induced neurotoxicity in vitro and in vivo. KLS-13019 was selected as a development candidate and attention was ...

    Abstract KLS-13019 is a structural analogue of cannabidiol, that shows improved bioavailability and potency in both preventing and reversing paclitaxel-induced neurotoxicity in vitro and in vivo. KLS-13019 was selected as a development candidate and attention was turned to development of a scalable synthesis. The original synthesis of KLS-13019 was not efficient, regioselective, or high yielding. Two new syntheses are reported that make use of the palladium catalyzed cross couplings to a chemically advanced intermediate
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2023.154369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2837: Show issues Location:
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  8. Article: Nonoperative Management of Lateral Epicondyle Tendinopathy: An Umbrella Review.

    Kinney, William R / Anderson, Brian R

    Journal of chiropractic medicine

    2023  Volume 22, Issue 3, Page(s) 204–211

    Abstract: Objective: The primary objective of this review was to summarize systematic reviews and meta-analyses reporting on nonoperative management of lateral epicondyle tendinopathy.: Methods: An umbrella review of all published systematic reviews and meta- ... ...

    Abstract Objective: The primary objective of this review was to summarize systematic reviews and meta-analyses reporting on nonoperative management of lateral epicondyle tendinopathy.
    Methods: An umbrella review of all published systematic reviews and meta-analyses was performed. Three databases were searched using the key words "tennis elbow," "lateral epicondylitis," "non-operative," and "non-surgical modalities." The search was limited to English-language systematic reviews and meta-analyses between the years of 2000 and 2022.
    Results: There were 114 systematic reviews/meta-analyses, of which 35 met our inclusion criteria. These articles reviewed the following nonoperative management strategies: ultrasound, shockwave therapy, injection procedures, low-level laser therapy, joint mobilizations, exercise therapy, and electrophysical modalities. Exercise therapy was beneficial in decreasing pain regardless of dosage or type. Conflicting results were seen with ultrasound, laser, and shockwave therapy. Corticosteroid injections provided the most short-term pain relief, and platelet-rich plasma and autologous blood injections were most effective in the long term.
    Conclusion: A variety of nonoperative interventions were found to be effective for short- and long-term pain relief as well as functional improvement, with most interventions indicating mixed results. Due to variations in study populations and study quality, results should be interpreted with caution.
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2365038-2
    ISSN 1556-3715 ; 1556-3707
    ISSN (online) 1556-3715
    ISSN 1556-3707
    DOI 10.1016/j.jcm.2023.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Assessing the Clinical Utility of SNP Microarray for Prader-Willi Syndrome due to Uniparental Disomy

    Santoro, Stephanie L. / Hashimoto, Sayaka / McKinney, Aimee / Mihalic Mosher, Theresa / Pyatt, Robert / Reshmi, Shalini C. / Astbury, Caroline / Hickey, Scott E.

    Cytogenetic and Genome Research

    2017  Volume 152, Issue 2, Page(s) 105–109

    Abstract: Maternal uniparental disomy (UPD) 15 is one of the molecular causes of Prader-Willi syndrome (PWS ...

    Institution Division of Molecular and Human Genetics, and Institute for Genomic Medicine, Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, OH, and Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA
    Abstract Maternal uniparental disomy (UPD) 15 is one of the molecular causes of Prader-Willi syndrome (PWS), a multisystem disorder which presents with neonatal hypotonia and feeding difficulty. Current diagnostic algorithms differ regarding the use of SNP microarray to detect PWS. We retrospectively examined the frequency with which SNP microarray could identify regions of homozygosity (ROH) in patients with PWS. We determined that 7/12 (58%) patients with previously confirmed PWS by methylation analysis and microsatellite-positive UPD studies had ROH (>10 Mb) by SNP microarray. Additional assessment of 5,000 clinical microarrays, performed from 2013 to present, determined that only a single case of ROH for chromosome 15 was not caused by an imprinting disorder or identity by descent. We observed that ROH for chromosome 15 is rarely incidental and strongly associated with hypotonic infants having features of PWS. Although UPD microsatellite studies remain essential to definitively establish the presence of UPD, SNP microarray has important utility in the timely diagnostic algorithm for PWS.
    Keywords Chromosome 15 ; Prader-Willi syndrome ; SNP microarray ; Uniparental disomy
    Language English
    Publishing date 2017-07-27
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Original Article
    ZDB-ID 2087824-2
    ISSN 1424-859X ; 1424-8581
    ISSN (online) 1424-859X
    ISSN 1424-8581
    DOI 10.1159/000478921
    Database Karger publisher's database

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  10. Article ; Online: Evaluating the sensitivity of mortality attributable to pollution to modeling Choices: A case study for Colorado.

    deSouza, Priyanka N / Anenberg, Susan / Fann, Neal / McKenzie, Lisa M / Chan, Elizabeth / Roy, Ananya / Jimenez, Jose L / Raich, William / Roman, Henry / Kinney, Patrick L

    Environment international

    2024  Volume 185, Page(s) 108416

    Abstract: We evaluated the sensitivity of estimated ... ...

    Abstract We evaluated the sensitivity of estimated PM
    MeSH term(s) Air Pollutants/adverse effects ; Air Pollutants/analysis ; Air Pollution/adverse effects ; Air Pollution/analysis ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Colorado/epidemiology ; Nitrogen Dioxide/analysis ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis
    Chemical Substances Air Pollutants ; Particulate Matter ; Nitrogen Dioxide (S7G510RUBH)
    Language English
    Publishing date 2024-01-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2024.108416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3131: Show issues Location:
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