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Article: Persistent Hiccups after Subthalamic Nucleus Deep Brain Stimulator Implantation for Parkinson's Disease: Case Report and Literature Review.

Waack, Andrew / Maddens, Michael E / Maddens, Nicholas J / Kuhlman, Adam / Staudt, Michael D

2023 Volume 15, Issue 1, Page(s) 153–162

Abstract: Hiccups are mediated by a reflex arc that consists of afferent, central, and efferent components. The structures involved in the central component have not been fully elucidated, although several brainstem structures have been implicated, including the ... ...

Abstract	Hiccups are mediated by a reflex arc that consists of afferent, central, and efferent components. The structures involved in the central component have not been fully elucidated, although several brainstem structures have been implicated, including the subthalamic nucleus (STN). Accordingly, Parkinson's disease (PD), a disease defined by the loss of dopaminergic neurons in the STN, has an interesting, although unspecified, relationship to hiccups. Hiccups have been described in association with PD and the use of dopaminergic medications. Interestingly, deep brain stimulation (DBS) of the STN appears to be implicated in the pathogenesis of hiccups as well. There have been sporadic reports of hiccups occurring in conjunction with STN-DBS. We present a case of hiccups occurring after STN-DBS for PD in a 65-year-old man. STN-DBS significantly improved his PD symptoms; however, he developed persistent and daily hiccups. As of writing, 24 months after surgery, the patient experiences hiccups several times per day with no associated gastrointestinal complaints and with significant improvement in his PD symptoms. This report describes the case details and summarizes the existing literature describing hiccups in patients undergoing surgical treatment for PD.
Language	English
Publishing date	2023-06-23
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2505302-4
ISSN	1662-680X
ISSN	1662-680X
DOI	10.1159/000531570
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Amantadine-Induced Craniofacial Myoclonus: Distinctive Iatrogenic Dysarthria in Parkinson's Disease.

Lin, Iris / Armengou-Garcia, Laura / Sasikumar, Sanskriti / Kuhlman, Greg / Fox, Susan H / Lang, Anthony E / Espay, Alberto J

Movement disorders clinical practice

2023 Volume 10, Issue 9, Page(s) 1408–1413

Abstract: Background: Amantadine is a widely prescribed medication in Parkinson's disease (PD). A distinctive craniofacial distribution of myoclonus with speech impairment is an underrecognized iatrogenic complication in amantadine-treated patients with PD.: ... ...

Abstract	Background: Amantadine is a widely prescribed medication in Parkinson's disease (PD). A distinctive craniofacial distribution of myoclonus with speech impairment is an underrecognized iatrogenic complication in amantadine-treated patients with PD. Cases: We report 7 patients with idiopathic PD (disease duration, 6-21 years) who developed speech-induced craniofacial-predominant myoclonus with "stuttering-like" dysarthria and speech arrests days to months after amantadine initiation or dose increase. Renal insufficiency was identified as a risk factor in 4 cases. In all cases, reduction or discontinuation of amantadine markedly attenuated the myoclonus and restored speech intelligibility. Literature review: Amantadine can induce subcortical segmental or generalized myoclonus. A report in 1996 of "vocal myoclonus" in an amantadine-treated patient with PD was the first observation of a focal distribution of myoclonus, particularly affecting speech. Since then, few cases of craniofacial myoclonus with speech impairment have been reported, none with accompanying video. With 1 exception, the craniofacial distribution was part of a generalized pattern of amantadine-induced myoclonus. Comorbid renal insufficiency is a recognized risk factor. Conclusions: Speech-induced craniofacial myoclonus, with marked "stuttering-like" dysarthria and speech arrests, is a disabling iatrogenic complication in PD that resolves upon amantadine discontinuation.
Language	English
Publishing date	2023-07-14
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2330-1619
ISSN (online)	2330-1619
DOI	10.1002/mdc3.13828
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The role of early life adversity and inflammation in stress-induced change in reward and risk processes among adolescents.

Kuhlman, Kate R / Cole, Steve W / Irwin, Michael R / Craske, Michelle G / Fuligni, Andrew J / Bower, Julienne E

Brain, behavior, and immunity

2023 Volume 109, Page(s) 78–88

Abstract: Background: Early life adversity (ELA) has long been associated with increased risk for stress-related psychopathology, particularly depression. The neuroimmune network hypothesis posits that ELA increases sensitivity to psychosocial stress, moderating ... ...

