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  1. Article: Wide-field calcium imaging of cortical activation and functional connectivity in externally- and internally-driven locomotion.

    West, Sarah L / Gerhart, Morgan L / Ebner, Timothy J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The neural dynamics underlying self-initiated versus sensory driven movements is central to understanding volitional action. Upstream motor cortices are associated with the generation of internally-driven movements over externally-driven. Here we ... ...

    Abstract The neural dynamics underlying self-initiated versus sensory driven movements is central to understanding volitional action. Upstream motor cortices are associated with the generation of internally-driven movements over externally-driven. Here we directly compare cortical dynamics during internally- versus externally-driven locomotion using wide-field Ca
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.10.536261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Wide-field calcium imaging of cortical activation and functional connectivity in externally- and internally-driven locomotion.

    West, Sarah L / Gerhart, Morgan L / Ebner, Timothy J

    Research square

    2023  

    Abstract: The neural dynamics underlying self-initiated versus sensory driven movements is central to understanding volitional action. Upstream motor cortices are associated with the generation of internally-driven movements over externally-driven. Here we ... ...

    Abstract The neural dynamics underlying self-initiated versus sensory driven movements is central to understanding volitional action. Upstream motor cortices are associated with the generation of internally-driven movements over externally-driven. Here we directly compare cortical dynamics during internally- versus externally-driven locomotion using wide-field Ca
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2776902/v1
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  3. Article ; Online: Commentary: Is Wearable Fitness Technology a Medically Approved Device? Yes and No.

    Scheid, Jennifer L / Reed, Jennifer L / West, Sarah L

    International journal of environmental research and public health

    2023  Volume 20, Issue 13

    Abstract: Wearable technologies, i.e., activity trackers and fitness watches, are extremely popular and have been increasingly integrated into medical research and clinical practice. To assist in optimizing health, wellness, or medical care, these devices require ... ...

    Abstract Wearable technologies, i.e., activity trackers and fitness watches, are extremely popular and have been increasingly integrated into medical research and clinical practice. To assist in optimizing health, wellness, or medical care, these devices require collaboration between researchers, healthcare providers, and wearable technology companies in order to clarify their clinical capabilities and educate consumers on the utilities and limitations of the wide-ranging wearable devices. Interestingly, activity trackers and fitness watches often track both health/wellness and medical information within the same device. In this commentary, we will focus our discussions regarding wearable technology on (1) defining and explaining the technical differences between tracking health, wellness, and medical information; (2) providing examples of health and wellness compared to medical tracking; (3) describing the potential medical benefits of wearable technology and its applications in clinical populations; and (4) elucidating the potential risks of wearable technology. We conclude that while wearable devices are powerful and informative tools, further research is needed to improve its clinical applications.
    MeSH term(s) Wearable Electronic Devices ; Fitness Trackers ; Exercise ; Biomedical Research ; Technology
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20136230
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  4. Article ; Online: Corrigendum to "Gene therapy for Fabry disease: Progress, challenges, and outlooks on gene-editing" [2021 Sep-Oct;134(1-2):117-131].

    Domm, Jakob M / Wootton, Sarah K / Medin, Jeffrey A / West, Michael L

    Molecular genetics and metabolism

    2023  Volume 139, Issue 1, Page(s) 107541

    Language English
    Publishing date 2023-02-26
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1418518-0
    ISSN 1096-7206 ; 1096-7192
    ISSN (online) 1096-7206
    ISSN 1096-7192
    DOI 10.1016/j.ymgme.2023.107541
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 617: Show issues Location:
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  5. Article: Antibiotic exposure is associated with decreased risk of psychiatric disorders.

    Kerman, Ilan A / Glover, Matthew E / Lin, Yezhe / West, Jennifer L / Hanlon, Alexandra L / Kablinger, Anita S / Clinton, Sarah M

    Frontiers in pharmacology

    2024  Volume 14, Page(s) 1290052

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1290052
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  6. Article ; Online: Normal Tissue Toxicity Prediction: Clinical Translation on the Horizon.

