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Article: Applications of metal-organic framework-based bioelectrodes.

Aggarwal, Vidushi / Solanki, Shipra / Malhotra, Bansi D

2022 Volume 13, Issue 30, Page(s) 8727–8743

Abstract: Metal-organic frameworks (MOFs) are an emerging class of porous nanomaterials that have opened new research possibilities. The inherent characteristics of MOFs such as their large surface area, high porosity, tunable pore size, stability, facile ... ...

Abstract	Metal-organic frameworks (MOFs) are an emerging class of porous nanomaterials that have opened new research possibilities. The inherent characteristics of MOFs such as their large surface area, high porosity, tunable pore size, stability, facile synthetic strategies and catalytic nature have made them promising materials for enormous number of applications, including fuel storage, energy conversion, separation, and gas purification. Recently, their high potential as ideal platforms for biomolecule immobilization has been discovered. MOF-enzyme-based materials have attracted the attention of researchers from all fields with the expansion of MOFs development, paving way for the fabrication of bioelectrochemical devices with unique characteristics. MOFs-based bioelectrodes have steadily gained interest, wherein MOFs can be utilized for improved biomolecule immobilization, electrolyte membranes, fuel storage, biocatalysis and biosensing. Likewise, applications of MOFs in point-of-care diagnostics, including self-powered biosensors, are exponentially increasing. This paper reviews the current trends in the fabrication of MOFs-based bioelectrodes with emphasis on their applications in biosensors and biofuel cells.
Language	English
Publishing date	2022-07-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d2sc03441g
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Disease-associated dysbiosis and potential therapeutic role of Akkermansia muciniphila, a mucus degrading bacteria of gut microbiome.

Aggarwal, Vidushi / Sunder, Sushant / Verma, Smita Rastogi

Folia microbiologica

2022 Volume 67, Issue 6, Page(s) 811–824

Abstract: The unique functionality of Akkermansia muciniphila in gut microbiota indicates it to be an indispensable microbe for human welfare. The importance of A. muciniphila lies in its potential to convert mucin into beneficial by-products, regulate intestinal ... ...

Abstract	The unique functionality of Akkermansia muciniphila in gut microbiota indicates it to be an indispensable microbe for human welfare. The importance of A. muciniphila lies in its potential to convert mucin into beneficial by-products, regulate intestinal homeostasis and maintain gut barrier integrity. It is also known to competitively inhibit other mucin-degrading bacteria and improve metabolic functions and immunity responses in the host. It finds a pivotal perspective in various diseases and their treatment. It has future as a promising probiotic, disease biomarker and therapeutic agent for chronic diseases. Disease-associated dysbiosis of A. muciniphila in the gut microbiome makes it a potential candidate as a biomarker for some diseases and can provide future theranostics by suggesting ways of diagnosis for the patients and best treatment method based on the screening results. Manipulation of A. muciniphila in gut microbiome may help in developing a novel personalized therapeutic action and can be a suitable next generation medicine. However, the actual pathway governing A. muciniphila interaction with hosts remains to be investigated. Also, due to the limited availability of products containing A. muciniphila, it is not exploited to its full potential. The present review aims at highlighting the potential of A. muciniphila in mucin degradation, contribution towards the gut health and host immunity and management of metabolic diseases such as obesity and type 2 diabetes, and respiratory diseases such as cystic fibrosis and COVID-19.
MeSH term(s)	Humans ; Gastrointestinal Microbiome ; Dysbiosis/therapy ; Diabetes Mellitus, Type 2 ; COVID-19 ; Verrucomicrobia/metabolism ; Mucins/metabolism ; Mucus
Chemical Substances	Mucins
Language	English
Publishing date	2022-05-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	240503-9
ISSN	1874-9356 ; 0015-5632
ISSN (online)	1874-9356
ISSN	0015-5632
DOI	10.1007/s12223-022-00973-6
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Article ; Online: Disease-associated dysbiosis and potential therapeutic role of Akkermansia muciniphila, a mucus degrading bacteria of gut microbiome

