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  1. Article ; Online: Comparative studies on the chemical composition and pharmacological effects of vinegar-processed antler glue modified from Lei Gong Pao Zhi Lun and traditional water-processed antler glue.

    Shi, Mengqi / Li, Tianshi / Zhao, Yan / He, Zhongmei / Zong, Ying / Chen, Weijia / Du, Rui

    Journal of ethnopharmacology

    2023  Volume 321, Page(s) 117508

    Abstract: ... of preparing antler glue by boiling antlers in vinegar and then concentrating them is recorded in Lei Gong Pao ... method of antler glue is water extraction and concentration. But Lei Gong Pao Zhi Lun differs in Chinese ... Zhi Lun (Master Lei's Discourse on Medicinal Processing). In modern times, the typical processing ...

    Abstract Ethnopharmacological relevance: Antler glue is a classic medicinal to enhance sexual function in traditional Chinese medicine (TCM), which was first recorded in Shen Nong Ben Cao Jing (Shennong's Classic of the Materia Medica). Vinegar-processing is a classic method of processing traditional Chinese medicine. The method of preparing antler glue by boiling antlers in vinegar and then concentrating them is recorded in Lei Gong Pao Zhi Lun (Master Lei's Discourse on Medicinal Processing). In modern times, the typical processing method of antler glue is water extraction and concentration. However, it is not clear whether there is a difference in the effect of these two processing methods on the chemical composition and pharmacological activity of antler glue.
    Aim of the study: The Chinese Pharmacopoeia (2020) records that the processing method of antler glue is water extraction and concentration. But Lei Gong Pao Zhi Lun differs in Chinese Pharmacopoeia (2020), which records the processing method of vinegar extraction and concentration. The effect of the two processing methods on antler glue's chemical composition and pharmacological activity is unknown. So this study aimed to elucidate the difference between different processing methods on the chemical composition and the treatment effect on oligoasthenospermia of antler glue.
    Materials and methods: So the automatic amino acid analyzer is used to determine the amino acid content of two different processing methods of antler glue. Proteomics was performed to detect the protein components of two different processing methods of antler glue and analyze them. Cyclophosphamide-induced mice models of oligoasthenospermia were used to study the different pharmacological effects of antler glue in two different processing methods. An automatic sperm analyzer observed the quantity and quality of sperm in mice epididymis. Serum sex hormone testosterone (T), luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in mice were tested using the enzyme-linked immunosorbent assay (ELISA) kits. Hematoxylin-eosin (H&E) staining was used to analyze pathological alterations in mouse testicular tissue. The transcriptome has been used to reveal the potential mechanism of antler glue in treating oligoasthenospermia. Mitochondrial complex activity assay kits were used to assay the activity of mitochondrial respiratory chain complex I-V in mouse testicular tissue. Western blot was used to determine the expression of related proteins in mouse testicular tissue.
    Results: Vinegar-processing can increase the alanine, proline, and glycine content in antler glue, reduce the length of protein peptides in antler glue, and produce a variety of unique proteins. Vinegar-processed antler glue (VAG) increased sperm density, sperm survival, sperm viability, and serum sex hormone levels in oligozoospermic mice. It reversed testicular damage caused by cyclophosphamide, and the effects were differently superior to those of water-processed antler glue (WAG). In addition, transcriptomics and related experiments have shown that VAG can increase the expression of Ndufa2, Uqcr11, Cox6b1, and Atp5i genes and proteins in mouse testis, thus promoting adenosine diphosphate (ATP) synthesis by increasing the activity of mitochondrial respiratory chain complexes I, III, IV and V. By promoting the oxidative phosphorylation process to produce more ATP, VAG can achieve the therapeutic effect of oligoasthenospermia.
    Conclusion: Vinegar-processing method can increase the content of active ingredients in antler glue. VAG increases ATP levels in the testes by promoting the process of oxidative phosphorylation to treat oligozoospermia.
    MeSH term(s) Humans ; Mice ; Male ; Animals ; Antlers/chemistry ; Acetic Acid ; Semen/chemistry ; Proteins ; Gonadal Steroid Hormones ; Oligospermia ; Amino Acids ; Cyclophosphamide ; Adenosine Triphosphate
    Chemical Substances Acetic Acid (Q40Q9N063P) ; Proteins ; Gonadal Steroid Hormones ; Amino Acids ; Cyclophosphamide (8N3DW7272P) ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2023-12-06
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Research on Innovative Design of Lei Feng’s Cultural and Tourism Souvenirs