    Kerns, Sarah L / Hall, William A / Marples, Brian / West, Catharine M L

    Seminars in radiation oncology

    2023  Volume 33, Issue 3, Page(s) 307–316

    Abstract: Improvements in radiotherapy delivery have enabled higher therapeutic doses and improved efficacy, contributing to the growing number of long-term cancer survivors. These survivors are at risk of developing late toxicity from radiotherapy, and the ... ...

    Abstract Improvements in radiotherapy delivery have enabled higher therapeutic doses and improved efficacy, contributing to the growing number of long-term cancer survivors. These survivors are at risk of developing late toxicity from radiotherapy, and the inability to predict who is most susceptible results in substantial impact on quality of life and limits further curative dose escalation. A predictive assay or algorithm for normal tissue radiosensitivity would allow more personalized treatment planning, reducing the burden of late toxicity, and improving the therapeutic index. Progress over the last 10 years has shown that the etiology of late clinical radiotoxicity is multifactorial and informs development of predictive models that combine information on treatment (eg, dose, adjuvant treatment), demographic and health behaviors (eg, smoking, age), co-morbidities (eg, diabetes, collagen vascular disease), and biology (eg, genetics, ex vivo functional assays). AI has emerged as a useful tool and is facilitating extraction of signal from large datasets and development of high-level multivariable models. Some models are progressing to evaluation in clinical trials, and we anticipate adoption of these into the clinical workflow in the coming years. Information on predicted risk of toxicity could prompt modification of radiotherapy delivery (eg, use of protons, altered dose and/or fractionation, reduced volume) or, in rare instances of very high predicted risk, avoidance of radiotherapy. Risk information can also be used to assist treatment decision-making for cancers where efficacy of radiotherapy is equivalent to other treatments (eg, low-risk prostate cancer) and can be used to guide follow-up screening in instances where radiotherapy is still the best choice to maximize tumor control probability. Here, we review promising predictive assays for clinical radiotoxicity and highlight studies that are progressing to develop an evidence base for clinical utility.
    MeSH term(s) Male ; Humans ; Quality of Life ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/pathology ; Dose Fractionation, Radiation ; Radiation Tolerance ; Radiation Injuries/etiology ; Radiation Injuries/prevention & control ; Radiotherapy Dosage
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2023.03.010
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    Zs.A 3654: Show issues Location:
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  7. Article ; Online: Commentary: Zebrafish as a Model for Osteoporosis-An Approach to Accelerating Progress in Drug and Exercise-Based Treatment.

    Dubale, Natnaiel M / Kapron, Carolyn M / West, Sarah L

    International journal of environmental research and public health

    2022  Volume 19, Issue 23

    Abstract: Osteoporosis (OP) is a degenerative disease characterized by reduced bone strength and increased fracture risk. As the global population continues to age, the prevalence and economic burden of osteoporosis can be expected to rise substantially, but there ...

    Abstract Osteoporosis (OP) is a degenerative disease characterized by reduced bone strength and increased fracture risk. As the global population continues to age, the prevalence and economic burden of osteoporosis can be expected to rise substantially, but there remain various gaps in the field of OP care. For instance, there is a lack of anti-fracture drugs with proven long-term efficacy. Likewise, though exercise remains widely recommended in OP prevention and management, data regarding the safety and efficacy for patients after vertebral fracture remain limited. This lack of evidence may be due to the cost and inherent difficulties associated with exercise-based OP research. Thus, the current research landscape highlights the need for novel research strategies that accelerate OP drug discovery and allow for the low-cost study of exercise interventions. Here, we outline an example of one strategy, the use of zebrafish, which has emerged as a potential model for the discovery of anti-osteoporosis therapeutics and study of exercise interventions. The strengths, limitations, and potential applications of zebrafish in OP research will be outlined.
    Language English
    Publishing date 2022-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192315866
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  8. Article ; Online: Opportunities of Wearable Technology to Increase Physical Activity in Individuals with Chronic Disease: An Editorial.

    Scheid, Jennifer L / West, Sarah L

    International journal of environmental research and public health

    2019  Volume 16, Issue 17

    Abstract: In this editorial, we will discuss one promising tool to encourage physical activity participation in individuals with chronic disease: The use of wearable technology. ...