Abstract	Background: Early life adversity (ELA) has long been associated with increased risk for stress-related psychopathology, particularly depression. The neuroimmune network hypothesis posits that ELA increases sensitivity to psychosocial stress, moderating the association between increases in peripheral markers of inflammation and decreases in reward outcomes linked to anhedonia and risk-taking behaviors. The present study examined this hypothesis in a sample of adolescents by using acute psychosocial stress to probe the role of inflammatory signaling in behavioral measures of reward and risk processing. Method: 80 adolescents [13.86 years (SD = 1.54); 45 % female], oversampled for ELA, underwent the Trier Social Stress Test for Children while providing blood samples immediately before and 60-minutes after stress onset. Blood samples were assayed for plasma IL-6. One hour before stress onset, and then 60 min after, participants completed computer-administered behavioral tasks measuring reward (Pirate Task) and risk (Balloon Analog Risk Task). Results: ELA moderated the association between increases in IL-6 and decreases in risk tolerance in pursuit of rewards (p = 0.003) and reward response bias (p = 0.04). Stress-induced increases in IL-6 were associated with decreases in pumps for rewards among adolescents exposed to high, relative to little or no, ELA. Further, greater IL-6 increases were associated with increases in bias toward high relative to low value rewards among adolescents with low adversity exposure but not among those exposed to higher adversity. Conclusions: The present study provides the first evidence in a pediatric sample that ELA may alter the role of stress-induced inflammation in reward and risk processing, and may extend our understanding of why stress leads to depression in this high-risk population.
MeSH term(s)	Humans ; Child ; Female ; Adolescent ; Male ; Stress, Psychological/psychology ; Interleukin-6 ; Adverse Childhood Experiences ; Inflammation ; Reward
Chemical Substances	Interleukin-6
Language	English
Publishing date	2023-01-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2023.01.004
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Article: Parameter estimation from spontaneous imbibition into volcanic tuff

Kuhlman, Kristopher L. / Mills, Melissa M. / Heath, Jason E. / Paul, Matthew J. / Wilson, Jennifer E. / Bower, John Eric

Vadose zone journal. 2022 Mar., v. 21, no. 2

2022

Abstract: ... when imbibition rather than drainage parameters are sought, when larger samples (e.g., including heterogeneity or ...

Abstract	Two‐phase fluid flow properties underlie quantitative prediction of water and gas movement, but constraining these properties typically requires multiple time‐consuming laboratory methods. The estimation of two‐phase flow properties (van Genuchten parameters, porosity, and intrinsic permeability) is illustrated in cores of vitric nonwelded volcanic tuff using Bayesian parameter estimation that fits numerical models to observations from spontaneous imbibition experiments. The uniqueness and correlation of the estimated parameters is explored using different modeling assumptions and subsets of the observed data. The resulting estimation process is sensitive to both moisture retention and relative permeability functions, thereby offering a comprehensive method for constraining both functions. The data collected during this relatively simple laboratory experiment, used in conjunction with a numerical model and a global optimizer, result in a viable approach for augmenting more traditional capillary pressure data obtained from hanging water column, membrane plate extractor, or mercury intrusion methods. This method may be useful when imbibition rather than drainage parameters are sought, when larger samples (e.g., including heterogeneity or fractures) need to be tested that cannot be accommodated in more traditional methods, or when in educational laboratory settings.
Keywords	Bayesian theory ; drainage ; imbibition ; laboratory experimentation ; mathematical models ; mercury ; permeability ; porosity ; prediction ; tuff ; vadose zone
Language	English
Dates of publication	2022-03
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2088189-7
ISSN	1539-1663
ISSN	1539-1663
DOI	10.1002/vzj2.20188
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Synthesis, insertion, and characterization of SARS-CoV-2 membrane protein within lipid bilayers.

Zhang, Yuanzhong / Anbir, Sara / McTiernan, Joseph / Li, Siyu / Worcester, Michael / Mishra, Pratyasha / Colvin, Michael E / Gopinathan, Ajay / Mohideen, Umar / Zandi, Roya / Kuhlman, Thomas E

Science advances

2024 Volume 10, Issue 9, Page(s) eadm7030

Abstract: Throughout history, coronaviruses have posed challenges to both public health and the global economy; nevertheless, methods to combat them remain rudimentary, primarily due to the absence of experiments to understand the function of various viral ... ...

Abstract	Throughout history, coronaviruses have posed challenges to both public health and the global economy; nevertheless, methods to combat them remain rudimentary, primarily due to the absence of experiments to understand the function of various viral components. Among these, membrane (M) proteins are one of the most elusive because of their small size and challenges with expression. Here, we report the development of an expression system to produce tens to hundreds of milligrams of M protein per liter of
MeSH term(s)	Humans ; Lipid Bilayers/chemistry ; SARS-CoV-2/metabolism ; Cryoelectron Microscopy ; COVID-19 ; Viral Matrix Proteins/metabolism ; Membrane Proteins ; Escherichia coli/metabolism
Chemical Substances	Lipid Bilayers ; Viral Matrix Proteins ; Membrane Proteins
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adm7030
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Article ; Online: Enhanced Immune Activation Following Acute Social Stress Among Adolescents With Early-Life Adversity.

