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  1. Article ; Online: AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis.

    Zhu, Hong Jie / Zhang, Bo / Wei, Wanqing / Liu, Shuang He / Xiang, Lang / Zhu, Jiapeng / Jiao, Rui Hua / Igarashi, Yasuhiro / Bashiri, Ghader / Liang, Yong / Tan, Ren Xiang / Ge, Hui Ming

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 4499

    Abstract: ... biochemical assay and isotope labelling experiments that AvmM catalyzes tandem dehydration and Michael-type ...

    Abstract Macrocyclization is an important process that affords morphed scaffold in biosynthesis of bioactive natural products. Nature has adapted diverse biosynthetic strategies to form macrocycles. In this work, we report the identification and characterization of a small enzyme AvmM that can catalyze the construction of a 16-membered macrocyclic ring in the biosynthesis of alchivemycin A (1). We show through in vivo gene deletion, in vitro biochemical assay and isotope labelling experiments that AvmM catalyzes tandem dehydration and Michael-type addition to generate the core scaffold of 1. Mechanistic studies by crystallography, DFT calculations and MD simulations of AvmM reveal that the reactions are achieved with assistance from the special tenuazonic acid like moiety of substrate. Our results thus uncover an uncharacterized macrocyclization strategy in natural product biosynthesis.
    MeSH term(s) Biological Products ; Catalysis ; Cyclization ; Dehydration ; Humans ; Macrolides
    Chemical Substances Biological Products ; Macrolides ; alchivemycin A
    Language English
    Publishing date 2022-08-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-32088-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Furnace and Fugue. A multimedia edition of Michael Maier’s Atalanta fugiens

    Sarah Lang

    RIDE, Vol

    2023  Volume 18

    Abstract: Furnace and Fugue is a digital edition of Michael Maier’s (1568-1622) opus magnum, the emblem book ... to enable the multimedia experience that Michael Maier had likely envisioned for Atalanta fugiens ...

    Abstract Furnace and Fugue is a digital edition of Michael Maier’s (1568-1622) opus magnum, the emblem book Atalanta fugiens (1617/18) in which Latin and German texts are paired with images and musical fugues in an enigmatic way to engage users of the book in deep meditation on alchemical subjects. The digital edition of the text itself, including an English translation based on a 17th century manuscript, is accompanied by a number of scholarly essays. A main feature is the MEI player, which includes a piano roll visualisation that allows users to experience the musicological makeup of Atalanta fugiens even without a background in music theory. The edition is a beautifully designed “haute couture” edition, intended to provide an example for the future of digital scholarly publishing. The project has used digital editing effectively to enable the multimedia experience that Michael Maier had likely envisioned for Atalanta fugiens. but which was previously inaccessible to most users of the book.
    Keywords mei viewer ; history of science ; history of alchemy ; multimedia edition ; translation ; History of scholarship and learning. The humanities ; AZ20-999 ; Information resources (General) ; ZA3040-5185
    Subject code 780
    Language German
    Publishing date 2023-12-01T00:00:00Z
    Publisher Institut für Dokumentologie und Editorik e. V.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis

    Hong Jie Zhu / Bo Zhang / Wanqing Wei / Shuang He Liu / Lang Xiang / Jiapeng Zhu / Rui Hua Jiao / Yasuhiro Igarashi / Ghader Bashiri / Yong Liang / Ren Xiang Tan / Hui Ming Ge

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 11

    Abstract: ... dehydration and Michael-type addition. ...

    Abstract Macrocyclization is an important process in bioactive natural product synthesis. Here, the authors report on the study of a macrocyclic ring constructing enzyme in the biosynthesis of alchivemycin A and using gene deletion, biochemical assays and isotope labelling show the enzyme catalyses tandem dehydration and Michael-type addition.
    Keywords Science ; Q
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Organocatalytic Asymmetric Michael/Dieckmann Cyclization Reaction of Alkynones To Construct Spirocyclopentene Oxindoles.

    Lang, Jiawen / Li, Yi / Kang, Tengfei / Feng, Xiaoming / Liu, Xiaohua

    Organic letters

    2019  Volume 21, Issue 17, Page(s) 6897–6902

    Abstract: A highly enantioselective conjugate addition/Dieckmann cyclization of 3-carboxymethyl substituted oxindoles with electron-deficient internal alkynes was achieved under the catalysis of a chiral guanidine catalyst and NaH. This protocol provides access to ...

