LIVIVO - Search results -

Search results

Result 1 - 10 of total 85

Search options

Article ; Online: Comparing nasal suction devices in children with bronchiolitis: A pilot randomized control trial.

Yusuf, Shabana / Watson, Elizabeth L / Hagan, Joseph L / Adekunle-Ojo, Aderonke O

2024 Volume 76, Page(s) 83–90

Abstract: Background/objectives: Bronchiolitis is the most common cause of lower respiratory tract infections that lead to hospitalizations in infants and young children.: Methods: In this randomized controlled pilot study, we compared two separate nasal ... ...

Abstract	Background/objectives: Bronchiolitis is the most common cause of lower respiratory tract infections that lead to hospitalizations in infants and young children. Methods: In this randomized controlled pilot study, we compared two separate nasal suction devices, namely the over counter device by the brand name of NoseFrida and the standard hospital device NeoSucker, in hospitalized children with bronchiolitis to assess equivalence of length of stay within a ± 5-h equivalence margin and to compare readmission rates and associated complications. Additionally, parental satisfaction for the NoseFrida device was measured with a six question (5-point Likert scale) survey. Results: There were 20 patients randomized to the NeoSucker group and 24 randomized to the NoseFrida group. The mean length of stay for the NoseFrida group was 33.5 ± 25.4 h compared to 31.0 ± 15.6 h in the NeoSucker group, which did not establish equivalence within the ±5-h equivalence margin (p = 0.352). Parents were generally satisfied with the NoseFrida. Patients treated with the two devices had similar frequencies of deep suctioning and readmission within 48 h. Conclusions: Although the mean length of stay was comparable for bronchiolitis patients treated with the NoseFrida and NeoSucker, the relatively small sample size and large amount of variability precluded demonstrating equivalence. Since this was a pilot, further studies are needed to evaluate the recommendation for the use of such devices in both the hospital setting and in the outpatient management of bronchiolitis.
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	632731-x
ISSN	1532-8449 ; 0882-5963
ISSN (online)	1532-8449
ISSN	0882-5963
DOI	10.1016/j.pedn.2024.01.021
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2871: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 375: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The Landscape of Pediatric Radiation Oncology in Nigeria.

Joseph, Adedayo / Akinsete, Adeseye M / Lasebikan, Nwamaka N / Adeneye, Samuel / Awofeso, Opeyemi M / Oladipo, Aishat T / Ajose, Azeezat O / Ojo, Oluwatimileyin / Merrell, Kenneth / Ngwa, Wilfred / Puthoff, David S / Onitilo, Adedayo A

JCO global oncology

2024 Volume 10, Page(s) e2300219

Abstract: Radiation therapy (RT) is an essential part of the multidisciplinary treatment of pediatric cancer. Over the past five decades, significant advances have been made in the delivery of RT, with better dose delivery to disease targets while minimizing ... ...

Abstract	Radiation therapy (RT) is an essential part of the multidisciplinary treatment of pediatric cancer. Over the past five decades, significant advances have been made in the delivery of RT, with better dose delivery to disease targets while minimizing exposure to nearby organs at risk. These advances have led to improved treatment outcomes, increased survival, and reduced treatment-related toxicities. Advanced treatment techniques, however, require significant investment in infrastructural and personnel resources. This review documents what is currently available regarding expertise and infrastructure for pediatric radiation oncology practice in Nigeria. It was performed to serve as a foundation for the creation and design of tailored solutions (initiatives and policies) to increase pediatric radiation availability, accessibility, and equity in Nigeria and ultimately improve pediatric cancer treatment outcomes in the region.
MeSH term(s)	Humans ; Child ; Radiation Oncology ; Nigeria ; Neoplasms/radiotherapy ; Medical Oncology ; Treatment Outcome
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Review ; Journal Article
ISSN	2687-8941
ISSN (online)	2687-8941
DOI	10.1200/GO.23.00219
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Clinical and Epidemiological Characteristics of Hospitalized COVID-19 Patients in an Isolation Centre in South-West Nigeria.

Dada, Samuel A / Dele-Ojo, Bolade F / Raimi, Taiwo H / Ojo, Peter / Adeoti, Adekunle O / Fadare, Joseph O / Rafiu, Mojeed O / Dada, Oluwamayowa E / Olabanji, Jimoh K

Cureus

2023 Volume 15, Issue 10, Page(s) e46992

Abstract: Introduction: The clinical presentation of coronavirus disease 2019 (COVID-19) can vary widely, and while the primary infection involves the respiratory system, other organs can also be affected. This study presents the clinical and epidemiological ... ...

