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Article ; Online: Features of cardiovascular magnetic resonance native T1 mapping in maintenance hemodialysis patients and their related factors.

Zhang, Changqin / Yao, Lijing / Liu, Min / Zhou, Yilun

2024 Volume 46, Issue 1, Page(s) 2310078

Abstract: Purpose: Increased myocardial T1 values on cardiovascular MRI (CMRI) have been shown to be a surrogate marker for myocardial fibrosis. The use of CMRI in patients on hemodialysis (HD) remains limited. This research aimed to explore the characteristics ... ...

Abstract	Purpose: Increased myocardial T1 values on cardiovascular MRI (CMRI) have been shown to be a surrogate marker for myocardial fibrosis. The use of CMRI in patients on hemodialysis (HD) remains limited. This research aimed to explore the characteristics of native T1 values in HD patients and identify factors related to T1 values. Methods: A total of thirty-two patients on HD and fourteen healthy controls were included in this study. All participants underwent CMRI. Using modified Look-Locker inversion recovery (MOLLI) sequence, native T1 mapping was achieved. Native CMRI T1 values were compared between the two groups. In order to analyze the relationship between T1 values and clinical parameters, correlation analysis was performed in patients on HD. Results: Patients on HD exhibited elevated global native T1 values compared to control subjects. In the HD group, the global native T1 value correlated positively with intact parathyroid hormone (iPTH) ( Conclusion: The global native T1 value was prolonged in HD patients compared with controls. In the HD group, the global T1 value correlated strongly with iPTH, triglycerides, and cardiac structural and functional parameters.
MeSH term(s)	Humans ; Heart ; Magnetic Resonance Imaging ; Myocardium ; Renal Dialysis/adverse effects ; Magnetic Resonance Spectroscopy ; Triglycerides ; Predictive Value of Tests ; Ventricular Function, Left
Chemical Substances	Triglycerides
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2024.2310078
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Article ; Online: Numerical simulation of autoclaved aerated concrete masonry wall subjected to close-in explosion and the structural damage assessment.

Liu, Sheng / Xu, Xiangyun / Zhang, Yilun / Zhou, Bukui / Yang, Kezhi

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3928

Abstract: In this study, we investigated the destructive effect of autoclaved aerated concrete (AAC) masonry walls subjected to close-in explosions. First, full-size refined finite-element models of the AAC masonry wall were established, and the accuracy of the ... ...

Abstract	In this study, we investigated the destructive effect of autoclaved aerated concrete (AAC) masonry walls subjected to close-in explosions. First, full-size refined finite-element models of the AAC masonry wall were established, and the accuracy of the models was verified by comparison with the test results. The destruction pattern and damage characteristics of the AAC wall were studied, and the effects of block size, wall thickness, mortar compressive strength, and explosion distance on the destruction degree of the AAC masonry walls were analyzed. The results showed that the destruction pattern of the AAC masonry wall subjected to close-in explosion manifested as punching damage in the middle of the wall. When the scaled distance remained unchanged, the punching damage area of the AAC masonry wall was positively correlated with the block size and negatively correlated with the wall thickness and mortar compressive strength. When the explosive equivalent remained unchanged and the explosion distance increased, the punching damage area first increased and then decreased. According to the damage mechanism of the AAC masonry wall, a calculation method for predicting the punching damage area of the AAC masonry wall was established, and the accuracy of this method was verified by comparing it with the numerical results. In addition, the damage criterion based on the punching damage area was established to determine the destruction levels of AAC masonry walls.
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54690-w
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Article ; Online: Free iliac crest grafting technology for the management of critical-sized tibial bone defect.

Cheng, Xiaoqiang / Yao, Yilun / Liu, Kang / Wu, Lei / Yang, Wengbo

BMC musculoskeletal disorders

2024 Volume 25, Issue 1, Page(s) 201

Abstract: Objective: To introduce the method and experience of treating critical-sized tibial bone defect by taking large iliac crest bone graft.: Methods: From January 2020 to January 2022, iliac crest bone grafting was performed in 20 patients (10 men and 10 ...

