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  1. Article ; Online: Review: The Landscape of Antiviral Therapy for COVID-19 in the Era of Widespread Population Immunity and Omicron-Lineage Viruses.

    Meyerowitz, Eric A / Li, Yijia

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 78, Issue 4, Page(s) 908–917

    Abstract: The goals of coronavirus disease 2019 (COVID-19) antiviral therapy early in the pandemic were to prevent severe disease, hospitalization, and death. As these outcomes have become infrequent in the age of widespread population immunity, the objectives ... ...

    Abstract The goals of coronavirus disease 2019 (COVID-19) antiviral therapy early in the pandemic were to prevent severe disease, hospitalization, and death. As these outcomes have become infrequent in the age of widespread population immunity, the objectives have shifted. For the general population, COVID-19-directed antiviral therapy should decrease symptom severity and duration and minimize infectiousness, and for immunocompromised individuals, antiviral therapy should reduce severe outcomes and persistent infection. The increased recognition of virologic rebound following ritonavir-boosted nirmatrelvir (NMV/r) and the lack of randomized controlled trial data showing benefit of antiviral therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection for standard-risk, vaccinated individuals remain major knowledge gaps. Here, we review data for selected antiviral agents and immunomodulators currently available or in late-stage clinical trials for use in outpatients. We do not review antibody products, convalescent plasma, systemic corticosteroids, IL-6 inhibitors, Janus kinase inhibitors, or agents that lack Food and Drug Administration approval or emergency use authorization or are not appropriate for outpatients.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Immunity, Herd ; COVID-19 Serotherapy ; Antiviral Agents/therapeutic use ; Ritonavir/therapeutic use
    Chemical Substances Antiviral Agents ; Ritonavir (O3J8G9O825)
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad685
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  2. Article ; Online: SARS-CoV-2 Transmission and Prevention in the Era of the Delta Variant.

    Meyerowitz, Eric A / Richterman, Aaron

    Infectious disease clinics of North America

    2022  Volume 36, Issue 2, Page(s) 267–293

    Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delta variant transmits much more rapidly than prior SARS-CoV-2 viruses. The primary mode of transmission is via short range aerosols that are emitted from the respiratory tract of an index ...

    Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delta variant transmits much more rapidly than prior SARS-CoV-2 viruses. The primary mode of transmission is via short range aerosols that are emitted from the respiratory tract of an index case. There is marked heterogeneity in the spread of this virus, with 10% to 20% of index cases contributing to 80% of secondary cases, while most index cases have no subsequent transmissions. Vaccination, ventilation, masking, eye protection, and rapid case identification with contact tracing and isolation can all decrease the transmission of this virus.
    MeSH term(s) COVID-19/prevention & control ; Humans ; SARS-CoV-2 ; Vaccination
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1077676-x
    ISSN 1557-9824 ; 0891-5520
    ISSN (online) 1557-9824
    ISSN 0891-5520
    DOI 10.1016/j.idc.2022.01.007
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  3. Article ; Online: Cervical lymphadenitis from Mycobacterium avium complex.

    Coe, Jared / Puius, Yoram / Jain, Harsh / Meyerowitz, Eric A

    BMJ case reports

    2024  Volume 17, Issue 3

    Abstract: We present an instructive case of cervical lymphadenitis in a young man without a history of HIV infection. The patient developed spontaneous left-sided neck swelling that progressed over 4 months. CT imaging demonstrated a necrotic left-sided neck mass ... ...

    Abstract We present an instructive case of cervical lymphadenitis in a young man without a history of HIV infection. The patient developed spontaneous left-sided neck swelling that progressed over 4 months. CT imaging demonstrated a necrotic left-sided neck mass within the cervical lymph node chain. He was initially prescribed azithromycin and rifampin for presumed cat scratch disease with improvement but incomplete resolution of symptoms. Blood cultures ordered 2 months later grew
    MeSH term(s) Male ; Humans ; Mycobacterium avium Complex ; Mycobacterium avium-intracellulare Infection/diagnosis ; Mycobacterium avium-intracellulare Infection/drug therapy ; HIV Infections/drug therapy ; Lymphadenitis/diagnosis ; Lymphadenitis/drug therapy ; Lymphadenitis/microbiology ; Rifampin/therapeutic use
    Chemical Substances Rifampin (VJT6J7R4TR)
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-256726
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  4. Article ; Online: A Defense of the Classical Model of Transmission of Respiratory Pathogens.

