Article: Endothelial KCa channels: Novel targets to reduce atherosclerosis-driven vascular dysfunction.
2023 Volume 14, Page(s) 1151244
Abstract: Elevated levels of cholesterol in the blood can induce endothelial dysfunction, a condition characterized by impaired nitric oxide production and decreased vasodilatory capacity. Endothelial dysfunction can promote vascular disease, such as ... ...
| Abstract | Elevated levels of cholesterol in the blood can induce endothelial dysfunction, a condition characterized by impaired nitric oxide production and decreased vasodilatory capacity. Endothelial dysfunction can promote vascular disease, such as atherosclerosis, where macrophages accumulate in the vascular intima and fatty plaques form that impair normal blood flow in conduit arteries. Current pharmacological strategies to treat atherosclerosis mostly focus on lipid lowering to prevent high levels of plasma cholesterol that induce endothelial dysfunction and atherosclerosis. While this approach is effective for most patients with atherosclerosis, for some, lipid lowering is not enough to reduce their cardiovascular risk factors associated with atherosclerosis (e.g., hypertension, cardiac dysfunction, stroke, etc.). For such patients, additional strategies targeted at reducing endothelial dysfunction may be beneficial. One novel strategy to restore endothelial function and mitigate atherosclerosis risk is to enhance the activity of Ca |
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| Language | English |
| Publishing date | 2023-03-31 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2587355-6 |
| ISSN | 1663-9812 |
| ISSN | 1663-9812 |
| DOI | 10.3389/fphar.2023.1151244 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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