Kuhlman, Kate R / Cole, Steve W / Craske, Michelle G / Fuligni, Andrew J / Irwin, Michael R / Bower, Julienne E

Biological psychiatry global open science

2022 Volume 3, Issue 2, Page(s) 213–221

Abstract: Background: Early-life adversity (ELA) has been linked to higher depression risk across the life span and chronic inflammatory conditions that contribute to earlier mortality. In this study, we characterized innate immune responses to acute social ... ...

Abstract	Background: Early-life adversity (ELA) has been linked to higher depression risk across the life span and chronic inflammatory conditions that contribute to earlier mortality. In this study, we characterized innate immune responses to acute social stress in a community sample of adolescents (mean age = 13.9 ± 1.6 years; 46.4% female) as a potential pathway linking ELA and depression pathogenesis. Methods: Parents reported their child's exposure to 9 ELAs, and adolescents participated in the Trier Social Stress Test for Children, with blood collected immediately before and then at 60 and 90 minutes thereafter. Overall, 65 adolescents had complete data for analysis of stress-induced changes in gene expression and 84 adolescents had complete data for circulating inflammatory markers. Results: Relative to adolescents exposed to no ELA (11.9%) or low ELA (ELA = 1-3; 67.9%), those exposed to high ELA (ELA = 4+; 20.2%) showed larger stress-associated increases in expression of both proinflammatory and innate antiviral gene transcripts in circulating blood. Consistent with a potential mediating role of sympathetic nervous system activity, promoter-based bioinformatics analyses implicated CREB transcription factor activity in structuring observed gene expression differences. These effects were accompanied by a smaller initial but protracted increase in circulating interleukin 6 in adolescents with high ELA. Conclusions: Results are consistent with the hypothesis that ELA may enhance cellular and gene regulatory reactivity to stress, which may, in turn, increase vulnerability to depression and other inflammation-related disease processes.
Language	English
Publishing date	2022-03-12
Publishing country	United States
Document type	Journal Article
ISSN	2667-1743
ISSN (online)	2667-1743
DOI	10.1016/j.bpsgos.2022.03.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Early life adversity exposure and circulating markers of inflammation in children and adolescents: A systematic review and meta-analysis.

Kuhlman, Kate R / Horn, Sarah R / Chiang, Jessica J / Bower, Julienne E

Brain, behavior, and immunity

2019 Volume 86, Page(s) 30–42

Abstract: This study provides a comprehensive review of the published research on the association between early life adversity and markers of inflammation in children and adolescents. We conducted a systematic review of the published literature on the association ... ...

Abstract	This study provides a comprehensive review of the published research on the association between early life adversity and markers of inflammation in children and adolescents. We conducted a systematic review of the published literature on the association between early life adversity and markers of inflammation in pediatric populations. To date, 27 studies have been published in this area representing a wide range of global populations and diverse methods of which nearly half were prospective, longitudinal studies. Of these 27, only 12 studies shared an inflammatory outcome with 4 or more other studies; 9 for CRP, and 6 for IL-6. The association between early life adversity and both CRP, z = .07 [.04, .10], and IL-6, z = .17 [-.07, .42], were small and only significant for CRP although comparable in magnitude to the effects observed in adult samples. Descriptively, the association between early life adversity and CRP appeared to be stronger in studies conducted in infants and adolescents compared with middle childhood. There was minimal evidence of publication bias for studies measuring CRP, but evidence of publication bias for studies using IL-6. Eight studies have looked at the association between early life adversity and stimulated inflammatory cytokines in vitro, and both the methods and results of these studies were mixed; the majority observed exaggerated production of inflammatory cytokines despite mixed methodological approaches that make comparisons across studies difficult. In summary, the evidence supporting an association between early life adversity and inflammation in pediatric samples is limited so far by the number of studies and their heterogeneous methodological approaches. More research that is grounded in a developmental framework and informed by the complexity of the innate immune system is needed in this area.
MeSH term(s)	Adolescent ; Adverse Childhood Experiences ; Biomarkers/blood ; C-Reactive Protein/analysis ; Child ; Cytokines/blood ; Humans ; Inflammation/blood ; Inflammation/etiology ; Prospective Studies
Chemical Substances	Biomarkers ; Cytokines ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2019-04-15
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Systematic Review
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2019.04.028
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Article ; Online: Parameter estimation from spontaneous imbibition into volcanic tuff

Kristopher L. Kuhlman / Melissa M. Mills / Jason E. Heath / Matthew J. Paul / Jennifer E. Wilson / John Eric Bower

Vadose Zone Journal, Vol 21, Iss 2, Pp n/a-n/a (2022)

2022

Abstract: ... when imbibition rather than drainage parameters are sought, when larger samples (e.g., including heterogeneity or ...

