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Article ; Online: T

Li, Wenbo / Xu, Feng / Zhu, Dan / van Zijl, Peter C M / Qin, Qin

2022 Volume 88, Issue 3, Page(s) 1292–1302

Abstract: Purpose: To develop a T: Methods: The venous isolation preparation was achieved by using an FT ... signal. A multi-echo readout was employed to obtain venous T: Results: The FT-VS-based methods yielded ...

Abstract	Purpose: To develop a T Methods: The venous isolation preparation was achieved by using an FT-VS inversion plus a nonselective inversion (NSI) pulse to null the arterial blood signal while minimally affected capillary blood flows out into the venular vasculature during the outflow time (TO), and then applying an Fourier transform based velocity selective saturation (FT-VSS) pulse to suppress the tissue signal. A multi-echo readout was employed to obtain venous T Results: The FT-VS-based methods yielded higher venous blood signal and temporal SNR with less CSF contamination than the velocity-selective saturation-based results. The averaged Y Conclusion: The feasibility of the FT-VS-based Y
MeSH term(s)	Brain/blood supply ; Cerebral Veins/diagnostic imaging ; Cerebrovascular Circulation/physiology ; Fourier Analysis ; Humans ; Oximetry/methods ; Oxygen ; Oxygen Consumption/physiology
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2022-05-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.29300
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Article ; Online: T

Hu, Hao / Chen, Lu / Zhang, Jiu-Lou / Chen, Wen / Chen, Huan-Huan / Liu, Hu / Shi, Hai-Bin / Wu, Fei-Yun / Xu, Xiao-Quan

Journal of magnetic resonance imaging : JMRI

2022 Volume 56, Issue 3, Page(s) 862–872

Abstract: ... To investigate the value of T: Study type: Retrospective.: Population: A total of 110 patients (49 ± 12 ... validation (n = 32) cohorts.: Field strength/sequence: 3.0 T, T: Assessment: W.C. and H.H. (6 and 10 ... conclusion: T: Level of evidence: 3 TECHNICAL EFFICACY: Stage 4. ...

Abstract	Background: MR imaging has been applied to determine therapeutic response to glucocorticoid (GC) before treatment in thyroid-associated ophthalmopathy (TAO), while the performance was still poor. Purpose: To investigate the value of T Study type: Retrospective. Population: A total of 110 patients (49 ± 12 years; male/female, n = 48/62; responsive/unresponsive, n = 62/48), divided into training (n = 78) and validation (n = 32) cohorts. Field strength/sequence: 3.0 T, T Assessment: W.C. and H.H. (6 and 10 years of experience, respectively) performed the measurements. Maximum, mean, and minimum signal intensity ratios (SIRs) of extraocular muscle (EOM) bellies were collected to construct a semiquantitative imaging model. Radiomics features from volumes of interest covering EOM bellies were extracted and three machine learning-based (logistic regression [LR]; decision tree [DT]; support vector machine [SVM]) models were built. Statistical tests: The diagnostic performances of models were evaluated using receiver operating characteristic curve analyses, and compared using DeLong test. Two-sided P < 0.05 was considered statistically significant. Results: The responsive group showed higher minimum signal intensity ratio (SIR Data conclusion: T Level of evidence: 3 TECHNICAL EFFICACY: Stage 4.
MeSH term(s)	Female ; Glucocorticoids/therapeutic use ; Graves Ophthalmopathy/diagnostic imaging ; Graves Ophthalmopathy/drug therapy ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Retrospective Studies ; Support Vector Machine
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2022-01-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.28088
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Zs.A 3648: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: T

Wang, Tong / Yan, Jinsong / Yuan, Hailin / Xu, Jianquan / Lam, Ho Yi / Yu, Xuanji / Lv, Chao / Du, Binyang / Tsui, Ophelia K C

ACS macro letters

2019 Volume 8, Issue 10, Page(s) 1280–1284

Abstract: We observe that ... ...

Abstract	We observe that the
Language	English
Publishing date	2019-09-18
Publishing country	United States
Document type	Journal Article
ISSN	2161-1653
ISSN (online)	2161-1653
DOI	10.1021/acsmacrolett.9b00568
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Article ; Online: t

Xu, Yulong / Shi, Xiaonan / Wu, Lipeng

RSC advances

2019 Volume 9, Issue 41, Page(s) 24025–24029

Abstract: Recently, inexpensive and readily ... ...

Abstract	Recently, inexpensive and readily available
Language	English
Publishing date	2019-08-02
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c9ra04242c
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Article ; Online: T

Li, Jingjing / You, Jia / Wu, Chen / Dai, Yue / Shi, Meilin / Dong, Lina / Xu, Kai

International journal of nanomedicine

2018 Volume 13, Page(s) 4607–4625

Abstract: Background: The development of T: Methods: In this work, we constructed an Fe: Results ... The prepared Fe: Conclusion: A T ...

