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  1. Book ; Online ; E-Book: Textbook of von Willebrand disease

    Federici, Augusto B. / Berntorp, Erik E. / Lillicrap, David / Montgomery, Robert R.

    basic and clinical aspects

    2024  

    Author's details edited by Augusto B. Federici, Erik E. Berntorp, David Lillicrap, Robert R. Montgomery
    Subject code 616.1/57
    Language English
    Size 1 Online-Ressource (xiii, 289 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Wiley Blackwell
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030714704
    ISBN 978-1-119-41949-5 ; 9781119419488 ; 1-119-41949-2 ; 1119419484
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article ; Online: Low von Willebrand factor phenotype: the enigma continues.

    Lillicrap, David

    Blood

    2022  Volume 139, Issue 14, Page(s) 2102–2103

    MeSH term(s) Humans ; Phenotype ; von Willebrand Diseases ; von Willebrand Factor/genetics
    Chemical Substances von Willebrand Factor
    Language English
    Publishing date 2022-02-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021013541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Disseminated intravascular coagulation in patients with 2019-nCoV pneumonia.

    Lillicrap, David

    Journal of thrombosis and haemostasis : JTH

    2020  Volume 18, Issue 4, Page(s) 786–787

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Disseminated Intravascular Coagulation ; Humans ; Pandemics ; Pneumonia ; Pneumonia, Viral ; Prognosis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-03-24
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.14781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Looking Back-And Forward.

    Lillicrap, David / Morrissey, James H

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 21, Issue 12, Page(s) 3285–3286

    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Editorial
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.09.024
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  5. Article ; Online: Evaluating the potential benefits of the extravascular pool of factor IX.

    Lillicrap, David

    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis

    2020  Volume 32, Issue 1, Page(s) 68–69

    MeSH term(s) Animals ; Blood Coagulation Tests ; Collagen Type IV/metabolism ; Factor IX/metabolism ; Factor IX/therapeutic use ; Hemophilia B/blood ; Hemophilia B/metabolism ; Hemophilia B/therapy ; Hemostasis ; Humans ; Mice ; Protein Binding
    Chemical Substances Collagen Type IV ; Factor IX (9001-28-9)
    Language English
    Publishing date 2020-11-06
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1033551-1
    ISSN 1473-5733 ; 0957-5235
    ISSN (online) 1473-5733
    ISSN 0957-5235
    DOI 10.1097/MBC.0000000000000969
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  6. Article ; Online: Priming the translational pipeline for hemostasis therapies.

    Lillicrap, David / Morrissey, James H

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 21, Issue 8, Page(s) 2005–2006

    MeSH term(s) Humans ; Hemostasis ; Proteomics
    Language English
    Publishing date 2023-07-19
    Publishing country England
    Document type Editorial
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Artificial intelligence, science, and learning.

    Lillicrap, David / Morrissey, James H

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 21, Issue 4, Page(s) 709

    MeSH term(s) Humans ; Artificial Intelligence ; Machine Learning
    Language English
    Publishing date 2023-02-28
    Publishing country England
    Document type Editorial
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.01.026
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  8. Article ; Online: Hemophilia A treatment innovation: factor VIII mimetic bispecific antibodies-generational enhancement.

    Lillicrap, David / Lenting, Peter

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 22, Issue 2, Page(s) 352–355

    MeSH term(s) Humans ; Factor VIII/therapeutic use ; Hemophilia A/drug therapy ; Antibodies, Bispecific/pharmacology ; Antibodies, Bispecific/therapeutic use ; Hemostatics ; Factor X
    Chemical Substances Factor VIII (9001-27-8) ; Antibodies, Bispecific ; Hemostatics ; Factor X (9001-29-0)
    Language English
    Publishing date 2023-09-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.10.026
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  9. Article: Current Understanding of Inherited Modifiers of FVIII Pharmacokinetic Variation.

    Swystun, Laura L / Lillicrap, David

    Pharmacogenomics and personalized medicine

    2023  Volume 16, Page(s) 239–252

    Abstract: The inherited bleeding disorder hemophilia A involves the quantitative deficiency of the coagulation cofactor factor VIII (FVIII). Prophylactic treatment of severe hemophilia A patients with FVIII concentrates aims to reduce the frequency of spontaneous ... ...

    Abstract The inherited bleeding disorder hemophilia A involves the quantitative deficiency of the coagulation cofactor factor VIII (FVIII). Prophylactic treatment of severe hemophilia A patients with FVIII concentrates aims to reduce the frequency of spontaneous joint bleeding and requires personalized tailoring of dosing regimens to account for the substantial inter-individual variability of FVIII pharmacokinetics. The strong reproducibility of FVIII pharmacokinetic (PK) metrics between repeat analyses in the same individual suggests this trait is genetically regulated. While the influence of plasma von Willebrand factor antigen (VWF:Ag) levels, ABO blood group, and patient age on FVIII PK is well established, estimates suggest these factors account for less than 35% of the overall variability in FVIII PK. More recent studies have identified genetic determinants that modify FVIII clearance or half-life including
    Language English
    Publishing date 2023-03-24
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2508173-1
    ISSN 1178-7066
    ISSN 1178-7066
    DOI 10.2147/PGPM.S383221
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  10. Article ; Online: Diagnosis and treatment of von Willebrand disease in 2024 and beyond.

    James, Paula / Leebeek, Frank / Casari, Caterina / Lillicrap, David

    Haemophilia : the official journal of the World Federation of Hemophilia

    2024  Volume 30 Suppl 3, Page(s) 103–111

    Abstract: Manuscript background and aim: The diagnosis and clinical care of patients with von Willebrand disease (VWD) has continued to evolve since the characterization of the von Willebrand factor (VWF) gene in 1985. This condition is almost certainly the most ... ...

    Abstract Manuscript background and aim: The diagnosis and clinical care of patients with von Willebrand disease (VWD) has continued to evolve since the characterization of the von Willebrand factor (VWF) gene in 1985. This condition is almost certainly the most common inherited bleeding disorder, and the major symptomatic burden of the disease is experienced by females during their reproductive years. Diagnosis relies on the identification of a personal and family history of excessive mucocutaneous bleeding, and laboratory features consistent with quantitative and/or qualitative abnormalities of VWF. This review focuses on three aspects of VWD management, with current updates and a look into the future.
    Manuscript themes: First, we will address the role of genetics in the diagnosis and possible therapies for VWD. With current technologies, VWD genetic diagnosis is usually confined to the confirmation of type 2 subtypes of the disease and type 3 VWD analysis for family planning. While type 3 VWD is a potential candidate for the application of gene therapy, no treatments are currently close to entering the clinic. Second, the peri-procedural management of patients with VWD remains an important element of care. The choice of product, its dose and schedule all require careful consideration depending upon the type and disruptive nature of the planned procedure. Lastly, in addition to gene therapy, several other novel therapeutic interventions are also being developed for bleeding and prophylaxis in VWD. These include a VWF aptamer interfering with VWF clearance and bioengineered forms of VWF.
    MeSH term(s) Female ; Humans ; von Willebrand Diseases/diagnosis ; von Willebrand Diseases/genetics ; von Willebrand Diseases/therapy ; von Willebrand Factor/genetics ; von Willebrand Factor/therapeutic use ; von Willebrand Disease, Type 3 ; Hemorrhage/diagnosis
    Chemical Substances von Willebrand Factor
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1229713-6
    ISSN 1365-2516 ; 1351-8216 ; 1355-0691
    ISSN (online) 1365-2516
    ISSN 1351-8216 ; 1355-0691
    DOI 10.1111/hae.14970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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