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Article ; Online: The actual burden of obesity-accounting for multimorbidity.

Tsur, Avishai M / Twig, Gilad

The lancet. Diabetes & endocrinology

2022 Volume 10, Issue 4, Page(s) 233–234

MeSH term(s)	Chronic Disease ; Humans ; Multimorbidity ; Obesity/epidemiology
Language	English
Publishing date	2022-03-03
Publishing country	England
Document type	Journal Article ; Comment
ISSN	2213-8595
ISSN (online)	2213-8595
DOI	10.1016/S2213-8587(22)00073-0
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Article ; Online: The existence of a bidirectional link between ischemic heart disease and fibromyalgia.

Mansour, Mahmoud / Ehrenberg, Scott / Mahroum, Naim / Tsur, Avishai M / Fisher, Lior / Amital, Howard

Coronary artery disease

2024 Volume 35, Issue 2, Page(s) 99–104

Abstract: Study objectives: Fibromyalgia (FM) is one of the most common causes of chronic widespread musculoskeletal pain, but also sleep disturbances, cognitive and psychological disorders. It has been suggested that FM may have a correlation with cardiovascular ...

Abstract	Study objectives: Fibromyalgia (FM) is one of the most common causes of chronic widespread musculoskeletal pain, but also sleep disturbances, cognitive and psychological disorders. It has been suggested that FM may have a correlation with cardiovascular events. In this study, we aimed to assess the association between FM and ischemic heart disease (IHD). Methods: A population-based cross-sectional study was conducted utilizing data retrieved from the largest medical records database in Israel, Clalit Health Services. Patients were defined as having FM or IHD when there were at least two such documented diagnoses in their medical records. The occurrence of IHD was compared between FM and age- and sex-frequency-matched healthy controls. A logistic regression model was used to estimate this association following an adjustment for conventional cardiovascular risk factors and depression. Results: An overall population of 18 598 FM patients and 36 985 age- and gender-matched controls were included in the study. The proportion of IHD amongst FM patients was increased in comparison to controls (9.2% and 6.2%, respectively; P < 0.001). Furthermore, FM demonstrated an independent association with IHD on multivariate analysis (odds ratio [OR], 1.43; 95% confidence intervals [CI], 1.33-1.54; P < 0.0001). Finally, IHD was also found to be independently associated with the diagnosis of FM (OR, 1.40; CI, 1.31-1.51; P < 0.0001). Conclusion: Our data suggest a bidirectional link between FM and IHD even after the adjustment for conventional cardiovascular risk factors. These findings should be considered when treating patients with either FM or IHD, and their routine interactional screening may be of clinical importance.
MeSH term(s)	Humans ; Fibromyalgia/diagnosis ; Fibromyalgia/epidemiology ; Fibromyalgia/complications ; Risk Factors ; Cross-Sectional Studies ; Myocardial Ischemia/diagnosis ; Myocardial Ischemia/epidemiology ; Myocardial Ischemia/complications ; Heart Disease Risk Factors
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1047268-x
ISSN	1473-5830 ; 0954-6928
ISSN (online)	1473-5830
ISSN	0954-6928
DOI	10.1097/MCA.0000000000001329
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Zs.A 3039: Show issues

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Article: Distance Learning in the Field of Medicine: Hope or Hype?

Tsur, Avishai M / Ziv, Amitai / Amital, Howard

The Israel Medical Association journal : IMAJ

2021 Volume 23, Issue 7, Page(s) 447–448

MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; Curriculum/trends ; Education, Distance/methods ; Education, Distance/organization & administration ; Education, Medical/organization & administration ; Education, Medical/trends ; Humans ; Israel ; Psychology, Educational ; SARS-CoV-2 ; Teaching/psychology ; Teaching/standards ; Telemedicine/methods
Language	English
Publishing date	2021-07-12
Publishing country	Israel
Document type	Editorial
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Zs.A 5470: Show issues

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Article ; Online: Hemorrhagic Shock in Isolated and Non-Isolated Pelvic Fractures: A Registries-Based Study.

Gottfried, Amir / Gendler, Sami / Chayen, David / Radomislensky, Irina / Mitchnik, Ilan Y / Epshtein, Elad / Tsur, Avishai M / Almog, Ofer / Talmy, Tomer

Prehospital emergency care

2024 Volume 28, Issue 4, Page(s) 589–597

Abstract: Background: Pelvic fractures resulting from high-energy trauma can frequently present with life-threatening hemodynamic instability that is associated with high mortality rates. The role of pelvic exsanguination in causing hemorrhagic shock is unclear, ... ...

