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Article ; Online: Correlation of Serum Zinc Levels with Postpartum Depression- A Casecontrol Study in North Karnataka

MM KAVITHA / Shravya Dharambhat / Narayan Mutalik / SH Chandrashekaraya / SV Kashinakunti

Journal of Clinical and Diagnostic Research, Vol 15, Iss 8, Pp BC01-BC

2021 Volume 03

Abstract: Introduction: Pregnancy is an important event in reproductive mother. At the same time it is associated with stress, which exaggerates the depression. Many factors leads to depression, among them nutrient deficiency like zinc, selenium, iron, calcium, ... ...

Abstract	Introduction: Pregnancy is an important event in reproductive mother. At the same time it is associated with stress, which exaggerates the depression. Many factors leads to depression, among them nutrient deficiency like zinc, selenium, iron, calcium, folic acid and vitamin B12 plays a major role. Aim: To estimate and compare serum zinc levels in females with postpartum depression subjects and healthy controls. To find the relationship between serum zinc levels and extent of postpartum depression. Materials and Methods: The present study was a hospitalbased case-control study, conducted over a period of three months. It included 40 postpartum depression cases and 40 healthy controls. All the participants were subjected to serum zinc levels estimation. Edinburgh Postnatal Depression Scale (EPDS) score was applied. The individuals who scored greater than 10 were taken as cases and those scoring less than 10 were taken as controls. Data was tabulated and results expressed as mean±SD, student's t-test and Pearson correlation test was applied for correlation. Results: The present study found decreased serum zinc levels in postpartum depression cases compared to controls. It was found serum zinc levels in cases were 21.63±15.73 μg/dL and 54.16±19.72 μg/dL in controls. There was a negative correlation between the severity of postnatal depression and the serum zinc levels. Not only this, but certain risk factors were also identified, such as age of the mother, months of postpartum, mode of delivery, and the education of the mother. Conclusion: Decreased serum zinc levels do indeed correlate to a change in maternal mental health, and then the knowledge would not only help in diagnosis by tests, but also further patient care.
Keywords	edinburgh postnatal depression scale ; maternal mental health ; trace element ; Medicine ; R
Subject code	150
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
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Article ; Online: Functional Analysis of

Saxena, Sonal / Maroju, Pranay Amruth / Choudhury, Sumana / Voina, Vidhya Chitta / Naik, Poonam / Gowdhaman, Kavitha / Kkani, Poornima / Chennoju, Kiranmai / Ganesh Kumar, S / Ramasubramanian, C / Prasad Rao, G / Jamma, Trinath / Narayan, Kumar Pranav / Mohan, K Naga

Genetics research

2021 Volume 2021, Page(s) 6698979

Abstract: A recent study showed the association of minor alleles ... ...

Abstract	A recent study showed the association of minor alleles of
MeSH term(s)	Alleles ; Case-Control Studies ; DNA (Cytosine-5-)-Methyltransferase 1/genetics ; Female ; Genetic Predisposition to Disease/genetics ; Genotype ; Humans ; Male ; Polymorphism, Single Nucleotide/genetics ; Schizophrenia/genetics
Chemical Substances	DNA (Cytosine-5-)-Methyltransferase 1 (EC 2.1.1.37) ; DNMT1 protein, human (EC 2.1.1.37)
Language	English
Publishing date	2021-03-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2412681-0
ISSN	1469-5073 ; 0016-6723
ISSN (online)	1469-5073
ISSN	0016-6723
DOI	10.1155/2021/6698979
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Article ; Online: Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment.

Narayan, Kavitha / Kang, Joonsoo

Seminars in immunology

2010 Volume 22, Issue 4, Page(s) 222–227

Abstract: The mechanism of T cell precursor commitment to the gammadelta or alphabeta T cell lineage remains unclear. While TCR signal strength has emerged as a key factor in lineage commitment based on TCR transgenic models, the entire TCR repertoire may not ... ...