    Gao Hong-he / Han Lu

    E3S Web of Conferences, Vol 179, p

    2020  Volume 02021

    Abstract: Lei Feng’s cultural tourist souvenirs are designed to meet the aesthetic needs of the young people ... By purchasing red tourist souvenirs, consumers can enhance their understanding and communication of Lei Feng’s ... According to the design principles and methods of red tourist souvenirs, the image features of Lei Feng and ...

    Abstract Lei Feng’s cultural tourist souvenirs are designed to meet the aesthetic needs of the young people. By purchasing red tourist souvenirs, consumers can enhance their understanding and communication of Lei Feng’s spiritual culture, promote them social positive energy and promote regional tourism economic growth. According to the design principles and methods of red tourist souvenirs, the image features of Lei Feng and related red cultural features are accurately extracted, and combined with the current development status of red tourist souvenir market, the organic combination of Lei Feng and related red elements and tourist souvenirs is achieved. In view of the current lack of cultural design of Lei Feng tourist souvenirs. Through in-depth investigation and analysis of red elements related to lei Feng’s tourist souvenirs that can deeply reflect the spirit and culture of Lei Feng.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model.

    Li, Qiaofeng / Lan, Taijin / He, Songhua / Chen, Weiwei / Li, Xiaolan / Zhang, Weiquan / Liu, Ying / Zhang, Qiuping / Chen, Xin / Han, Yaoyao / Su, Zhiheng / Zhu, Dan / Guo, Hongwei

    Chinese medicine

    2021  Volume 16, Issue 1, Page(s) 99

    Abstract: Background: Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang ...