Aggarwal, Vidushi / Sunder, Sushant / Verma, Smita Rastogi

Folia Microbiol. 2022 Dec., v. 67, no. 6 p.811-824

2022

Abstract	The unique functionality of Akkermansia muciniphila in gut microbiota indicates it to be an indispensable microbe for human welfare. The importance of A. muciniphila lies in its potential to convert mucin into beneficial by-products, regulate intestinal homeostasis and maintain gut barrier integrity. It is also known to competitively inhibit other mucin-degrading bacteria and improve metabolic functions and immunity responses in the host. It finds a pivotal perspective in various diseases and their treatment. It has future as a promising probiotic, disease biomarker and therapeutic agent for chronic diseases. Disease-associated dysbiosis of A. muciniphila in the gut microbiome makes it a potential candidate as a biomarker for some diseases and can provide future theranostics by suggesting ways of diagnosis for the patients and best treatment method based on the screening results. Manipulation of A. muciniphila in gut microbiome may help in developing a novel personalized therapeutic action and can be a suitable next generation medicine. However, the actual pathway governing A. muciniphila interaction with hosts remains to be investigated. Also, due to the limited availability of products containing A. muciniphila, it is not exploited to its full potential. The present review aims at highlighting the potential of A. muciniphila in mucin degradation, contribution towards the gut health and host immunity and management of metabolic diseases such as obesity and type 2 diabetes, and respiratory diseases such as cystic fibrosis and COVID-19.
Keywords	COVID-19 infection ; absorption barrier ; biomarkers ; cystic fibrosis ; dysbiosis ; homeostasis ; immunity ; intestinal microorganisms ; intestines ; medicine ; mucins ; mucus ; noninsulin-dependent diabetes mellitus ; obesity ; precision medicine ; probiotics ; social welfare
Language	English
Dates of publication	2022-12
Size	p. 811-824.
Publishing place	Springer Netherlands
Document type	Article ; Online
Note	Review
ZDB-ID	240503-9
ISSN	1874-9356 ; 0015-5632
ISSN (online)	1874-9356
ISSN	0015-5632
DOI	10.1007/s12223-022-00973-6
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Article: Diagnosing rare intraductal biliary neoplasms - Intraductal papillary neoplasm of the bile duct: A case report with typical imaging findings.

Pandey, Saumya / Agarwal, Nitin / Gupta, Vidushi / Sharma, Ashok / Aggarwal, Anil / Gupta, Sunita / Krishan, Ram

SA journal of radiology

2022 Volume 26, Issue 1, Page(s) 2387

Abstract: Intraductal papillary neoplasm of the bile duct (IPN-B) is a rare preinvasive intraductal pathology of the biliary tract. It should be differentiated from other more common benign or malignant causes of biliary obstruction and dilatation such as calculi ... ...

Abstract	Intraductal papillary neoplasm of the bile duct (IPN-B) is a rare preinvasive intraductal pathology of the biliary tract. It should be differentiated from other more common benign or malignant causes of biliary obstruction and dilatation such as calculi or cholangiocarcinoma because the management and prognosis of this condition differs significantly. This case report describes a case of IPN-B in a 45-year-old female patient who presented with non-specific complaints of chronic abdominal pain without jaundice for three months.
Language	English
Publishing date	2022-04-29
Publishing country	South Africa
Document type	Case Reports
ZDB-ID	2475950-8
ISSN	2078-6778 ; 1027-202X
ISSN (online)	2078-6778
ISSN	1027-202X
DOI	10.4102/sajr.v26i1.2387
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Article ; Online: A 16-Year-Old-Girl With Asthma, Palpable Purpura, and Hypereosinophilia.

Singh, Jasmine / Randev, Shivani / Kumar, Pankaj / Mahajan, Vidushi / Aggarwal, Phiza / Sharma, Aman / Guglani, Vishal

Chest

2022 Volume 161, Issue 5, Page(s) e305–e308

Abstract: Case presentation: A 16-year-old girl presented to the ED with complaints of loose stools, abdominal pain, and rash over her legs for the last 7 days. There was no history of fever, vomiting, oral ulcers, or mucosal bleeds. In the past, she had received ...

Abstract	Case presentation: A 16-year-old girl presented to the ED with complaints of loose stools, abdominal pain, and rash over her legs for the last 7 days. There was no history of fever, vomiting, oral ulcers, or mucosal bleeds. In the past, she had received a diagnosis of asthma. She had been taking oral montelukast every day for the past year and using a formoterol-budesonide dry powder inhaler irregularly, only during episodes of acute exacerbations. There was a history of significant but undocumented weight loss. On day 3 of hospital admission, she developed numbness over her right foot.
MeSH term(s)	Administration, Inhalation ; Adolescent ; Asthma/diagnosis ; Asthma/drug therapy ; Bronchodilator Agents/therapeutic use ; Budesonide/therapeutic use ; Drug Combinations ; Eosinophilia/diagnosis ; Ethanolamines/therapeutic use ; Female ; Formoterol Fumarate ; Humans ; IgA Vasculitis ; Purpura
Chemical Substances	Bronchodilator Agents ; Drug Combinations ; Ethanolamines ; Budesonide (51333-22-3) ; Formoterol Fumarate (W34SHF8J2K)
Language	English
Publishing date	2022-05-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2021.12.632
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Article ; Online: Diagnosing rare intraductal biliary neoplasms – Intraductal papillary neoplasm of the bile duct