Abstract	The mechanism of T cell precursor commitment to the gammadelta or alphabeta T cell lineage remains unclear. While TCR signal strength has emerged as a key factor in lineage commitment based on TCR transgenic models, the entire TCR repertoire may not possess the same discriminatory power. A counterbalance to the TCR as the lineage determinant is the pre-existing heterogeneity in gene expression among precursors, which suggests that single precursors are unlikely to respond homogeneously to a given instructive signal.
MeSH term(s)	Animals ; Cell Lineage ; Humans ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Receptors, Antigen, T-Cell, alpha-beta/metabolism ; Receptors, Antigen, T-Cell, gamma-delta/immunology ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Signal Transduction ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
Chemical Substances	Receptors, Antigen, T-Cell, alpha-beta ; Receptors, Antigen, T-Cell, gamma-delta
Language	English
Publishing date	2010-05-06
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1018141-6
ISSN	1096-3618 ; 1044-5323
ISSN (online)	1096-3618
ISSN	1044-5323
DOI	10.1016/j.smim.2010.04.003
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Article: Molecular events that regulate alphabeta versus gammadelta T cell lineage commitment: old suspects, new players and different game plans.

Narayan, Kavitha / Kang, Joonsoo

Current opinion in immunology

2007 Volume 19, Issue 2, Page(s) 169–175

Abstract: The divergence of alphabeta and gammadelta T cells from a common precursor in the thymus is regulated by multiple cell-intrinsic and cell-extrinsic factors, most of which are not well defined. Recent studies have provided crucial data regarding the ... ...

Abstract	The divergence of alphabeta and gammadelta T cells from a common precursor in the thymus is regulated by multiple cell-intrinsic and cell-extrinsic factors, most of which are not well defined. Recent studies have provided crucial data regarding the precise timing of lineage commitment and some clarification on the extent of the involvement of Notch and T-cell receptor signaling in this process. Combined with new insights into the differential regulation of molecular pathways active in alphabeta and gammadelta precursors, these data have led to the generation of a revised model of lineage commitment.
MeSH term(s)	Animals ; Cell Lineage/genetics ; Lymphopoiesis/genetics ; Mice ; Multipotent Stem Cells/chemistry ; Multipotent Stem Cells/immunology ; Receptors, Antigen, T-Cell, alpha-beta/analysis ; Receptors, Antigen, T-Cell, alpha-beta/metabolism ; Receptors, Antigen, T-Cell, gamma-delta/analysis ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Receptors, Notch/physiology ; T-Lymphocytes/immunology ; Thymus Gland/cytology ; Thymus Gland/immunology
Chemical Substances	Receptors, Antigen, T-Cell, alpha-beta ; Receptors, Antigen, T-Cell, gamma-delta ; Receptors, Notch
Language	English
Publishing date	2007-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1035767-1
ISSN	1879-0372 ; 0952-7915
ISSN (online)	1879-0372
ISSN	0952-7915
DOI	10.1016/j.coi.2007.01.002
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Article ; Online: Interleukin-17-Producing γδ T Cells Originate from SOX13

Spidale, Nicholas A / Sylvia, Katelyn / Narayan, Kavitha / Miu, Bing / Frascoli, Michela / Melichar, Heather J / Zhihao, Wu / Kisielow, Jan / Palin, Amy / Serwold, Thomas / Love, Paul / Kobayashi, Michihiro / Yoshimoto, Momoko / Jain, Nitya / Kang, Joonsoo

Immunity

2018 Volume 49, Issue 5, Page(s) 857–872.e5

Abstract: Lineage-committed αβ and γδ T cells are thought to originate from common intrathymic multipotent progenitors following instructive T cell receptor (TCR) signals. A subset of lymph node and mucosal ... ...

Abstract	Lineage-committed αβ and γδ T cells are thought to originate from common intrathymic multipotent progenitors following instructive T cell receptor (TCR) signals. A subset of lymph node and mucosal Vγ2
MeSH term(s)	Animals ; Autoantigens/genetics ; Autoantigens/metabolism ; Biomarkers ; Gene Expression Profiling ; Gene Regulatory Networks ; Humans ; Immunophenotyping ; Interleukin-17/metabolism ; Mice ; Mice, Knockout ; Mice, Transgenic ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Signal Transduction ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Transcriptome
Chemical Substances	Autoantigens ; Biomarkers ; Interleukin-17 ; Receptors, Antigen, T-Cell, gamma-delta ; Sox13 protein, mouse
Language	English
Publishing date	2018-11-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2018.09.010
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Article: Effect of metabolic inhibitors on growth and carotenoid production in Dunaliella bardawil.

Mysore Doddaiah, Kavitha / Narayan, Anila / Gokare Aswathanarayana, Ravishankar / Ravi, Sarada

Journal of food science and technology

2011 Volume 50, Issue 6, Page(s) 1130–1136

Abstract: Dunaliella bardawil, a green alga accumulates high amount of β-carotene under stress conditions. This organism has been exploited for β-carotene at industrial scale. In the present work, various metabolic inhibitors like diphenylamine (DPA), nicotine, ... ...