Abstract	Introduction: The clinical presentation of coronavirus disease 2019 (COVID-19) can vary widely, and while the primary infection involves the respiratory system, other organs can also be affected. This study presents the clinical and epidemiological characteristics of hospitalized COVID-19 patients in a tertiary hospital in Ado Ekiti, South-West Nigeria. Materials and methods: This is a retrospective study involving COVID-19 patients admitted to the isolation ward between August 2020 and January 2021. The data used for this study was obtained from the patient's medical record, which includes demographic characteristics, clinical presentation, baseline co-morbidities, and laboratory investigations. Results: The average age of the patients was 60.3 years, and more than two-thirds were male. The most common symptoms were fever, shortness of breath, cough, and tiredness. Comorbidities identified among the patients included diabetes mellitus, heart disease, obesity, and chronic kidney disease. The most common radiological findings were bilateral homogeneous patchy opacities and peripheral fluffy infiltrates. The overall mortality rate was 21.9%, with 13 deaths in patients with severe disease. Age and duration of admission were found to be significant predictors of death. Conclusion: The results of this study provide valuable insights into the clinical presentation of COVID-19 in Nigeria and may guide future management strategies for similar infections.
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.46992
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Deletion of PTEN in microglia ameliorates chronic neuroinflammation following repetitive mTBI.

Pearson, Andrew / Ortiz, Camila / Eisenbaum, Max / Arrate, Clara / Browning, Mackenzie / Mullan, Michael / Bachmeier, Corbin / Crawford, Fiona / Ojo, Joseph O

Molecular and cellular neurosciences

2023 Volume 125, Page(s) 103855

Abstract: Traumatic brain injury is a leading cause of morbidity and mortality in adults and children in developed nations. Following the primary injury, microglia, the resident innate immune cells of the CNS, initiate several inflammatory signaling cascades and ... ...

Abstract	Traumatic brain injury is a leading cause of morbidity and mortality in adults and children in developed nations. Following the primary injury, microglia, the resident innate immune cells of the CNS, initiate several inflammatory signaling cascades and pathophysiological responses that may persist chronically; chronic neuroinflammation following TBI has been closely linked to the development of neurodegeneration and neurological dysfunction. Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that have been shown to regulate several key mechanisms in the inflammatory response to TBI. Increasing evidence has shown that the modulation of the PI3K/AKT signaling pathway has the potential to influence the cellular response to inflammatory stimuli. However, directly targeting PI3K signaling poses several challenges due to its regulatory role in several cell survival pathways. We have previously identified that the phosphatase and tensin homolog deleted on chromosome 10 (PTEN), the major negative regulator of PI3K/AKT signaling, is dysregulated following exposure to repetitive mild traumatic brain injury (r-mTBI). Moreover, this dysregulated PI3K/AKT signaling was correlated with chronic microglial-mediated neuroinflammation. Therefore, we interrogated microglial-specific PTEN as a therapeutic target in TBI by generating a microglial-specific, Tamoxifen inducible conditional PTEN knockout model using a CX3CR1 Cre recombinase mouse line PTEN
MeSH term(s)	Animals ; Mice ; Brain Injuries, Traumatic/metabolism ; Disease Models, Animal ; Inflammation/metabolism ; Mice, Inbred C57BL ; Microglia/metabolism ; Neuroinflammatory Diseases ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Pten protein, mouse (EC 3.1.3.67)
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1046640-x
ISSN	1095-9327 ; 1044-7431
ISSN (online)	1095-9327
ISSN	1044-7431
DOI	10.1016/j.mcn.2023.103855
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3035: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Impact assessment of increasing renewable energy penetration on voltage instability tendencies of power system buses using a QV-based index.

Adetokun, Bukola Babatunde / Muriithi, Christopher Maina / Ojo, Joseph Olorunfemi / Oghorada, Oghenewvogaga

Scientific reports

2023 Volume 13, Issue 1, Page(s) 9782

Abstract: This paper presents a QV-based approach called Critical Voltage-Reactive Power Ratio (CVQR) index to assess the voltage instability tendencies of power system buses with increase in renewable energy (RE) penetration within the power system. The buses are ...