    Abstract A highly enantioselective conjugate addition/Dieckmann cyclization of 3-carboxymethyl substituted oxindoles with electron-deficient internal alkynes was achieved under the catalysis of a chiral guanidine catalyst and NaH. This protocol provides access to a wide range of synthetically useful optically active spirocyclopentenone oxindoles and their derivatives under mild reaction conditions.
    Language English
    Publishing date 2019-08-16
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.9b02519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Organocatalytic Asymmetric Michael/Dieckmann Cyclization Reaction of Alkynones To Construct Spirocyclopentene Oxindoles

    Lang, Jiawen / Li, Yi / Kang, Tengfei / Feng, Xiaoming / Liu, Xiaohua

    Organic letters. 2019 Aug. 16, v. 21, no. 17

    2019  

    Abstract: A highly enantioselective conjugate addition/Dieckmann cyclization of 3-carboxymethyl substituted oxindoles with electron-deficient internal alkynes was achieved under the catalysis of a chiral guanidine catalyst and NaH. This protocol provides access to ...

    Abstract A highly enantioselective conjugate addition/Dieckmann cyclization of 3-carboxymethyl substituted oxindoles with electron-deficient internal alkynes was achieved under the catalysis of a chiral guanidine catalyst and NaH. This protocol provides access to a wide range of synthetically useful optically active spirocyclopentenone oxindoles and their derivatives under mild reaction conditions.
    Keywords alkynes ; catalysts ; catalytic activity ; chemical structure ; cyclization reactions ; enantioselectivity ; guanidines
    Language English
    Dates of publication 2019-0816
    Size p. 6897-6902.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.9b02519
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Michael J. Fox Foundation LRRK2 Consortium: geographical differences in returning genetic research data to study participants.

    Alcalay, Roy N / Aasly, Jan / Berg, Daniela / Bressman, Susan / Brice, Alexis / Brockmann, Kathrin / Chan, Piu / Clark, Lorraine / Cormier, Florence / Corvol, Jean-Christophe / Durr, Alexandra / Facheris, Maurizio / Farrer, Matthew / Foroud, Tatiana M / Gasser, Thomas / Giladi, Nir / Halter, Cheryl / Lang, Anthony / Langston, J William /
    Marras, Connie / Marti-Masso, Jose-Felix / Ruiz Martinez, Javier / Mejia-Santana, Helen / Mirelman, Anat / Pont-Sunyer, Claustre / Orr-Urtreger, Avi / Raymond, Deborah / Saunders-Pullman, Rachel / Schüle, Birgitt / Tanner, Caroline / Tolosa, Eduardo / Urkowitz, Alison / Vilas, Dolores / Wise, Adina / Marder, Karen

    Genetics in medicine : official journal of the American College of Medical Genetics

    2014  Volume 16, Issue 8, Page(s) 644–645

    MeSH term(s) Foundations/organization & administration ; Genetic Research ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ; Parkinson Disease/genetics ; Patient Access to Records/psychology ; Protein Serine-Threonine Kinases/genetics
    Chemical Substances LRRK2 protein, human (EC 2.7.11.1) ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2014-07-31
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1455352-1
    ISSN 1530-0366 ; 1098-3600
    ISSN (online) 1530-0366
    ISSN 1098-3600
    DOI 10.1038/gim.2014.55
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5059: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article: Synthesis of a muscarinic receptor antagonist via a diastereoselective Michael reaction, selective deoxyfluorination and aromatic metal-halogen exchange reaction.

    Mase, T / Houpis, I N / Akao, A / Dorziotis, I / Emerson, K / Hoang, T / Iida, T / Itoh, T / Kamei, K / Kato, S / Kato, Y / Kawasaki, M / Lang, F / Lee, J / Lynch, J / Maligres, P / Molina, A / Nemoto, T / Okada, S /
    Reamer, R / Song, J Z / Tschaen, D / Wada, T / Zewge, D / Volante, R P / Reider, P J / Tomimoto, K

    The Journal of organic chemistry

    2001  Volume 66, Issue 20, Page(s) 6775–6786

    Abstract: ... catalyzed diastereoselective Michael reaction of dioxolane 7 with 2-cyclopenten-1-one (5) to establish ...