Abstract	Background: Pelvic fractures resulting from high-energy trauma can frequently present with life-threatening hemodynamic instability that is associated with high mortality rates. The role of pelvic exsanguination in causing hemorrhagic shock is unclear, as associated injuries frequently accompany pelvic fractures. This study aims to compare the incidence of hemorrhagic shock and in-hospital outcomes in patients with isolated and non-isolated pelvic fractures. Methods: Registries-based study of trauma patients hospitalized following pelvic fractures. Data from 1997 to 2021 were cross-referenced between the Israel Defense Forces Trauma Registry (IDF-TR), documenting prehospital care, and Israel National Trauma Registry (INTR) recording hospitalization data. Patients with isolated pelvic fractures were defined as having an Abbreviated Injury Scale (AIS) <3 in other anatomical regions, and compared with patients sustaining pelvic fracture and at least one associated injury (AIS ≥ 3). Signs of profound shock upon emergency department (ED) arrival were defined as either a systolic blood pressure <90 mmHg and/or a heart rate >130 beats per min. Results: Overall, 244 hospitalized trauma patients with pelvic fractures were included, most of whom were males (84.4%) with a median age of 21 years. The most common injury mechanisms were motor vehicle collisions (64.8%), falls from height (13.1%) and gunshot wounds (11.5%). Of these, 68 (27.9%) patients sustained isolated pelvic fractures. In patients with non-isolated fractures, the most common regions with a severe associated injury were the thorax and abdomen. Signs of shock were recorded for 50 (20.5%) patients upon ED arrival, but only four of these had isolated pelvic fractures. In-hospital mortality occurred among 18 (7.4%) patients, all with non-isolated fractures. Conclusion: In young patients with pelvic fractures, severe associated injuries were common, but isolated pelvic fractures rarely presented with profound shock upon arrival. Prehospital management protocols for pelvic fractures should prioritize prompt evacuation and resuscitative measures aimed at addressing associated injuries.
MeSH term(s)	Humans ; Shock, Hemorrhagic/etiology ; Shock, Hemorrhagic/epidemiology ; Registries ; Male ; Female ; Pelvic Bones/injuries ; Israel/epidemiology ; Adult ; Fractures, Bone/epidemiology ; Middle Aged ; Emergency Medical Services/statistics & numerical data ; Incidence ; Adolescent ; Young Adult ; Abbreviated Injury Scale ; Injury Severity Score
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1461751-1
ISSN	1545-0066 ; 1090-3127
ISSN (online)	1545-0066
ISSN	1090-3127
DOI	10.1080/10903127.2024.2322014
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Zs.A 4762: Show issues

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Article ; Online: The risk of osteoporosis in patients with ankylosing spondylitis-A large retrospective matched cohort study.

Sharif, Kassem / Tsur, Avishai M / Ben-Shabat, Niv / Watad, Abdulla / Cohen, Arnon D / Amital, Howard

Medicina clinica

2023 Volume 160, Issue 9, Page(s) 373–378

Abstract: Background: Ankylosing spondylitis (AS) is associated with increased bone turnover and systemic inflammation. Osteoporosis is common but frequently underappreciated in AS, studies regarding the incidence of osteoporosis in AS are limited and based on ... ...

Abstract	Background: Ankylosing spondylitis (AS) is associated with increased bone turnover and systemic inflammation. Osteoporosis is common but frequently underappreciated in AS, studies regarding the incidence of osteoporosis in AS are limited and based on small cohorts. The aim of this study is to assess the risk of osteoporosis in patients with AS compared to matched controls. Methods: A population based retrospective cohort study using data retrieved from a large electronic medical record in Israel, the Clalit health services. Included patients that were diagnosed with AS from January 2002 to December 2018 were followed for development of osteoporosis. The incidence of osteoporosis was compared between AS and controls and a logistic regression model was used to assess the interaction between AS and osteoporosis. Results: The study included 5476 AS patients, and 27,657 age- and sex-frequency matched controls. The incidence of osteoporosis in AS patients was significantly higher than controls (4.7% vs 2.8%, p<0.001) in the whole cohort as well as when stratified by sex. Osteoporosis developed earlier in patients with AS versus controls (4.1 vs 5.2 years, p<0.001). In multivariate analysis and after adjustment to several potential confounders, AS was found to independently associated with osteoporosis (HR 1.83, 95%CI 1.58-2.11, p<0.0001). Conclusions: Our study confirms the higher incidence and earlier development of osteoporosis in patients with AS. Such finding highlights the increased need of awareness and earlier detection of such comorbidity allowing prompt treatment to prevent undesired sequalae including increased risk of fractures.
MeSH term(s)	Humans ; Spondylitis, Ankylosing/complications ; Spondylitis, Ankylosing/epidemiology ; Spondylitis, Ankylosing/diagnosis ; Retrospective Studies ; Cohort Studies ; Osteoporosis/epidemiology ; Osteoporosis/etiology ; Osteoporosis/diagnosis ; Fractures, Bone ; Risk Factors
Language	Spanish
Publishing date	2023-01-23
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2022.10.013
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Ua VI Zs.279: Show issues

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Article ; Online: Palpitation in women with silicone breast implants: association with autoantibodies against autonomic nervous system.

