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  1. Article: Acute compartment syndrome of the leg caused by cocaine use, creatine supplementation and vigorous exercise.

    Robles, Emilio L / Pache, Killian M / Gluck, Joshua S

    Journal of surgical case reports

    2022  Volume 2022, Issue 11, Page(s) rjac502

    Abstract: Delayed diagnosis of acute compartment syndrome (ACS) can be catastrophic. Reporting abnormal presentations to facilitate timely diagnosis and treatment is vital. We present a case of ACS in the deep posterior compartment of the leg with an unusual ... ...

    Abstract Delayed diagnosis of acute compartment syndrome (ACS) can be catastrophic. Reporting abnormal presentations to facilitate timely diagnosis and treatment is vital. We present a case of ACS in the deep posterior compartment of the leg with an unusual presentation and cause. The patient presented to the emergency department complaining of numbness on the plantar aspect of his left foot, and described a history of cocaine use, increased exercise and creatine supplementation. The patient was diagnosed with acute deep posterior compartment syndrome of the left leg and underwent a lower extremity fasciotomy. There are case reports demonstrating that strenuous activity, drug use and creatine supplementation cause increased compartment pressures and ACS. Rare in the literature is a case where these activities occur concurrently with the abnormal presentation of symptoms seen in this case. We hope this case brings awareness of atraumatic risk factors and uncommon presentations to the medical community.
    Language English
    Publishing date 2022-11-03
    Publishing country England
    Document type Case Reports
    ZDB-ID 2580919-2
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjac502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The clinical significance of cervical tears' anatomical location - A retrospective study.

    Gluck, Ohad / David, Maayan / Kovo, Michal / Mor, Liat / Kleiner, Ilia / Weiner, Eran / Ginath, Shimon

    European journal of obstetrics, gynecology, and reproductive biology

    2024  Volume 295, Page(s) 215–218

    Abstract: Objective: Up to 4.8% of all vaginal deliveries are complicated by significant cervical tears related to maternal compromise, yet the location of the cervical tear and its impact on the attributed risk have not been studied to date. This study aimed to ... ...

    Abstract Objective: Up to 4.8% of all vaginal deliveries are complicated by significant cervical tears related to maternal compromise, yet the location of the cervical tear and its impact on the attributed risk have not been studied to date. This study aimed to determine the associations between the location and characteristics of cervical tears with short-term maternal complications and outcomes.
    Methods: This is a retrospective cohort study. Included were all patients that delivered vaginally at our institute between the years 2009-2020 and were diagnosed with a cervical tear. Maternal complications were compared between cases with posterior cervical tears and cases with anterior or lateral cervical tears. Exclusion criteria included patients who delivered by cesarean delivery and preterm labor below 37.0 weeks of gestation.
    Results: Overall, 96 patients were diagnosed with posterior cervical tears, while 117 patients were diagnosed with anterior or lateral tears. Maternal demographics and pregnancy characteristics were similar between the groups. There were also no differences in delivery outcomes between the groups. Patients with posterior cervical tears had a higher rate of disseminated intravascular coagulation (DIC) (6.25 % vs. 0.9 %, p = 0.04) and prolonged hospitalization (35.4 % vs. 23.1 %, p = 0.05), as compared to patients with anterior or lateral tears. There were no differences in other maternal complications.
    Conclusions: Cases of posterior cervical tears are at higher risk for maternal adverse outcomes (DIC and prolonged hospitalization), as compared to cases of anterior or lateral tears.
    MeSH term(s) Pregnancy ; Infant, Newborn ; Female ; Humans ; Retrospective Studies ; Clinical Relevance ; Delivery, Obstetric/adverse effects ; Cesarean Section
    Language English
    Publishing date 2024-02-10
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2024.02.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cortex-wide transcranial localization microscopy with fluorescently labeled red blood cells.

    Zhou, Quanyu / Glück, Chaim / Tang, Lin / Glandorf, Lukas / Droux, Jeanne / El Amki, Mohamad / Wegener, Susanne / Weber, Bruno / Razansky, Daniel / Chen, Zhenyue

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 3526

    Abstract: ... functional cerebral angiography with 4.9 µm spatial resolution and 1 s temporal resolution. When combined ...

