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  1. Article ; Online: Disposable Isolation Device to Reduce COVID-19 Contamination During CT Scanning.

    Amalou, Amel / Turkbey, Baris / Xu, Sheng / Turkbey, Evrim / An, Peng / Carrafiello, Gianpaolo / Ierardi, Anna Maria / Suh, Robert / Amalou, Hayet / Wood, Bradford J

    Academic radiology

    2020  Volume 27, Issue 8, Page(s) 1119–1125

    Abstract: Rationale and objectives: The use of chest computed tomography (CT) in the era of the COVID-19 pandemic raises concern regarding the transmission risks to patients and staff caused by CT room contamination. Meanwhile the Center for Disease Control ... ...

    Abstract Rationale and objectives: The use of chest computed tomography (CT) in the era of the COVID-19 pandemic raises concern regarding the transmission risks to patients and staff caused by CT room contamination. Meanwhile the Center for Disease Control guidance for air exchange in between patients may heavily impact workflows. To design a portable custom isolation device to reduce imaging equipment contamination during a pandemic.
    Materials and methods: Center for Disease Control air exchange guidelines and requirements were reviewed. Device functional requirements were outlined and designed. Engineering requirements were reviewed. Methods of practice and risk mitigation plans were outlined including donning and doffing procedures and failure modes. Cost impact was assessed in terms of CT patient throughput.
    Results: CT air exchange solutions and alternatives were reviewed. Multiple isolation bag device designs were considered. Several designs were custom fabricated, prototyped and reduced to practice. A final design was tested on volunteers for comfort, test-fit, air seal, and breathability. Less than 14 times enhanced patient throughput was estimated, in an ideal setting, which could more than counterbalance the cost of the device itself.
    Conclusion: A novel isolation bag device is feasible for use in CT and might facilitate containment and reduce contamination in radiology departments during the COVID Pandemic.
    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Disposable Equipment/standards ; Equipment Contamination/prevention & control ; Feasibility Studies ; Health Personnel ; Humans ; Infection Control/methods ; Medical Waste Disposal/methods ; Pandemics/prevention & control ; Patient Isolation/instrumentation ; Patient Isolation/methods ; Personal Protective Equipment ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Radiography, Thoracic/methods ; SARS-CoV-2 ; Tomography, X-Ray Computed/adverse effects ; Tomography, X-Ray Computed/instrumentation
    Chemical Substances Medical Waste Disposal
    Keywords covid19
    Language English
    Publishing date 2020-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2020.05.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Image-Guided Robotics for Standardized and Automated Biopsy and Ablation.

    Christou, Anna S / Amalou, Amel / Lee, HooWon / Rivera, Jocelyne / Li, Rui / Kassin, Michael T / Varble, Nicole / Tsz Ho Tse, Zion / Xu, Sheng / Wood, Bradford J

    Seminars in interventional radiology

    2021  Volume 38, Issue 5, Page(s) 565–575

    Abstract: Image-guided robotics for biopsy and ablation aims to minimize procedure times, reduce needle manipulations, radiation, and complications, and enable treatment of larger and more complex tumors, while facilitating standardization for more uniform and ... ...

    Abstract Image-guided robotics for biopsy and ablation aims to minimize procedure times, reduce needle manipulations, radiation, and complications, and enable treatment of larger and more complex tumors, while facilitating standardization for more uniform and improved outcomes. Robotic navigation of needles enables standardized and uniform procedures which enhance reproducibility via real-time precision feedback, while avoiding radiation exposure to the operator. Robots can be integrated with computed tomography (CT), cone beam CT, magnetic resonance imaging, and ultrasound and through various techniques, including stereotaxy, table-mounted, floor-mounted, and patient-mounted robots. The history, challenges, solutions, and questions facing the field of interventional radiology (IR) and interventional oncology are reviewed, to enable responsible clinical adoption and value definition via ergonomics, workflows, business models, and outcome data. IR-integrated robotics is ready for broader adoption. The robots are coming!
    Language English
    Publishing date 2021-11-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 848341-3
    ISSN 1098-8963 ; 0739-9529
    ISSN (online) 1098-8963
    ISSN 0739-9529
    DOI 10.1055/s-0041-1739164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Targeted early chest CT in COVID-19 outbreaks as diagnostic tool for containment of the pandemic-A multinational opinion.

