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  1. Article ; Online: Disseminated intravascular coagulation: A devastating systemic disorder of special concern with COVID-19.

    Singh, Parmvir / Schwartz, Robert A

    Dermatologic therapy

    2020  Volume 33, Issue 6, Page(s) e14053

    Abstract: Disseminated intravascular coagulation (DIC) is linked with severe COVID-19, prompting considerable concern. DIC can be a devastating systemic disorder. It is often markedly manifest on the skin as acrocyanosis or as petechiae and purpura with ... ...

    Abstract Disseminated intravascular coagulation (DIC) is linked with severe COVID-19, prompting considerable concern. DIC can be a devastating systemic disorder. It is often markedly manifest on the skin as acrocyanosis or as petechiae and purpura with progression to hemorrhagic bullae. Subcutaneous hematomas may occur, as may thrombotic findings including necrosis and gangrene. The most common cause is infection, with special emphasis now on COVID-19. We have reviewed the medical literature under the search terms "Disseminated intravascular coagulation" and "consumption coagulopathy" for the past two decades in the English language using Medline and Google Scholar to update special concerns and considerations, focusing on those with COVID-19. Skin findings with DIC may be prominent. The severity of cutaneous lesions often correlates with the gravity of systemic disease. DIC is most effectively treated by addressing the underlying cause and resuscitating the patient using supportive measures. It is pivotal to recognize and treat DIC early, before deadly complications, such as multiple organ failure, arise.
    MeSH term(s) Blood Coagulation ; COVID-19/blood ; COVID-19/complications ; COVID-19/therapy ; COVID-19/virology ; Disseminated Intravascular Coagulation/blood ; Disseminated Intravascular Coagulation/diagnosis ; Disseminated Intravascular Coagulation/therapy ; Disseminated Intravascular Coagulation/virology ; Early Diagnosis ; Host-Pathogen Interactions ; Humans ; Predictive Value of Tests ; Prognosis ; Risk Assessment ; Risk Factors ; SARS-CoV-2/pathogenicity
    Keywords covid19
    Language English
    Publishing date 2020-09-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.14053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5181: Show issues Location:
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  2. Article ; Online: Disseminated intravascular coagulation

    Singh, Parmvir / Schwartz, Robert A.

    Dermatologic Therapy ; ISSN 1396-0296 1529-8019

    A devastating systemic disorder of special concern with COVID ‐19

    2020  

    Keywords Dermatology ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/dth.14053
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Disseminated intravascular coagulation: A devastating systemic disorder of special concern with COVID-19

    Singh, Parmvir / Schwartz, Robert A

    Dermatol Ther

    Abstract: Disseminated intravascular coagulation (DIC) is linked with severe COVID-19, prompting considerable concern. DIC can be a devastating systemic disorder. It is often markedly manifest on the skin as acrocyanosis or as petechiae and purpura with ... ...

    Abstract Disseminated intravascular coagulation (DIC) is linked with severe COVID-19, prompting considerable concern. DIC can be a devastating systemic disorder. It is often markedly manifest on the skin as acrocyanosis or as petechiae and purpura with progression to hemorrhagic bullae. Subcutaneous hematomas may occur, as may thrombotic findings including necrosis and gangrene. The most common cause is infection, with special emphasis now on COVID-19. We have reviewed the medical literature under the search terms "Disseminated intravascular coagulation" and "consumption coagulopathy" for the past two decades in the English language using Medline and Google Scholar to update special concerns and considerations, focusing on those with COVID-19. Skin findings with DIC may be prominent. The severity of cutaneous lesions often correlates with the gravity of systemic disease. DIC is most effectively treated by addressing the underlying cause and resuscitating the patient using supportive measures. It is pivotal to recognize and treat DIC early, before deadly complications, such as multiple organ failure, arise.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #671608
    Database COVID19

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  4. Article: Benign Metastasis?! What an Oxymoron!

    Singh, Parmvir / John, Ann M / Lambert, W Clark

    Skinmed

    2016  Volume 14, Issue 1, Page(s) 29–31

    MeSH term(s) Humans ; Neoplasm Metastasis ; Terminology as Topic
    Language English
    Publishing date 2016-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171125-2
    ISSN 1540-9740
    ISSN 1540-9740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6041: Show issues Location:
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  5. Article: Diagnostic Pitfalls of the "Nothin' Slide".