Saumya Pandey / Nitin Agarwal / Vidushi Gupta / Ashok Sharma / Anil Aggarwal / Sunita Gupta / Ram Krishan

South African Journal of Radiology, Vol 26, Iss 1, Pp e1-e

A case report with typical imaging findings

2022 Volume 5

Abstract	Intraductal papillary neoplasm of the bile duct (IPN-B) is a rare preinvasive intraductal pathology of the biliary tract. It should be differentiated from other more common benign or malignant causes of biliary obstruction and dilatation such as calculi or cholangiocarcinoma because the management and prognosis of this condition differs significantly. This case report describes a case of IPN-B in a 45-year-old female patient who presented with non-specific complaints of chronic abdominal pain without jaundice for three months.
Keywords	intraductal neoplasms ; solid-cystic ; papillary growth ; biliary dilatation ; mucin production ; communicating ; hyperenhancing ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	AOSIS
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cilnidipine loaded poly (ε-caprolactone) nanoparticles for enhanced oral delivery: optimization using DoE, physical characterization, pharmacokinetic, and pharmacodynamic evaluation.

Diwan, Rimpy / Ravi, Punna Rao / Agarwal, Shubham Ishwar / Aggarwal, Vidushi

Pharmaceutical development and technology

2021 Volume 26, Issue 3, Page(s) 278–290

Abstract: Cilnidipine (CND), an anti-hypertensive drug, possesses low oral bioavailability due to its poor aqueous solubility, low dissolution rate, and high gut wall metabolism. In the present study, an attempt has been made to prepare CND loaded polycaprolactone ...

Abstract	Cilnidipine (CND), an anti-hypertensive drug, possesses low oral bioavailability due to its poor aqueous solubility, low dissolution rate, and high gut wall metabolism. In the present study, an attempt has been made to prepare CND loaded polycaprolactone based nanoparticles (CND-PCL-NPs) by nanoprecipitation method applying the concepts of Design of Experiments. Critical factors affecting particle size and loading efficiency (LE%) were assessed by a hybrid design approach, comprising of Mini Run Resolution IV design followed by Box-Behnken design. Particle size, PDI, zeta potential and LE% of optimized formulations of CND-PCL-NPs were 220.3 ± 2.6 nm, 0.25 ± 0.1, -19.5 ± 0.9 mV, and 46.4 ± 1.8%, respectively. No significant changes were observed in the physical stability of nanoparticles when stored at 25 °C/60% RH over a period of 3 months. Oral pharmacokinetic studies revealed that
MeSH term(s)	Administration, Oral ; Animals ; Antihypertensive Agents/administration & dosage ; Antihypertensive Agents/pharmacokinetics ; Antihypertensive Agents/pharmacology ; Calcium Channel Blockers/administration & dosage ; Calcium Channel Blockers/pharmacokinetics ; Calcium Channel Blockers/pharmacology ; Dihydropyridines/administration & dosage ; Dihydropyridines/pharmacokinetics ; Dihydropyridines/pharmacology ; Drug Carriers/chemistry ; Male ; Nanoparticles/chemistry ; Polyesters/chemistry ; Rats, Wistar ; Rats
Chemical Substances	Antihypertensive Agents ; Calcium Channel Blockers ; Dihydropyridines ; Drug Carriers ; Polyesters ; polycaprolactone (24980-41-4) ; cilnidipine (97T5AZ1JIP)
Language	English
Publishing date	2021-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1331774-x
ISSN	1097-9867 ; 1083-7450
ISSN (online)	1097-9867
ISSN	1083-7450
DOI	10.1080/10837450.2020.1864643
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Article ; Online: Pharmacodynamic, pharmacokinetic and physical characterization of cilnidipine loaded solid lipid nanoparticles for oral delivery optimized using the principles of design of experiments.

Diwan, Rimpy / Ravi, Punna Rao / Pathare, Nikita Shantaram / Aggarwal, Vidushi

Colloids and surfaces. B, Biointerfaces

2020 Volume 193, Page(s) 111073

Abstract: Cilnidipine (CND), an anti-hypertensive drug, is known to have low oral bioavailability due to its poor aqueous solubility, low dissolution rate and high gut wall metabolism. In the present study, CND loaded compritol based nanoparticles (CND-CMP-NPs) ... ...

