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  1. Article ; Online: Distinct viral clades of SARS-CoV-2: Implications for modeling of viral spread.

    Brufsky, Adam

    Journal of medical virology

    2020  Volume 92, Issue 9, Page(s) 1386–1390

    MeSH term(s) COVID-19/epidemiology ; Forecasting ; Humans ; Models, Theoretical ; Mutation ; Pandemics ; Phylogeny ; SARS-CoV-2/genetics ; United States/epidemiology ; Virulence
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25902
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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  2. Article: Predicting clinical benefit from continuation of cyclin dependent kinase (CDK) 4/6 inhibitors beyond progression.

    Foldi, Julia / Brufsky, Adam

    Annals of translational medicine

    2023  Volume 11, Issue 9, Page(s) 327

    Language English
    Publishing date 2023-04-07
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-23-965
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  3. Article ; Online: Hyperglycemia, hydroxychloroquine, and the COVID-19 pandemic.

    Brufsky, Adam

    Journal of medical virology

    2020  Volume 92, Issue 7, Page(s) 770–775

    Abstract: Coronavirus disease-2019 (COVID-19) infection and its severity can be explained by the concentration of glycosylated severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral particles in the lung epithelium, the concentration of glycosylated ... ...

    Abstract Coronavirus disease-2019 (COVID-19) infection and its severity can be explained by the concentration of glycosylated severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral particles in the lung epithelium, the concentration of glycosylated angiotensin-converting enzyme receptor 2 (ACE2) in the lung epithelium, and the degree and control of the pulmonary immune response to the SARS-CoV-2 spike protein at approximately day 8 to 10 after symptom onset, which may be related to both. Binding of ACE2 by SARS-CoV-2 in COVID-19 also suggests that prolonged uncontrolled hyperglycemia, and not just a history of diabetes mellitus, may be important in the pathogenesis of the disease. It is tempting to consider that the same mechanism acts in COVID-19 as in SARS, where an overactive macrophage M1 inflammatory response, as neutralizing antibodies to the SARS-CoV-2 spike protein form at day 7 to 10, results in acute respiratory distress syndrome (ARDS) in susceptible patients. It also allows consideration of agents, such as hydroxychloroquine, which may interfere with this overly brisk macrophage inflammatory response and perhaps influence the course of the disease, in particular, those that blunt but do not completely abrogate the M1 to M2 balance in macrophage polarization, as well as viral load, which in SARS appears to be temporally related to the onset of ARDS.
    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Antibodies, Neutralizing/biosynthesis ; Antibody-Dependent Cell Cytotoxicity/drug effects ; Antiviral Agents/therapeutic use ; Azithromycin/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/metabolism ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/metabolism ; Glucose/immunology ; Glucose/metabolism ; Glycosylation/drug effects ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Hydroxychloroquine/therapeutic use ; Hyperglycemia/complications ; Hyperglycemia/drug therapy ; Hyperglycemia/epidemiology ; Hyperglycemia/metabolism ; Incidence ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/virology ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/immunology ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/metabolism ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism
    Chemical Substances Antibodies, Neutralizing ; Antiviral Agents ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Glucose (IY9XDZ35W2)
    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25887
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: P-REALITY X: A Real-World Analysis of Palbociclib Plus an Aromatase Inhibitor in HR+/HER2- Metastatic Breast Cancer-A Podcast.

    Brufsky, Adam / Gallagher, Christopher

    Targeted oncology

    2023  Volume 18, Issue 3, Page(s) 321–326

    Abstract: Stringent enrollment criteria can limit the diversity of patient populations in clinical trials and, consequently, the generalizability of clinical trial data to real-world clinical practice. In this podcast, we discuss how real-world data in ... ...