Abstract	Background: The development of T Methods: In this work, we constructed an Fe Results: The prepared Fe Conclusion: A T
MeSH term(s)	Animals ; Cattle ; Cell Death ; Cell Line, Tumor ; Cell Survival ; Contrast Media/chemistry ; Ferric Compounds/chemistry ; Gadolinium/chemistry ; Kidney Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Mice ; Mice, Inbred BALB C ; NIH 3T3 Cells ; Nanoparticles/chemistry ; Polyethylenes/chemistry ; Porosity ; Quaternary Ammonium Compounds/chemistry ; Serum Albumin, Bovine/metabolism ; Silicon Dioxide/chemistry ; Tissue Distribution ; Toxicity Tests
Chemical Substances	Contrast Media ; Ferric Compounds ; Polyethylenes ; Quaternary Ammonium Compounds ; ferric oxide (1K09F3G675) ; poly-N,N-dimethyl-N,N-diallylammonium chloride (26062-79-3) ; Serum Albumin, Bovine (27432CM55Q) ; Silicon Dioxide (7631-86-9) ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2018-08-10
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S168660
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Zs.A 6606: Show issues

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Article ; Online: T

Han, Xiaorui / Hong, Guoju / Chen, Leilei / Zhao, Man / Guo, Yuan / Xu, Ling / Wu, Mei / Leng, Xiaoming / Sun, Ping

Journal of magnetic resonance imaging : JMRI

2018 Volume 49, Issue 3, Page(s) 760–767

Abstract: ... Purpose: To investigate the diagnostic performance of T: Study type: Prospective.: Subjects: Forty ... gradient echo (MERGE), and T: Assessment: Pseudocolor images and MERGE images were combined in the AW4.5 ... workstation. The region of interest (ROI) of the hip cartilage was 4-6 mm². The sagittal T: Statistical ...

Abstract	Background: In the future, biochemical MRI might provide a valuable noninvasive quantitative analysis of the biochemical composition of cartilage in osteonecrosis of the femoral head (ONFH). Purpose: To investigate the diagnostic performance of T Study type: Prospective. Subjects: Forty-seven patients with ONFH (stage I to III according to the ARCO criteria) and 24 volunteers (control group) were recruited for the prospective study. Sequence: Conventional MRI, multiple echo recalled gradient echo (MERGE), and T Assessment: Pseudocolor images and MERGE images were combined in the AW4.5 workstation. The region of interest (ROI) of the hip cartilage was 4-6 mm². The sagittal T Statistical tests: One-way analysis of variance (ANOVA), LSD t-tests, Pearson correlation analysis, and receiver operator characteristic (ROC) curves. The significance level was set at P < 0.05. Results: The T Data conclusion: Both T Level of evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:760-767.
MeSH term(s)	Adolescent ; Adult ; Algorithms ; Cartilage, Articular/pathology ; Case-Control Studies ; Female ; Femur Head/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Osteonecrosis/diagnostic imaging ; Prospective Studies ; ROC Curve ; Reproducibility of Results ; Young Adult
Language	English
Publishing date	2018-11-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.26267
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Zs.A 3648: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: T

Tao, Hongyue / Hu, Yiwen / Qiao, Yang / Ma, Kui / Yan, Xu / Hua, Yinghui / Chen, Shuang

Journal of magnetic resonance imaging : JMRI

2017 Volume 47, Issue 1, Page(s) 69–77

Abstract: ... calcaneofibular ligament (CFL) tear using T: Materials and methods: In all, 27 patients including 17 ... underwent T: Results: The T: Conclusion: Chronic LAI with ATFL tear had a trend of increasing ... cartilage T: Level of evidence: 1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:69-77. ...

Abstract	Purpose: To quantitatively evaluate the cartilage alteration of talus for chronic lateral ankle instability (LAI) with isolated anterior talofibular ligament (ATFL) tear and combined ATFL and calcaneofibular ligament (CFL) tear using T Materials and methods: In all, 27 patients including 17 with isolated ATFL tear and 10 with ATFL+CFL tear, and 21 healthy subjects were recruited. All participants underwent T Results: The T Conclusion: Chronic LAI with ATFL tear had a trend of increasing cartilage T Level of evidence: 1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:69-77.
MeSH term(s)	Adult ; Ankle/diagnostic imaging ; Ankle Injuries/diagnostic imaging ; Ankle Joint/diagnostic imaging ; Cartilage/diagnostic imaging ; Cartilage/injuries ; Disease Progression ; Female ; Healthy Volunteers ; Humans ; Joint Instability/diagnostic imaging ; Lateral Ligament, Ankle/diagnostic imaging ; Lateral Ligament, Ankle/injuries ; Magnetic Resonance Imaging ; Male ; Observer Variation ; Talus ; Young Adult
Language	English
Publishing date	2017-04-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.25745
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Article ; Online: T

Li, Shen / Gao, Ying / Lv, Hao / Zhang, Miaomiao / Wang, Lili / Jiang, Rui / Xu, Chengai / Wang, Xueshi / Gao, Ming / He, Yukun / Li, Jie / Li, Wei-Dong

Psychoneuroendocrinology

2017 Volume 88, Page(s) 54–60

Abstract: ... levels were conducted as part of routine medical care. The results showed baseline thyroxine (T ...

