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  1. Article ; Online: Perilipin 1 Antibodies in Patients With Acquired Generalized Lipodystrophy.

    Savage, David B

    Diabetes

    2022  Volume 72, Issue 1, Page(s) 16–18

    MeSH term(s) Humans ; Lipodystrophy, Congenital Generalized ; Perilipin-1 ; Lipodystrophy ; Insulin Resistance ; Antibodies
    Chemical Substances Perilipin-1 ; Antibodies
    Language English
    Publishing date 2022-12-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/dbi22-0022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.175: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The role of lipid droplet associated proteins in inherited human disorders.

    Duan, Xiaowen / Savage, David B

    FEBS letters

    2023  

    Abstract: Proteins which associate with the surface of lipid droplets are intimately involved in the regulation of the droplets. Several human inherited disorders have now been linked to loss- and, in some cases, likely gain-of-function mutations in the genes ... ...

    Abstract Proteins which associate with the surface of lipid droplets are intimately involved in the regulation of the droplets. Several human inherited disorders have now been linked to loss- and, in some cases, likely gain-of-function mutations in the genes encoding these proteins. These are summarised in this Graphical Review.
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 282: Show issues Location:
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  3. Article ; Online: Lipase tug of war: PNPLA3 sequesters ABHD5 from ATGL.

    Romeo, Stefano / Savage, David B

    Nature metabolism

    2019  Volume 1, Issue 5, Page(s) 505–506

    Language English
    Publishing date 2019-10-14
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-019-0067-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: α-Carboxysome Size Is Controlled by the Disordered Scaffold Protein CsoS2.

    Oltrogge, Luke M / Chen, Allen W / Chaijarasphong, Thawatchai / Turnšek, Julia B / Savage, David F

    Biochemistry

    2023  Volume 63, Issue 2, Page(s) 219–229

    Abstract: Carboxysomes are protein microcompartments that function in the bacterial ... ...

    Abstract Carboxysomes are protein microcompartments that function in the bacterial CO
    MeSH term(s) Bacterial Proteins/chemistry ; Carbon Dioxide/metabolism ; Ribulose-Bisphosphate Carboxylase/metabolism ; Peptides/metabolism ; Carbonic Anhydrases/metabolism ; Organelles/metabolism
    Chemical Substances Bacterial Proteins ; Carbon Dioxide (142M471B3J) ; Ribulose-Bisphosphate Carboxylase (EC 4.1.1.39) ; Peptides ; Carbonic Anhydrases (EC 4.2.1.1)
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.3c00403
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 217: Show issues Location:
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  5. Article: Gastrinoma With Relatively Low Gastrin Levels: A Case Report.

    Winczura, Amelia / Saggi, Bob / Savage-Lobeck, David

    Cureus

    2023  Volume 15, Issue 7, Page(s) e41686

    Abstract: Gastrinomas can often be cured with surgical removal if detected early enough. We present a case report where a patient was diagnosed with gastrinoma with relatively low serum gastrin levels after subsequent duodenojejunostomy, gastrojejunostomy, total ... ...

    Abstract Gastrinomas can often be cured with surgical removal if detected early enough. We present a case report where a patient was diagnosed with gastrinoma with relatively low serum gastrin levels after subsequent duodenojejunostomy, gastrojejunostomy, total gastrectomy, and cholecystectomy. With this case report, we hope to promote a higher level of awareness of pancreatic neuroendocrine (NE) tumors and educate clinicians on the full effects of proton pump inhibitor (PPI) use on patient workup, diagnostics, and care.
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.41686
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  6. Article ; Online: What lipodystrophies teach us about the metabolic syndrome.

    Mann, Jake P / Savage, David B

    The Journal of clinical investigation

    2019  Volume 129, Issue 10, Page(s) 4009–4021

    Abstract: Lipodystrophies are the result of a range of inherited and acquired causes, but all are characterized by perturbations in white adipose tissue function and, in many instances, its mass or distribution. Though patients are often nonobese, they typically ... ...

    Abstract Lipodystrophies are the result of a range of inherited and acquired causes, but all are characterized by perturbations in white adipose tissue function and, in many instances, its mass or distribution. Though patients are often nonobese, they typically manifest a severe form of the metabolic syndrome, highlighting the importance of white fat in the "safe" storage of surplus energy. Understanding the molecular pathophysiology of congenital lipodystrophies has yielded useful insights into the biology of adipocytes and informed therapeutic strategies. More recently, genome-wide association studies focused on insulin resistance have linked common variants to genes implicated in adipose biology and suggested that subtle forms of lipodystrophy contribute to cardiometabolic disease risk at a population level. These observations underpin the use of aligned treatment strategies in insulin-resistant obese and lipodystrophic patients, the major goal being to alleviate the energetic burden on adipose tissue.
    MeSH term(s) Adipocytes/metabolism ; Adipocytes/pathology ; Adipose Tissue, White/metabolism ; Adipose Tissue, White/pathology ; Animals ; Humans ; Lipodystrophy/genetics ; Lipodystrophy/metabolism ; Lipodystrophy/pathology ; Metabolic Syndrome/genetics ; Metabolic Syndrome/metabolism ; Metabolic Syndrome/pathology ; Obesity/genetics ; Obesity/metabolism ; Obesity/pathology
    Language English
    Publishing date 2019-08-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI129190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.184: Show issues Location:
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  7. Article ; Online: Association of insulin resistance with the accumulation of saturated intramyocellular lipid: A comparison with other fat stores.

