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  1. Book ; Online ; E-Book: Ancistrocladus naphthylisoquinoline alkaloids

    Kinghorn, A. Douglas

    (Progress in the Chemistry of Organic Natural Products, ; 119)

    2023  

    Abstract: This book describes a unique class of secondary metabolites, the mono- and dimeric-naphthylisoquinoline alkaloids. They exclusively occur in lianas of the palaeotropical Ancistrocladaceae and Dioncophyllaceae plant families. Their unprecedented ... ...

    Author's details edited by A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, Verena M Dirsch
    Series title Progress in the Chemistry of Organic Natural Products, ; 119
    Progress in the chemistry of organic natural products
    Collection Progress in the chemistry of organic natural products
    Abstract This book describes a unique class of secondary metabolites, the mono- and dimeric-naphthylisoquinoline alkaloids. They exclusively occur in lianas of the palaeotropical Ancistrocladaceae and Dioncophyllaceae plant families. Their unprecedented structures include stereogenic centers and rotationally hindered, and therefore stereogenic, axes. Extended recent investigations on six Ancistrocladus species from Asia, as reported in this contribution, shed light on their fascinating phytochemical productivity, with over 100 intriguing natural products. This high chemodiversity arises from a similarly unique biosynthesis from acetate-malonate units, following a novel polyketidic pathway to plant-derived isoquinoline alkaloids. Some of the compounds show most promising anti-parasitic activities. Additionally, strategies for the regio- and stereoselective total synthesis of the alkaloids, including the directed construction of the chiral axis, are also presented.
    Keywords Alkaloids ; Botanical chemistry
    Subject code 769
    Language English
    Size 1 online resource (344 pages) :, illustrations (black and white, and colour)
    Edition 1st ed. 2023.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-031-10457-9 ; 9783031104565 ; 978-3-031-10457-2 ; 3031104560
    DOI 10.1007/978-3-031-10457-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Antimalarial Natural Products

    Kinghorn, A. Douglas

    (Progress in the Chemistry of Organic Natural Products, ; 117)

    2022  

    Abstract: This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, ... ...

    Author's details edited by A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, Verena M. Dirsch
    Series title Progress in the Chemistry of Organic Natural Products, ; 117
    Progress in the chemistry of organic natural products
    Collection Progress in the chemistry of organic natural products
    Abstract This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature’s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.
    Keywords Natural products ; Medicinal chemistry ; Parasitology ; Chemistry, Organic ; Pharmaceutical chemistry ; Natural Products ; Medicinal Chemistry ; Organic Chemistry ; Pharmaceutics
    Subject code 572
    Language English
    Size 1 online resource (115 pages)
    Edition 1st ed. 2022.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-89873-3 ; 9783030898724 ; 978-3-030-89873-1 ; 3030898725
    DOI 10.1007/978-3-030-89873-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Conference proceedings: Keynote Lecture 14 “Discovery of Anticancer Agents of Diverse Natural Origin”

    Kinghorn, A. Douglas

    Planta Medica

    2023  Volume 89, Issue 14

    Event/congress 71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Trinity College Dublin Ireland, 2023-07-02
    Language English
    Publishing date 2023-11-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/s-0043-1773843
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.157: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Online ; E-Book: Phytocannabinoids

    Kinghorn, A. Douglas / Falk, Heinz / Gibbons, Simon / Kobayashi, Jun'ichi / Chandra, S.

    unraveling the complex chemistry and pharmacology of Cannabis sativa

    (Progress in the chemistry of organic natural products ; 103)

    2017  

    Author's details A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Jun'ichi Kobayashi, editors ; with contributions by S. Chandra [und 13 weiteren]
    Series title Progress in the chemistry of organic natural products ; 103
    Collection
    Language English
    Size 1 Online-Ressource (vii, 131 Seiten)
    Publisher Springer International Publishing
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019352492
    ISBN 978-3-319-45541-9 ; 9783319455396 ; 3-319-45541-9 ; 3319455397
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Honoring the Memory of George Robert (Bob) Pettit II and Kuo-Hsiung (K.-H.) Lee, Trailblazers in the Field of Natural Products.

    Proteau, Philip J / Kinghorn, A Douglas

    Journal of natural products

    2022  Volume 85, Issue 4, Page(s) 763–764

    MeSH term(s) Biological Products
    Chemical Substances Biological Products
    Language English
    Publishing date 2022-02-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.2c00115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1144: Show issues Location:
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  6. Article ; Online: Changes for Volume 82.

    Kinghorn, A Douglas

    Journal of natural products

    2019  Volume 82, Issue 1, Page(s) 1

    MeSH term(s) Biological Products ; Periodicals as Topic
    Chemical Substances Biological Products
    Language English
    Publishing date 2019-01-21
    Publishing country United States
    Document type Editorial
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.8b01055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dr. Philip J. Proteau to Become the New Editor-in-Chief of the

    Kinghorn, A Douglas

    Journal of natural products

    2019  Volume 82, Issue 12, Page(s) 3207

    MeSH term(s) Biological Products ; Editorial Policies ; History, 21st Century ; Personnel Selection ; Publishing
    Chemical Substances Biological Products
    Language English
    Publishing date 2019-12-21
    Publishing country United States
    Document type Biography ; Editorial ; Historical Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.9b01157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: Changes for Volume 81.

    Kinghorn, A Douglas

    Journal of natural products

    2018  Volume 81, Issue 1, Page(s) 1

    Language English
    Publishing date 2018-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.7b01078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
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  9. Article ; Online: Bioactive and unusual steroids from Penicillium fungi.

    Lindsay, Charmaine A / Kinghorn, A Douglas / Rakotondraibe, Harinantenaina L

    Phytochemistry

    2023  Volume 209, Page(s) 113638

    Abstract: Penicillium fungi are represented by various species and can be found worldwide and thrive in a range of environments, such as in the soil, air, and indoors, and in marine environments, as well as food products. Chemical investigation of species of this ... ...

    Abstract Penicillium fungi are represented by various species and can be found worldwide and thrive in a range of environments, such as in the soil, air, and indoors, and in marine environments, as well as food products. Chemical investigation of species of this genus has led to the discovery of compounds from several structural classes with varied bioactivities. As an example, this genus has been a source of bioactive and structurally unusual steroids. The scope of this short review is to cover specialized metabolites of the steroid class and the cytotoxic, antimicrobial, anti-inflammatory as well as phytotoxic activities of these compounds. Other steroids that possess unusual structures, with significant bioactivity yet to determined, will also be discussed to further demonstrate the structural diversity of this compound class from Penicillium fungi, and hopefully inspire the further exploration of such compounds to uncover their activity.
    MeSH term(s) Penicillium/chemistry ; Fungi/chemistry ; Anti-Infective Agents/chemistry ; Steroids/pharmacology ; Steroids/metabolism ; Antineoplastic Agents/chemistry
    Chemical Substances Anti-Infective Agents ; Steroids ; Antineoplastic Agents
    Language English
    Publishing date 2023-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2023.113638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Z 1586: Show issues
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  10. Article ; Online: Celebrating 25 Years of Co-Publication of the

    Proteau, Philip J / Kinghorn, A Douglas

    Journal of natural products

    2021  Volume 84, Issue 12, Page(s) 3009–3010

    MeSH term(s) Biological Products ; Pharmacognosy ; Publishing ; Societies, Scientific
    Chemical Substances Biological Products
    Language English
    Publishing date 2021-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.1c01130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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