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Article: Survival benefit of thermal ablation therapy for patients with stage II-III non-small cell lung cancer: A propensity-matched analysis.

Yang, Wei-Yu / He, Yu / Hu, Qikang / Peng, Muyun / Zhang, Zhe / Xie, Shouzhi / Yu, Fenglei

2022 Volume 12, Page(s) 984932

Abstract: Background: Thermal ablation (TA) is considered a safe alternative to surgical resection for the treatment of non-small cell lung cancer (NSCLC). While previous studies have shown that TA is beneficial for stage I NSCLC patients, however, few have ... ...

Abstract	Background: Thermal ablation (TA) is considered a safe alternative to surgical resection for the treatment of non-small cell lung cancer (NSCLC). While previous studies have shown that TA is beneficial for stage I NSCLC patients, however, few have reported on TA efficacy in patients with stage II-III NSCLC. The current study investigated the impact of TA on the overall survival (OS) and cancer-specific survival (CSS) of patients with stage II-III NSCLC. Methods: Data on patients with stage II-III NSCLC who did not undergo surgical resection between 2004 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM), Kaplan-Meier survival curves, and Cox regression were used for statistical analyses. Results: A total of 57,959 stage II-III NSCLC patients who did not undergo surgical resection were included in this study, 261 of whom received TA. Overall, TA was associated with a longer OS ( Conclusion: TA could be an effective alternative treatment for stage II-III NSCLC patients unsuitable for surgical resection, particularly those ≥70 years of age, with tumor size ≤3.0 cm, or who have not received radiotherapy.
Language	English
Publishing date	2022-08-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.984932
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Article ; Online: Thermal ablation versus radiotherapy for inoperable stage III non-small cell lung cancer: a propensity score matching analysis.

Yang, Wei-Yu / He, Yu / Peng, Muyun / Zhang, Zhe / Xie, Shouzhi / Wu, Zeyu / Hu, Qikang / Yu, Fenglei

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

2022 Volume 40, Issue 1, Page(s) 2154577

Abstract: Objective: To compare the survival benefits of thermal ablation (TA) and radiotherapy in inoperable patients with stage III non-small cell lung cancer (NSCLC).: Method: A retrospective analysis was conducted using the data from the Surveillance, ... ...

Abstract	Objective: To compare the survival benefits of thermal ablation (TA) and radiotherapy in inoperable patients with stage III non-small cell lung cancer (NSCLC). Method: A retrospective analysis was conducted using the data from the Surveillance, Epidemiology, and End Results (SEER) program. Propensity score matching (PSM) was conducted to balance potential baseline confounding factors. Survival analyses were conducted using Kaplan-Meier and Cox regression methods. Results: The present study included 33,393 inoperable patients with stage III NSCLC, including 106 patients treated with TA and 33,287 patients treated with radiotherapy. No statistical difference in overall survival (OS) ( Conclusion: For inoperable stage III NSCLC, the survival benefit of TA was comparable to radiotherapy. TA may be a potential therapeutic modality for inoperable stage III NSCLC.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/surgery ; Lung Neoplasms/surgery ; Retrospective Studies ; Propensity Score ; Treatment Outcome
Language	English
Publishing date	2022-12-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632526-9
ISSN	1464-5157 ; 0265-6736
ISSN (online)	1464-5157
ISSN	0265-6736
DOI	10.1080/02656736.2022.2154577
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Article ; Online: Combined quantitative T2 mapping and [

Zhang, Miao / Huang, Hui / Liu, Wei / Tang, Lihong / Li, Qikang / Wang, Jia / Huang, Xinyun / Lin, Xiaozhu / Meng, Hongping / Wang, Jin / Zhan, Shikun / Li, Biao / Luo, Jie

European radiology

2022 Volume 32, Issue 9, Page(s) 6108–6117

Abstract: Objectives: To investigate whether quantitative T2 mapping is complementary to [: Methods: We acquired routine structural MRI, T2-weighted FLAIR, whole brain T2 mapping, and [: Results: Routine structural MRI and T2w-FLAIR lateralized 47.8% (22/46) ...