Abstract	Dunaliella bardawil, a green alga accumulates high amount of β-carotene under stress conditions. This organism has been exploited for β-carotene at industrial scale. In the present work, various metabolic inhibitors like diphenylamine (DPA), nicotine, basta, glyphosate, DCMU [3-(3',4'-dichlophenyl)-1,1-dimethylurea] and caffeine were used in autotrophic medium, to understand their influence on carotenoid biosynthesis. The results indicated that these metabolic inhibitors influenced the production of carotenoids like wise, DPA and basta increased the contents of β-carotene (1.7 fold), glyphosate and DCMU for lutein (2.4 and 2 fold) caffeine for biomass yields (1.1 fold), while nicotine decreased the biomass yield (3.6 fold), β-carotene (2 fold) and lutein (10.5 fold).
Language	English
Publishing date	2011-06-22
Publishing country	India
Document type	Journal Article
ZDB-ID	242498-8
ISSN	0975-8402 ; 0022-1155
ISSN (online)	0975-8402
ISSN	0022-1155
DOI	10.1007/s13197-011-0429-6
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Article ; Online: Correction: Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored.

Thomas, Beena Elizabeth / Thiruvengadam, Kannan / S, Rani / Kadam, Dileep / Ovung, Senthanro / Sivakumar, Shrutha / Yogendra Shivakumar, Shri Vijay Bala / Paradkar, Mandar / Gupte, Nikhil / Suryavanshi, Nishi / Dolla, C K / Gupte, Akshay N / Kohli, Rewa / Pradhan, Neeta / Sivaramakrishnan, Gomathi Narayan / Gaikwad, Sanjay / Kagal, Anju / Dhanasekaran, Kavitha / Deluca, Andrea /

Golub, Jonathan E / Mave, Vidya / Chandrasekaran, Padmapriyadarshini / Gupta, Amita

PloS one

2019 Volume 14, Issue 11, Page(s) e0224914

Abstract: This corrects the article DOI: 10.1371/journal.pone.0220507.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.pone.0220507.].
Language	English
Publishing date	2019-11-01
Publishing country	United States
Document type	Published Erratum
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0224914
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Article: Management of neutralizing antibodies against beta-IFN in beta-IFN-treated multiple sclerosis patients.

Pachner, Andrew R / Brady, Jennifer / Steiner, Israel / Narayan, Kavitha

Journal of neurology

2008 Volume 255, Issue 11, Page(s) 1815–1817

MeSH term(s)	Adult ; Anti-Inflammatory Agents/therapeutic use ; Antibodies/blood ; Drug Therapy, Combination ; Female ; Humans ; Interferon-beta/immunology ; Interferon-beta/therapeutic use ; Methylprednisolone/therapeutic use ; Middle Aged ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/immunology ; Neutralization Tests ; Risk Factors ; Young Adult
Chemical Substances	Anti-Inflammatory Agents ; Antibodies ; Interferon-beta (77238-31-4) ; Methylprednisolone (X4W7ZR7023)
Language	English
Publishing date	2008-11-22
Publishing country	Germany
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-008-0854-2
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Article: Intrathecal antibody production in an animal model of multiple sclerosis.

Pachner, Andrew R / Li, Libin / Narayan, Kavitha

Journal of neuroimmunology

2007 Volume 185, Issue 1-2, Page(s) 57–63

Abstract: Although the central nervous system (CNS) is thought to be immunoprivileged, under special circumstances it can produce antibody. Antibody production within the CNS, called intrathecal antibody production (ITAbP), is a prominent feature of neurological ... ...