    Abstract An efficient synthesis of a structurally unique, novel M(3) antagonist 1 is described. Compound 1 is conveniently disconnected retrosynthetically at the amide bond to reveal the acid portion 2 and the amine fragment 3. The synthesis of key intermediate 2 is highlighted by a ZnCl(2)-MAEP complex 19 catalyzed diastereoselective Michael reaction of dioxolane 7 with 2-cyclopenten-1-one (5) to establish the contiguous quaternary-tertiary chiral centers and a subsequent geminal difluorination of ketone 17 using Deoxofluor in the presence of catalytic BF(3).OEt(2). The synthesis of the amine moiety 3 is highlighted by the discovery of a novel n-Bu(3)MgLi magnesium-halogen exchange reaction for selective functionalization of 2,6-dibromopyridine. This new and practical metalation protocol obviated cryogenic conditions and upon quenching with DMF gave 6-bromo-2-formylpyridine (26) in excellent yield. Further transformations afforded the amine fragment 3 via reductive amination with 35, Pd-catalyzed aromatic amination, and deprotection. Finally, the highly convergent synthesis of 1 was accomplished by coupling of the two fragments. This synthesis has been used to prepare multi-kilogram quantities of the bulk drug.
    MeSH term(s) Amides/chemical synthesis ; Animals ; Humans ; Hydrocarbons, Fluorinated/chemical synthesis ; Muscarinic Antagonists/chemical synthesis ; Receptor, Muscarinic M3 ; Receptors, Muscarinic/drug effects ; Stereoisomerism
    Chemical Substances Amides ; Hydrocarbons, Fluorinated ; Muscarinic Antagonists ; Receptor, Muscarinic M3 ; Receptors, Muscarinic
    Language English
    Publishing date 2001-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/jo0157425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Online: Elastomers: From Theory to Applications

    Heinrich, Gert / Lang, Michael

    2023  

    Keywords Technology: general issues ; Chemical engineering ; polymer nanocomposites ; filled rubber ; particle network ; filler flocculation ; fictive strain ; structural relaxation ; Tool-Narayanaswamy-Moynihan model ; jamming ; cationic polymerization ; 4-vinylbenzocyclobutene ; random copolymer ; crosslink ; soft material ; stimuli-responsive gel ; magnetic elastomer ; percolation ; SANS ; SAXS ; silica ; zinc oxide ; partial structure factors ; small angle scattering ; natural rubber ; natural latex ; viscosity stabilizer ; hydroxylamine sulfate ; storage hardening ; elastomers ; polymer networks ; elastic modulus ; loops ; heterogeneities ; fatigue life ; hysteresis loss ; temperature increase ; S-N curve ; high surface area graphite ; functionalization ; serinol pyrrole ; ultimate properties ; fracture resistance ; filled elastomers ; stress softening ; filler-induced hysteresis ; cluster mechanics ; FEM simulation ; crosslinking ; TiO2 ; nanomaterials ; stimuli-responsive materials ; smart materials ; polychloroprene ; ageing ; mechanical properties ; rubber elasticity theory ; silicon rubber (PDMS) ; dynamic thermomechanical analyses ; storage modulus ; mechanical loss factor ; viscoelastic gripper ; rubber foam ; filler ; charcoal ; compression set ; recovery ; thermodynamics
    Language English
    Size 1 electronic resource (218 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030377157
    ISBN 9783036569314 ; 3036569316
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  9. Article ; Online: Deciphering polymer networks.

    Lang, Michael

    Nature materials

    2023  Volume 22, Issue 11, Page(s) 1283–1284

    Language English
    Publishing date 2023-10-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2088679-2
    ISSN 1476-4660 ; 1476-1122
    ISSN (online) 1476-4660
    ISSN 1476-1122
    DOI 10.1038/s41563-023-01696-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online ; E-Book: Viszeralchirurgische Operationen und technische Varianten

    Korenkov, Michael / Germer, Christoph-Thomas / Lang, Hauke

    Ösophagus - Leber - Pankreas - endokrine Chirurgie - metabolische Chirurgie

    2021  

    Author's details Michael Korenkov, Christoph-Thomas Germer, Hauke Lang Hrsg
    Keywords Electronic books
    Language German
    Size 1 Online-Ressource (XVII, 405 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020943035
    ISBN 978-3-662-60475-5 ; 9783662604748 ; 3-662-60475-2 ; 3662604744
    DOI 10.1007/978-3-662-60475-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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