Abstract	Objectives: To investigate whether quantitative T2 mapping is complementary to [ Methods: We acquired routine structural MRI, T2-weighted FLAIR, whole brain T2 mapping, and [ Results: Routine structural MRI and T2w-FLAIR lateralized 47.8% (22/46) of MTLE patients, and FDG PET lateralized 84.8% (39/46). T2 mapping combined with [ Conclusions: The combination of quantitative T2 mapping and [ Key points: • Quantitative T2 mapping and
MeSH term(s)	Epilepsy, Temporal Lobe/diagnostic imaging ; Fluorodeoxyglucose F18 ; Humans ; Magnetic Resonance Imaging/methods ; Positron-Emission Tomography/methods ; Temporal Lobe ; Tomography, X-Ray Computed
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2022-03-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-022-08707-5
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Zs.A 3300: Show issues

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Article ; Online: Disease named entity recognition by combining conditional random fields and bidirectional recurrent neural networks.

Wei, Qikang / Chen, Tao / Xu, Ruifeng / He, Yulan / Gui, Lin

Database : the journal of biological databases and curation

2016 Volume 2016

Abstract: The recognition of disease and chemical named entities in scientific articles is a very important subtask in information extraction in the biomedical domain. Due to the diversity and complexity of disease names, the recognition of named entities of ... ...

Abstract	The recognition of disease and chemical named entities in scientific articles is a very important subtask in information extraction in the biomedical domain. Due to the diversity and complexity of disease names, the recognition of named entities of diseases is rather tougher than those of chemical names. Although there are some remarkable chemical named entity recognition systems available online such as ChemSpot and tmChem, the publicly available recognition systems of disease named entities are rare. This article presents a system for disease named entity recognition (DNER) and normalization. First, two separate DNER models are developed. One is based on conditional random fields model with a rule-based post-processing module. The other one is based on the bidirectional recurrent neural networks. Then the named entities recognized by each of the DNER model are fed into a support vector machine classifier for combining results. Finally, each recognized disease named entity is normalized to a medical subject heading disease name by using a vector space model based method. Experimental results show that using 1000 PubMed abstracts for training, our proposed system achieves an F1-measure of 0.8428 at the mention level and 0.7804 at the concept level, respectively, on the testing data of the chemical-disease relation task in BioCreative V.Database URL: http://219.223.252.210:8080/SS/cdr.html.
Language	English
Publishing date	2016
Publishing country	England
Document type	Journal Article
ZDB-ID	2496706-3
ISSN	1758-0463 ; 1758-0463
ISSN (online)	1758-0463
ISSN	1758-0463
DOI	10.1093/database/baw140
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Article ; Online: Integrated System for On-Site Rapid and Safe Screening of COVID-19.

Zhang, Dongheyu / Guo, Yuntao / Zhang, Liyang / Wang, Yao / Peng, Siqi / Duan, Simeng / Geng, Lin / Zhang, Xiao / Wang, Wei / Yang, Mengjie / Wu, Guizhen / Chen, Jiayi / Feng, Zihao / Wang, Xinyuan / Wu, Yue / Jiang, Haotian / Zhang, Qikang / Sun, Jingjun / Li, Shenwei /

He, Yuping / Xiao, Meng / Xu, Yingchun / Wang, Hongqiu / Liu, Peipei / Zhou, Qun / Luo, Haiyun

Analytical chemistry

2022 Volume 94, Issue 40, Page(s) 13810–13819

Abstract: Since the outbreak of coronavirus disease 2019 (COVID-19), the epidemic has been spreading around the world for more than 2 years. Rapid, safe, and on-site detection methods of COVID-19 are in urgent demand for the control of the epidemic. Here, we ... ...

