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  1. Article: [No title information]

    Francioli, Patrick

    Revue medicale suisse

    2020  Volume 16, Issue 699, Page(s) 1334

    Title translation Aérosol et rôle des super-disséminateurs.
    MeSH term(s) Aerosols/analysis ; COVID-19 ; Humans
    Chemical Substances Aerosols
    Language French
    Publishing date 2020-07-10
    Publishing country Switzerland
    Document type News
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5998: Show issues Location:
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  2. Article: [No title information]

    Francioli, Patrick

    Revue medicale suisse

    2020  Volume 16, Issue 696, Page(s) 1178

    Title translation La parole, source d’aérosols potentiellement infectieux !
    MeSH term(s) Aerosols ; COVID-19 ; Communicable Diseases ; Humans ; Speech
    Chemical Substances Aerosols
    Language French
    Publishing date 2020-06-03
    Publishing country Switzerland
    Document type News
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5998: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article: [No title information]

    Francioli, Patrick

    Revue medicale suisse

    2020  Volume 16, Issue 692, Page(s) 970

    Title translation Masques contre le COVID : une évidence.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Humans ; Masks ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; Reproducibility of Results ; SARS-CoV-2
    Language French
    Publishing date 2020-05-06
    Publishing country Switzerland
    Document type News
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5998: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article: [No title information]

    Francioli, Patrick

    Revue medicale suisse

    2020  Volume 16, Issue 698, Page(s) 1274

    Title translation Distanciation sociale, masques, protection oculaire: comment prévenir la transmission interpersonnelle de SARS-CoV-2.
    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Eye Protective Devices ; Head Protective Devices ; Humans ; Masks ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Social Isolation
    Language French
    Publishing date 2020-06-16
    Publishing country Switzerland
    Document type News
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5998: Show issues Location:
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  6. Article ; Online: Variant Score Ranker-a web application for intuitive missense variant prioritization.

    Du, Juanjiangmeng / Sudarsanam, Monica / Pérez-Palma, Eduardo / Ganna, Andrea / Francioli, Laurent / Iqbal, Sumaiya / Niestroj, Lisa-Marie / Leu, Costin / Weisburd, Ben / Poterba, Tim / Nürnberg, Peter / Daly, Mark J / Palotie, Aarno / May, Patrick / Lal, Dennis

    Bioinformatics (Oxford, England)

    2020  Volume 35, Issue 21, Page(s) 4478–4479

    Abstract: Motivation: The correct classification of missense variants as benign or pathogenic remains challenging. Pathogenic variants are expected to have higher deleterious prediction scores than benign variants in the same gene. However, most of the existing ... ...

    Abstract Motivation: The correct classification of missense variants as benign or pathogenic remains challenging. Pathogenic variants are expected to have higher deleterious prediction scores than benign variants in the same gene. However, most of the existing variant annotation tools do not reference the score range of benign population variants on gene level.
    Results: We present a web-application, Variant Score Ranker, which enables users to rapidly annotate variants and perform gene-specific variant score ranking on the population level. We also provide an intuitive example of how gene- and population-calibrated variant ranking scores can improve epilepsy variant prioritization.
    Availability and implementation: http://vsranker.broadinstitute.org.
    Supplementary information: Supplementary data are available at Bioinformatics online.
    MeSH term(s) Mutation, Missense ; Software
    Language English
    Publishing date 2020-06-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btz252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Maladies infectieuses: regard sur une trajectoire.

    Francioli, Patrick / Lew, Daniel

    Revue medicale suisse

    2006  Volume 2, Issue 60, Page(s) 891–892

    Title translation Infectious disease: look over a trajectory.
    MeSH term(s) Communicable Diseases ; Forecasting ; Humans ; Public Health
    Language French
    Publishing date 2006-04-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5998: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Etat fébrile sans signes cliniques évidents: s'agit-il d'un sepsis? Peut-on déterminer son étiologie rapidement?