    Abstract Large-scale imaging of brain activity with high spatio-temporal resolution is crucial for advancing our understanding of brain function. The existing neuroimaging techniques are largely limited by restricted field of view, slow imaging speed, or otherwise do not have the adequate spatial resolution to capture brain activities on a capillary and cellular level. To address these limitations, we introduce fluorescence localization microscopy aided with sparsely-labeled red blood cells for cortex-wide morphological and functional cerebral angiography with 4.9 µm spatial resolution and 1 s temporal resolution. When combined with fluorescence calcium imaging, the proposed method enables extended recordings of stimulus-evoked neuro-vascular changes in the murine brain while providing simultaneous multiparametric readings of intracellular neuronal activity, blood flow velocity/direction/volume, and vessel diameter. Owing to its simplicity and versatility, the proposed approach will become an invaluable tool for deciphering the regulation of cortical microcirculation and neurovascular coupling in health and disease.
    MeSH term(s) Animals ; Erythrocytes/metabolism ; Erythrocytes/cytology ; Microscopy, Fluorescence/methods ; Mice ; Cerebral Cortex/blood supply ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/metabolism ; Male ; Mice, Inbred C57BL ; Cerebral Angiography/methods ; Calcium/metabolism ; Cerebrovascular Circulation/physiology ; Fluorescent Dyes/chemistry ; Neurovascular Coupling/physiology ; Neurons/metabolism ; Neurons/physiology ; Microcirculation
    Chemical Substances Calcium (SY7Q814VUP) ; Fluorescent Dyes
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-47892-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recordings in an integrating central neuron provide a quick way for identifying appropriate anaesthetic use in fish.

    Machnik, Peter / Schirmer, Elisabeth / Glück, Laura / Schuster, Stefan

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 17541

    Abstract: In animal husbandry, livestock industry and research facilities, anaesthetic agents are frequently used to moderate stressful intervention. For mammals and birds, procedures have been established to fine-tune anaesthesia according to the intervention. In ...

    Abstract In animal husbandry, livestock industry and research facilities, anaesthetic agents are frequently used to moderate stressful intervention. For mammals and birds, procedures have been established to fine-tune anaesthesia according to the intervention. In ectothermic vertebrates, however, and despite changes in legislation and growing evidence on their cognitive abilities, the presently available information is insufficient to make similarly informed decisions. Here we suggest a straightforward way for rapidly filling this gap. By recording from a command neuron in the brain of fish whose crucial role requires it to integrate and process information from all sensory systems and to relay it to motor output pathways, the specific effects of candidate anaesthesia on central processing of sensory information can directly and efficiently be probed. Our approach allows a rapid and reliable way of deciding if and at which concentration a given anaesthetic affects the central nervous system and sensory processing. We employ our method to four anaesthetics commonly used in fish and demonstrate that our method quickly and with small numbers of animals provides the critical data for informed decisions on anaesthetic use.
    MeSH term(s) Anesthetics/pharmacology ; Animals ; Brain/metabolism ; Goldfish/physiology ; Neurons/metabolism ; Synaptic Transmission/drug effects
    Chemical Substances Anesthetics
    Language English
    Publishing date 2018-12-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-36130-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pre-hospital emergency anaesthesia in trauma patients: An observational study from a state-wide Australian pre-hospital and retrieval service.

    Maclure, Paul / Gluck, Samuel / Kerin, Kate / Boyle, Laura / Ellis, Daniel

    Emergency medicine Australasia : EMA

    2022  Volume 34, Issue 5, Page(s) 711–716

    Abstract: Objective: To assess the performance of an Australian pre-hospital and retrieval medicine (PHRM) service against the National Institute for Health and Care Excellence (NICE) standard which recommends that pre-hospital emergency anaesthesia (PHEA) in ... ...

    Abstract Objective: To assess the performance of an Australian pre-hospital and retrieval medicine (PHRM) service against the National Institute for Health and Care Excellence (NICE) standard which recommends that pre-hospital emergency anaesthesia (PHEA) in trauma patients should be conducted within 45-min of first contact with emergency services.
    Methods: Retrospective observational study of all adult trauma patients in which PHEA was conducted by the PHRM service covering a 5-year period from January 2015 to December 2019.
    Results: Over the 5-year study period, 1509 (22%) of the PHRM service workload comprised primary retrievals from scene. Most 1346 (89%) of these cases had a primary diagnosis of trauma. Of these we have complete data for 328 of the 337 cases requiring a PHEA and 121 (37%) patients received this within the recommended 45-min time frame. The service attended in rapid response vehicles (n = 160, 49%), rotary wing (n = 151, 46%) and fixed wing (n = 17, 5%) transport modalities. For a service covering 983 482 km
    Conclusions: In a cohort of 337 patients treated by a dedicated PHRM service in South Australia, the median time to PHEA was 54 (38-80) min with only 37% of patients receiving PHEA within 45 min from the activation of the team. Despite differing patient demographics, the percentage of patients receiving PHEA within the recommended time frame was greater than a similar cohort from the UK. However, both data sets still fall short of recommended targets.
    MeSH term(s) Adult ; Anesthesia ; Australia ; Emergency Medical Services ; Hospitals ; Humans ; Polyhydroxyethyl Methacrylate/analogs & derivatives ; Retrospective Studies
    Chemical Substances Polyhydroxyethyl Methacrylate (25249-16-5) ; poly(2-hydroxyethyl acrylate) (26022-14-0)
    Language English
    Publishing date 2022-03-30
    Publishing country Australia
    Document type Journal Article ; Observational Study
    ZDB-ID 2161824-0
    ISSN 1742-6723 ; 1742-6731 ; 1035-6851
    ISSN (online) 1742-6723
    ISSN 1742-6731 ; 1035-6851
    DOI 10.1111/1742-6723.13969
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  6. Article ; Online: Wie erleben Nutzer*innen die Versorgung? Vom Mehrwert partizipativ-kollaborativer Forschung.