Abstract	Since the outbreak of coronavirus disease 2019 (COVID-19), the epidemic has been spreading around the world for more than 2 years. Rapid, safe, and on-site detection methods of COVID-19 are in urgent demand for the control of the epidemic. Here, we established an integrated system, which incorporates a machine-learning-based Fourier transform infrared spectroscopy technique for rapid COVID-19 screening and air-plasma-based disinfection modules to prevent potential secondary infections. A partial least-squares discrimination analysis and a convolutional neural network model were built using the collected infrared spectral dataset containing 857 training serum samples. Furthermore, the sensitivity, specificity, and prediction accuracy could all reach over 94% from the results of the field test regarding 968 blind testing samples. Additionally, the disinfection modules achieved an inactivation efficiency of 99.9% for surface and airborne tested bacteria. The proposed system is conducive and promising for point-of-care and on-site COVID-19 screening in the mass population.
MeSH term(s)	COVID-19/diagnosis ; Humans ; Least-Squares Analysis ; Neural Networks, Computer ; Spectroscopy, Fourier Transform Infrared/methods
Language	English
Publishing date	2022-10-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c02337
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Zs.A 4033: Show issues

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Article ; Online: WITHDRAWN: Clinical effectiveness of neoadjuvant chemotherapy in advanced gastric cancer: An updated meta-analysis of 12 randomized controlled trials.

Xiong, Binghong / Ma, Li / Huang, Wei / Cheng, Yong / Zhao, Qikang / Liu, Jingshan

Surgical oncology

2014

Abstract: This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

Abstract	This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
Language	English
Publishing date	2014-11-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1107810-8
ISSN	1879-3320 ; 0960-7404
ISSN (online)	1879-3320
ISSN	0960-7404
DOI	10.1016/j.suronc.2014.11.005
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Zs.A 3409: Show issues

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Article ; Online: Expression and purification of a rapidly degraded protein, TMEM8B-a, in mammalian cell line.

Wang, Li / Fan, Min / Zeng, Chao / Li, Wei / Hu, Qikang / Liu, Wenliang / Huang, Xingchun / Li, Guiyuan / Yu, Fenglei

Protein expression and purification

2018 Volume 151, Page(s) 38–45

Abstract: TMEM8B-a protein is the longer, predominant isoform of the TMEM8B gene product, which is a tumor metastasis suppressor in nasopharyngeal carcinoma (NPC) and lung cancer. TMEM8B-a is rapidly degraded via the proteasome pathway mediated by ezrin in many ... ...

Abstract	TMEM8B-a protein is the longer, predominant isoform of the TMEM8B gene product, which is a tumor metastasis suppressor in nasopharyngeal carcinoma (NPC) and lung cancer. TMEM8B-a is rapidly degraded via the proteasome pathway mediated by ezrin in many NPC and lung cancer cell lines, but TMEM8B-a is not ubiquitinated. In this study, we report the recombinant production of full-length modified TMEM8B-a in mammalian cells. We used the PiggyBac transposon system to efficiently generate normal and lung cancer cell lines with stable TMEM8B-a protein expression. 293FT cells were the best host cell line to express TMEM8B-a protein. Then, we treated the stable 293FT cell lines with various small-molecule inhibitors and demonstrated that treatment with MG-132 and bortezomib, which target the proteasome and disrupt its function, could prevent TMEM8B-a degradation and induce protein expression in 293FT cells. Finally, we utilized the combination of Twin-Strep-tag and Strep-Tactin XT resin to successfully purify the TMEM8B-a protein. The final yield was estimated to be approximately 10-20 μg of the purified TMEM8B-a per 3.0 × 10
MeSH term(s)	Bortezomib/pharmacology ; Cell Line ; Humans ; Leupeptins/pharmacology ; Membrane Proteins/biosynthesis ; Membrane Proteins/isolation & purification ; Proteasome Endopeptidase Complex/metabolism ; Proteasome Inhibitors/pharmacology ; Protein Isoforms/biosynthesis ; Protein Isoforms/isolation & purification ; Proteolysis ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/isolation & purification ; Transfection ; Tumor Suppressor Proteins/biosynthesis ; Tumor Suppressor Proteins/isolation & purification
Chemical Substances	Leupeptins ; Membrane Proteins ; Proteasome Inhibitors ; Protein Isoforms ; Recombinant Proteins ; TMEM8B protein, human ; Tumor Suppressor Proteins ; Bortezomib (69G8BD63PP) ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; benzyloxycarbonylleucyl-leucyl-leucine aldehyde (RF1P63GW3K)
Language	English
Publishing date	2018-06-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1055455-5
ISSN	1096-0279 ; 1046-5928
ISSN (online)	1096-0279
ISSN	1046-5928
DOI	10.1016/j.pep.2018.06.002
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Zs.A 3084: Show issues

