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Article: Regional spinal cord volumes and pain profiles in AQP4-IgG + NMOSD and MOGAD.

Asseyer, Susanna / Zmira, Ofir / Busse, Laura / Pflantzer, Barak / Schindler, Patrick / Schmitz-Hübsch, Tanja / Paul, Friedemann / Chien, Claudia

Frontiers in neurology

2024 Volume 15, Page(s) 1308498

Abstract: Objective: Aquaporin-4-antibody-seropositive (AQP4-IgG+) Neuromyelitis Optica Spectrum Disorder (NMOSD) and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder (MOGAD) are relapsing neuroinflammatory diseases, frequently leading to chronic ... ...

Abstract	Objective: Aquaporin-4-antibody-seropositive (AQP4-IgG+) Neuromyelitis Optica Spectrum Disorder (NMOSD) and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder (MOGAD) are relapsing neuroinflammatory diseases, frequently leading to chronic pain. In both diseases, the spinal cord (SC) is often affected by myelitis attacks. We hypothesized that regional SC volumes differ between AQP4-IgG + NMOSD and MOGAD and that pain intensity is associated with lower SC volumes. To evaluate changes in the SC white matter (WM), gray matter (GM), and pain intensity in patients with recent relapses (myelitis or optic neuritis), we further profiled phenotypes in a case series with longitudinal imaging and clinical data. Methods: Cross-sectional data from 36 participants were analyzed in this retrospective study, including 20 AQP4-IgG + NMOSD and 16 MOGAD patients. Pain assessment was performed in all patients by the Brief Pain Inventory and painDETECT questionnaires. Segmentation of SC WM, GM, cervical cord volumes (combined volume of WM + GM) was performed at the C2/C3 cervical level. WM% and GM% were calculated using the cervical cord volume as a whole per patient. The presence of pain, pain severity, and clinical disability was evaluated and tested for associations with SC segmentations. Additionally, longitudinal data were deeply profiled in a case series of four patients with attacks between two MRI visits within one year. Results: In AQP4-IgG + NMOSD, cervical cord volume was associated with mean pain severity within 24 h (β = -0.62, Conclusion: In AQP4-IgG + NMOSD, lower cervical cord volume was associated with increased pain. Furthermore, cord GM changes were detected between MRI visits in patients with disease-related attacks in both groups. Regional SC MRI measures are pertinent for monitoring disease-related cord pathology in AQP4-IgG + NMOSD and MOGAD.
Language	English
Publishing date	2024-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2024.1308498
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Article ; Online: Dynamic control of contractile resistance to iPSC-derived micro-heart muscle arrays.

Schuftan, David / Kooh, Yasaman Kargar Gaz / Guo, Jingxuan / Sun, Yuwen / Aryan, Lavanya / Stottlemire, Bryce / Berkland, Cory / Genin, Guy M / Huebsch, Nathaniel

Journal of biomedical materials research. Part A

2023 Volume 112, Issue 4, Page(s) 534–548

Abstract: Many types of cardiovascular disease are linked to the mechanical forces placed on the heart. However, our understanding of how mechanical forces exactly affect the cellular biology of the heart remains incomplete. In vitro models based on cardiomyocytes ...