Elroy, Tal / Halpert, Gilad / Tsur, Avishai M / Heidecke, Harald / Amital, Howard / Shoenfeld, Yehuda

Immunologic research

2023 Volume 72, Issue 1, Page(s) 155–161

Abstract: We explored a possible association between palpitation manifestation in women with silicone breast implants (SBIs) with circulating level of autoantibodies directed against autonomic nervous system (ANS) receptors. The study was conducted in 93 women ... ...

Abstract	We explored a possible association between palpitation manifestation in women with silicone breast implants (SBIs) with circulating level of autoantibodies directed against autonomic nervous system (ANS) receptors. The study was conducted in 93 women with SBIs who arrived to our clinic with diverse symptoms thought to be associated with their implants. Titers of 11 various autoantibodies were measured in the sera of women with SBIs who experienced palpitations (Palpitations, n = 47), did not experience palpitations (Non, n = 46), and healthy women (Control, n = 36). A significant reduction in anti-α2-adrenergic receptor (A2AR, P = 0.035), anti-β2-adrenergic receptor (B2AR, P = 0.027), antimuscarinic receptors M1R (P = 0.048), and anti-M2R (P = 0.039) autoantibodies was found in the 'Palpitations' group as compared with the 'Non' group. Anti-B2AR (P = 0.042), anti-M1R (P = 0.017), and anti-M2R (P = 0.0015) autoantibodies were also significantly reduced in 'Palpitations' as compared with the 'Control' group. Our study shows possible association between autoantibodies directed against ANS receptors, with existing complaints of palpitations in women with SBIs.
MeSH term(s)	Humans ; Female ; Autoantibodies ; Breast Implants/adverse effects ; Silicones ; Receptors, Adrenergic
Chemical Substances	Autoantibodies ; Silicones ; Receptors, Adrenergic
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	632857-x
ISSN	1559-0755 ; 0257-277X
ISSN (online)	1559-0755
ISSN	0257-277X
DOI	10.1007/s12026-023-09425-w
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Zs.A 1755: Show issues

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Article: Predictors of Short-Term Trauma Laparotomy Outcomes in an Integrated Military-Civilian Health System: A 23-Year Retrospective Cohort Study.

Gendler, Sami / Gelikas, Shaul / Talmy, Tomer / Nadler, Roy / Tsur, Avishai M / Radomislensky, Irina / Bodas, Moran / Glassberg, Elon / Almog, Ofer / Benov, Avi / Chen, Jacob

Journal of clinical medicine

2024 Volume 13, Issue 7

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13071830
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Article ; Online: Adolescent and Childhood Obesity and Excess Morbidity and Mortality in Young Adulthood-a Systematic Review.

Horesh, Adi / Tsur, Avishai M / Bardugo, Aya / Twig, Gilad

Current obesity reports

2021 Volume 10, Issue 3, Page(s) 301–310

Abstract: Purpose of review: Rates of childhood obesity have been soaring in recent decades. The association between obesity in adulthood and excess morbidity and mortality has been readily established, whereas the association of childhood and adolescent obesity ... ...

Abstract	Purpose of review: Rates of childhood obesity have been soaring in recent decades. The association between obesity in adulthood and excess morbidity and mortality has been readily established, whereas the association of childhood and adolescent obesity has not. The purpose of this review is to summarize existing data regarding the association of the presence of obesity in childhood/adolescence and early-onset adverse outcomes in adulthood, with specific focus on young adults under the age of 45 years. Recent findings: Diabetes, cancer, and cardiometabolic outcomes in midlife are closely linked to childhood and adolescent obesity. Childhood and adolescent obesity confer major risks of excess and premature morbidity and mortality, which may be evident before age 30 years in both sexes. The scientific literature is mixed regarding the independent risk of illness, which may be attributed to childhood BMI regardless of adult BMI, and additional data is required to establish causality between the two. Nonetheless, the increasing prevalence of childhood and adolescent obesity may impose an increase of disease burden in midlife, emphasizing the need for effective interventions to be implemented at a young age.
MeSH term(s)	Adolescent ; Adult ; Body Mass Index ; Child ; Diabetes Mellitus ; Female ; Humans ; Male ; Middle Aged ; Morbidity ; Pediatric Obesity/epidemiology ; Prevalence ; Risk Factors ; Young Adult
Language	English
Publishing date	2021-05-05
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ISSN	2162-4968
ISSN (online)	2162-4968
DOI	10.1007/s13679-021-00439-9
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Article: Isolated Versus Non-isolated Traumatic Brain Injuries Identification and Decision Making: A Comparative Study.