Abstract	Objective: To introduce the method and experience of treating critical-sized tibial bone defect by taking large iliac crest bone graft. Methods: From January 2020 to January 2022, iliac crest bone grafting was performed in 20 patients (10 men and 10 women) with critical-sized tibial bone defect. The mean length of bone defect was 13.59 ± 3.41. Bilateral iliac crest grafts were harvested, including the inner and outer plates of the iliac crest and iliac spine. The cortical bone screw was used to integrate two iliac bone blocks into one complex. Locking plate was used to fix the graft-host complex, supplemented with reconstruction plate to increase stability when necessary. Bone healing was evaluated by cortical bone fusion on radiographs at follow-up, iliac pain was assessed by VAS score, and lower limb function was assessed by ODI score. Complications were also taken into consideration. Results: The average follow-up time was 27.4 ± 5.6 (Range 24-33 months), the mean VAS score was 8.8 ± 1.9, the mean ODI score was 11.1 ± 1.8, and the number of cortical bone fusion in the bone graft area was 3.5 ± 0.5. Satisfactory fusion was obtained in all cases of iliac bone transplant-host site. No nonunion, shift or fracture was found in all cases. No infection and bone resorption were observed that need secondary surgery. One patient had dorsiflexion weakness of the great toe. Hypoesthesia of the dorsal foot was observed in 2 patients. Ankle stiffness and edema occurred in 3 patients. Complications were significantly improved by physical therapy and rehabilitation training. Conclusion: For the cases of critical-sized tibial bone defect, the treatment methods are various. In this paper, we have obtained satisfactory results by using large iliac bone graft to treat bone defect. This approach can not only restore the integrity of the tibia, but also obtain good stability with internal fixation, and operation skills are more acceptable for surgeons. Therefore, it provides an alternative surgical method for clinicians.
MeSH term(s)	Male ; Humans ; Female ; Tibia/diagnostic imaging ; Tibia/surgery ; Ilium/transplantation ; Fractures, Bone ; Fracture Fixation, Internal ; Plastic Surgery Procedures ; Bone Transplantation/methods ; Treatment Outcome
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-024-07335-y
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Article ; Online: Enhanced interlayer adhesion of wetted graphene oxide by confined water bridge.

Zhao, Yanyan / Zhou, Ke / Liu, Yilun

The Journal of chemical physics

2023 Volume 159, Issue 2

Abstract: Graphene oxide (GO) sheets are widely used as building blocks in flexible electronic devices, structural materials, and energy storage technology owing to physicochemical flexibility and remarkable mechanical properties. GO exists as lamellar structures ... ...

Abstract	Graphene oxide (GO) sheets are widely used as building blocks in flexible electronic devices, structural materials, and energy storage technology owing to physicochemical flexibility and remarkable mechanical properties. GO exists as lamellar structures in these applications and, thus, it urges to enhance interface interaction to prevent interfacial failure. This study explores the adhesion of GO with and without intercalated water utilizing steered molecular dynamics (SMD) simulations. We find the interfacial adhesion energy (γ) depends on the synergistic effect of the types of functional groups, the degree of oxidation (c), and water content (wt). The intercalated monolayer water confined within GO flakes can improve the γ by more than 50% whereas the interlayer spacing is enlarged. The enhancement of adhesion is from the cooperative hydrogen bonding bridges between confined water and functional group on GO. Furthermore, the optimal water content wt = 20% and oxidation degree c = 20% are obtained. Our findings provide an experimentally available way to improve interlayer adhesion through molecular intercalation, which opens the possibility of high-performance laminate nanomaterial-based films for versatile applications.
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0155956
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Article ; Online: MicroRNA-3653-3p inhibited papillary thyroid carcinoma progression by regulating CRIPTO-1.

Bai, Xiaojun / Xu, Yanjun / Liu, Yilun

Cellular and molecular biology (Noisy-le-Grand, France)

2023 Volume 69, Issue 14, Page(s) 272–276

Abstract: Papillary thyroid carcinoma (PTC) is the most common endocrine malignant tumor and the metastasis of PTC often leads to unfavorable prognosis. Thus, the purpose of the current research was to mainly explore the role of miR-3653-3p in PTC progression. The ...