    Singh, Parmvir / Kim, Hee Jin / John, Ann M / Lambert, W Clark

    Skinmed

    2016  Volume 14, Issue 2, Page(s) 115–118

    Language English
    Publishing date 2016-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171125-2
    ISSN 1540-9740
    ISSN 1540-9740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article: Aggressive Mimicry in Dermatology: When a Basal or Squamous Cell Carcinoma Mimics a Spindle Cell Tumor.

    John, Ann M / Singh, Parmvir / Handler, Marc Z / Lambert, W Clark

    Skinmed

    2018  Volume 16, Issue 1, Page(s) 39–41

    MeSH term(s) Carcinoma/pathology ; Carcinoma, Basal Cell/pathology ; Carcinoma, Basal Cell/surgery ; Diagnosis, Differential ; Humans ; Male ; Middle Aged ; Shoulder ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery
    Language English
    Publishing date 2018-02-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2171125-2
    ISSN 1540-9740
    ISSN 1540-9740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6041: Show issues Location:
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  7. Article: Whack-a-mole!: An Economic Solution to a Medical Problem.

    John, Ann M / Singh, Parmvir / John, Elizabeth S / Handler, Marc Z / Lambert, W Clark

    Skinmed

    2018  Volume 16, Issue 6, Page(s) 404–406

    MeSH term(s) Adult ; Biopsy/economics ; Biopsy/standards ; Female ; Humans ; Quality Control ; Skin Neoplasms/pathology
    Language English
    Publishing date 2018-12-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2171125-2
    ISSN 1540-9740
    ISSN 1540-9740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6041: Show issues Location:
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  8. Article ; Online: Interstitial granulomatous dermatitis and granulomatous arteritis in the setting of PD-1 inhibitor therapy for metastatic melanoma.

    Singh, Parmvir / Wolfe, Scott P / Alloo, Allireza / Gottesman, Silvija P

    Journal of cutaneous pathology

    2019  Volume 47, Issue 1, Page(s) 65–69

    Abstract: Checkpoint inhibition has become an important target in the management of malignant melanoma. As anti-CTLA4 inhibitors and anti-PD1 antibodies are increasingly utilized, reports of immune-related adverse events (IRAEs) are becoming more frequent. Common ... ...

    Abstract Checkpoint inhibition has become an important target in the management of malignant melanoma. As anti-CTLA4 inhibitors and anti-PD1 antibodies are increasingly utilized, reports of immune-related adverse events (IRAEs) are becoming more frequent. Common noted cutaneous IRAEs are morbilliform, lichenoid, bullous, granulomatous, psoriasiform, and eczematous eruptions. We report a case of interstitial granulomatous dermatitis and granulomatous arteritis in the setting of nivolumab (anti-PD1) monotherapy for metastatic melanoma. There are many different causes for granulomatous vasculitis, such as herpes virus infection, lymphoproliferative disorders, systemic vasculitis, and inflammatory bowel disease. This report adds to the growing literature on granulomatous IRAEs due to checkpoint inhibition.
    MeSH term(s) Drug Eruptions/metabolism ; Drug Eruptions/pathology ; Female ; Humans ; Melanoma/drug therapy ; Melanoma/metabolism ; Melanoma/pathology ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Proteins/antagonists & inhibitors ; Nivolumab/administration & dosage ; Nivolumab/adverse effects ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Skin Neoplasms/drug therapy ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology ; Vasculitis, Central Nervous System/chemically induced ; Vasculitis, Central Nervous System/metabolism ; Vasculitis, Central Nervous System/pathology ; Melanoma, Cutaneous Malignant
    Chemical Substances Neoplasm Proteins ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor ; Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2019-08-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/cup.13562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1043: Show issues Location:
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  9. Article: The Skin: A Time Capsule.

    Singh, Parmvir / John, Ann M / Lai, Yi C / Handler, Marc Z / Lambert, W Clark

    Skinmed

    2016  Volume 14, Issue 5, Page(s) 372–373

    Language English
    Publishing date 2016-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171125-2
    ISSN 1540-9740
    ISSN 1540-9740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6041: Show issues Location:
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  10. Article: Cancer From the Cut: How Surgical Flaps Can Move Incidental Tumors to Different Locations.

    John, Ann M / Singh, Parmvir / Sharma, Divya / Lambert, W Clark

    Skinmed

    2015  Volume 13, Issue 5, Page(s) 377–378

    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171125-2
    ISSN 1540-9740
    ISSN 1540-9740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6041: Show issues Location:
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