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  1. Article: Distal Row Carpectomy-A Possible Salvage Procedure of Severe Carpal Trauma.

    Brodbeck, Rebekka / Horch, Raymund E / Arkudas, Andreas

    Plastic and reconstructive surgery. Global open

    2015  Volume 3, Issue 8, Page(s) e480

    Abstract: Complex fracture dislocations of the wrist often result in posttraumatic arthrosis. In trying to avoid total arthrodesis, alternative treatment strategies have been investigated. For this purpose, we present the case of a 56-year-old male patient who ... ...

    Abstract Complex fracture dislocations of the wrist often result in posttraumatic arthrosis. In trying to avoid total arthrodesis, alternative treatment strategies have been investigated. For this purpose, we present the case of a 56-year-old male patient who sustained a direct trauma during a circular saw accident, resulting in the destruction of the distal carpal row among other things. However, the proximal carpal row was found completely intact. We indicated an emergency distal row carpectomy. Eighteen months postoperatively, the patient showed very good range of movement with no pain, and radiologically, the proximal carpal row was still intact, with no signs of an incipient radiocarpal arthrosis. This case demonstrates the successful removal of the distal carpal row in terms of a distal row carpectomy.
    Language English
    Publishing date 2015-08-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000000404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7091: Show issues Location:
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  2. Article: Plastic and Reconstructive Surgery in the Treatment of Oncological Perineal and Genital Defects.

    Brodbeck, Rebekka / Horch, Raymund E / Arkudas, Andreas / Beier, Justus P

    Frontiers in oncology

    2015  Volume 5, Page(s) 212

    Abstract: Defects of the perineum may result from ablative procedures of different malignancies. The evolution of more radical excisional surgery techniques resulted in an increase in large defects of the perineum. The perineogenital region per se has many ... ...

    Abstract Defects of the perineum may result from ablative procedures of different malignancies. The evolution of more radical excisional surgery techniques resulted in an increase in large defects of the perineum. The perineogenital region per se has many different functions for urination, bowel evacuation, sexuality, and reproduction. Up-to-date individual and interdisciplinary surgical treatment concepts are necessary to provide optimum oncological as well as quality of life outcome. Not only the reconstructive method but also the timing of the reconstruction is crucial. In cases of postresectional exposition of e.g., pelvic or femoral vessels or intrapelvic and intra-abdominal organs, simultaneous flap procedure is mandatory. In particular, the reconstructive armamentarium of the plastic surgeon should include not only pedicled flaps but also free microsurgical flaps so that no compromise in terms of the extent of the oncological resection has to be accepted. For intra-abdominally and/or pelvic tumors of the rectum, the anus, or the female reproductive system, which were resected through an abdominally and a sacrally surgical access, simultaneous vertical rectus abdominis myocutaneous (VRAM) flap reconstruction is recommendable. In terms of soft tissue sarcoma of the pelvic/caudal abdomen/proximal thigh region, two-stage reconstructions are possible. This review focuses on the treatment of perineum, genitals, and pelvic floor defects after resection of malignant tumors, giving a distinct overview of the different types of defects faced in this region and describing a number of reconstructive techniques, especially VRAM flap and pedicled flaps like antero-lateral thigh flap or free flaps. Finally, this review outlines some considerations concerning timing of the different operative steps.
    Language English
    Publishing date 2015-10-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2015.00212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The potential role of telocytes in Tissue Engineering and Regenerative Medicine.

    Boos, Anja M / Weigand, Annika / Brodbeck, Rebekka / Beier, Justus P / Arkudas, Andreas / Horch, Raymund E

    Seminars in cell & developmental biology

    2016  Volume 55, Page(s) 70–78

    Abstract: Research and ideas for potential applications in the field of Tissue Engineering (TE) and Regenerative Medicine (RM) have been constantly increasing over recent years, basically driven by the fundamental human dream of repairing and regenerating lost ... ...

    Abstract Research and ideas for potential applications in the field of Tissue Engineering (TE) and Regenerative Medicine (RM) have been constantly increasing over recent years, basically driven by the fundamental human dream of repairing and regenerating lost tissue and organ functions. The basic idea of TE is to combine cells with putative stem cell properties with extracellular matrix components, growth factors and supporting matrices to achieve independently growing tissue. As a side effect, in the past years, more insights have been gained into cell-cell interaction and how to manipulate cell behavior. However, to date the ideal cell source has still to be found. Apart from commonly known various stem cell sources, telocytes (TC) have recently attracted increasing attention because they might play a potential role for TE and RM. It becomes increasingly evident that TC provide a regenerative potential and act in cellular communication through their network-forming telopodes. While TE in vitro experiments can be the first step, the key for elucidating their regenerative role will be the investigation of the interaction of TC with the surrounding tissue. For later clinical applications further steps have to include an upscaling process of vascularization of engineered tissue. Arteriovenous loop models to vascularize such constructs provide an ideal platform for preclinical testing of future therapeutic concepts in RM. The following review article should give an overview of what is known so far about the potential role of TC in TE and RM.
    Language English
    Publishing date 2016-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2016.01.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2918: Show issues Location:
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  4. Conference proceedings: Züchtung von körpereigenem gefäßversorgtem Knochenersatzgewebe für die Therapie von komplexen Knochendefekten