    von Peter, Sebastian / Glück, Rosa / Göppert, Lena / Ziegenhagen, Jenny / Krispin, Helene / Jänchen, Patrick / Beeker, Timo

    Psychiatrische Praxis

    2022  Volume 49, Issue 1, Page(s) 8–10

    Title translation How do Users Experience Psychiatric Care? The Value of Participatory-Collaborative Research.
    MeSH term(s) Germany ; Humans ; Psychotherapy
    Language German
    Publishing date 2022-01-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124981-2
    ISSN 1439-0876 ; 0303-4259
    ISSN (online) 1439-0876
    ISSN 0303-4259
    DOI 10.1055/a-1695-6019
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  7. Article ; Online: Distinct signatures of calcium activity in brain mural cells.

    Glück, Chaim / Ferrari, Kim David / Binini, Noemi / Keller, Annika / Saab, Aiman S / Stobart, Jillian L / Weber, Bruno

    eLife

    2021  Volume 10

    Abstract: Pericytes have been implicated in various neuropathologies, yet little is known about their function and signaling pathways in health. Here, we characterized calcium dynamics of cortical mural cells in anesthetized or ... ...

    Abstract Pericytes have been implicated in various neuropathologies, yet little is known about their function and signaling pathways in health. Here, we characterized calcium dynamics of cortical mural cells in anesthetized or awake
    MeSH term(s) Animals ; Brain/metabolism ; Brain/pathology ; Calcium/metabolism ; Calcium Signaling/physiology ; Capillaries/metabolism ; Female ; Male ; Mice ; Muscle, Smooth, Vascular/diagnostic imaging ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/metabolism ; Pericytes/cytology ; Pericytes/physiology ; Receptor, Platelet-Derived Growth Factor beta/metabolism ; Vasoconstriction ; Veins/metabolism
    Chemical Substances Receptor, Platelet-Derived Growth Factor beta (EC 2.7.10.1) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-07-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.70591
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  8. Article ; Online: SARS-CoV-2-directed antibodies persist for more than six months in a cohort with mild to moderate COVID-19.

    Glück, Vivian / Grobecker, Sonja / Tydykov, Leonid / Salzberger, Bernd / Glück, Thomas / Weidlich, Tanja / Bertok, Manuela / Gottwald, Christine / Wenzel, Jürgen J / Gessner, André / Schmidt, Barbara / Peterhoff, David

    Infection

    2021  Volume 49, Issue 4, Page(s) 739–746

    Abstract: ... parameters and severity of disease.: Methods: Anti-SARS-CoV-2 S protein-specific IgG, IgA and IgM ...

    Abstract Objective: To follow serological immune responses of front-line healthcare workers after PCR-confirmed COVID-19 for a mean of 30 weeks, describe the time-course of SARS-CoV-2 spike protein-specific IgG, IgA and IgM levels and to identify associations of the immune response with symptoms, demographic parameters and severity of disease.
    Methods: Anti-SARS-CoV-2 S protein-specific IgG, IgA and IgM antibodies were measured at three time points during the 30-week follow-up. COVID-19-specific symptoms were assessed with standardized questionnaires.
    Results: 95% of the participants mounted an IgG response with only modest decline after week 12. IgG-type antibodies were still detectable in almost 90% of the subjects at 30 weeks. IgA and IgM responses were less robust and antibody titers decreased more rapidly. At 30 weeks, only 25% still had detectable IgA-type and none had IgM-type antibodies. Higher age and higher disease severity were independently associated with higher IgG antibody levels, albeit with wide variations.
    Conclusion: Serological immune responses after COVID-19 show considerable inter-individual variability, but show an association with increasing age and higher severity of disease. IgG-type anti-SARS-CoV-2 antibodies remain positive in 90% of the individuals 30 weeks after onset of symptoms.
    MeSH term(s) Adolescent ; Adult ; Algorithms ; Antibodies, Viral/blood ; COVID-19/immunology ; Cohort Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunoglobulin A/blood ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Male ; Middle Aged ; SARS-CoV-2/immunology ; Severity of Illness Index ; Surveys and Questionnaires ; Time Factors ; Young Adult
    Chemical Substances Antibodies, Viral ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M
    Language English
    Publishing date 2021-03-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-021-01598-6
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  9. Article ; Online: Immunity after COVID-19 and vaccination: follow-up study over 1 year among medical personnel.