Abstract	Second-generation antipsychotic agents (SGAs) cause serious metabolic side effects, including weight gain, dyslipidemia, and glucose metabolism abnormalities, which occur by unknown mechanisms. Therefore, the search for prospective markers for antipsychotic-induced weight gain (AIWG) has been of major interest. So far, predictive factors predisposing patients to the develop obesity and related metabolic disturbances induced by SGAs have been relatively less studied among large samples of Chinese schizophrenic patients. In this study, 264 Han Chinese inpatients diagnosed with schizophrenia or schizoaffective disorder initiated treatment with olanzapine (n=131) or risperidone (n=133) and were followed for 12weeks. Anthropometric measurements and laboratory analyses of thyroid hormone, fasting plasma glucose (FPG), and lipid levels were conducted as part of routine medical care. The results showed baseline thyroxine (T
MeSH term(s)	Adult ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Asian Continental Ancestry Group/genetics ; Benzodiazepines/adverse effects ; Biomarkers, Pharmacological/blood ; Body Mass Index ; China ; Female ; Humans ; Inpatients ; Male ; Middle Aged ; Obesity/drug therapy ; Psychotic Disorders/drug therapy ; Risperidone/adverse effects ; Schizophrenia/physiopathology ; Thyroxine/analysis ; Thyroxine/blood ; Waist-Hip Ratio ; Weight Gain/drug effects
Chemical Substances	Antipsychotic Agents ; Biomarkers, Pharmacological ; Benzodiazepines (12794-10-4) ; Risperidone (L6UH7ZF8HC) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2017-11-21
Publishing country	England
Document type	Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197636-9
ISSN	1873-3360 ; 0306-4530
ISSN (online)	1873-3360
ISSN	0306-4530
DOI	10.1016/j.psyneuen.2017.11.010
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Article ; Online: The T

Zhang, Wenzhe / Xu, Shiru / Zhang, Rongrong / Li, Zhuqing / Li, Nianyu / Zhang, Xiruo / Lu, Yueshuang / Bian, Yuehong / Yang, Ping / Fang, Fang / Qin, Yingying / Jiao, Xue

American journal of reproductive immunology (New York, N.Y. : 1989)

2023 Volume 89, Issue 4, Page(s) e13685

Abstract: ... Design: Levels of IL-22 and IL-22BP, IL-22-producing T cells, and IL22RA1/IL10R2 expression were ... association between T ...

Abstract	Research question: Is deficiency of IL-22 associated with premature ovarian insufficiency (POI)? Design: Levels of IL-22 and IL-22BP, IL-22-producing T cells, and IL22RA1/IL10R2 expression were measured and compared among 29 patients with POI, 42 with precursor stage of POI (pre-POI) and 46 control women. Correlation of serum IL-22 and IL-22 Results: IL-22 levels in serum significantly differed among control women and patients with pre-POI and POI, with the lowest concentrations in POI group (p = .019). Significant reduction of peripheral CD4 Conclusions: Our study first demonstrated the significant association between T
MeSH term(s)	Female ; Humans ; Follicle Stimulating Hormone ; Menopause, Premature ; Primary Ovarian Insufficiency ; Interleukin-22
Chemical Substances	Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2023-02-21
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604542-x
ISSN	1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
ISSN (online)	1600-0897
ISSN	0271-7352 ; 8755-8920 ; 1046-7408
DOI	10.1111/aji.13685
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Book ; Online: T-Rex

Liu, Yifeng / Xu, Hanwen / Fang, Tangqi / Xi, Haocheng / Liu, Zixuan / Zhang, Sheng / Poon, Hoifung / Wang, Sheng

Text-assisted Retrosynthesis Prediction

2024

Abstract: ... molecules. Here, we propose T-Rex, a text-assisted retrosynthesis prediction approach that exploits pre ... trained text language models, such as ChatGPT, to assist the generation of reactants. T-Rex first exploits ... for each reactants and examines which group of reactants can best synthesize the target molecule. We observed that T ...

Abstract	As a fundamental task in computational chemistry, retrosynthesis prediction aims to identify a set of reactants to synthesize a target molecule. Existing template-free approaches only consider the graph structures of the target molecule, which often cannot generalize well to rare reaction types and large molecules. Here, we propose T-Rex, a text-assisted retrosynthesis prediction approach that exploits pre-trained text language models, such as ChatGPT, to assist the generation of reactants. T-Rex first exploits ChatGPT to generate a description for the target molecule and rank candidate reaction centers based both the description and the molecular graph. It then re-ranks these candidates by querying the descriptions for each reactants and examines which group of reactants can best synthesize the target molecule. We observed that T-Rex substantially outperformed graph-based state-of-the-art approaches on two datasets, indicating the effectiveness of considering text information. We further found that T-Rex outperformed the variant that only use ChatGPT-based description without the re-ranking step, demonstrate how our framework outperformed a straightforward integration of ChatGPT and graph information. Collectively, we show that text generated by pre-trained language models can substantially improve retrosynthesis prediction, opening up new avenues for exploiting ChatGPT to advance computational chemistry. And the codes can be found at https://github.com/lauyikfung/T-Rex.
Keywords	Computer Science - Computation and Language
Subject code	400
Publishing date	2024-01-25
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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