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Article ; Online: Concussion serum biomarkers: A quest for the Holy Grail?

Bigler, Erin D / Deibert, Ellen

2018 Volume 91, Issue 23, Page(s) 1035–1037

MeSH term(s)	Athletes ; Biomarkers ; Brain Concussion ; Humans ; Students
Chemical Substances	Biomarkers
Language	English
Publishing date	2018-11-07
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000006609
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Article ; Online: White Parents' Socialization of Racial Attitudes: A Commentary on Scott et al. (2020).

Bigler, Rebecca S / Pahlke, Erin / Williams, Amber D / Vittrup, Brigitte

Perspectives on psychological science : a journal of the Association for Psychological Science

2021 Volume 17, Issue 3, Page(s) 901–910

Abstract: In the September 2020 issue ... ...

Abstract	In the September 2020 issue of
MeSH term(s)	Attitude ; Child ; Humans ; Parenting/psychology ; Parents/psychology ; Racism/psychology ; Socialization
Language	English
Publishing date	2021-12-09
Publishing country	United States
Document type	Case Reports ; Journal Article ; Comment
ZDB-ID	2224911-4
ISSN	1745-6924 ; 1745-6916
ISSN (online)	1745-6924
ISSN	1745-6916
DOI	10.1177/17456916211029947
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Article ; Online: Fingerprinting of chlorinated paraffins and their transformation products in plastic consumer products.

Mendo Diaz, O / Tell, A / Knobloch, M / Canonica, E / Walder, C / Buser, A M / Stalder, U / Bigler, L / Kern, S / Bleiner, D / Heeb, N V

Chemosphere

2023 Volume 338, Page(s) 139552

Abstract: Chlorinated paraffins (CPs) can be classified according to their length as short-chain (SC, ... ...

Abstract	Chlorinated paraffins (CPs) can be classified according to their length as short-chain (SC, C
MeSH term(s)	Humans ; Hydrocarbons, Chlorinated/analysis ; Chlorine/analysis ; Paraffin/analysis ; Plastics ; Environmental Monitoring/methods ; China
Chemical Substances	Hydrocarbons, Chlorinated ; Chlorine (4R7X1O2820) ; Paraffin (8002-74-2) ; Plastics
Language	English
Publishing date	2023-07-20
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.139552
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Article ; Online: Benchmarking animal handling outcomes on cow-calf operations and identifying associated factors.

Calaba, Elaine / Clowser, Michaela / Weller, Zachary D / Bigler, Libby / Fulton, Jesse / Edwards-Callaway, Lily N

Translational animal science

2022 Volume 6, Issue 3, Page(s) txac106

Abstract: The assessment of animal handling is commonly included in cattle care programs. The guidelines set in the National Cattlemen's Beef Association Beef Checkoff funded Beef Quality Assurance (BQA) program are often used for assessing handling on feedlot, ... ...

Abstract	The assessment of animal handling is commonly included in cattle care programs. The guidelines set in the National Cattlemen's Beef Association Beef Checkoff funded Beef Quality Assurance (BQA) program are often used for assessing handling on feedlot, stocker, and cow-calf operations. There is limited information about animal handling on cow-calf operations. Thus, the objectives of this study were to: (1) quantify handling outcomes on cow-calf operations and compare them to national BQA program thresholds, and (2) investigate factors associated with handling outcomes. Researchers visited 76 operations across the United States to observe the following outcomes, adapted from the BQA program, during the processing of cows or yearling heifers: Prod Use, Miscatch, Vocalization, Jump, Slip/Stumble, Fall and Run. One hundred cows or less (depending on herd size) were observed moving through a restraint system at each operation. Other information specific to the animal type, facilities, and management were also gathered to be explored as potential predictors of handling outcomes. Data were summarized using descriptive statistics on an operation basis and analyzed with multi-predictor ANOVA or Kruskal-Wallis tests to assess the relationship between outcomes and possible explanatory factors. Predictors included in the final analyses were: BQA certification (BQA), animal temperament (TEMP), region (REGION), chute style (CHUTE), and visual contact with humans (VISUAL). The 76 operations were sampled in 24 states (Central,
Language	English
Publishing date	2022-08-01
Publishing country	England
Document type	Journal Article
ISSN	2573-2102
ISSN (online)	2573-2102
DOI	10.1093/tas/txac106
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Article ; Online: Medicolegal Issues in Traumatic Brain Injury.