    Abstract Background: Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang nationality, the largest ethnic minority among 56 nationalities in China. It consists of three herbs, namely Eclipta prostrata (L.) L., Smilax glabra Roxb, and Centella asiatica (L.) Urb. It has been widely used as health protection tea for hundreds of years to prevent hypertension in Guangxi Zhuang Autonomous Region. The purpose of this study is to validate the antihypertensive effect of LFG on the spontaneously hypertensive rat (SHR) model, and to further identify the effective components and anti-hypertension mechanism of LFG.
    Methods: The effects of LFG on blood pressure, body weight, and heart rate were investigated in vivo using the SHR model. The levels of NO, ANG II, and ET-1 in the serum were measured, and pathological changes in the heart were examined by H&E staining. The main active components of LFG, their corresponding targets, and hypertension associated pathways were discerned through network pharmacology analysis based on the Traditional Chinese Medicine Systems Pharmacology (TCMSP), Traditional Chinese Medicine Integrated Database (TCMID), and the Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine (BATMAN-TCM). Then the predicted results were further verified by molecular biology experiments such as RT-qPCR and western blot. Additionally, the potential active compounds were predicted by molecular docking technology, and the chemical constituents of LFG were analyzed and identified by UPLC-QTOF/MS technology. Finally, an in vitro assay was performed to investigate the protective effects of potential active compounds against hydrogen peroxide (H
    Results: LFG could effectively reduce blood pressure and increase serum NO content in SHR model. Histological results showed that LFG could ameliorate pathological changes such as cardiac hypertrophy and interstitial inflammation. From network pharmacology analysis, 53 candidate active compounds of LFG were collected, which linked to 765 potential targets, and 828 hypertension associated targets were retrieved, from which 12 overlapped targets both related to candidate active compounds from LFG and hypertension were screened and used as the potential targets of LFG on antihypertensive effect. The molecular biology experiments of the 12 overlapped targets showed that LFG could upregulate the mRNA and protein expressions of NOS3 and proto-oncogene tyrosine-protein kinase SRC (SRC) in the thoracic aorta. Pathway enrichment analysis showed that the PI3K-AKT signaling pathway was closely related to the expression of NOS3 and SRC. Moreover, western blot results showed that LFG significantly increased the protein expression levels of PI3K and phosphorylated AKT in SHR model, suggesting that LFG may active the PI3K-AKT signaling pathway to decrease hypertension. Molecular docking study further supported that p-hydroxybenzoic acid, cedar acid, shikimic acid, salicylic acid, nicotinic acid, linalool, and histidine can be well binding with NOS3, SRC, PI3K, and AKT. UPLC-QTOF/MS analysis confirmed that p-hydroxybenzoic acid, shikimic acid, salicylic acid, and nicotinic acid existed in LFG. Pre-treatment of HUVEC with nicotinic acid could alleviate the effect on cell viability induced by H
    Conclusions: LFG can reduce the blood pressure in SHR model, which might be attributed to increasing the NO level in serum for promoting vasodilation via upregulating SRC expression level and activating the PI3K-AKT-NOS3 signaling pathway. Nicotinic acid might be the potential compound for LFG antihypertensive effect.
    Language English
    Publishing date 2021-10-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2260322-0
    ISSN 1749-8546
    ISSN 1749-8546
    DOI 10.1186/s13020-021-00507-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Application of Convolutional Neural Network on Lei Bamboo Above-Ground-Biomass (AGB) Estimation Using Worldview-2

    Dong, Luofan / Du, Huaqiang / Han, Ning / Li, Xuejian / Zhu, Di’en / Mao, Fangjie / Zhang, Meng / Zheng, Junlong / Liu, Hua / Huang, Zihao / He, Shaobai

    Remote Sensing. 2020 Mar. 16, v. 12, no. 6

    2020  

    Abstract: Above-ground biomass (AGB) directly relates to the productivity of forests. Precisely, AGB mapping for regional forests based on very high resolution (VHR) imagery is widely needed for evaluation of productivity. However, the diversity of variables and ... ...

    Abstract Above-ground biomass (AGB) directly relates to the productivity of forests. Precisely, AGB mapping for regional forests based on very high resolution (VHR) imagery is widely needed for evaluation of productivity. However, the diversity of variables and algorithms and the difficulties inherent in high resolution optical imagery make it complex. In this paper, we explored the potentials of the state-of-art algorithm convolutional neural networks (CNNs), which are widely used for its high-level representation, but rarely applied for AGB estimation. Four experiments were carried out to compare the performance of CNNs and other state-of-art Machine Learning (ML) algorithms: (1) performance of CNN using bands, (2) performance of Random Forest (RF), support vector regression (SVR), artificial neural network (ANN) on bands, and vegetation indices (VIs). (3) Performance of RF, SVR, and ANN on gray-level co-occurrence matrices (GLCM), and exploratory spatial data analysis (ESDA), and (4) performance of RF, SVR, and ANN based on all combined data and ESDA+VIs. CNNs reached satisfactory results (with R² = 0.943) even with limited input variables (i.e., only bands). In comparison, RF and SVR with elaborately designed data obtained slightly better accuracy than CNN. For examples, RF based on GLCM textures reached an R² of 0.979 and RF based on all combined data reached a close R² of 0.974. However, the results of ANN were much worse (with the best R² of 0.885).
    Keywords aboveground biomass ; algorithms ; artificial intelligence ; bamboos ; forests ; neural networks ; regression analysis ; remote sensing ; spatial data ; vegetation index
    Language English
    Dates of publication 2020-0316
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2513863-7
    ISSN 2072-4292
    ISSN 2072-4292
    DOI 10.3390/rs12060958
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Application of Convolutional Neural Network on Lei Bamboo Above-Ground-Biomass (AGB) Estimation Using Worldview-2