Abstract	Many types of cardiovascular disease are linked to the mechanical forces placed on the heart. However, our understanding of how mechanical forces exactly affect the cellular biology of the heart remains incomplete. In vitro models based on cardiomyocytes derived from human induced pluripotent stem cells (iPSC-CM) enable researchers to develop medium to high-throughput systems to study cardiac mechanobiology at the cellular level. Previous models have been developed to enable the study of mechanical forces, such as cardiac afterload. However, most of these models require exogenous extracellular matrix (ECM) to form cardiac tissues. Recently, a system was developed to simulate changes in afterload by grafting ECM-free micro-heart muscle arrays to elastomeric substrates of discrete stiffnesses. In the present study, we extended this system by combining the elastomer-grafted tissue arrays with a magnetorheological elastomeric substrate. This system allows iPSC-CM based micro-heart muscle arrays to experience dynamic changes in contractile resistance to mimic dynamically altered afterload. Acute changes in substrate stiffness led to acute changes in the calcium dynamics and contractile forces, illustrating the system's ability to dynamically elicit changes in tissue mechanics by dynamically changing contractile resistance.
MeSH term(s)	Humans ; Induced Pluripotent Stem Cells ; Myocytes, Cardiac ; Mechanical Phenomena ; Extracellular Matrix ; Myocardial Contraction
Language	English
Publishing date	2023-11-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2099989-6
ISSN	1552-4965 ; 1549-3296 ; 0021-9304
ISSN (online)	1552-4965
ISSN	1549-3296 ; 0021-9304
DOI	10.1002/jbm.a.37642
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Article ; Online: Pathologies auto-immunes et inflammatoires associées à la sclérodermie systémique : profils cliniques, sérologiques et pronostiques. Série rétrospective bi-centrique en région PACA.

Hübsch, T / Mettler, C / Poisnel, E / Antoine, C / Cambon, A / Delarbre, D / Dutasta, F / Karkowski, L / Pangnarind, V / Paris, J-F / Defuentes, G / Granel-Rey, B

La Revue de medecine interne

2023 Volume 44, Issue 8, Page(s) 402–409

Abstract: Introduction: Systemic sclerosis (SSc) is a rare auto-immune disease, affecting principally women between 40 and 60 years old. It is caracterised by a cutaneous and visceral fibrosis, an alteration of the microvascular network and the presence of ... ...

Title translation	Autoimmune and inflammatory pathologies associated with systemic scleroderma: Clinical, serological and prognostic profiles. Bi-centric retrospective series in the PACA region.
Abstract	Introduction: Systemic sclerosis (SSc) is a rare auto-immune disease, affecting principally women between 40 and 60 years old. It is caracterised by a cutaneous and visceral fibrosis, an alteration of the microvascular network and the presence of autoantibodies. SSc can be associated with another connectivite tissue disease or to other autoimmune diseases, thus defining the overlap syndrome. The goal of our study is to describe these overlap syndromes. Methods: We have analysed the data of a retrospective and bicentrique cohort, from the internal medicine unit of Hôpital Nord in Marseille and from the internal medicine unit of the Hôpital Sainte-Anne in Toulon, of patients followed for a SSc between January 1st, 2019 and December 1st, 2021. We have collected clinical, imunological features, associated auto-immune and inflammatory diseases with its morbidity and mortality. Results: The cohort included 151 patients including 134 limited cutaneous SSc. Fifty-two (34.4%) patients presented at least one associated auto-immune or inflammatory disease. The association of two connectivite tissue diseases including SSc was found in 24 patients (15.9%), a third with Sjögren's syndrome and a third with autoimmune myositis. The principal associated disease to SSc was the autoimmune thyroiditis found in 17 patients (11.3%). The occurrence of complications (hospitalization, long-term oxygene therapy, death) was not significantly different depending on the existence or not of an overlap syndrom. Conclusion: SSc is often associated with other autoimmune diseases. This interrelation between associated pathologies and SSc, modifying sometimes the evolution of SSc, enhances the need of a personalized follow-up.
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Retrospective Studies ; Prognosis ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/diagnosis ; Scleroderma, Systemic/epidemiology ; Autoimmune Diseases/complications ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/epidemiology ; Autoantibodies ; Connective Tissue Diseases/complications
Chemical Substances	Autoantibodies
Language	French
Publishing date	2023-04-24
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2023.03.013
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Article ; Online: Engineered tissue geometry and Plakophilin-2 regulate electrophysiology of human iPSC-derived cardiomyocytes.