Abstract	Cilnidipine (CND), an anti-hypertensive drug, is known to have low oral bioavailability due to its poor aqueous solubility, low dissolution rate and high gut wall metabolism. In the present study, CND loaded compritol based nanoparticles (CND-CMP-NPs) were prepared by emulsification-solvent evaporation method applying the concepts of design of experiments. Critical factors affecting particle size and loading efficiency (LE%) were assessed by hybrid design approach, comprising of Mini Run Resolution IV design followed by Box-Behnken design. Particle size, PDI, zeta potential and LE% of optimized formulations of CND-CMP-NPs were 207.1 ± 2.9 nm, 0.27 ± 0.1, -22.2 ± 1.9 mV and 15.9 ± 1.3% respectively. No significant changes were observed in physical stability of NPs when stored at 25 °C/60% RH over a period of three months. Pharmacokinetic studies revealed that F
MeSH term(s)	Administration, Oral ; Animals ; Dihydropyridines/administration & dosage ; Dihydropyridines/chemical synthesis ; Dihydropyridines/chemistry ; Dihydropyridines/pharmacokinetics ; Drug Delivery Systems ; Drug Design ; Lipids/administration & dosage ; Lipids/chemistry ; Male ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Particle Size ; Rats ; Rats, Wistar ; Surface Properties
Chemical Substances	Dihydropyridines ; Lipids ; cilnidipine (97T5AZ1JIP)
Language	English
Publishing date	2020-04-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2020.111073
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Guidelines for endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA): Joint Indian Chest Society (ICS)/Indian Association for Bronchology (IAB) recommendations.

Mohan, Anant / Madan, Karan / Hadda, Vijay / Mittal, Saurabh / Suri, Tejas / Shekh, Irfan / Guleria, Randeep / Khader, Abdul / Chhajed, Prashant / Christopher, Devasahayam J / Swarnakar, Rajesh / Agarwal, Ritesh / Aggarwal, Ashutosh Nath / Aggarwal, Shubham / Agrawal, Gyanendra / Ayub, Irfan Ismail / Bai, Muniza / Baldwa, Bhvya / Chauhan, Abhishek /

Chawla, Rakesh / Chopra, Manu / Choudhry, Dhruva / Dhar, Raja / Dhooria, Sahajal / Garg, Rakesh / Goel, Ayush / Goel, Manoj / Goyal, Rajiv / Gupta, Nishkarsh / Manjunath, B G / Iyer, Hariharan / Jain, Deepali / Khan, Ajmal / Kumar, Raj / Koul, Parvaiz A / Lall, Ajay / Arunachalam, M / Madan, Neha K / Mehta, Ravindra / Loganathan, N / Nath, Alok / Nangia, Vivek / Nene, Amita / Patel, Dharmesh / Pattabhiraman, V R / Raja, Arun / Rajesh, Benin / Rangarajan, Amith / Rathi, Vidushi / Sehgal, Inderpaul Singh / Shankar, Sujay H / Sindhwani, Girish / Singh, Pawan K / Srinivasan, Arjun / Talwar, Deepak / Thangakunam, Balamugesh / Tiwari, Pawan / Tyagi, Rahul / Chandra, V Naren / Sharada, V / Vadala, Rohit / Venkatnarayan, Kavitha

Lung India : official organ of Indian Chest Society

2023 Volume 40, Issue 4, Page(s) 368–400

Abstract: Over the past decade, endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has become an indispensable tool in the diagnostic armamentarium of the pulmonologist. As the expertise with EBUS-TBNA has evolved and several innovations ... ...

Abstract	Over the past decade, endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has become an indispensable tool in the diagnostic armamentarium of the pulmonologist. As the expertise with EBUS-TBNA has evolved and several innovations have occurred, the indications for its use have expanded. However, several aspects of EBUS-TBNA are still not standardized. Hence, evidence-based guidelines are needed to optimize the diagnostic yield and safety of EBUS-TBNA. For this purpose, a working group of experts from India was constituted. A detailed and systematic search was performed to extract relevant literature pertaining to various aspects of EBUS-TBNA. The modified GRADE system was used for evaluating the level of evidence and assigning the strength of recommendations. The final recommendations were framed with the consensus of the working group after several rounds of online discussions and a two-day in-person meeting. These guidelines provide evidence-based recommendations encompassing indications of EBUS-TBNA, pre-procedure evaluation, sedation and anesthesia, technical and procedural aspects, sample processing, EBUS-TBNA in special situations, and training for EBUS-TBNA.
Language	English
Publishing date	2023-07-07
Publishing country	India
Document type	Journal Article
ZDB-ID	2410801-7
ISSN	0974-598X ; 0970-2113
ISSN (online)	0974-598X
ISSN	0970-2113
DOI	10.4103/lungindia.lungindia_510_22
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