Bez, Maxim / Bez, Dana / Tsur, Avishai M / Nadler, Roy / Benov, Avi / Chen, Jacob

The Israel Medical Association journal : IMAJ

2022 Volume 24, Issue 9, Page(s) 574–578

Abstract: Background: Traumatic brain injury (TBI) is a significant cause of death in the battlefield. TBI can be challenging to diagnose in the combat setting and remains a substantial challenge for advanced life support (ALS) providers.: Objectives: To ... ...

Abstract	Background: Traumatic brain injury (TBI) is a significant cause of death in the battlefield. TBI can be challenging to diagnose in the combat setting and remains a substantial challenge for advanced life support (ALS) providers. Objectives: To compare prehospital and hospitalization characteristics between isolated and non-isolated TBI. To examine the effects of TBI with coexisting injuries on patient evaluation and outcomes based on the Israeli Defense Forces Trauma Registry and the Israeli National Trauma Registry of soldiers hospitalized for TBI between the years 2006-2017. Methods: A total of 885 casualties were eligible for our study, of whom 271 (30%) had isolated TBI. Only 35% of hospitalized patients with isolated TBI were defined as urgent by the ALS providers versus 67% in the non-isolated TBI group (P < 0.001). Results: Overall, 29% of the TBIs in the non-isolated group were missed by the ALS providers vs. 11% in the isolated group. Conclusions: Concomitant injuries may delay the diagnosis of TBI by ALS providers. These findings should be considered in the prehospital evaluation to potentially improve the care and outcome of head injury patients.
MeSH term(s)	Brain Injuries, Traumatic/diagnosis ; Brain Injuries, Traumatic/epidemiology ; Brain Injuries, Traumatic/therapy ; Decision Making ; Hospitalization ; Humans ; Military Personnel ; Registries
Language	English
Publishing date	2022-09-27
Publishing country	Israel
Document type	Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Zs.A 5470: Show issues

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Article: Intraosseous administration of freeze-dried plasma in the prehospital setting.

Rittblat, Mor / Gavish, Lilach / Tsur, Avishai M / Gelikas, Shaul / Benov, Avi / Shlaifer, Amir

The Israel Medical Association journal : IMAJ

2022 Volume 24, Issue 9, Page(s) 591–595

Abstract: Background: Freeze dried plasma (FDP) is a commonly used replacement fluid in the prehospital setting when blood products are unavailable. It is normally administered via a peripheral intravenous (PIV) line. However, in severe casualties, when ... ...

Abstract	Background: Freeze dried plasma (FDP) is a commonly used replacement fluid in the prehospital setting when blood products are unavailable. It is normally administered via a peripheral intravenous (PIV) line. However, in severe casualties, when establishing a PIV is difficult, administration via intraosseous vascular access is a practical alternative, particularly under field conditions. Objectives: To evaluate the indications and success rate of intraosseous administration of FDP in casualties treated by the Israel Defense Forces (IDF). Methods: A retrospective analysis of data from the IDF-Trauma Registry was conducted. It included all casualties treated with FDP via intraosseous from 2013 to 2019 with additional data on the technical aspects of deployment collected from the caregivers of each case. Results: Of 7223 casualties treated during the study period, intravascular access was attempted in 1744; intraosseous in 87 of those. FDP via intraosseous was attempted in 15 (0.86% of all casualties requiring intravascular access). The complication rate was 73% (11/15 of casualties). Complications were more frequent when the event included multiple casualties or when the injury included multiple organs. Of the 11 failed attempts, 5 were reported as due to slow flow of the FDP through the intraosseous apparatus. Complications in the remaining six were associated with deployment of the intraosseous device. Conclusions: Administration of FDP via intraosseous access in the field requires a high skill level.
MeSH term(s)	Emergency Medical Services ; Freeze Drying ; Humans ; Infusions, Intraosseous ; Plasma ; Retrospective Studies
Language	English
Publishing date	2022-09-28
Publishing country	Israel
Document type	Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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