Simmons, Daniel W / Malayath, Ganesh / Schuftan, David R / Guo, Jingxuan / Oguntuyo, Kasoorelope / Ramahdita, Ghiska / Sun, Yuwen / Jordan, Samuel D / Munsell, Mary K / Kandalaft, Brennan / Pear, Missy / Rentschler, Stacey L / Huebsch, Nathaniel

APL bioengineering

2024 Volume 8, Issue 1, Page(s) 16118

Abstract: Engineered heart tissues have been created to study cardiac biology and disease in a setting that more closely ... ...

Abstract	Engineered heart tissues have been created to study cardiac biology and disease in a setting that more closely mimics
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ISSN	2473-2877
ISSN (online)	2473-2877
DOI	10.1063/5.0160677
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Article ; Online: DIASCoPE: Directly integrated acoustic system combined with pressure experiments-A new method for fast acoustic velocity measurements at high pressure.

Whitaker, Matthew L / Baldwin, Kenneth J / Huebsch, William R

The Review of scientific instruments

2017 Volume 88, Issue 3, Page(s) 34901

Abstract: ... conditions of pressure and temperature in a multi-anvil apparatus has been installed at Beamline 6-BM-B ...

Abstract	A new experimental system to measure elastic wave velocities in samples in situ under extreme conditions of pressure and temperature in a multi-anvil apparatus has been installed at Beamline 6-BM-B of the Advanced Photon Source at Argonne National Laboratory. This system allows for measurement of acoustic velocities via ultrasonic interferometry, and makes use of the synchrotron beam to measure sample densities via X-ray diffraction and sample lengths using X-radiographic imaging. This system is fully integrated into the automated software controls of the beamline and is capable of collecting robust data on elastic wave travel times in less than 1 s, which is an improvement of more than one to two orders of magnitude over existing systems. Moreover, this fast data collection time has been shown to have no effect on the obtained travel time results. This allows for more careful study of time-dependent phenomena with tighter snapshots in time of processes that would otherwise be lost or averaged out in other acoustic measurement systems.
Language	English
Publishing date	2017-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/1.4977596
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Article ; Online: Retinal ganglion cell loss is associated with future disability worsening in early relapsing-remitting multiple sclerosis.

Wauschkuhn, Josephine / Solorza Buenrostro, Gilberto / Aly, Lilian / Asseyer, Susanna / Wicklein, Rebecca / Hartberger, Julia Maria / Ruprecht, Klemens / Mühlau, Mark / Schmitz-Hübsch, Tanja / Chien, Claudia / Berthele, Achim / Brandt, Alexander U / Korn, Thomas / Paul, Friedemann / Hemmer, Bernhard / Zimmermann, Hanna G / Knier, Benjamin

European journal of neurology

2023 Volume 30, Issue 4, Page(s) 982–990

Abstract: Background and purpose: Thinning of the retinal combined ganglion cell and inner plexiform layer (GCIP) as measured by optical coherence tomography (OCT) is a common finding in patients with multiple sclerosis. This study aimed to investigate whether a ... ...