Zasler, Nathan D / Bigler, Erin

Physical medicine and rehabilitation clinics of North America

2017 Volume 28, Issue 2, Page(s) 379–391

Abstract: The role of the physiatrist in provision of medicolegal expert testimony in cases involving traumatic brain injury is challenging and complex. This article provides an overview of how such work should be conducted from a practical perspective including ... ...

Abstract	The role of the physiatrist in provision of medicolegal expert testimony in cases involving traumatic brain injury is challenging and complex. This article provides an overview of how such work should be conducted from a practical perspective including discussion of ethical, legal, medical, and business aspects of such activities. Additionally, pointers are provided with regards to how information including preinjury, injury, and postinjury (including neuroimaging and neuropsychological data) should be considered and integrated into medicolegal opinions and testimony.
MeSH term(s)	Brain Injuries, Traumatic/physiopathology ; Brain Injuries, Traumatic/psychology ; Disability Evaluation ; Ethics, Medical ; Expert Testimony ; Humans ; Neuroimaging
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1196791-2
ISSN	1558-1381 ; 1047-9651
ISSN (online)	1558-1381
ISSN	1047-9651
DOI	10.1016/j.pmr.2016.12.012
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Article: Reduced Lateralization of Multiple Functional Brain Networks in Autistic Males.

Peterson, Madeline / Prigge, Molly B D / Floris, Dorothea L / Bigler, Erin D / Zielinski, Brandon / King, Jace B / Lange, Nicholas / Alexander, Andrew L / Lainhart, Janet E / Nielsen, Jared A

bioRxiv : the preprint server for biology

2023

Abstract: ... lateralized Language (d = -0.89), right-lateralized Salience/Ventral Attention-A (d = 0.55), and right ... lateralized Control-B (d = 0.51) networks, with the direction of these group differences indicating less ...

Abstract	Background: Autism spectrum disorder has been linked to a variety of organizational and developmental deviations in the brain. One such organizational difference involves hemispheric lateralization, which may be localized to language-relevant regions of the brain or distributed more broadly. Methods: In the present study, we estimated brain hemispheric lateralization in autism based on each participant's unique functional neuroanatomy rather than relying on group-averaged data. Additionally, we explored potential relationships between the lateralization of the language network and behavioral phenotypes including verbal ability, language delay, and autism symptom severity. We hypothesized that differences in hemispheric asymmetries in autism would be limited to the language network, with the alternative hypothesis of pervasive differences in lateralization. We tested this and other hypotheses by employing a cross-sectional dataset of 118 individuals (48 autistic, 70 neurotypical). Using resting-state fMRI, we generated individual network parcellations and estimated network asymmetries using a surface area-based approach. A series of multiple regressions were then used to compare network asymmetries for eight significantly lateralized networks between groups. Results: We found significant group differences in lateralization for the left-lateralized Language (d = -0.89), right-lateralized Salience/Ventral Attention-A (d = 0.55), and right-lateralized Control-B (d = 0.51) networks, with the direction of these group differences indicating less asymmetry in autistic individuals. These differences were robust across different datasets from the same participants. Furthermore, we found that language delay stratified language lateralization, with the greatest group differences in language lateralization occurring between autistic individuals with language delay and neurotypical individuals. Limitations: The generalizability of our findings is restricted due to the male-only sample and greater representation of individuals with high verbal and cognitive performance. Conclusions: These findings evidence a complex pattern of functional lateralization differences in autism, extending beyond the Language network to the Salience/Ventral Attention-A and Control-B networks, yet not encompassing all networks, indicating a selective divergence rather than a pervasive one. Furthermore, a differential relationship was identified between Language network lateralization and specific symptom profiles (namely, language delay) of autism.
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.12.15.571928
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Article ; Online: Novel Oppositional Defiant Disorder or Conduct Disorder 24 Months After Traumatic Brain Injury in Children and Adolescents.

Lowet, Daniel S / Vaida, Florin / Hesselink, John R / Ewing-Cobbs, Linda / Schachar, Russell J / Chapman, Sandra B / Bigler, Erin D / Wilde, Elisabeth A / Saunders, Ann E / Yang, Tony T / Tymofiyeva, Olga / Huang, Mingxiong / Max, Jeffrey E

The Journal of neuropsychiatry and clinical neurosciences

2023 Volume 36, Issue 1, Page(s) 53–62

Abstract: Objective: The authors sought to identify predictive factors of new-onset or novel oppositional defiant disorder or conduct disorder assessed 24 months after traumatic brain injury (TBI).: Methods: Children ages 5 to 14 years who had experienced TBI ... ...