    Lew, Daniel / Francioli, Patrick

    Revue medicale suisse

    2005  Volume 1, Issue 13, Page(s) 867–868

    Title translation Febrile state without clinically evident signs: does it mean sepsis? Can one make a rapid determination?.
    MeSH term(s) Diagnosis, Differential ; Fever/etiology ; Humans ; Sepsis/complications ; Sepsis/diagnosis ; Time Factors
    Language French
    Publishing date 2005-03-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5998: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Established and emerging waterborne nosocomial infections.

    Merlani, Giorgio M / Francioli, Patrick

    Current opinion in infectious diseases

    2003  Volume 16, Issue 4, Page(s) 343–347

    Abstract: Purpose of review: To assess the recent advances in the field of waterborne nosocomial infections.: Recent findings: In the last year, many publications have confirmed the importance of well known nosocomial waterborne pathogens such as Legionella ... ...

    Abstract Purpose of review: To assess the recent advances in the field of waterborne nosocomial infections.
    Recent findings: In the last year, many publications have confirmed the importance of well known nosocomial waterborne pathogens such as Legionella spp. or other Gram-negative bacteria, especially non-fermentative bacilli. There have also been numerous reports of outbreaks or pseudo-outbreaks caused by Mycobacteria spp. The most intriguing information relates to the possibility that some fungi causing nosocomial infections may originate from the hospital water distribution system.
    Summary: Despite progress in understanding the pathogenesis of nosocomial waterborne infections, outbreaks, pseudo-outbreaks and sporadic infections still occur. Targeted quality control of hospital water, updated procedures for the appropriate use of sterile and non-sterile water, coupled with surveillance constitute the cornerstones of prevention of these infections.
    MeSH term(s) Communicable Diseases, Emerging/epidemiology ; Cross Infection/epidemiology ; Hospitals ; Humans ; Water Microbiology ; Water Supply
    Language English
    Publishing date 2003-07-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645085-4
    ISSN 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/00001432-200308000-00006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2462: Show issues Location:
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  10. Article ; Online: Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci.

    Lessard, Samuel / Francioli, Laurent / Alfoldi, Jessica / Tardif, Jean-Claude / Ellinor, Patrick T / MacArthur, Daniel G / Lettre, Guillaume / Orkin, Stuart H / Canver, Matthew C

    Proceedings of the National Academy of Sciences of the United States of America

    2017  Volume 114, Issue 52, Page(s) E11257–E11266

    Abstract: The CRISPR-Cas9 nuclease system holds enormous potential for therapeutic genome editing of a wide spectrum of diseases. Large efforts have been made to further understanding of on- and off-target activity to assist the design of CRISPR-based therapies ... ...

    Abstract The CRISPR-Cas9 nuclease system holds enormous potential for therapeutic genome editing of a wide spectrum of diseases. Large efforts have been made to further understanding of on- and off-target activity to assist the design of CRISPR-based therapies with optimized efficacy and safety. However, current efforts have largely focused on the reference genome or the genome of cell lines to evaluate guide RNA (gRNA) efficiency, safety, and toxicity. Here, we examine the effect of human genetic variation on both on- and off-target specificity. Specifically, we utilize 7,444 whole-genome sequences to examine the effect of variants on the targeting specificity of ∼3,000 gRNAs across 30 therapeutically implicated loci. We demonstrate that human genetic variation can alter the off-target landscape genome-wide including creating and destroying protospacer adjacent motifs (PAMs). Furthermore, single-nucleotide polymorphisms (SNPs) and insertions/deletions (indels) can result in altered on-target sites and novel potent off-target sites, which can predispose patients to treatment failure and adverse effects, respectively; however, these events are rare. Taken together, these data highlight the importance of considering individual genomes for therapeutic genome-editing applications for the design and evaluation of CRISPR-based therapies to minimize risk of treatment failure and/or adverse outcomes.
    MeSH term(s) CRISPR-Cas Systems ; Genetic Loci ; Genetic Therapy ; Humans ; Polymorphism, Single Nucleotide ; RNA, Guide, CRISPR-Cas Systems/genetics
    Chemical Substances RNA, Guide, CRISPR-Cas Systems
    Language English
    Publishing date 2017-12-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1714640114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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