    Abstract Stringent enrollment criteria can limit the diversity of patient populations in clinical trials and, consequently, the generalizability of clinical trial data to real-world clinical practice. In this podcast, we discuss how real-world data in heterogeneous patient populations can complement clinical trial data in informing treatment decision making for patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) metastatic breast cancer. Specifically, our focus is on P-REALITY X, an observational retrospective analysis that was recently published in npj Breast Cancer. P-REALITY X used real-world data from the Flatiron database to compare the effectiveness of palbociclib plus an aromatase inhibitor versus an aromatase inhibitor alone as first-line treatment for patients with HR+/HER2- metastatic breast cancer. After stabilized inverse probability treatment weighting to control for observed confounders, both overall survival and real-world progression-free survival were significantly prolonged with palbociclib plus an aromatase inhibitor versus an aromatase inhibitor alone. Furthermore, overall survival and real-world progression-free survival benefits were observed across most subgroups examined. We discuss the clinical implications of P-REALITY X data, including how these results add to data from prior randomized clinical trials and real-world studies in supporting the use of first-line palbociclib plus an aromatase inhibitor as a standard-of-care treatment for patients with HR+/HER2- metastatic breast cancer. We also provide an example of how to integrate and describe key information about the P-REALITY X study in plain language when discussing palbociclib as a therapeutic option with patients.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/pathology ; Aromatase Inhibitors/pharmacology ; Aromatase Inhibitors/therapeutic use ; Retrospective Studies ; Receptor, ErbB-2/metabolism ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Chemical Substances Aromatase Inhibitors ; palbociclib (G9ZF61LE7G) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2023-05-06
    Publishing country France
    Document type Observational Study ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2222136-0
    ISSN 1776-260X ; 1776-2596
    ISSN (online) 1776-260X
    ISSN 1776-2596
    DOI 10.1007/s11523-023-00968-4
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  6. Article ; Online: Hyperglycemia, hydroxychloroquine, and the COVID‐19 pandemic

    Brufsky, Adam

    Journal of Medical Virology

    2020  Volume 92, Issue 7, Page(s) 770–775

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25887
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Distinct viral clades of SARS‐CoV‐2

    Brufsky, Adam

    Journal of Medical Virology

    Implications for modeling of viral spread

    2020  Volume 92, Issue 9, Page(s) 1386–1390

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25902
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Hyperglycemia, hydroxychloroquine, and the COVID-19 pandemic

    Brufsky, Adam

    J Med Virol

    Abstract: Coronavirus disease-2019 (COVID-19) infection and its severity can be explained by the concentration of glycosylated severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral particles in the lung epithelium, the concentration of glycosylated ... ...

    Abstract Coronavirus disease-2019 (COVID-19) infection and its severity can be explained by the concentration of glycosylated severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral particles in the lung epithelium, the concentration of glycosylated angiotensin-converting enzyme receptor 2 (ACE2) in the lung epithelium, and the degree and control of the pulmonary immune response to the SARS-CoV-2 spike protein at approximately day 8 to 10 after symptom onset, which may be related to both. Binding of ACE2 by SARS-CoV-2 in COVID-19 also suggests that prolonged uncontrolled hyperglycemia, and not just a history of diabetes mellitus, may be important in the pathogenesis of the disease. It is tempting to consider that the same mechanism acts in COVID-19 as in SARS, where an overactive macrophage M1 inflammatory response, as neutralizing antibodies to the SARS-CoV-2 spike protein form at day 7 to 10, results in acute respiratory distress syndrome (ARDS) in susceptible patients. It also allows consideration of agents, such as hydroxychloroquine, which may interfere with this overly brisk macrophage inflammatory response and perhaps influence the course of the disease, in particular, those that blunt but do not completely abrogate the M1 to M2 balance in macrophage polarization, as well as viral load, which in SARS appears to be temporally related to the onset of ARDS.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32293710
    Database COVID19

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  9. Article: nab

    Brufsky, Adam

    Experimental hematology & oncology

    2017  Volume 6, Page(s) 7

    Abstract: Purpose: The purpose of this systematic review is to discuss recent studies and ongoing trials of : Methods: PubMed and selected congress proceedings were searched for studies of : Results: Sixty-three studies, including 23 in early-stage and 30 ... ...

    Abstract Purpose: The purpose of this systematic review is to discuss recent studies and ongoing trials of
    Methods: PubMed and selected congress proceedings were searched for studies of
    Results: Sixty-three studies, including 23 in early-stage and 30 in metastatic breast cancer (some studies not classifiable by setting), were included in this analysis. Trials of neoadjuvant
    Conclusions: nab
    Language English
    Publishing date 2017-03-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2669066-4
    ISSN 2162-3619
    ISSN 2162-3619
    DOI 10.1186/s40164-017-0066-5
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  10. Article ; Online: Is there room for bevacizumab in metastatic breast cancer?

    Brufsky, Adam

    The Lancet. Oncology

    2016  Volume 17, Issue 9, Page(s) 1175–1176

    Language English
    Publishing date 2016-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(16)30295-9
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    Zs.MO 460: Show issues

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