    Abstract In this editorial, we will discuss one promising tool to encourage physical activity participation in individuals with chronic disease: The use of wearable technology.
    MeSH term(s) Chronic Disease ; Exercise ; Humans ; Wearable Electronic Devices
    Language English
    Publishing date 2019-08-28
    Publishing country Switzerland
    Document type Editorial
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph16173124
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  9. Article ; Online: Infant Communication Across the Transition to Walking: Developmental Cascades Among Infant Siblings of Children with Autism.

    L West, Kelsey / E Steward, Sarah / Roemer Britsch, Emily / M Iverson, Jana

    Journal of autism and developmental disorders

    2023  

    Abstract: New motor skills can shape how infants communicate with their caregivers. For example, learning to walk allows infants to move faster and farther than they previously could, in turn allowing them to approach their caregivers more frequently to gesture or ...

    Abstract New motor skills can shape how infants communicate with their caregivers. For example, learning to walk allows infants to move faster and farther than they previously could, in turn allowing them to approach their caregivers more frequently to gesture or vocalize. Does the link between walking and communication differ for infants later diagnosed with autism spectrum disorder (ASD), whose communicative and motor development differs from their neurotypically developing peers? We prospectively followed two groups of infants longitudinally during the transition from crawling to walking: (1) N = 25 infants with no family history of ASD; and (2) N = 91 infants with an older sibling with ASD. Fifteen infants were later diagnosed with ASD, and 26 infants showed a language delay (but did not receive an ASD diagnosis). After learning to walk, infants without ASD or language delay showed considerable changes in their communication: They gestured more frequently, and increasingly coordinated their gestures and vocalizations with locomotion (e.g., by approaching a caregiver and showing a toy). Infants with language delay showed similar but attenuated growth in their communication. However, infants later diagnosed with ASD did not display enhanced communication after they began to walk.
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-023-06030-6
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    Zs.A 765: Show issues Location:
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  10. Article ; Online: Perceived Exertion during Moderate and Vigorous Physical Activity While Mask Wearing: A Quantitative and Qualitative Pilot Study.

    Scheid, Jennifer L / Edwards, Corinne / Seils, Michael / West, Sarah L

    International journal of environmental research and public health

    2022  Volume 19, Issue 9

    Abstract: There is limited research examining the perception of exertion during exercise while wearing a facemask. The current study examined if mask usage during moderate or vigorous physical activity (MVPA) changed the self-reported perception of exertion. ... ...

    Abstract There is limited research examining the perception of exertion during exercise while wearing a facemask. The current study examined if mask usage during moderate or vigorous physical activity (MVPA) changed the self-reported perception of exertion. Seventy-two adults (18 years and older) who were physically active before the COVID-19 pandemic completed a questionnaire that assessed exercise habits and perceptions of mask wearing during MVPA. Participants reported their ratings of perceived exertion (RPE, on a scale of 1−10) while exercising. Wearing a mask resulted in higher RPE vs. no mask during both vigorous (8.4 ± 0.2 vs. 7.4 ± 0.1; p < 0.001) and moderate PA (6.6 ± 0.2 vs. 5.6 ± 0.2; p < 0.001). Qualitative analysis revealed mostly negative perceptions of exercising while wearing a mask, including respiratory issues, detriments to cardiovascular endurance, and general discomfort. A total of 40% of participants reported that they stopped exercising in an indoor/public setting because of a mask mandate in their region. Participants reported participating in less vigorous PA (4.7 ± 0.4 vs. 4.0 ± 0.4 h/week; p = 0.046), but not less moderate PA (3.3 ± 0.3 vs. 3.0 ± 0.3 h/week; p = 0.443) pre vs. during the pandemic. Our study suggests that facemask usage during MVPA causes an increase in RPE and may be one reason for a decrease in vigorous PA during the COVID-19 pandemic.
    MeSH term(s) Adult ; COVID-19/epidemiology ; COVID-19/prevention & control ; Exercise ; Humans ; Pandemics ; Physical Exertion ; Pilot Projects ; SARS-CoV-2
    Language English
    Publishing date 2022-05-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19095698
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