Abstract	Papillary thyroid carcinoma (PTC) is the most common endocrine malignant tumor and the metastasis of PTC often leads to unfavorable prognosis. Thus, the purpose of the current research was to mainly explore the role of miR-3653-3p in PTC progression. The expression level of miR-3653-3p in PTC was determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR), and Cell Counting Kit-8 (CCK-8) assay and colony formation assay were recruited to assess the ability of miR-3653-3p on cell proliferation. Next, transwell assay and Matrigel assay were involved to examine the ability of miR-3653-3p on cell migration and invasion. At last, Dual-Luciferase reporter assay and Western blotting were recruited to validate the down-stream target of miR-3653-3p. Results showed that miR-3653-3p was down-expressed in PTC, and upregulated miR-3653-3p inhibited cell proliferation, cell migration, and cell invasion in vitro. In addition, CRIPTO-1 was a downstream target of miR-3653-3p, and miR-3653-3p inhibited PTC progression via regulating CRIPTO-1. In sum, this research verifies that miR-3653-3p suppresses cell proliferation, migration, and invasion in PTC via regulating CRIPTO-1. These findings provide new insight into the underlying mechanism of PTC progression and may be useful in finding biomarkers and therapeutic targets of PTC.
MeSH term(s)	Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Thyroid Cancer, Papillary/genetics ; Thyroid Cancer, Papillary/pathology ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cell Movement/genetics ; Gene Expression Regulation, Neoplastic
Chemical Substances	MicroRNAs
Language	English
Publishing date	2023-12-20
Publishing country	France
Document type	Journal Article
ZDB-ID	1161779-2
ISSN	1165-158X ; 0145-5680
ISSN (online)	1165-158X
ISSN	0145-5680
DOI	10.14715/cmb/2023.69.14.45
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Article ; Online: Understanding the Human RECQ5 Helicase-Connecting the Dots from DNA to Clinics.

Mo, Chiefe / Shiozaki, Yukari / Omabe, Kenneth / Liu, Yilun

Cells

2023 Volume 12, Issue 16

Abstract: RECQ5, a member of the conserved RECQ helicase family, is the sole human RECQ homolog that has not been linked to a hereditary developmental syndrome. Nonetheless, dysregulation of RECQ5 has emerged as a significant clinical concern, being linked to ... ...

Abstract	RECQ5, a member of the conserved RECQ helicase family, is the sole human RECQ homolog that has not been linked to a hereditary developmental syndrome. Nonetheless, dysregulation of RECQ5 has emerged as a significant clinical concern, being linked to cancer predisposition, cardiovascular disease, and inflammation. In cells, RECQ5 assumes a crucial role in the regulation of DNA repair pathways, particularly in the repair of DNA double-strand breaks and inter-strand DNA crosslinks. Moreover, RECQ5 exhibits a capacity to modulate gene expression by interacting with transcription machineries and their co-regulatory proteins, thus safeguarding against transcription-induced DNA damage. This review aims to provide an overview of the multifaceted functions of RECQ5 and its implications in maintaining genomic stability. We will discuss the potential effects of clinical variants of RECQ5 on its cellular functions and their underlying mechanisms in the pathogenesis of cancer and cardiovascular disease. We will review the impact of RECQ5 variants in the field of pharmacogenomics, specifically their influence on drug responses, which may pave the way for novel therapeutic interventions targeting RECQ5 in human diseases.
MeSH term(s)	Humans ; Cardiovascular Diseases/genetics ; DNA ; RecQ Helicases/genetics ; DNA Breaks, Double-Stranded ; DNA Damage
Chemical Substances	DNA (9007-49-2) ; RecQ Helicases (EC 3.6.4.12)
Language	English
Publishing date	2023-08-10
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12162037
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Article ; Online: Quantifying the Structure of Water and Hydrated Monovalent Ions by Density Functional Theory-Based Molecular Dynamics.

Zhou, Ke / Qian, Chen / Liu, Yilun

The journal of physical chemistry. B

2022

Abstract: The accurate description of the structures of water and hydrated ions is important in electrochemical desalination, ion separation, and supercapacitors. In this work, we present an ab initio atomistic simulation-based study to explore the structure of ... ...

Abstract	The accurate description of the structures of water and hydrated ions is important in electrochemical desalination, ion separation, and supercapacitors. In this work, we present an ab initio atomistic simulation-based study to explore the structure of water and hydrated monovalent ions (Li
Language	English
Publishing date	2022-11-30
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.2c05330
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Article ; Online: Bone marrow mesenchymal stem cells suppress activated CD4

Zhang, Yan / Liu, Liang / Wang, Xiaobo / Shen, Xuezhen / Pei, Yilun / Liu, Yi

Biochemical and biophysical research communications

2024 Volume 702, Page(s) 149591

Abstract: Background: Bone marrow mesenchymal stem cells (BMSCs) mediated immunomodulation by secreting certain bioactive cytokines has been recognized as a promising approach for disease treatment. However, microenvironmental oxygen tension affect ... ...