Abstract	Although the central nervous system (CNS) is thought to be immunoprivileged, under special circumstances it can produce antibody. Antibody production within the CNS, called intrathecal antibody production (ITAbP), is a prominent feature of neurological infections and inflammatory diseases, and is thought to possibly contribute to disease in multiple sclerosis (MS), but it has not been extensively studied. We investigated ITAbP in a viral model of MS. ELISpot, real-time RT-PCR for IgG mRNA in CNS tissue, and CSF analysis were used to assess ITAbP in two types of SJL mice infected with one of two strains of Theiler's murine encephalomyelitis virus (TMEV). The amplitude of ITAbP increased during the first 4 months of infection. TMEV viral load remained high during the course of the infection, which likely was the main stimulus for ITAbP, since within samples of infected CNS tissues, levels of IgG gene expression were highly correlated with viral RNA levels, and a large percentage of intrathecally produced antibody was directed against TMEV. This study provides the first extensive analysis of ITAbP in TMEV infection, and demonstrates that, in this animal model of MS, antibody production within the CNS is likely driven by the presence of the causative pathogen.
MeSH term(s)	Animals ; Antibodies, Viral/biosynthesis ; Antibodies, Viral/cerebrospinal fluid ; Antibody Formation ; Central Nervous System/immunology ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Female ; Immunoglobulin G/biosynthesis ; Immunoglobulin G/cerebrospinal fluid ; Maus Elberfeld virus/immunology ; Mice ; Multiple Sclerosis/immunology ; RNA, Messenger/analysis ; Reverse Transcriptase Polymerase Chain Reaction
Chemical Substances	Antibodies, Viral ; Immunoglobulin G ; RNA, Messenger
Language	English
Publishing date	2007-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	8335-5
ISSN	1872-8421 ; 0165-5728
ISSN (online)	1872-8421
ISSN	0165-5728
DOI	10.1016/j.jneuroim.2007.01.017
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Article: Antibody-secreting cells in the central nervous system in an animal model of MS: Phenotype, association with disability, and in vitro production of antibody.

Pachner, Andrew R / Brady, Jennifer / Narayan, Kavitha

Journal of neuroimmunology

2007 Volume 190, Issue 1-2, Page(s) 112–120

Abstract: Little is known about antibody production within the central nervous system, called intrathecal antibody production (ITAbP). Mice infected with Theiler's murine encephalomyocarditis virus (TMEV) develop an immune-mediated demyelinating disease(TMEV-IDD), ...

Abstract	Little is known about antibody production within the central nervous system, called intrathecal antibody production (ITAbP). Mice infected with Theiler's murine encephalomyocarditis virus (TMEV) develop an immune-mediated demyelinating disease(TMEV-IDD), characterized by progressive weakness associated with robust ITAbP, CNS inflammation and demyelination. TMEV-IDD represents an excellent model of human multiple sclerosis (MS), especially its progressive disability. The mechanism of the weakness in this disease is unknown but there is considerable evidence that it is immune-mediated. Our hypothesis was that the disability in the model is induced by robust ITAbP by antibody-secreting cells(ASCs) in the CNS. We further hypothesized that these ASCs are predominantly CD138+ plasma cells, driven by the persistence of virus at high levels in the central nervous system (CNS) as well as high levels of B-cell activating factor (BAFF). In order to test these hypotheses we infected mice with TMEV, and correlated measures of ITAbP with disability. Measures of ITAbP were ELISpot and IgG gene expression, while disability was tested by Rotarod. We found that disability was highly correlated with ITAbP, assayed by number of CNS ASCs as well as amount of IgG mRNA. CNS ASCs were primarily CD138+, and produced high levels of IgG enriched for reactivity to TMEV. There were high levels of BAFF production in the CNS, but these levels were only minimally higher in infected mice than in uninfected controls. TMEV and IgG RNA were distributed throughout the spinal cord. These data are the first demonstrating that ITAbP is highly correlated with disability in TMEV infection, an excellent model of human MS. Our data raise the possibility that ITAbP contributes significantly to disability, both in this model and in MS.
MeSH term(s)	Animals ; Antibodies/immunology ; B-Cell Activating Factor/immunology ; Cardiovirus Infections/immunology ; Cardiovirus Infections/physiopathology ; Cardiovirus Infections/virology ; Central Nervous System/cytology ; Central Nervous System/immunology ; Central Nervous System/physiopathology ; Disease Models, Animal ; Disease Progression ; Female ; Immunoglobulin G/immunology ; Mice ; Multiple Sclerosis/immunology ; Multiple Sclerosis/physiopathology ; Multiple Sclerosis/virology ; Phenotype ; Plasma Cells/immunology ; Plasma Cells/secretion ; Plasma Cells/virology ; RNA, Messenger/metabolism ; Spinal Cord/cytology ; Spinal Cord/immunology ; Spinal Cord/physiopathology ; Syndecan-1/immunology ; Theilovirus/immunology
Chemical Substances	Antibodies ; B-Cell Activating Factor ; Immunoglobulin G ; RNA, Messenger ; Sdc1 protein, mouse ; Syndecan-1
Language	English
Publishing date	2007-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	8335-5
ISSN	1872-8421 ; 0165-5728
ISSN (online)	1872-8421
ISSN	0165-5728
DOI	10.1016/j.jneuroim.2007.09.001
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