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  1. Article ; Online: Zhuang Gu Guan Jie Wan

    Bin Liu / Danping Fan / Wen Sun / Kang Zheng / Guoming Pang / Xiaojuan He / Cheng Xiao / Cheng Lu

    Evidence-Based Complementary and Alternative Medicine, Vol

    Reasonable Application Can Alleviate the Liver Injury for Osteoarthritis Treatment

    2018  Volume 2018

    Abstract: ... Chinese patent medicine, Zhuang Gu Guan Jie Wan (ZGGJW) has been brought into focus recently ...

    Abstract The potential toxicity of herbal drugs, particularly drug-induced liver injury (DILI), has received extensive attention as the use of Chinese herbal medicine has rapidly increased globally. As a classic Chinese patent medicine, Zhuang Gu Guan Jie Wan (ZGGJW) has been brought into focus recently because of its satisfactory therapeutic effects on osteoarthritis (OA) as well as its unanticipated side effects. This study aimed to decipher the puzzling phenomenon of liver injury developing in response to ZGGJW that varies by the subtype of OA. Normal, anterior cruciate ligament transaction (ACLT) and partial medial meniscectomy (MMx) induced OA and ovariectomy combined with ACLT and partial MMx induced rat models were used and treated orally with ZGGJW or distilled water for 30 days. The results from histopathology, biochemistry, and immunohistochemistry showed that ZGGJW induced liver injury, increased the level of malondialdehyde (MDA), and decreased the levels of total antioxidation capability (T-AOC), superoxide dismutase (SOD), interleukin-22 (IL-22), and signal transducer and activator of transcription factor 3 (STAT3) in the liver of normal rats, while liver injury was alleviated and showed different tendencies in the above markers for ACLT and partial MMx induction rats and ovariectomy combined with ACLT and partial MMx induction rats after ZGGJW treatment. In the OA disease states, hepatic injury induced by ZGGJW could be associated with an impairment in antioxidant capacity and the high levels of IL-22 and STAT3 after ZGGJW treatment may be responsible for the slight hepatic injury of ZGGJW based on the subtype of OA. This study provides a novel approach to better understanding of the risks and limitations when using potentially toxic Chinese patent medicine in clinical applications.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Zhuang Gu Guan Jie Wan: Reasonable Application Can Alleviate the Liver Injury for Osteoarthritis Treatment.

    Liu, Bin / Fan, Danping / Sun, Wen / Zheng, Kang / Pang, Guoming / He, Xiaojuan / Xiao, Cheng / Lu, Cheng

    Evidence-based complementary and alternative medicine : eCAM

    2018  Volume 2018, Page(s) 6716529

    Abstract: ... Chinese patent medicine, Zhuang Gu Guan Jie Wan (ZGGJW) has been brought into focus recently ...

    Abstract The potential toxicity of herbal drugs, particularly drug-induced liver injury (DILI), has received extensive attention as the use of Chinese herbal medicine has rapidly increased globally. As a classic Chinese patent medicine, Zhuang Gu Guan Jie Wan (ZGGJW) has been brought into focus recently because of its satisfactory therapeutic effects on osteoarthritis (OA) as well as its unanticipated side effects. This study aimed to decipher the puzzling phenomenon of liver injury developing in response to ZGGJW that varies by the subtype of OA. Normal, anterior cruciate ligament transaction (ACLT) and partial medial meniscectomy (MMx) induced OA and ovariectomy combined with ACLT and partial MMx induced rat models were used and treated orally with ZGGJW or distilled water for 30 days. The results from histopathology, biochemistry, and immunohistochemistry showed that ZGGJW induced liver injury, increased the level of malondialdehyde (MDA), and decreased the levels of total antioxidation capability (T-AOC), superoxide dismutase (SOD), interleukin-22 (IL-22), and signal transducer and activator of transcription factor 3 (STAT3) in the liver of normal rats, while liver injury was alleviated and showed different tendencies in the above markers for ACLT and partial MMx induction rats and ovariectomy combined with ACLT and partial MMx induction rats after ZGGJW treatment. In the OA disease states, hepatic injury induced by ZGGJW could be associated with an impairment in antioxidant capacity and the high levels of IL-22 and STAT3 after ZGGJW treatment may be responsible for the slight hepatic injury of ZGGJW based on the subtype of OA. This study provides a novel approach to better understanding of the risks and limitations when using potentially toxic Chinese patent medicine in clinical applications.
    Language English
    Publishing date 2018-11-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2018/6716529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5995: Show issues Location:
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  3. Article: C21 steroid derivatives from the Dai herbal medicine Dai-Bai-Jie, the dried roots of Marsdenia tenacissima, and their screening for anti-HIV activity

    Pang, Xu / Kang, Li-Ping / Fang, Xiao-Mei / Yu, He-Shui / Han, Li-Feng / Zhao, Yang / Zhang, Li-Xia / Yu, Li-Yan / Ma, Bai-Ping

    Natural medicines. 2018 Jan., v. 72, no. 1

    2018  

    Abstract: ... marsdenin (27), were isolated from the Dai herbal medicine Dai-Bai-Jie, derived from the roots ...