    Boos, Anja Miriam / Weigand, Annika / Brodbeck, Rebekka / Arkudas, Andreas / Hess, Andreas / Gerber, Thomas / Horch, Raymund / Beier, Justus

    2015  , Page(s) 15dgch455

    Event/congress 132. Kongress der Deutschen Gesellschaft für Chirurgie; München; Deutsche Gesellschaft für Chirurgie; 2015
    Keywords Medizin, Gesundheit
    Publishing date 2015-04-24
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/15dgch455
    Database German Medical Science

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  5. Conference proceedings: Die Rolle der plastisch-rekonstruktiven Chirurgie in der interdisziplinären chirurgischen Behandlung von Sarkomen – eine retrospektive Studie 2004–2014

    Beier, Justus P. / Brodbeck, Rebekka / Croner, Roland S. / Arkudas, Andreas / Schmitz, Marweh / Lang, Werner / Hohenberger, Werner / Horch, Raymund E.

    2015  , Page(s) 15dgch417

    Event/congress 132. Kongress der Deutschen Gesellschaft für Chirurgie; München; Deutsche Gesellschaft für Chirurgie; 2015
    Keywords Medizin, Gesundheit
    Publishing date 2015-04-24
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/15dgch417
    Database German Medical Science

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  6. Conference proceedings: Die Rolle der Plastischen Chirurgie in der interdisziplinären chirurgischen Sarkomtherapie – eine retrospektive Studie 2004–2014

    Beier, Justus P. / Brodbeck, Rebekka / Sterzinger, Sebastian / Arkudas, Andreas / Schmitz, Marweh / Vassos, Nikolaos / Hohenberger, Werner / Horch, Raymund E.

    2015  , Page(s) 142

    Event/congress 46. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 20. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC); Berlin; ; Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen; 2015
    Keywords Medizin, Gesundheit ; Sarkom ; Sarkomchirurgie ; interdisziplinäre Chirurgie
    Publishing date 2015-09-28
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/15dgpraec142
    Database German Medical Science

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  7. Article ; Online: The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis.

    Moreth, Kristin / Brodbeck, Rebekka / Babelova, Andrea / Gretz, Norbert / Spieker, Tilmann / Zeng-Brouwers, Jinyang / Pfeilschifter, Josef / Young, Marian F / Schaefer, Roland M / Schaefer, Liliana

    The Journal of clinical investigation

    2010  Volume 120, Issue 12, Page(s) 4251–4272

    Abstract: CXCL13 is a key B cell chemoattractant and marker of disease activity in patients with SLE; however, the mechanism of its induction has not been identified yet. Here, we have shown that the proteoglycan biglycan triggers CXCL13 expression via TLR2/4 in ... ...

    Abstract CXCL13 is a key B cell chemoattractant and marker of disease activity in patients with SLE; however, the mechanism of its induction has not been identified yet. Here, we have shown that the proteoglycan biglycan triggers CXCL13 expression via TLR2/4 in macrophages and dendritic cells. In vivo, levels of biglycan were markedly elevated in the plasma and kidneys of human SLE patients and lupus-prone (MRL/lpr) mice. Overexpression of soluble biglycan in MRL/lpr mice raised plasma and renal levels of CXCL13 and caused accumulation of B cells with an enhanced B1/B cell ratio in the kidney, worsening of organ damage, and albuminuria. Importantly, biglycan also triggered CXCL13 expression and B cell infiltration in the healthy kidney. Conversely, biglycan deficiency improved systemic and renal outcome in lupus-prone mice, with lower levels of autoantibodies, less enlargement of the spleen and lymph nodes, and reduction in renal damage and albuminuria. This correlated with a marked decline in circulating and renal CXCL13 and a reduction in the number of B cells in the kidney. Collectively, our results describe what we believe to be a novel mechanism for the regulation of CXCL13 by biglycan, a host-derived ligand for TLR2/4. Blocking biglycan-TLR2/4 interactions might be a promising strategy for the management of SLE and other B cell-mediated inflammatory disease entities.
    MeSH term(s) Adolescent ; Adult ; Animals ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; Biglycan/blood ; Biglycan/deficiency ; Biglycan/genetics ; Biglycan/metabolism ; Case-Control Studies ; Chemokine CXCL13/blood ; Chemokine CXCL13/metabolism ; Chemokines/blood ; Cytokines/blood ; Diabetic Nephropathies/immunology ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Female ; Graft Rejection/immunology ; Graft Rejection/pathology ; Humans ; Kidney/immunology ; Kidney/metabolism ; Kidney/pathology ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/metabolism ; Lupus Erythematosus, Systemic/pathology ; Lupus Nephritis/immunology ; Lupus Nephritis/metabolism ; Lupus Nephritis/pathology ; Macrophages/immunology ; Macrophages/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred MRL lpr ; Mice, Inbred NZB ; Mice, Knockout ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; Toll-Like Receptor 2/metabolism ; Toll-Like Receptor 4/metabolism ; Young Adult
    Chemical Substances BGN protein, human ; Bgn protein, mouse ; Biglycan ; CXCL13 protein, human ; Chemokine CXCL13 ; Chemokines ; Cxcl13 protein, mouse ; Cytokines ; Tlr2 protein, mouse ; Tlr4 protein, mouse ; Toll-Like Receptor 2 ; Toll-Like Receptor 4
    Language English
    Publishing date 2010-11-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI42213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.184: Show issues Location:
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