    Amalou, Amel / Türkbey, Barış / Sanford, Tom / Harmon, Stephanie / Türkbey, Evrim B / Xu, Sheng / An, Peng / Carrafiello, Gianpaolo / Cariati, Maurizio / Patella, Francesca / Obinata, Hirofumi / Mori, Hitoshi / Sun, Kaiyuan / Spiro, David J / Suh, Robert / Amalou, Hayet / Wood, Bradford J

    Diagnostic and interventional radiology (Ankara, Turkey)

    2020  Volume 26, Issue 4, Page(s) 292–295

    MeSH term(s) Betacoronavirus/genetics ; Betacoronavirus/isolation & purification ; COVID-19 ; China/epidemiology ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Disease Outbreaks/prevention & control ; Disease Transmission, Infectious/prevention & control ; Early Diagnosis ; Humans ; Internationality ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Prevalence ; Reverse Transcriptase Polymerase Chain Reaction/methods ; SARS-CoV-2 ; Sensitivity and Specificity ; Thorax/diagnostic imaging ; Tomography, X-Ray Computed/economics ; Tomography, X-Ray Computed/methods
    Keywords covid19
    Language English
    Publishing date 2020-05-19
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2184145-7
    ISSN 1305-3612 ; 1305-3612
    ISSN (online) 1305-3612
    ISSN 1305-3612
    DOI 10.5152/dir.2020.20231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Disposable Isolation Device to Reduce COVID-19 Contamination During CT Scanning

    Amalou, Amel / Turkbey, Baris / Xu, Sheng / Turkbey, Evrim / An, Peng / Carrafiello, Gianpaolo / Ierardi, Anna Maria / Suh, Robert / Amalou, Hayet / Wood, Bradford J.

    Academic Radiology

    2020  Volume 27, Issue 8, Page(s) 1119–1125

    Keywords Radiology Nuclear Medicine and imaging ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1355509-1
    ISSN 1076-6332
    ISSN 1076-6332
    DOI 10.1016/j.acra.2020.05.017
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Improving detection of prostate cancer foci via information fusion of MRI and temporal enhanced ultrasound.

    Sedghi, Alireza / Mehrtash, Alireza / Jamzad, Amoon / Amalou, Amel / Wells, William M / Kapur, Tina / Kwak, Jin Tae / Turkbey, Baris / Choyke, Peter / Pinto, Peter / Wood, Bradford / Xu, Sheng / Abolmaesumi, Purang / Mousavi, Parvin

    International journal of computer assisted radiology and surgery

    2020  Volume 15, Issue 7, Page(s) 1215–1223

    Abstract: Purpose: The detection of clinically significant prostate cancer (PCa) is shown to greatly benefit from MRI-ultrasound fusion biopsy, which involves overlaying pre-biopsy MRI volumes (or targets) with real-time ultrasound images. In previous literature, ...

    Abstract Purpose: The detection of clinically significant prostate cancer (PCa) is shown to greatly benefit from MRI-ultrasound fusion biopsy, which involves overlaying pre-biopsy MRI volumes (or targets) with real-time ultrasound images. In previous literature, machine learning models trained on either MRI or ultrasound data have been proposed to improve biopsy guidance and PCa detection. However, quantitative fusion of information from MRI and ultrasound has not been explored in depth in a large study. This paper investigates information fusion approaches between MRI and ultrasound to improve targeting of PCa foci in biopsies.
    Methods: We build models of fully convolutional networks (FCN) using data from a newly proposed ultrasound modality, temporal enhanced ultrasound (TeUS), and apparent diffusion coefficient (ADC) from 107 patients with 145 biopsy cores. The architecture of our models is based on U-Net and U-Net with attention gates. Models are built using joint training through intermediate and late fusion of the data. We also build models with data from each modality, separately, to use as baseline. The performance is evaluated based on the area under the curve (AUC) for predicting clinically significant PCa.
    Results: Using our proposed deep learning framework and intermediate fusion, integration of TeUS and ADC outperforms the individual modalities for cancer detection. We achieve an AUC of 0.76 for detection of all PCa foci, and 0.89 for PCa with larger foci. Results indicate a shared representation between multiple modalities outperforms the average unimodal predictions.
    Conclusion: We demonstrate the significant potential of multimodality integration of information from MRI and TeUS to improve PCa detection, which is essential for accurate targeting of cancer foci during biopsy. By using FCNs as the architecture of choice, we are able to predict the presence of clinically significant PCa in entire imaging planes immediately, without the need for region-based analysis. This reduces the overall computational time and enables future intra-operative deployment of this technology.
    MeSH term(s) Humans ; Image-Guided Biopsy/methods ; Magnetic Resonance Imaging/methods ; Male ; Models, Theoretical ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Ultrasonography/methods
    Language English
    Publishing date 2020-05-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2365628-1
    ISSN 1861-6429 ; 1861-6410
    ISSN (online) 1861-6429
    ISSN 1861-6410
    DOI 10.1007/s11548-020-02172-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Targeted early chest CT in COVID-19 outbreaks as diagnostic tool for containment of the pandemic-A multinational opinion