    Abstract Twenty-three new C21 steroidal glycosides, marstenacissides C1–C10 (1–10), D1–D7 (11–17) and E1–E6 (18–23), and four new C21 steroids, 11α,12β-O-ditigloyl-tenacigenin C (24), 11α-O-benzoyl-12β-O-tigloyl-tenacigenin C (25), 11α-O-tigloyl-12β-O-benzoyl-tenacigenin C (26) and 11α-O-tigloyl-12β-O-benzoyl-marsdenin (27), were isolated from the Dai herbal medicine Dai-Bai-Jie, derived from the roots of Marsdenia tenacissima. The chemical structures of all compounds were established by spectroscopic techniques, including high-resolution mass spectrometry and NMR spectroscopy, as well as by comparison with reported spectral data. The anti-HIV activities of these compounds were screened, and the compounds obtained displayed inhibitory effects against HIV-1 with inhibition rates of 36.4–81.3% at 30 μM.
    Keywords Human immunodeficiency virus 1 ; Marsdenia tenacissima ; antiretroviral properties ; chemical structure ; glycosides ; herbal medicines ; mass spectrometry ; nuclear magnetic resonance spectroscopy ; roots ; screening ; spectral analysis ; steroids
    Language English
    Dates of publication 2018-01
    Size p. 166-180.
    Publishing place Springer Singapore
    Document type Article
    ZDB-ID 1201350-x
    ISSN 1340-3443
    ISSN 1340-3443
    DOI 10.1007/s11418-017-1126-1
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 2692: Show issues Location:
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  4. Book: Jie shi bing zhen liao quan shu

    Fan, Sixing / Pang, Siming

    (Zhongguo Zhong xi yi zhuan ke zhuan bing lin chuang da xi)

    2000  

    Title translation Complete book on diagnosis and treatment of calculi.
    Author's details zhu shen Wu Jieping ; zhu bian Fan Sixing, Pang Siming
    Series title Zhongguo Zhong xi yi zhuan ke zhuan bing lin chuang da xi
    MeSH term(s) Calculi. ; Medicine, Chinese Traditional
    Language Chinese
    Size 5, 519 p. ;, 27 cm.
    Edition Di 1 ban.
    Publisher Zhongguo yi yao ke ji chu ban she
    Publishing place Beijing
    Document type Book
    ISBN 9787506720342 ; 7506720345
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Article ; Online: Linear and Nonlinear Behaviors of the Photoreceptor Coupled Network.

    Pang, Ji-Jie / Jiang, Xiaolong / Wu, Samuel M

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2024  Volume 44, Issue 16

    Abstract: Photoreceptors are electrically coupled to one another, and the spatiotemporal properties of electrical synapses in a two-dimensional retinal network are still not well studied, because of the limitation of the single electrode or pair recording ... ...

    Abstract Photoreceptors are electrically coupled to one another, and the spatiotemporal properties of electrical synapses in a two-dimensional retinal network are still not well studied, because of the limitation of the single electrode or pair recording techniques which do not allow simultaneously measuring responses of multiple photoreceptors at various locations in the retina. A multiple electrode recording system is needed. In this study, we investigate the network properties of the two-dimensional rod coupled array of the salamander retina (both sexes were used) by using the newly available multiple patch electrode system that allows simultaneous recordings from up to eight cells and to determine the electrical connectivity among multiple rods. We found direct evidence that voltage signal spread in the rod-rod coupling network in the absence of
    MeSH term(s) Animals ; Photoreceptor Cells/physiology ; Retina/physiology ; Urodela/physiology
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.1433-23.2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1668: Show issues Location:
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  6. Article ; Online: Dietary Niacin Intake and Mortality Among Individuals With Nonalcoholic Fatty Liver Disease.

    Pan, Jie / Zhou, Yujia / Pang, Nengzhi / Yang, Lili

    JAMA network open

    2024  Volume 7, Issue 2, Page(s) e2354277

    Abstract: Importance: Evidence regarding the effect of dietary niacin intake on the risk of mortality among patients with nonalcoholic fatty liver disease (NAFLD) is scarce.: Objective: To examine the association of dietary niacin intake with all-cause ... ...