    Meyerowitz, Eric A / Richterman, Aaron

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue 7, Page(s) 1318

    MeSH term(s) Humans ; Respiratory Tract Infections
    Language English
    Publishing date 2021-01-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab016
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  5. Article ; Online: Case 5-2024: A 36-Year-Old Man with Fevers.

    Meyerowitz, Eric A / Guha Roy, Shambo / Neilan, Anne M / Ross, Douglas S / Mahowald, Grace K

    The New England journal of medicine

    2024  Volume 390, Issue 7, Page(s) 653–660

    MeSH term(s) Male ; Humans ; Adult ; Fever/etiology ; Lung/diagnostic imaging
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcpc2312724
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  6. Article ; Online: A 35-Year-Old Man With An Itch.

    Bernardo, Raffaele M / Meyerowitz, Eric A

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue 9, Page(s) 1733–1734

    MeSH term(s) Adult ; Humans ; Male ; Pruritus/etiology
    Language English
    Publishing date 2021-10-16
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab117
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  7. Article: Indirect Protection by Reducing Transmission: Ending the Pandemic With Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination.

    Richterman, Aaron / Meyerowitz, Eric A / Cevik, Muge

    Open forum infectious diseases

    2021  Volume 9, Issue 2, Page(s) ofab259

    Language English
    Publishing date 2021-05-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofab259
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  8. Article: Implementation of an Mpox Vaccination Program at a Large Sexual Health Clinic in the Bronx-Lessons in Vaccine Equity.

    Irshad, Usama / Bishop, Derek / Mullis, Caroline / Toro, Justin / Zingman, Barry S / Meyerowitz, Eric A

    Open forum infectious diseases

    2023  Volume 10, Issue 11, Page(s) ofad544

    Abstract: Mpox caused a global outbreak in 2022. Among 249 people who received mpox vaccination at a sexual health clinic in the Bronx, New York, those with private vs public insurance were more likely to complete the series. No mpox cases were seen during follow- ... ...

    Abstract Mpox caused a global outbreak in 2022. Among 249 people who received mpox vaccination at a sexual health clinic in the Bronx, New York, those with private vs public insurance were more likely to complete the series. No mpox cases were seen during follow-up at a median 121 days (IQR, 97-139).
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad544
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  9. Article ; Online: Clinical course and management of COVID-19 in the era of widespread population immunity.

    Meyerowitz, Eric A / Scott, Jake / Richterman, Aaron / Male, Victoria / Cevik, Muge

    Nature reviews. Microbiology

    2023  Volume 22, Issue 2, Page(s) 75–88

    Abstract: The clinical implications of COVID-19 have changed since SARS-CoV-2 first emerged in humans. The current high levels of population immunity, due to prior infection and/or vaccination, have been associated with a vastly decreased overall risk of severe ... ...

    Abstract The clinical implications of COVID-19 have changed since SARS-CoV-2 first emerged in humans. The current high levels of population immunity, due to prior infection and/or vaccination, have been associated with a vastly decreased overall risk of severe disease. Some people, particularly those with immunocompromising conditions, remain at risk for severe outcomes. Through the course of the pandemic, variants with somewhat different symptom profiles from the original SARS-CoV-2 virus have emerged. The management of COVID-19 has also changed since 2020, with the increasing availability of evidence-based treatments in two main classes: antivirals and immunomodulators. Selecting the appropriate treatment(s) for patients with COVID-19 requires a deep understanding of the evidence and an awareness of the limitations of applying data that have been largely based on immune-naive populations to patients today who most likely have vaccine-derived and/or infection-derived immunity. In this Review, we provide a summary of the clinical manifestations and approaches to caring for adult patients with COVID-19 in the era of vaccine availability and the dominance of the Omicron subvariants, with a focus on the management of COVID-19 in different patient groups, including immunocompromised, pregnant, vaccinated and unvaccinated patients.
    MeSH term(s) Adult ; Female ; Pregnancy ; Humans ; COVID-19 ; Immunity, Herd ; SARS-CoV-2 ; Vaccination ; Vaccines ; Disease Progression
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2139054-X
    ISSN 1740-1534 ; 1740-1526
    ISSN (online) 1740-1534
    ISSN 1740-1526
    DOI 10.1038/s41579-023-01001-1
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  10. Article ; Online: Transmission of SARS-CoV-2.

    Meyerowitz, Eric A / Richterman, Aaron / Gandhi, Rajesh T / Sax, Paul E

    Annals of internal medicine

    2021  Volume 174, Issue 7, Page(s) 1037

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-07-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L21-0166
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