    Glück, Vivian / Grobecker, Sonja / Köstler, Josef / Tydykov, Leonid / Bertok, Manuela / Weidlich, Tanja / Gottwald, Christine / Salzberger, Bernd / Wagner, Ralf / Zeman, Florian / Koller, Michael / Gessner, André / Schmidt, Barbara / Glück, Thomas / Peterhoff, David

    Infection

    2021  Volume 50, Issue 2, Page(s) 439–446

    Abstract: Background: The long-term course of immunity among individuals with a history of COVID-19, in particular among those who received a booster vaccination, has not been well defined so far.: Methods: SARS-CoV-2-specific antibody levels were measured by ... ...

    Abstract Background: The long-term course of immunity among individuals with a history of COVID-19, in particular among those who received a booster vaccination, has not been well defined so far.
    Methods: SARS-CoV-2-specific antibody levels were measured by ELISA over 1 year among 136 health care workers infected during the first COVID-19 wave and in a subgroup after booster vaccination approximately 1 year later. Furthermore, spike-protein-reactive memory T cells were quantified approximately 7 months after the infection and after booster vaccination. Thirty healthy individuals without history of COVID-19 who were routinely vaccinated served as controls.
    Results: Levels of SARS-CoV-2-specific IgM- and IgA-antibodies showed a rapid decay over time, whereas IgG-antibody levels decreased more slowly. Among individuals with history of COVID-19, booster vaccination induced very high IgG- and to a lesser degree IgA-antibodies. Antibody levels were significantly higher after booster vaccination than after recovery from COVID-19. After vaccination with a two-dose schedule, healthy control subjects developed similar antibody levels as compared to individuals with history of COVID-19 and booster vaccination. SARS-CoV-2-specific memory T cell counts did not correlate with antibody levels. None of the study participants suffered from a reinfection.
    Conclusions: Booster vaccination induces high antibody levels in individuals with a history of COVID-19 that exceeds by far levels observed after recovery. SARS-CoV-2-specific antibody levels of similar magnitude were achieved in healthy, COVID-19-naïve individuals after routine two-dose vaccination.
    MeSH term(s) Antibodies, Viral ; COVID-19/prevention & control ; Follow-Up Studies ; Humans ; SARS-CoV-2 ; Vaccination
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2021-09-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-021-01703-9
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  10. Article ; Online: cGAS-STING drives ageing-related inflammation and neurodegeneration.

    Gulen, Muhammet F / Samson, Natasha / Keller, Alexander / Schwabenland, Marius / Liu, Chong / Glück, Selene / Thacker, Vivek V / Favre, Lucie / Mangeat, Bastien / Kroese, Lona J / Krimpenfort, Paul / Prinz, Marco / Ablasser, Andrea

    Nature

    2023  Volume 620, Issue 7973, Page(s) 374–380

    Abstract: Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated impairment and ... ...

    Abstract Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated impairment and disease
    MeSH term(s) Animals ; Humans ; Mice ; Aging/metabolism ; Aging/pathology ; Brain/metabolism ; Brain/pathology ; Bystander Effect ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/pathology ; DNA/immunology ; Inflammation/enzymology ; Inflammation/metabolism ; Membrane Proteins/metabolism ; Memory Disorders/enzymology ; Memory Disorders/metabolism ; Microglia/metabolism ; Mitochondria/metabolism ; Neurodegenerative Diseases/enzymology ; Neurodegenerative Diseases/metabolism ; Nucleotidyltransferases/metabolism ; Organ Specificity ; Signal Transduction ; Hippocampus/metabolism ; Hippocampus/pathology
    Chemical Substances cGAS protein, human (EC 2.7.7.-) ; cGAS protein, mouse (EC 2.7.7.-) ; DNA (9007-49-2) ; Membrane Proteins ; Nucleotidyltransferases (EC 2.7.7.-) ; STING1 protein, human ; Sting1 protein, mouse
    Language English
    Publishing date 2023-08-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06373-1
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