    Abstract Importance: Evidence regarding the effect of dietary niacin intake on the risk of mortality among patients with nonalcoholic fatty liver disease (NAFLD) is scarce.
    Objective: To examine the association of dietary niacin intake with all-cause mortality and cardiovascular disease (CVD) mortality among individuals with NAFLD.
    Design, setting, and participants: This cohort study used data from the National Health and Nutrition Examination Survey (2003-2018). In total, 4315 adults aged 20 years or older with NAFLD were included, with NAFLD defined using the United States Fatty Liver Index.
    Exposure: Dietary niacin intake levels.
    Main outcomes and measures: Weighted Cox proportional hazards models and restricted cubic splines were used to estimate hazard ratios and 95% CIs for all-cause and CVD mortality. Data were analyzed March 1 to September 1, 2023.
    Results: This cohort study included data from 4315 participants in the analysis (mean [SD] age, 52.5 [16.2] years; 1670 participants ≥60 years [weighted, 30.9%]; 2351 men [weighted, 55.0%]). During a median (IQR) follow-up of 8.8 (4.6-11.8) years, 566 deaths were recorded, of which 197 were attributed to CVD. Compared with participants with a niacin intake of 18.4 mg or lower (the lowest tertile), the multivariable-adjusted hazard ratios for participants with a niacin intake of 26.7 mg or higher (the highest tertile) were 0.70 (95% CI, 0.50-0.96) for all-cause mortality (P = .03 for trend) and 0.65 (95% CI, 0.35-1.20) for CVD mortality (P = .16 for trend).
    Conclusions and relevance: Findings from this cohort study suggest that higher dietary niacin intake may be associated with lower risk of all-cause mortality among individuals with NAFLD. There was no evident inverse association between dietary niacin intake and the risk of CVD mortality.
    MeSH term(s) Adult ; Male ; Humans ; Middle Aged ; Non-alcoholic Fatty Liver Disease ; Niacin ; Cohort Studies ; Nutrition Surveys ; Cardiovascular Diseases
    Chemical Substances Niacin (2679MF687A)
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.54277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Roles of the ocular pressure, pressure-sensitive ion channel, and elasticity in pressure-induced retinal diseases.

    Pang, Ji-Jie

    Neural regeneration research

    2020  Volume 16, Issue 1, Page(s) 68–72

    Abstract: The intraocular pressure inside the human eye maintains 10-21 mmHg above the atmospheric pressure. Elevation of intraocular pressure is highly correlated with the retinopathy in glaucoma, and changes in the exterior pressure during mountain hiking, air ... ...

    Abstract The intraocular pressure inside the human eye maintains 10-21 mmHg above the atmospheric pressure. Elevation of intraocular pressure is highly correlated with the retinopathy in glaucoma, and changes in the exterior pressure during mountain hiking, air traveling, and diving may also induce vision decline and retinopathy. The pathophysiological mechanism of these pressure-induced retinal disorders has not been completely clear. Retinal neurons express pressure-sensitive channels intrinsically sensitive to pressure and membrane stretch, such as the transient receptor potential channel (TRP) family permeable to Ca
    Language English
    Publishing date 2020-08-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.286953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: An unusual interventional approach to treat Type 2 Abernethy malformation in children: two case reports.

    Yan, Jiayu / Yin, Jie / Zhang, Dan / Lv, Chuankai / Pang, Wenbo / Chen, Yajun

    Gastroenterology report

    2024  Volume 12, Issue 1, Page(s) goad075

    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2710871-5
    ISSN 2052-0034
    ISSN 2052-0034
    DOI 10.1093/gastro/goad075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Light responses and amacrine cell modulation of morphologically-identified retinal ganglion cells in the mouse retina.

    Pang, Ji-Jie / Gao, Fan / Wu, Samuel M

    Vision research

    2023  Volume 205, Page(s) 108187

    Abstract: By analyzing light-evoked spike responses, cation currents ( ... ...

    Abstract By analyzing light-evoked spike responses, cation currents (ΔI
    MeSH term(s) Animals ; Mice ; Retinal Ganglion Cells/physiology ; Amacrine Cells/physiology ; Retina/physiology ; Strychnine ; Chlorides ; Cations
    Chemical Substances Strychnine (H9Y79VD43J) ; Chlorides ; Cations
    Language English
    Publishing date 2023-02-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 200427-6
    ISSN 1878-5646 ; 0042-6989
    ISSN (online) 1878-5646
    ISSN 0042-6989
    DOI 10.1016/j.visres.2023.108187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Consequences of plateau pika disturbance on plant-soil carbon and nitrogen in alpine meadows.

    Xu, Xue Ting / Wang, Yi Mo / Wang, Xiao Zheng / Li, Jie Na / Li, Jie / Yang, Ding / Guo, Zheng Gang / Pang, Xiao Pan

    Frontiers in plant science

    2024  Volume 15, Page(s) 1362125

    Abstract: The presence of burrowing mammals can have extensive effects on plants and soils, creating bare soil patches in alpine meadows and potentially altering plant-soil carbon (C) and nitrogen (N). This study focuses on the plateau pika ( ...

    Abstract The presence of burrowing mammals can have extensive effects on plants and soils, creating bare soil patches in alpine meadows and potentially altering plant-soil carbon (C) and nitrogen (N). This study focuses on the plateau pika (
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2024.1362125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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