    Amalou, Amel / Türkbey, Baris / Sanford, Tom / Harmon, Stephanie / Türkbey, Evrim B / Xu, Sheng / An, Peng / Carrafiello, Gianpaolo / Cariati, Maurizio / Patella, Francesca / Obinata, Hirofumi / Mori, Hitoshi / Sun, Kaiyuan / Spiro, David J / Suh, Robert / Amalou, Hayet / Wood, Bradford J

    Diagn Interv Radiol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #154920
    Database COVID19

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  7. Article: Disposable Isolation Device to Reduce COVID-19 Contamination During CT Scanning

    Amalou, Amel / Turkbey, Baris / Xu, Sheng / Turkbey, Evrim / An, Peng / Carrafiello, Gianpaolo / Ierardi, Anna Maria / Suh, Robert / Amalou, Hayet / Wood, Bradford J

    Acad Radiol

    Abstract: RATIONALE AND OBJECTIVES: The use of chest computed tomography (CT) in the era of the COVID-19 pandemic raises concern regarding the transmission risks to patients and staff caused by CT room contamination. Meanwhile the Center for Disease Control ... ...

    Abstract RATIONALE AND OBJECTIVES: The use of chest computed tomography (CT) in the era of the COVID-19 pandemic raises concern regarding the transmission risks to patients and staff caused by CT room contamination. Meanwhile the Center for Disease Control guidance for air exchange in between patients may heavily impact workflows. To design a portable custom isolation device to reduce imaging equipment contamination during a pandemic. MATERIALS AND METHODS: Center for Disease Control air exchange guidelines and requirements were reviewed. Device functional requirements were outlined and designed. Engineering requirements were reviewed. Methods of practice and risk mitigation plans were outlined including donning and doffing procedures and failure modes. Cost impact was assessed in terms of CT patient throughput. RESULTS: CT air exchange solutions and alternatives were reviewed. Multiple isolation bag device designs were considered. Several designs were custom fabricated, prototyped and reduced to practice. A final design was tested on volunteers for comfort, test-fit, air seal, and breathability. Less than 14 times enhanced patient throughput was estimated, in an ideal setting, which could more than counterbalance the cost of the device itself. CONCLUSION: A novel isolation bag device is feasible for use in CT and might facilitate containment and reduce contamination in radiology departments during the COVID Pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #361518
    Database COVID19

    Kategorien

  8. Article ; Online: Preparation of a radiology department in an Italian hospital dedicated to COVID-19 patients.

    Ierardi, Anna Maria / Wood, Bradford J / Arrichiello, Antonio / Bottino, Nicola / Bracchi, Laura / Forzenigo, Laura / Andrisani, Maria Carmela / Vespro, Valentina / Bonelli, Cristian / Amalou, Amel / Turkbey, Evrim B / Turkbey, Baris I / Granata, Giuseppe / Pinto, Antonio / Grasselli, Giacomo / Stocchetti, Nino / Carrafiello, Gianpaolo

    La Radiologia medica

    2020  Volume 125, Issue 9, Page(s) 894–901

    Abstract: Preparedness for the ongoing coronavirus disease 2019 (COVID-19) and its spread in Italy called for setting up of adequately equipped and dedicated health facilities to manage sick patients while protecting healthcare workers, uninfected patients, and ... ...