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Article ; Online: Adaptation in 5-HT

Zuo, Wanhong / Wu, Liangzhi / Mei, Qinghua / Zuo, Qikang / Zhou, Zhongyang / Fu, Rao / Li, Wenting / Wu, Wei / Matthew, Leberer / Ye, Jiang-Hong

Neuropharmacology

2019 Volume 158, Page(s) 107747

Abstract: Alcoholics often experience hyperalgesia, especially during abstinence, yet the underlying cellular and molecular bases are unclear. Recent evidence suggests that 5-HT type 2 receptors (5- ... ...

Abstract	Alcoholics often experience hyperalgesia, especially during abstinence, yet the underlying cellular and molecular bases are unclear. Recent evidence suggests that 5-HT type 2 receptors (5-HT
MeSH term(s)	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives ; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology ; Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/antagonists & inhibitors ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Central Nervous System Depressants/adverse effects ; Central Nervous System Depressants/pharmacology ; Enzyme Inhibitors/pharmacology ; Ethanol/adverse effects ; Ethanol/pharmacology ; Excitatory Postsynaptic Potentials/drug effects ; Glutamic Acid/metabolism ; Habenula/cytology ; Habenula/drug effects ; Habenula/metabolism ; Neurons/drug effects ; Neurons/metabolism ; Nociception/drug effects ; RNA, Messenger/drug effects ; RNA, Messenger/metabolism ; Rats ; Receptor, Serotonin, 5-HT2A/drug effects ; Receptor, Serotonin, 5-HT2A/genetics ; Receptor, Serotonin, 5-HT2C/drug effects ; Receptor, Serotonin, 5-HT2C/genetics ; Receptors, Serotonin, 5-HT2/metabolism ; Serotonin 5-HT2 Receptor Antagonists/pharmacology ; Substance Withdrawal Syndrome/etiology ; Substance Withdrawal Syndrome/metabolism
Chemical Substances	Central Nervous System Depressants ; Enzyme Inhibitors ; RNA, Messenger ; Receptor, Serotonin, 5-HT2A ; Receptor, Serotonin, 5-HT2C ; Receptors, Serotonin, 5-HT2 ; Serotonin 5-HT2 Receptor Antagonists ; Ethanol (3K9958V90M) ; Glutamic Acid (3KX376GY7L) ; KN 62 (63HM46XPOW) ; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine (84477-87-2) ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17)
Language	English
Publishing date	2019-08-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2019.107747
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Article ; Online: Hypouricemic and Nephroprotective Effects of an Active Fraction from Polyrhachis Vicina Roger On Potassium Oxonate-Induced Hyperuricemia in Rats.

Su, Qibiao / Su, Hua / Nong, Zhihuan / Li, Dongmei / Wang, Laiyou / Chu, Shifeng / Liao, Lizhen / Zhao, Jie / Zeng, Xianbiao / Ya, Qikang / He, Fei / Lu, Wenjie / Wei, Baowei / Wei, Guining / Chen, Naihong

Kidney & blood pressure research

2018 Volume 43, Issue 1, Page(s) 220–233

Abstract: Background/aims: The objective of this study is to evaluate the hypouricemic and nephroprotective effects of an active fraction from Polyrhachis vicina Roger (AFPR) in potassium oxonate-induced hyperuricemic rats.: Methods: Hyperuricemia was induced ... ...