Abstract	Background: Bone marrow mesenchymal stem cells (BMSCs) mediated immunomodulation by secreting certain bioactive cytokines has been recognized as a promising approach for disease treatment. However, microenvironmental oxygen tension affect immunomodulatory functions and activate autophagy in BMSCs. The mechanism governing BMSCs immunomodulation in hypoxia hasn't been expounded clearly. The aim of this study is to investigate the function of pathological hypoxia on immunomodulatory properties of bone marrow mesenchymal stem cells and its possible mechanism. Methods: BMSCs were cultured in either normoxia (21 % oxygen) or hypoxia (0.1 % oxygen) for 24 h, then electron microscopy (EM) and immunofluorescence staining were used to detect the activation of autophagy. Besides autophagy-related markers were monitored by Western blotting. Atg5 siRNA induced autophagic inhibition. Additional, gene expression levels of Real-time fluorescence quantitative PCR and Western blot were used to detect BMSCs related cytokines. Both the proliferation and apoptosis of CD4 Result: Compared with normal BMSCs, Hypo-BMSCs enhanced the immunosuppressive effect of BMSCs on CD4 Conclusions: Our findings reveal that BMSCs possess significant immunosuppression on CD4
MeSH term(s)	Humans ; Transforming Growth Factor beta/metabolism ; Interleukin-10/metabolism ; Cell Proliferation ; CD4-Positive T-Lymphocytes ; Hypoxia/metabolism ; Mesenchymal Stem Cells ; Autophagy ; Oxygen/metabolism ; Bone Marrow Cells
Chemical Substances	Transforming Growth Factor beta ; Interleukin-10 (130068-27-8) ; Oxygen (S88TT14065) ; IL10 protein, human
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2024.149591
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Article ; Online: Mapping of Spatial Distribution of Street Vendors Based on Street-View Images and Deep-Learning Technology

Liu Yuchen / Chen Xiaochun / Liu Yilun / Wu Xiaofang / Chen Feixiang

Redai dili, Vol 43, Iss 6, Pp 1098-

2023 Volume 1110

Abstract: Street vendors are an indispensable part of the urban social ecosystem, but due to a lack of comprehensive understanding, many cities have adopted simple eviction policies, resulting in the gradual marginalization and stigmatization of the street economy. ...

Abstract	Street vendors are an indispensable part of the urban social ecosystem, but due to a lack of comprehensive understanding, many cities have adopted simple eviction policies, resulting in the gradual marginalization and stigmatization of the street economy. The efficient governance of street vendors requires the comprehensive investigation of their business scale and spatial distribution information. However, traditional methods have limitations in terms of automatically surveying large-scale street vendor information, particularly spatial distribution. This paper proposes a method for the automatic investigation spatial distribution of street vendors based on street-view images and a deep-learning object recognition model. Street-view images were collected at fixed intervals according to the urban road network, and 1,957 images containing one or more vendors were selected through human-machine interaction to establish street vendor label data. To achieve high recognition model accuracy, the category labels were subdivided into four categories: ground stalls, table stalls, tricycle stalls, and small truck stalls, based on the goods carriers used by street vendors. A deep neural-network-based image object detection model based on YOLO v4 was constructed to identify street vendors in the street-view image library, with an average F1 value of 0.77 and an mAP of 0.67. The accuracy of the model was satisfactory for investigating the number and location of street vendors covering the main roads in the city and then applying a kernel density distribution model to evaluate the spatial distribution pattern of street vendors. Using street vendors in Guangzhou as a case study, the proposed automatic investigation model identified 26,119 street vendors from 3,339,062 street-view images. The results showed that the street vendors were distributed in a multicenter aggregation pattern in the central urban area, mainly concentrated in areas with high pedestrian traffic, such as subway stations and urban villages; their numbers ...
Keywords	informal economy ; street vendor ; street-view image ; deep learning ; yolo deep neural network ; guangzhou ; Geography (General) ; G1-922
Subject code	600
Language	Chinese
Publishing date	2023-06-01T00:00:00Z
Publisher	Editorial Committee of Tropical Geography
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: EEPD1: Breaking and Rescuing the Replication Fork.

Liu, Yilun

PLoS genetics

2016 Volume 12, Issue 2, Page(s) e1005742

MeSH term(s)	DNA Helicases/genetics ; Endodeoxyribonucleases/genetics ; Genomic Instability ; Homologous Recombination/genetics ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Recombinational DNA Repair/genetics
Chemical Substances	Intracellular Signaling Peptides and Proteins ; Endodeoxyribonucleases (EC 3.1.-) ; DNA Helicases (EC 3.6.4.-)
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Comment ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1005742
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