Abstract	Background and purpose: Thinning of the retinal combined ganglion cell and inner plexiform layer (GCIP) as measured by optical coherence tomography (OCT) is a common finding in patients with multiple sclerosis. This study aimed to investigate whether a single retinal OCT analysis allows prediction of future disease activity after a first demyelinating event. Methods: This observational cohort study included 201 patients with recently diagnosed clinically isolated syndrome or relapsing-remitting multiple sclerosis from two German tertiary referral centers. Individuals underwent neurological examination, magnetic resonance imaging, and OCT at baseline and at yearly follow-up visits. Results: Patients were included at a median disease duration of 2.0 months. During a median follow-up of 59 (interquartile range = 43-71) months, 82% of patients had ongoing disease activity as demonstrated by failing the no evidence of disease activity 3 (NEDA-3) criteria, and 19% presented with confirmed disability worsening. A GCIP threshold of ≤77 μm at baseline identified patients with a high risk for NEDA-3 failure (hazard ratio [HR] = 1.7, 95% confidence interval [CI] = 1.1-2.8, p = 0.04), and GCIP measures of ≤69 μm predicted disability worsening (HR = 2.2, 95% CI = 1.2-4.3, p = 0.01). Higher rates of annualized GCIP loss increased the risk for disability worsening (HR = 2.5 per 1 μm/year increase of GCIP loss, p = 0.03). Conclusions: Ganglion cell thickness as measured by OCT after the initial manifestation of multiple sclerosis may allow early risk stratification as to future disease activity and progression.
MeSH term(s)	Humans ; Retinal Ganglion Cells/pathology ; Multiple Sclerosis, Relapsing-Remitting/pathology ; Multiple Sclerosis/pathology ; Retina/pathology ; Cohort Studies ; Tomography, Optical Coherence/methods
Language	English
Publishing date	2023-01-29
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.15681
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Zs.A 4738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Associations of myeloid cells with cellular and humoral responses following vaccinations in patients with neuroimmunological diseases.

Wang, Meng / Dehlinger, Adeline / Zapata, Camila Fernández / Golan, Maya / Gallaccio, Gerardina / Sander, Leif E / Schlickeiser, Stephan / Kunkel, Desiree / Schmitz-Hübsch, Tanja / Sawitzki, Birgit / Karni, Arnon / Braun, Julian / Loyal, Lucie / Thiel, Andreas / Bellmann-Strobl, Judith / Paul, Friedemann / Meyer-Arndt, Lil / Böttcher, Chotima

Nature communications

2023 Volume 14, Issue 1, Page(s) 7728

Abstract: Disease-modifying therapies (DMTs) are widely used in neuroimmunological diseases such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Although these treatments are known to predispose patients to infections and affect ... ...

Abstract	Disease-modifying therapies (DMTs) are widely used in neuroimmunological diseases such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Although these treatments are known to predispose patients to infections and affect their responses to vaccination, little is known about the impact of DMTs on the myeloid cell compartment. In this study, we use mass cytometry to examine DMT-associated changes in the innate immune system in untreated and treated patients with MS (n = 39) or NMOSD (n = 23). We also investigated the association between changes in myeloid cell phenotypes and longitudinal responsiveness to homologous primary, secondary, and tertiary SARS-CoV-2 mRNA vaccinations. Multiple DMT-associated myeloid cell clusters, in particular CD64
MeSH term(s)	Humans ; Myeloid Cells ; Granulocytes ; Myeloid Progenitor Cells ; Vaccination ; Multiple Sclerosis/drug therapy ; Neuromyelitis Optica ; Antibodies, Viral
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2023-11-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-43553-z
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Article ; Online: Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers.

Cerebellum (London, England)

2023

Abstract: With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid, finely granulated, digital health measures are highly warranted to augment clinical and patient-reported outcome measures. Gait and balance disturbances most often ... ...

Abstract	With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid, finely granulated, digital health measures are highly warranted to augment clinical and patient-reported outcome measures. Gait and balance disturbances most often present as the first signs of degenerative cerebellar ataxia and are the most reported disabling features in disease progression. Thus, digital gait and balance measures constitute promising and relevant performance outcomes for clinical trials.This narrative review with embedded consensus will describe evidence for the sensitivity of digital gait and balance measures for evaluating ataxia severity and progression, propose a consensus protocol for establishing gait and balance metrics in natural history studies and clinical trials, and discuss relevant issues for their use as performance outcomes.
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2112586-7
ISSN	1473-4230 ; 1473-4222
ISSN (online)	1473-4230
ISSN	1473-4222
DOI	10.1007/s12311-023-01625-2
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Zs.A 5795: Show issues

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Article: Integrated Isogenic Human Induced Pluripotent Stem Cell-Based Liver and Heart Microphysiological Systems Predict Unsafe Drug-Drug Interaction.