Abstract	Objective: The authors sought to identify predictive factors of new-onset or novel oppositional defiant disorder or conduct disorder assessed 24 months after traumatic brain injury (TBI). Methods: Children ages 5 to 14 years who had experienced TBI were recruited from consecutive hospital admissions. Soon after injury, participants were assessed for preinjury characteristics, including psychiatric disorders, socioeconomic status (SES), psychosocial adversity, and family function, and the presence and location of lesions were documented by MRI. Psychiatric outcomes, including novel oppositional defiant disorder or conduct disorder, were assessed 24 months after injury. Results: Of the children without preinjury oppositional defiant disorder, conduct disorder, or disruptive behavior disorder not otherwise specified who were recruited in this study, 165 were included in this sample; 95 of these children returned for the 24-month assessment. Multiple imputation was used to address attrition. The prevalence of novel oppositional defiant disorder or conduct disorder was 23.7 out of 165 (14%). In univariable analyses, novel oppositional defiant disorder or conduct disorder was significantly associated with psychosocial adversity (p=0.049) and frontal white matter lesions (p=0.016) and was marginally but not significantly associated with SES. In the final multipredictor model, frontal white matter lesions were significantly associated with novel oppositional defiant disorder or conduct disorder (p=0.021), and psychosocial adversity score was marginally but not significantly associated with the outcome. The odds ratio of novel oppositional defiant disorder or conduct disorder among the children with versus those without novel depressive disorder was significantly higher for girls than boys (p=0.025), and the odds ratio of novel oppositional defiant disorder or conduct disorder among the children with versus those without novel attention-deficit hyperactivity disorder (ADHD) was significantly higher for boys than girls (p=0.006). Conclusion: Approximately 14% of children with TBI developed oppositional defiant disorder or conduct disorder. The risk for novel oppositional defiant disorder or conduct disorder can be understood from a biopsychosocial perspective. Sex differences were evident for comorbid novel depressive disorder and comorbid novel ADHD.
MeSH term(s)	Child ; Humans ; Adolescent ; Female ; Male ; Conduct Disorder/complications ; Conduct Disorder/epidemiology ; Conduct Disorder/psychology ; Oppositional Defiant Disorder ; Attention Deficit and Disruptive Behavior Disorders/epidemiology ; Attention Deficit Disorder with Hyperactivity/psychology ; Comorbidity ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/diagnostic imaging ; Brain Injuries, Traumatic/epidemiology
Language	English
Publishing date	2023-08-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036340-3
ISSN	1545-7222 ; 0895-0172
ISSN (online)	1545-7222
ISSN	0895-0172
DOI	10.1176/appi.neuropsych.20220094
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Article ; Online: Persistent MRI Findings Unique to Blast and Repetitive Mild TBI: Analysis of the CENC/LIMBIC Cohort Injury Characteristics.

Military medicine

2024

Abstract: ... related mTBI. Several volumetric (i.e., hippocampal subfields, etc.) and diffusion (i.e., corona radiata ...

Abstract	Introduction: MRI represents one of the clinical tools at the forefront of research efforts aimed at identifying diagnostic and prognostic biomarkers following traumatic brain injury (TBI). Both volumetric and diffusion MRI findings in mild TBI (mTBI) are mixed, making the findings difficult to interpret. As such, additional research is needed to continue to elucidate the relationship between the clinical features of mTBI and quantitative MRI measurements. Material and methods: Volumetric and diffusion imaging data in a sample of 976 veterans and service members from the Chronic Effects of Neurotrauma Consortium and now the Long-Term Impact of Military-Relevant Brain Injury Consortium observational study of the late effects of mTBI in combat with and without a history of mTBI were examined. A series of regression models with link functions appropriate for the model outcome were used to evaluate the relationships among imaging measures and clinical features of mTBI. Each model included acquisition site, participant sex, and age as covariates. Separate regression models were fit for each region of interest where said region was a predictor. Results: After controlling for multiple comparisons, no significant main effect was noted for comparisons between veterans and service members with and without a history of mTBI. However, blast-related mTBI were associated with volumetric reductions of several subregions of the corpus callosum compared to non-blast-related mTBI. Several volumetric (i.e., hippocampal subfields, etc.) and diffusion (i.e., corona radiata, superior longitudinal fasciculus, etc.) MRI findings were noted to be associated with an increased number of repetitive mTBIs versus. Conclusions: In deployment-related mTBI, significant findings in this cohort were only observed when considering mTBI sub-groups (blast mechanism and total number/dose). Simply comparing healthy controls and those with a positive mTBI history is likely an oversimplification that may lead to non-significant findings, even in consortium analyses.
Language	English
Publishing date	2024-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usae031
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Article ; Online: Assessing Pediatric Mild Traumatic Brain Injury and Its Recovery Using Resting-State Magnetoencephalography Source Magnitude Imaging and Machine Learning.