Abstract	Background/aims: The objective of this study is to evaluate the hypouricemic and nephroprotective effects of an active fraction from Polyrhachis vicina Roger (AFPR) in potassium oxonate-induced hyperuricemic rats. Methods: Hyperuricemia was induced by potassium oxonate in male rats. AFPR was orally administered to hyperuricemic rats for 12 consecutive weeks. Serum, liver and kidney samples were collected for effects and mechanism analysis. The levels of serum uric acid (SUA) were measured by the phosphotungstic acid method, xanthine oxidase (XOD) activity in the hepatic and serum samples were measured by ultraviolet spectrophotometry, serum levels of interleukin-1 (IL-1β), interleukin-1 (IL-6) and tumor necrosis factor-α (TNF-α) were measured by ELISA, the levels of serum creatinine (SCr), blood urea nitrogen (BUN), super oxide dismutase (SOD) and malondialdehyde (MDA) in serum were determined by colorimetric method. Protein expression of renal URAT1, GLUT9, and OAT1 were analyzed by Western blot. Results: AFPR significantly decreased the levels of SUA, serum and hepatic XOD, SCr, BUN, and MDA as well as increased SOD. In addition, AFPR treatment significantly reduced the levels of proinflammatory cytokines in serum, including IL-1β, IL-6 and TNF-α. Moreover, we found the significant decrease in protein expression of URAT1 and GLUT9, and the significant increase in protein expression of OAT1 in the kidney in AFPR treated groups compared to the model groups of hyperuricemia. Conclusion: These findings suggest that AFPR has anti-hyperuricemic activity attributed to the inhibition of uric acid generation in the liver and probably to the enhancement of urate excretion in the kidney, and possess nephroprotective effect in hyperuricemic rats due to its anti-inflammatory and antioxidant activities.
MeSH term(s)	Animals ; Anti-Inflammatory Agents ; Antioxidants ; Ants/chemistry ; Hyperuricemia/chemically induced ; Hyperuricemia/drug therapy ; Kidney/metabolism ; Liver/metabolism ; Male ; Oxonic Acid/adverse effects ; Protective Agents/isolation & purification ; Protective Agents/pharmacology ; Rats ; Uric Acid/antagonists & inhibitors
Chemical Substances	Anti-Inflammatory Agents ; Antioxidants ; Protective Agents ; Uric Acid (268B43MJ25) ; potassium oxonate (4R7FFA00RX) ; Oxonic Acid (5VT6420TIG)
Language	English
Publishing date	2018-02-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1326018-2
ISSN	1423-0143 ; 1420-4096
ISSN (online)	1423-0143
ISSN	1420-4096
DOI	10.1159/000487675
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Zs.A 1458: Show issues

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Article ; Online: Smad4 promotes diabetic nephropathy by modulating glycolysis and OXPHOS.

EMBO reports

2020 Volume 21, Issue 2, Page(s) e48781

Abstract: Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease. TGF-β1/Smad3 signalling plays a major pathological role in DN; however, the contribution of Smad4 has not been examined. Smad4 depletion in the kidney using anti-Smad4 locked ... ...

Abstract	Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease. TGF-β1/Smad3 signalling plays a major pathological role in DN; however, the contribution of Smad4 has not been examined. Smad4 depletion in the kidney using anti-Smad4 locked nucleic acid halted progressive podocyte damage and glomerulosclerosis in mouse type 2 DN, suggesting a pathogenic role of Smad4 in podocytes. Smad4 is upregulated in human and mouse podocytes during DN. Conditional Smad4 deletion in podocytes protects mice from type 2 DN, independent of obesity. Mechanistically, hyperglycaemia induces Smad4 localization to mitochondria in podocytes, resulting in reduced glycolysis and oxidative phosphorylation and increased production of reactive oxygen species. This operates, in part, via direct binding of Smad4 to the glycolytic enzyme PKM2 and reducing the active tetrameric form of PKM2. In addition, Smad4 interacts with ATPIF1, causing a reduction in ATPIF1 degradation. In conclusion, we have discovered a mitochondrial mechanism by which Smad4 causes diabetic podocyte injury.
MeSH term(s)	Animals ; Diabetes Mellitus/metabolism ; Diabetic Nephropathies/genetics ; Diabetic Nephropathies/metabolism ; Glycolysis/genetics ; Kidney ; Mice ; Podocytes/metabolism ; Reactive Oxygen Species/metabolism
Chemical Substances	Reactive Oxygen Species
Language	English
Publishing date	2020-01-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020896-0
ISSN	1469-3178 ; 1469-221X
ISSN (online)	1469-3178
ISSN	1469-221X
DOI	10.15252/embr.201948781
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Zs.A 5433: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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