Lee-Montiel, Felipe T / Laemmle, Alexander / Charwat, Verena / Dumont, Laure / Lee, Caleb S / Huebsch, Nathaniel / Okochi, Hideaki / Hancock, Matthew J / Siemons, Brian / Boggess, Steven C / Goswami, Ishan / Miller, Evan W / Willenbring, Holger / Healy, Kevin E

Frontiers in pharmacology

2021 Volume 12, Page(s) 667010

Abstract: Three-dimensional (3D) microphysiological systems (MPSs) mimicking human organ ... ...

Abstract	Three-dimensional (3D) microphysiological systems (MPSs) mimicking human organ function
Language	English
Publishing date	2021-05-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.667010
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Article ; Online: Racial, Ethnic, Sex, and Age Differences in COVID-19 Cases, Hospitalizations, and Deaths Among Incarcerated People and Staff in Correctional Facilities in Six Jurisdictions, United States, March-July 2020.

D'Inverno, Ashley S / Myles, Ranell L / Jamison, Calla R / Williams, Samantha P / Hagan, Liesl M / Handanagic, Senad / Lambert, Lauren A / Clarke, Kristie E N / Allen, Jeffery / Beard, Olivia / Dusseau, Charles / Feldman, Rachel / Huebsch, Rebecca / Hutchinson, Justine / Kall, Denise / King-Mohr, Jessica / Long, Michael / McClure, Elizabeth S / Meddaugh, Paul /

Pontones, Pam / Rose, Jacqueline / Sredl, Megan / VonBank, Brittany / Zipprich, Jennifer

Journal of racial and ethnic health disparities

2023

Abstract: Objectives: To examine disparities by sex, age group, and race and ethnicity in COVID-19 confirmed cases, hospitalizations, and deaths among incarcerated people and staff in correctional facilities.: Methods: Six U.S. jurisdictions reported data on ... ...

Abstract	Objectives: To examine disparities by sex, age group, and race and ethnicity in COVID-19 confirmed cases, hospitalizations, and deaths among incarcerated people and staff in correctional facilities. Methods: Six U.S. jurisdictions reported data on COVID-19 confirmed cases, hospitalizations, and deaths stratified by sex, age group, and race and ethnicity for incarcerated people and staff in correctional facilities during March 1- July 31, 2020. We calculated incidence rates and rate ratios (RR) and absolute rate differences (RD) by sex, age group, and race and ethnicity, and made comparisons to the U.S. general population. Results: Compared with the U.S. general population, incarcerated people and staff had higher COVID-19 case incidence (RR = 14.1, 95% CI = 13.9-14.3; RD = 6,692.2, CI = 6,598.8-6,785.5; RR = 6.0, CI = 5.7-6.3; RD = 2523.0, CI = 2368.1-2677.9, respectively); incarcerated people also had higher rates of COVID-19-related deaths (RR = 1.6, CI = 1.4-1.9; RD = 23.6, CI = 14.9-32.2). Rates of COVID-19 cases, hospitalizations, and deaths among incarcerated people and corrections staff differed by sex, age group, and race and ethnicity. The COVID-19 hospitalization (RR = 0.9, CI = 0.8-1.0; RD = -48.0, CI = -79.1- -16.8) and death rates (RR = 0.8, CI = 0.6-1.0; RD = -11.8, CI = -23.5- -0.1) for Black incarcerated people were lower than those for Black people in the general population. COVID-19 case incidence, hospitalizations, and deaths were higher among older incarcerated people, but not among staff. Conclusions: With a few exceptions, living or working in a correctional setting was associated with higher risk of COVID-19 infection and resulted in worse health outcomes compared with the general population; however, Black incarcerated people fared better than their U.S. general population counterparts.
Language	English
Publishing date	2023-08-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2760524-3
ISSN	2196-8837 ; 2197-3792
ISSN (online)	2196-8837
ISSN	2197-3792
DOI	10.1007/s40615-023-01746-8
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