Abstract	Abstract Two‐phase fluid flow properties underlie quantitative prediction of water and gas movement, but constraining these properties typically requires multiple time‐consuming laboratory methods. The estimation of two‐phase flow properties (van Genuchten parameters, porosity, and intrinsic permeability) is illustrated in cores of vitric nonwelded volcanic tuff using Bayesian parameter estimation that fits numerical models to observations from spontaneous imbibition experiments. The uniqueness and correlation of the estimated parameters is explored using different modeling assumptions and subsets of the observed data. The resulting estimation process is sensitive to both moisture retention and relative permeability functions, thereby offering a comprehensive method for constraining both functions. The data collected during this relatively simple laboratory experiment, used in conjunction with a numerical model and a global optimizer, result in a viable approach for augmenting more traditional capillary pressure data obtained from hanging water column, membrane plate extractor, or mercury intrusion methods. This method may be useful when imbibition rather than drainage parameters are sought, when larger samples (e.g., including heterogeneity or fractures) need to be tested that cannot be accommodated in more traditional methods, or when in educational laboratory settings.
Keywords	Environmental sciences ; GE1-350 ; Geology ; QE1-996.5
Subject code	310
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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Article ; Online: Assessing the Impact of Structured Reports for Fluoroscopic Double-Contrast Barium Esophagrams.

Galgano, Samuel J / Kirkland, Mason / Kuhlman, Taylor / Khalaf, Ahmed / Morgan, Desiree E / Canon, Cheri L / Zarzour, Jessica G

Dysphagia

2021 Volume 37, Issue 5, Page(s) 1266–1270

Abstract: Fluoroscopic barium swallow examinations are a commonly performed radiologic study in the evaluation of dysphagia. These studies remain essential in the diagnostic work-up despite the increasing utilization of endoscopy, but current residents are often ... ...

Abstract	Fluoroscopic barium swallow examinations are a commonly performed radiologic study in the evaluation of dysphagia. These studies remain essential in the diagnostic work-up despite the increasing utilization of endoscopy, but current residents are often less experienced with fluoroscopy. Structured reporting has been demonstrated to improve comprehensiveness of reports in multiple settings, but has not been evaluated for barium swallow examinations. A retrospective review identified patients who underwent barium swallow examinations pre-structured reporting in 2017 and followed a multidisciplinary proposal for and adoption of an optional structured report in 2020. Reports were assessed for comprehensiveness by evaluating presence/absence each element (total of 10 elements). Differences in report elements between groups and multiple subgroups was performed utilizing a Mann-Whitney U test. χ
MeSH term(s)	Barium ; Barium Sulfate ; Contrast Media ; Deglutition ; Deglutition Disorders/diagnostic imaging ; Fluoroscopy ; Humans
Chemical Substances	Contrast Media ; Barium (24GP945V5T) ; Barium Sulfate (25BB7EKE2E)
Language	English
Publishing date	2021-11-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	632764-3
ISSN	1432-0460 ; 0179-051X
ISSN (online)	1432-0460
ISSN	0179-051X
DOI	10.1007/s00455-021-10382-5
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Article ; Online: Evaluation of Hepatotoxicity from Peptide Receptor Radionuclide Therapy in Patients with Gastroenteropancreatic Neuroendocrine Tumors and a Very High Liver Tumor Burden.

Gococo-Benore, Denise A / Kuhlman, Justin / Parent, Ephraim E / Sharma, Akash / Accurso, Joseph / Yang, Ming / Kendi, Ayse Tuba / Johnson, Geoff / Sonbol, Mohamad Bassam / Hobday, Timothy / Halfdanarson, Thorvardur R / Starr, Jason

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2023 Volume 64, Issue 6, Page(s) 880–884

Abstract: The aim of the current study was to describe the risk of hepatotoxicity for patients with gastroenteropancreatic neuroendocrine tumors undergoing peptide receptor radionuclide therapy (PRRT) with a very high liver tumor burden, defined as tumor involving ...

Abstract	The aim of the current study was to describe the risk of hepatotoxicity for patients with gastroenteropancreatic neuroendocrine tumors undergoing peptide receptor radionuclide therapy (PRRT) with a very high liver tumor burden, defined as tumor involving more than 75% of the liver.
MeSH term(s)	Humans ; Neuroendocrine Tumors/pathology ; Octreotide/adverse effects ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Liver Neoplasms/drug therapy ; Chemical and Drug Induced Liver Injury/etiology ; Receptors, Peptide ; Radioisotopes ; Organometallic Compounds/adverse effects
Chemical Substances	Octreotide (RWM8CCW8GP) ; Receptors, Peptide ; Radioisotopes ; Organometallic Compounds
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.122.264533
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Zs.MO 328: Show issues

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