    Abstract Preparedness for the ongoing coronavirus disease 2019 (COVID-19) and its spread in Italy called for setting up of adequately equipped and dedicated health facilities to manage sick patients while protecting healthcare workers, uninfected patients, and the community. In our country, in a short time span, the demand for critical care beds exceeded supply. A new sequestered hospital completely dedicated to intensive care (IC) for isolated COVID-19 patients needed to be designed, constructed, and deployed. Along with this new initiative, the new concept of "Pandemic Radiology Unit" was implemented as a practical solution to the emerging crisis, born out of a critical and urgent acute need. The present article describes logistics, planning, and practical design issues for such a pandemic radiology and critical care unit (e.g., space, infection control, safety of healthcare workers, etc.) adopted in the IC Hospital Unit for the care and management of COVID-19 patients.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Cross Infection/prevention & control ; Hospital Design and Construction ; Hospitals, Isolation/organization & administration ; Humans ; Intensive Care Units/organization & administration ; Italy/epidemiology ; Pandemics/prevention & control ; Personal Protective Equipment ; Personnel Staffing and Scheduling/organization & administration ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; Radiography ; Radiology Department, Hospital/organization & administration ; SARS-CoV-2 ; Tomography, X-Ray Computed/instrumentation ; Ultrasonography
    Keywords covid19
    Language English
    Publishing date 2020-07-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
    DOI 10.1007/s11547-020-01248-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Image-Guided Robotics for Standardized and Automated Biopsy and Ablation

    Christou, Anna S. / Amalou, Amel / Lee, HooWon / Rivera, Jocelyne / Li, Rui / Kassin, Michael T. / Varble, Nicole / Tsz Ho Tse, Zion / Xu, Sheng / Wood, Bradford J.

    Seminars in Interventional Radiology

    (Advances in IR)

    2021  Volume 38, Issue 05, Page(s) 565–575

    Abstract: Image-guided robotics for biopsy and ablation aims to minimize procedure times, reduce needle manipulations, radiation, and complications, and enable treatment of larger and more complex tumors, while facilitating standardization for more uniform and ... ...

    Series title Advances in IR
    Abstract Image-guided robotics for biopsy and ablation aims to minimize procedure times, reduce needle manipulations, radiation, and complications, and enable treatment of larger and more complex tumors, while facilitating standardization for more uniform and improved outcomes. Robotic navigation of needles enables standardized and uniform procedures which enhance reproducibility via real-time precision feedback, while avoiding radiation exposure to the operator. Robots can be integrated with computed tomography (CT), cone beam CT, magnetic resonance imaging, and ultrasound and through various techniques, including stereotaxy, table-mounted, floor-mounted, and patient-mounted robots. The history, challenges, solutions, and questions facing the field of interventional radiology (IR) and interventional oncology are reviewed, to enable responsible clinical adoption and value definition via ergonomics, workflows, business models, and outcome data. IR-integrated robotics is ready for broader adoption. The robots are coming!
    Keywords biopsy ; ablation ; robotics ; stereotactic navigation ; treatment planning ; interventional radiology
    Language English
    Publishing date 2021-11-24
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 848341-3
    ISSN 1098-8963 ; 0739-9529
    ISSN (online) 1098-8963
    ISSN 0739-9529
    DOI 10.1055/s-0041-1739164
    Database Thieme publisher's database

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  10. Article ; Online: Correction to: CT and clinical assessment in asymptomatic and pre-symptomatic patients with early SARS-CoV-2 in outbreak settings.

    Varble, Nicole / Blain, Maxime / Kassin, Michael / Xu, Sheng / Turkbey, Evrim B / Amalou, Amel / Long, Dilara / Harmon, Stephanie / Sanford, Thomas / Yang, Dong / Xu, Ziyue / Xu, Daguang / Flores, Mona / An, Peng / Carrafiello, Gianpaolo / Obinata, Hirofumi / Mori, Hitoshi / Tamura, Kaku / Malayeri, Ashkan A /
    Holland, Steven M / Palmore, Tara / Sun, Kaiyuan / Turkbey, Baris / Wood, Bradford J

    European radiology

    2020  Volume 31, Issue 6, Page(s) 4406

    Language English
    Publishing date 2020-12-21
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-020-07552-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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