    Azhar, Mueed / Watson, Laura P E / De Lucia Rolfe, Emanuella / Ferraro, Michele / Carr, Katherine / Worsley, Jieniean / Boesch, Chris / Hodson, Leanne / Chatterjee, Krishna K / Kemp, Graham J / Savage, David B / Sleigh, Alison

    NMR in biomedicine

    2024  , Page(s) e5117

    Abstract: It has been shown using proton magnetic resonance spectroscopy ( ...

    Abstract It has been shown using proton magnetic resonance spectroscopy (
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1000976-0
    ISSN 1099-1492 ; 0952-3480
    ISSN (online) 1099-1492
    ISSN 0952-3480
    DOI 10.1002/nbm.5117
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2869: Show issues Location:
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  8. Article ; Online: Improving Blood Vessel Tortuosity Measurements via Highly Sampled Numerical Integration of the Frenet-Serret Equations.

    Brummer, Alexander B / Hunt, David / Savage, Van

    IEEE transactions on medical imaging

    2020  Volume 40, Issue 1, Page(s) 297–309

    Abstract: Measures of vascular tortuosity-how curved and twisted a vessel is-are associated with a variety of vascular diseases. Consequently, measurements of vessel tortuosity that are accurate and comparable across modality, resolution, and size are greatly ... ...

    Abstract Measures of vascular tortuosity-how curved and twisted a vessel is-are associated with a variety of vascular diseases. Consequently, measurements of vessel tortuosity that are accurate and comparable across modality, resolution, and size are greatly needed. Yet in practice, precise and consistent measurements are problematic-mismeasurements, inability to calculate, or contradictory and inconsistent measurements occur within and across studies. Here, we present a new method of measuring vessel tortuosity that ensures improved accuracy. Our method relies on numerical integration of the Frenet-Serret equations. By reconstructing the three-dimensional vessel coordinates from tortuosity measurements, we explain how to identify and use a minimally-sufficient sampling rate based on vessel radius while avoiding errors associated with oversampling and overfitting. Our work identifies a key failing in current practices of filtering asymptotic measurements and highlights inconsistencies and redundancies between existing tortuosity metrics. We demonstrate our method by applying it to manually constructed vessel phantoms with known measures of tortuousity, and 9,000 vessels from medical image data spanning human cerebral, coronary, and pulmonary vascular trees, and the carotid, abdominal, renal, and iliac arteries.
    MeSH term(s) Carotid Arteries/diagnostic imaging ; Humans
    Language English
    Publishing date 2020-12-29
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 622531-7
    ISSN 1558-254X ; 0278-0062
    ISSN (online) 1558-254X
    ISSN 0278-0062
    DOI 10.1109/TMI.2020.3025467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2546: Show issues Location:
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  9. Article: Preventing osteolytic lesions and osteomyelitis in multiple myeloma.

    Dao, Aiken / McDonald, Michelle M / Savage, Paul B / Little, David G / Schindeler, Aaron

    Journal of bone oncology

    2022  Volume 37, Page(s) 100460

    Abstract: Multiple myeloma is a hematological malignancy affecting the plasma cells. It is the second most common hematologic cancer in adults. Over 90% of patients develop local osteolytic lesions and skeletal-related events at some point during the progression ... ...

    Abstract Multiple myeloma is a hematological malignancy affecting the plasma cells. It is the second most common hematologic cancer in adults. Over 90% of patients develop local osteolytic lesions and skeletal-related events at some point during the progression of the disease. Bone lesions can induce severe pain and immobility and can also increase the risk of fractures and osteomyelitis. Skeletal complications are associated with poor clinical outcomes, affecting quality of life and mortality. Current standards of care for myeloma, e.g., autologous stem-cell transplantation (ASCT) and chemotherapy, do not lessen the risk of adverse events in bone. Once bone lesions are present, bone-targeted interventions are limited, with bone antiresorptive drugs being a mainstay of treatment. This review highlights the growing literature surrounding osteolytic lesions and bone infections associated with multiple myeloma and assesses current and emerging treatments. Emerging evidence from clinical trials suggests that denosumab can reduce skeletal-related events, and the potential application of bortezomib/1D11 can reduce bone destruction and pathological fractures in MM patients. Once established, bone lesions are prone to develop osteomyelitis - especially in immunocompromised individuals. Antibiotics and surgical interventions have been used to manage bone infections in most reported cases. As the bone infection risk associated with MM bone lesions become more evident, there is scope to improve patient management by mitigating this risk with prophylactic antimicrobial therapy.
    Language English
    Publishing date 2022-10-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2212-1366
    ISSN 2212-1366
    DOI 10.1016/j.jbo.2022.100460
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  10. Article ; Online: Exploring Masses and Internal Mass Distributions of Single Carboxysomes in Free Solution Using Fluorescence and Interferometric Scattering in an Anti-Brownian Trap.

    Lavania, Abhijit A / Carpenter, William B / Oltrogge, Luke M / Perez, Davis / Turnšek, Julia B / Savage, David F / Moerner, W E

    The journal of physical chemistry. B

    2022  Volume 126, Issue 43, Page(s) 8747–8759

    Abstract: Carboxysomes are self-assembled bacterial microcompartments that facilitate carbon assimilation by colocalizing the enzymes of ... ...

    Abstract Carboxysomes are self-assembled bacterial microcompartments that facilitate carbon assimilation by colocalizing the enzymes of CO
    MeSH term(s) Organelles/metabolism ; Interferometry ; Carbon Dioxide/metabolism ; Carbon ; Motion ; Bacterial Proteins/metabolism
    Chemical Substances Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0) ; Bacterial Proteins
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.2c05939
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