Abstract	This paper presents a QV-based approach called Critical Voltage-Reactive Power Ratio (CVQR) index to assess the voltage instability tendencies of power system buses with increase in renewable energy (RE) penetration within the power system. The buses are thus ranked according to the order in which they are impacted by increase in renewable energy penetration. Simulations were performed using DIgSILENT PowerFactory and result analyses were done with MATLAB. The developed CVQR index has been employed to assess the effect of increasing RE generation on grid voltage stability. This index provides information on the voltage instability tendencies of all non-slack buses of the RE-integrated grid and the buses are ranked from the weakest to the strongest. The rankings obtained from the developed CVQR has been compared with five commonly-used indices and the result of the comparison verifies the accuracy of the proposed index. IEEE 14-bus and IEEE 39-bus New England systems have been used to evaluate the proposed CVQR index and various scenarios of RE system combinations and placements have been considered. Voltage collapse condition is indicated whenever the CVQR index associated with any bus becomes positive (CVQR > 0). This index can as well be applied to other power system networks. The overall ranking of the buses based on the CVQR index can provide insights on the most appropriate location for large inductive loads or compensating devices, which can either absorb or inject reactive power into the power system, thereby influencing the system's voltage stability.
MeSH term(s)	Motor Vehicles ; Renewable Energy ; New England
Language	English
Publishing date	2023-06-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-36843-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Identification of potential inhibitors of cholinergic and β-secretase enzymes from phytochemicals derived from Gongronema latifolium Benth leaf: an integrated computational analysis.

Gyebi, Gideon Ampoma / Ogunyemi, Oludare M / Ibrahim, Ibrahim M / Ogunro, Olalekan B / Afolabi, Saheed O / Ojo, Rotimi J / Anyanwu, Gabriel O / El-Saber Batiha, Gaber / Adebayo, Joseph O

Molecular diversity

2023

Abstract: Neurodegenerative disorders (NDDs) are associated with increased activities of the brain acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and β-secretase enzyme (BACE1). Inhibition of these enzymes affords therapeutic option for managing NDDs ... ...

Abstract	Neurodegenerative disorders (NDDs) are associated with increased activities of the brain acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and β-secretase enzyme (BACE1). Inhibition of these enzymes affords therapeutic option for managing NDDs such as Alzheimer's disease (AD) and Parkinson's disease (PD). Although, Gongronema latifolium Benth (GL) has been widely documented in ethnopharmacological and scientific reports for the management of NDDs, there is paucity of information on its underlying mechanism and neurotherapeutic constituents. Herein, 152 previously reported Gongronema latifolium derived-phytochemicals (GLDP) were screened against hAChE, hBChE and hBACE-1 using molecular docking, molecular dynamics (MD) simulations, free energy of binding calculations and cluster analysis. The result of the computational analysis identified silymarin, alpha-amyrin and teraxeron with the highest binding energies (-12.3, -11.2, -10.5 Kcal/mol) for hAChE, hBChE and hBACE-1 respectively as compared with those of the reference inhibitors (-12.3, -9.8 and - 9.4 for donepezil, propidium and aminoquinoline compound respectively). These best docked phytochemicals were found to be orientated in the hydrophobic gorge where they interacted with the choline-binding pocket in the A-site and P-site of the cholinesterase and subsites S1, S3, S3' and flip (67-75) residues of the pocket of the BACE-1. The best docked phytochemicals complexed with the target proteins were stable in a 100 ns molecular dynamic simulation. The interactions with the catalytic residues were preserved during the simulation as observed from the MMGBSA decomposition and cluster analyses. The presence of these phytocompounds most notably silymarin, which demonstrated dual high binding tendencies to both cholinesterases, were identified as potential neurotherapeutics subject to further investigation.
Language	English
Publishing date	2023-06-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1376507-3
ISSN	1573-501X ; 1381-1991
ISSN (online)	1573-501X
ISSN	1381-1991
DOI	10.1007/s11030-023-10658-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4946: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Knowledge, practice and technique of facemask usage among healthcare workers in a tertiary hospital in Ado-Ekiti, Nigeria.

Babatola, Adefunke / Solomon, Oluremi / Ojo, Temitope / Solomon, Olusoji / Olatunya, Oladele / Fadare, Joseph / Oluwadiya, Kehinde

Scientific African

2023 Volume 19, Page(s) e01559

Abstract: Introduction: Infection prevention and control remains very key to safety in healthcare settings and community. The use of personal protective equipment is now more relevant especially with the advent of COVID-19 pandemic. This study aimed to assess the ...