Huang, Ming-Xiong / Angeles-Quinto, Annemarie / Robb-Swan, Ashley / De-la-Garza, Bianca G / Huang, Charles W / Cheng, Chung-Kuan / Hesselink, John R / Bigler, Erin D / Wilde, Elisabeth A / Vaida, Florin / Troyer, Emily A / Max, Jeffrey E

Journal of neurotrauma

2023 Volume 40, Issue 11-12, Page(s) 1112–1129

Abstract: The objectives of this machine-learning (ML) resting-state magnetoencephalography (rs-MEG) study involving children with mild traumatic brain injury (mTBI) and orthopedic injury (OI) controls were to define a neural injury signature of mTBI and to ... ...

Abstract	The objectives of this machine-learning (ML) resting-state magnetoencephalography (rs-MEG) study involving children with mild traumatic brain injury (mTBI) and orthopedic injury (OI) controls were to define a neural injury signature of mTBI and to delineate the pattern(s) of neural injury that determine behavioral recovery. Children ages 8-15 years with mTBI (
MeSH term(s)	Humans ; Child ; Brain Concussion/diagnosis ; Brain Concussion/complications ; Magnetoencephalography/methods ; Brain ; Post-Concussion Syndrome/diagnosis ; Brain Injuries/complications
Language	English
Publishing date	2023-04-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2022.0220
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Article ; Online: Novel Oppositional Defiant Disorder 12 Months After Traumatic Brain Injury in Children and Adolescents.

Lowet, Daniel S / Vaida, Florin / Hesselink, John R / Levin, Harvey S / Ewing-Cobbs, Linda / Schachar, Russell J / Chapman, Sandra B / Bigler, Erin D / Wilde, Elisabeth A / Saunders, Ann E / Yang, Tony T / Tymofiyeva, Olga / Max, Jeffrey E

The Journal of neuropsychiatry and clinical neurosciences

2022 Volume 34, Issue 2, Page(s) 149–157

Abstract: Objective: The investigators examined the factors predictive of novel oppositional defiant disorder in the 6-12 months following traumatic brain injury (TBI).: Methods: Children ages 5-14 years old who experienced a TBI were recruited from ... ...

Abstract	Objective: The investigators examined the factors predictive of novel oppositional defiant disorder in the 6-12 months following traumatic brain injury (TBI). Methods: Children ages 5-14 years old who experienced a TBI were recruited from consecutive admissions to five hospitals. Participants were evaluated soon after injury (baseline) for preinjury characteristics, including psychiatric disorders, adaptive function, family function, psychosocial adversity, family psychiatric history, socioeconomic status, and injury severity, to develop a biopsychosocial predictive model for development of novel oppositional defiant disorder. MRI analyses were conducted to examine potential brain lesions. Psychiatric outcome, including that of novel oppositional defiant disorder, was assessed 12 months after injury. Results: Although 177 children were recruited for the study, 120 children without preinjury oppositional defiant disorder, conduct disorder, or disruptive behavior disorder not otherwise specified (DBD NOS) returned for the 12-month assessment. Of these 120 children, seven (5.8%) exhibited novel oppositional defiant disorder, and none developed conduct disorder or DBD NOS in the 6-12 months postinjury. Novel oppositional defiant disorder was significantly associated with lower socioeconomic status, higher psychosocial adversity, and lower preinjury adaptive functioning. Conclusions: These results demonstrate that novel oppositional defiant disorder following TBI selectively and negatively affects an identifiable group of children. Both proximal (preinjury adaptive function) and distal (socioeconomic status and psychosocial adversity) psychosocial variables significantly increase risk for this outcome.
MeSH term(s)	Adolescent ; Attention Deficit and Disruptive Behavior Disorders/epidemiology ; Attention Deficit and Disruptive Behavior Disorders/etiology ; Brain Injuries, Traumatic/complications ; Child ; Child, Preschool ; Humans ; Magnetic Resonance Imaging ; Social Class
Language	English
Publishing date	2022-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036340-3
ISSN	1545-7222 ; 0895-0172
ISSN (online)	1545-7222
ISSN	0895-0172
DOI	10.1176/appi.neuropsych.21060149
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