    Luofan Dong / Huaqiang Du / Ning Han / Xuejian Li / Di’en Zhu / Fangjie Mao / Meng Zhang / Junlong Zheng / Hua Liu / Zihao Huang / Shaobai He

    Remote Sensing, Vol 12, Iss 6, p

    2020  Volume 958

    Abstract: Above-ground biomass (AGB) directly relates to the productivity of forests. Precisely, AGB mapping for regional forests based on very high resolution (VHR) imagery is widely needed for evaluation of productivity. However, the diversity of variables and ... ...

    Abstract Above-ground biomass (AGB) directly relates to the productivity of forests. Precisely, AGB mapping for regional forests based on very high resolution (VHR) imagery is widely needed for evaluation of productivity. However, the diversity of variables and algorithms and the difficulties inherent in high resolution optical imagery make it complex. In this paper, we explored the potentials of the state-of-art algorithm convolutional neural networks (CNNs), which are widely used for its high-level representation, but rarely applied for AGB estimation. Four experiments were carried out to compare the performance of CNNs and other state-of-art Machine Learning (ML) algorithms: (1) performance of CNN using bands, (2) performance of Random Forest (RF), support vector regression (SVR), artificial neural network (ANN) on bands, and vegetation indices (VIs). (3) Performance of RF, SVR, and ANN on gray-level co-occurrence matrices (GLCM), and exploratory spatial data analysis (ESDA), and (4) performance of RF, SVR, and ANN based on all combined data and ESDA+VIs. CNNs reached satisfactory results (with R 2 = 0.943) even with limited input variables (i.e., only bands). In comparison, RF and SVR with elaborately designed data obtained slightly better accuracy than CNN. For examples, RF based on GLCM textures reached an R 2 of 0.979 and RF based on all combined data reached a close R 2 of 0.974. However, the results of ANN were much worse (with the best R 2 of 0.885).
    Keywords deep learning (dl) ; machine learning (ml) ; above ground biomass (agb) ; very high-resolution imagery ; textures ; Science ; Q
    Subject code 006 ; 333
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model

    Qiaofeng Li / Taijin Lan / Songhua He / Weiwei Chen / Xiaolan Li / Weiquan Zhang / Ying Liu / Qiuping Zhang / Xin Chen / Yaoyao Han / Zhiheng Su / Dan Zhu / Hongwei Guo

    Chinese Medicine, Vol 16, Iss 1, Pp 1-

    2021  Volume 21

    Abstract: Abstract Background Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang ...

    Abstract Abstract Background Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang nationality, the largest ethnic minority among 56 nationalities in China. It consists of three herbs, namely Eclipta prostrata (L.) L., Smilax glabra Roxb, and Centella asiatica (L.) Urb. It has been widely used as health protection tea for hundreds of years to prevent hypertension in Guangxi Zhuang Autonomous Region. The purpose of this study is to validate the antihypertensive effect of LFG on the spontaneously hypertensive rat (SHR) model, and to further identify the effective components and anti-hypertension mechanism of LFG. Methods The effects of LFG on blood pressure, body weight, and heart rate were investigated in vivo using the SHR model. The levels of NO, ANG II, and ET-1 in the serum were measured, and pathological changes in the heart were examined by H&E staining. The main active components of LFG, their corresponding targets, and hypertension associated pathways were discerned through network pharmacology analysis based on the Traditional Chinese Medicine Systems Pharmacology (TCMSP), Traditional Chinese Medicine Integrated Database (TCMID), and the Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine (BATMAN-TCM). Then the predicted results were further verified by molecular biology experiments such as RT-qPCR and western blot. Additionally, the potential active compounds were predicted by molecular docking technology, and the chemical constituents of LFG were analyzed and identified by UPLC-QTOF/MS technology. Finally, an in vitro assay was performed to investigate the protective effects of potential active compounds against hydrogen peroxide (H2O2) induced oxidative damage in human umbilical vein endothelial cells (HUVEC). Results LFG could effectively reduce blood pressure and increase serum NO content in SHR model. Histological results showed that LFG could ameliorate pathological changes such as cardiac hypertrophy and interstitial inflammation. From network ...
    Keywords Centella asiatica (L.) Urb ; Eclipta prostrata (L.) L ; Smilax glabra Roxb ; Hypertension ; Network pharmacology ; Other systems of medicine ; RZ201-999
    Subject code 500
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book: Yi xue mei jie sheng wu fen lei

    He, Lie

    2016  

    Author's details He Lie, Zhang Huarong zhu bian
    MeSH term(s) Disease Vectors/classification ; Disease Reservoirs/classification
    Language Chinese
    Size 10, 556 pages :, illustrations
    Edition Di 1 ban.
    Document type Book
    ISBN 9787502642198 ; 7502642196
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Book: Zhongguo you lei zai pei

    He, Tianfu

    1999  

    Author's details He Tianfu zhu bian
    Keywords Citrus ; Citrus fruits
    Language Chinese
    Size 2, 2, 2, 8, 413 p., [16] p. of plates :, ill. (some col.) ;, 27 cm.
    Edition Di 1 ban.
    Publisher Zhongguo nong ye chu ban she ; Xin hua shu dian Beijing fa xing suo fa xing
    Publishing place Beijing shi
    Document type Book
    ISBN 7109059200 ; 9787109059207
    Database NAL-Catalogue (AGRICOLA)

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  9. Book: Quan guo ming yi yan an lei bian

    He, Liancheng

    (Minguo ming yi zhu zuo jing hua)

    2003  

    Title translation Medical cases collection from China's famous doctors.
    Author's details He Lianchen bian ; Wang Demin, Cui Jingyan dian jiao ; Lu Zhizheng shen ding
    Series title Minguo ming yi zhu zuo jing hua
    MeSH term(s) Medicine, Chinese Traditional ; Materia Medica
    Keywords China
    Language Chinese
    Size Fuzhou Shi :, Fujian ke xue ji shu chu ban she,, 2003.
    Edition Di 1 ban.
    Publishing place 3, 3, 17, 607 p
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article: [Review of external therapy for internal diseases in Ming yi lei an (Classified Medical Records of Famous Doctors)].

    Li, J / Yang, J / He, J

    Zhonghua yi shi za zhi (Beijing, China : 1980)

    1999  Volume 29, Issue 3, Page(s) 151–152

    Abstract: External therapy was applied for internal diseases in 78 case records in Classified Medical Records of Famous Doctors, including 19 kinds of external therapies for 41 categories of internal disease involving 40 famous doctors. The external therapy ... ...

    Abstract External therapy was applied for internal diseases in 78 case records in Classified Medical Records of Famous Doctors, including 19 kinds of external therapies for 41 categories of internal disease involving 40 famous doctors. The external therapy embodied the principle of "treatment according to differential diagnosis of Zhen "of TMC", "regular treatment", "contrary treatment" and multiple routes of administration were given in accordance with the differentiation, demonstrating that ancient doctors paid high attention to external therapy for internal diseases.
    MeSH term(s) China ; Disease ; History, Ancient ; History, Early Modern 1451-1600 ; History, Medieval ; History, Modern 1601- ; Humans ; Intestinal Diseases/history ; Therapeutics/history
    Language Chinese
    Publishing date 1999-07
    Publishing country China
    Document type English Abstract ; Historical Article ; Journal Article
    ZDB-ID 1052411-3
    ISSN 0255-7053
    ISSN 0255-7053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4688: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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