Abstract	Introduction: Infection prevention and control remains very key to safety in healthcare settings and community. The use of personal protective equipment is now more relevant especially with the advent of COVID-19 pandemic. This study aimed to assess the knowledge, attitude, practice and technique of wearing facemask among healthcare workers at Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria. Methods: A descriptive cross-sectional questionnaire-based study explored knowledge, attitude and reported practice on the use of facemask. Also, a checklist was used to directly observe how participants put on and remove facemasks. Results: Of the 450 respondents, 316 (70.2%) had good knowledge score. Only 255 (56.7%) had good attitude and barely half of the respondents 229 (50.9%) had good practice. However, the majority of those who were observed had good technique of wearing facemask 387 (86.4%). Also, 188 (41.8%) of the healthcare workers believed that face shield alone offers adequate protection against transmission of COVID-19. Conclusions: Our finding suggests that knowledge does not translate to good practice. Furthermore, the fact that two out of every five healthcare workers held erroneous belief about face shield, and another one-third had poor knowledge points to the need for training and retraining of healthcare workers with the aim of reinforcing the need for consistent and correct use of facemasks. This should have a salubrious effect on the community knowledge of COVID-19 prevention as healthcare workers are believed to be the most common sources of health information to the lay public.
Language	English
Publishing date	2023-01-21
Publishing country	Netherlands
Document type	Journal Article
ISSN	2468-2276
ISSN (online)	2468-2276
DOI	10.1016/j.sciaf.2023.e01559
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The effect of intervention versus watchful waiting on disease progression and overall survival in smoldering multiple myeloma: a systematic review of randomized controlled trials.

Ojo, Ademola S / Ojukwu, Somtochukwu G / Asemota, Joseph / Akinyemi, Oluwasegun / Araoye, Mojisola O / Saleh, Mohammed / Ali, Ahmed / Sarma, Ravi

Journal of cancer research and clinical oncology

2022 Volume 148, Issue 4, Page(s) 897–911

Abstract: Background: Smoldering multiple myeloma (SMM) is an intermediate pre-malignant condition with individuals having a distinct risk of progression to overt myeloma. The optimal management option has remained controversial due to the heterogeneous nature of ...

Abstract	Background: Smoldering multiple myeloma (SMM) is an intermediate pre-malignant condition with individuals having a distinct risk of progression to overt myeloma. The optimal management option has remained controversial due to the heterogeneous nature of the condition in which progression to overt diseases is variable. The question of who, when, and what to use for the treatment of SMM remains equivocal. We performed a systematic review of randomized controlled trials and summarized the current evidence supporting the best approach to the management of SMM. Methods: A comprehensive literature search of Medline/PubMed, PubMed Central, Embase, Scopus, Web of Science, Wiley Cochrane Library, CINAHL, clinicaltrial.gov, and conference proceedings of ASCO, ASH, EHA, and ESMO was performed on October 25, 2020. Synthesis of the result was done using narrative analysis. Result: Of the total 1560 identified records, 10 eligible studies involving 1157 patients made up of 580 in the intervention group and 577 in the control group were included in this review. Three early trials of melphalan and prednisone fail to demonstrate any significant impact on disease progression with major toxicities reported. Three trials on bisphosphonate monotherapy show reduced skeletal-related events without any clinical effect on disease progression. Lenalidomide monotherapy or as part of a combination therapy demonstrates superiority in delaying disease progression over observation. Only Lenalidomide and dexamethasone combination demonstrated superior overall survival over observation across the trials. Conclusion: Trials of lenalidomide in a less intensive approach has shown promise in delaying disease progression and should be investigated further in clinical trials.
MeSH term(s)	Disease Progression ; Humans ; Lenalidomide/therapeutic use ; Randomized Controlled Trials as Topic ; Smoldering Multiple Myeloma/drug therapy ; Watchful Waiting
Chemical Substances	Lenalidomide (F0P408N6V4)
Language	English
Publishing date	2022-01-20
Publishing country	Germany
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-022-03920-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.10: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Prenatal anaemia and risk of postpartum haemorrhage: a cohort analysis of data from the Predict-PPH study.

Okunade, Kehinde S / Adejimi, Adebola A / Olumodeji, Ayokunle M / Olowe, Atinuke / Oyedeji, Olufemi A / Ademuyiwa, Iyabo Y / Adelabu, Hameed / Toks-Omage, Eselobu / Okoro, Austin C / Davies, Nosimot / Adenekan, Muisi A / Ojo, Temitope / Rabiu, Kabiru A / Oshodi, Yusuf A / Ugwu, Aloy O / Olowoselu, Festus O / Akinmola, Olukayode O / Olamijulo, Joseph A / Oluwole, Ayodeji A

BMC public health

2024 Volume 24, Issue 1, Page(s) 1028

Abstract: Background: Most previous clinical studies investigating the connection between prenatal anaemia and postpartum haemorrhage (PPH) have reported conflicting results.: Objectives: We examined the association between maternal prenatal anaemia and the ... ...

Abstract	Background: Most previous clinical studies investigating the connection between prenatal anaemia and postpartum haemorrhage (PPH) have reported conflicting results. Objectives: We examined the association between maternal prenatal anaemia and the risk of PPH in a large cohort of healthy pregnant women in five health institutions in Lagos, Southwest Nigeria. Methods: This was a prospective cohort analysis of data from the Predict-PPH study that was conducted between January and June 2023. The study enrolled n = 1222 healthy pregnant women giving birth in five hospitals in Lagos, Nigeria. The study outcome, WHO-defined PPH, is postpartum blood loss of at least 500 milliliters. We used a multivariable logistic regression model with a backward stepwise conditional approach to examine the association between prenatal anaemia of increasing severity and PPH while adjusting for confounding factors. Results: Of the 1222 women recruited to the Predict-PPH study between January and June 2023, 1189 (97·3%) had complete outcome data. Up to 570 (46.6%) of the enrolled women had prenatal anaemia while 442 (37.2%) of those with complete follow-up data had WHO-defined PPH. After controlling for potential confounding factors, maternal prenatal anaemia was independently associated with PPH (adjusted odds ratio = 1.37, 95% confidence interval: 1.05-1.79). However, on the elimination of interaction effects of coexisting uterine fibroids and mode of delivery on this association, a sensitivity analysis yielded a lack of significant association between prenatal anaemia and PPH (adjusted odds ratio = 1.27, 95% confidence interval: 0.99-1.64). We also recorded no statistically significant difference in the median postpartum blood loss in women across the different categories of anaemia (P = 0.131). Conclusion: Our study revealed that prenatal anaemia was not significantly associated with PPH. These findings challenge the previously held belief of a suspected link between maternal anaemia and PPH. This unique evidence contrary to most previous studies suggests that other factors beyond prenatal anaemia may contribute more significantly to the occurrence of PPH. This highlights the importance of comprehensive assessment and consideration of various maternal health factors in predicting and preventing this life-threatening obstetric complication.
MeSH term(s)	Pregnancy ; Humans ; Female ; Nigeria/epidemiology ; Postpartum Hemorrhage/epidemiology ; Prospective Studies ; Anemia/epidemiology ; Family ; Vitamins
Chemical Substances	Vitamins
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-18446-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Lack of Excess Cardiovascular Risks among First Degree Relatives of Persons with Diabetes Mellitus

Taiwo H Raimi / Bolade Folasade Dele-Ojo / Samuel A Dada / Joseph O Fadare

Journal of Clinical and Diagnostic Research, Vol 15, Iss 2, Pp OC33-OC

Is Lifestyle the Cause?

2021 Volume 37

Abstract: Introduction: The prevalence of Diabetes Mellitus (DM) is rising worldwide with a projected increase of more than 50% in next three decades. Family History of Diabetes (FHD) is a recognised risk factor for DM, but development of DM in relatives of people ...

Abstract	Introduction: The prevalence of Diabetes Mellitus (DM) is rising worldwide with a projected increase of more than 50% in next three decades. Family History of Diabetes (FHD) is a recognised risk factor for DM, but development of DM in relatives of people with the disease, who carry susceptible genes, is dependent on interaction with other factors such as nutrition, physical activity and environment. Aim: To determine the prevalence of metabolic syndrome and impact of lifestyle on the CVD risk factors among adult Nigerian with FHD. Materials and Methods: This was a cross-sectional study among staff and students of Ekiti State University and Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria. Eightysix participants with FHD were age and sex-matched with 86 participants who had no FHD. Relevant demographic and lifestyle information were obtained, and clinical measurements of Body Mass Index (BMI), waist and hip circumferences and blood pressures were obtained by standard protocols. Fasting plasma glucose and lipid panel were determined. Metabolic syndrome was defined according to the International Diabetes Federation criteria (IDF). The clinical, laboratory and other variables of the people with FHD and those without FHD were compared with Pearson’s Chi-Square and Student’s t-test. Results: The age, clinical, anthropometric and laboratory parameters were similar between the two groups. Participants with FHD consume more poultry (17.6% vs 3.5%) and less red meat (27.1% vs 37.2%) than those without FHD (p=0.036), but the level of physical activity and consumption of fruits/ vegetables, and smoking did not differ between the two groups. Metabolic syndrome was equally prevalent between the people with or without FHD (p=0.846). There was no significant difference (p>0.05), in the prevalence of CVD risk factors, such as hypertension, hyperglycaemia, dyslipidaemia, and obesity between the two groups. Conclusion: The prevalence of metabolic syndrome was similar among people with or without FHD. Healthy ...
Keywords	genetics ; metabolic syndrome ; type 2 diabetes ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED