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  1. Article: Recent advances in treatments of adult immune thrombocytopenia.

    Kim, Dae Sik

    Blood research

    2022  Volume 57, Issue S1, Page(s) 112–119

    Abstract: Immune thrombocytopenia (ITP) is isolated thrombocytopenia characterized by autoimmune-mediated disruption of platelet without other etiologies. Treatments for chronic ITP consist of corticosteroids, intravenous immunoglobulins, anti-D immunoglobulin, ... ...

    Abstract Immune thrombocytopenia (ITP) is isolated thrombocytopenia characterized by autoimmune-mediated disruption of platelet without other etiologies. Treatments for chronic ITP consist of corticosteroids, intravenous immunoglobulins, anti-D immunoglobulin, rituximab, thrombopoietin receptor agonists, immunosuppressants and splenectomy. Although current therapies are effective in over two-thirds of patients, some patients are refractory to therapies or fail to achieve long-term responses. Recently, great advance has been made in identifying various mechanisms involved in ITP pathogenesis, and new treatments targeting these pathways are being developed. Novel agents such as splenic tyrosine kinase inhibitor, Bruton kinase inhibitor, plasma cell targeting therapies, neonatal Fc receptor inhibitor, platelet desialylation inhibitor, and inhibition of the classical complement pathway are expected to be effective for ITP treatment. This review summarizes current strategies and emerging therapies of ITP.
    Language English
    Publishing date 2022-04-28
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2711910-5
    ISSN 2288-0011 ; 2287-979X
    ISSN (online) 2288-0011
    ISSN 2287-979X
    DOI 10.5045/br.2022.2022038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: p-Terphenyl glucosides from the culture broth of Phlebiopsis castanea.

    Choi, Dae-Cheol / Ki, Dae-Won / Kim, Ji-Yul / Lee, In-Kyoung / Yun, Bong-Sik

    The Journal of antibiotics

    2023  Volume 76, Issue 7, Page(s) 430

    Language English
    Publishing date 2023-05-25
    Publishing country England
    Document type Published Erratum
    ZDB-ID 390800-8
    ISSN 1881-1469 ; 0021-8820 ; 0368-3532
    ISSN (online) 1881-1469
    ISSN 0021-8820 ; 0368-3532
    DOI 10.1038/s41429-023-00630-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Ginseng Berry Juice (GBJ) Regulates the Inflammation in Acute Ulcerative Mouse Models and the Major Bioactive Substances Are Ginsenosides Rb3, Rc, Rd, and Re.

    Lee, Soon-Young / Song, Seung-Yub / Lee, Sung-Ho / Kim, Gye-Yeop / Park, Jin-Woo / Bae, Chun-Sik / Park, Dae-Hun / Cho, Seung-Sik

    Nutrients

    2024  Volume 16, Issue 7

    Abstract: ... Panax ... ...

    Abstract Panax ginseng
    MeSH term(s) Animals ; Mice ; Fruit ; Ginsenosides/pharmacology ; Panax ; Inflammation/drug therapy ; Gastritis ; Ethanol ; Anti-Inflammatory Agents/pharmacology
    Chemical Substances ginsenoside Rb3 (68406-26-8) ; Ginsenosides ; Ethanol (3K9958V90M) ; Anti-Inflammatory Agents
    Language English
    Publishing date 2024-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16071031
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  4. Article ; Online: Clinical experience of consolidative radiotherapy for localized metastatic non-small cell lung cancer who showed favorable tumor response after systemic treatment.

    Kim, Hakyoung / Kim, Sun Myung / Hwang, Jeongeun / Yang, Dae Sik

    Discover. Oncology

    2024  Volume 15, Issue 1, Page(s) 64

    Abstract: Background: Our study has aimed to assess the effects of consolidative high-dose radiotherapy on clinical outcomes in patients with localized metastatic non-small cell lung cancer (NSCLC) who showed favorable tumor response after systemic treatment.: ... ...

    Abstract Background: Our study has aimed to assess the effects of consolidative high-dose radiotherapy on clinical outcomes in patients with localized metastatic non-small cell lung cancer (NSCLC) who showed favorable tumor response after systemic treatment.
    Methods: We retrospectively reviewed the medical records of 83 patients with localized metastatic NSCLC, who received systemic therapy followed by consolidative local radiotherapy at the Korea University Guro Hospital between March 2017 and June 2022. In the current study, we defined localized metastatic disease as the presence of one to three metastatic sites at the time of diagnosis. And patients who showed favorable tumor response after systemic treatment, including oligo-progressive disease at the thoracic site which was amenable to curative high-dose local radiotherapy, were included. The planned total dose and fraction size mainly depended on the location of lesions.
    Results: The median follow-up time after consolidative radiotherapy was 16 months (range: 5-52 months). The overall 2-year progression-free survival rates were 81.4%. Of 83 patients, only four (4.3%), treated with intensity-modulated radiation therapy, showed an in-field local recurrence. Interestingly, only one patient experienced a local failure among the 20 patients who showed an oligo-progressive disease at the thoracic site on the tumor response evaluation after systemic treatment. Regarding treatment-related pulmonary toxicity, three patients with grade-3 and one patient with grade-4 radiation pneumonitis were presented.
    Conclusions: If the disease is sufficiently controlled and localized by systemic therapy, local consolidative radiotherapy is thought to improves local control rates with acceptable treatment-related toxicities in patients with localized metastatic NSCLC, especially those with oligo-progressive disease.
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ISSN 2730-6011
    ISSN (online) 2730-6011
    DOI 10.1007/s12672-024-00896-3
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  5. Article ; Online: Three new phthalide derivatives from culture broth of Dentipellis fragilis and their cytotoxic activities.

    Ki, Dae-Won / Choi, Dae-Cheol / Won, Yeong-Seon / Lee, Seung-Jae / Kim, Young-Hee / Lee, In-Kyoung / Yun, Bong-Sik

    The Journal of antibiotics

    2024  

    Abstract: Three new phthalide derivatives (1‒3) together with two known compounds, erinaceolactone B (4) and hericerin III (5), were isolated from the culture broth of Dentipellis fragilis. The chemical structures of 1‒5 were determined by analyses of their 1D-, ... ...

    Abstract Three new phthalide derivatives (1‒3) together with two known compounds, erinaceolactone B (4) and hericerin III (5), were isolated from the culture broth of Dentipellis fragilis. The chemical structures of 1‒5 were determined by analyses of their 1D-, 2D-NMR, and MS. The absolute configuration of 1 was determined by CD analysis. The isolated compounds were assessed for their cytotoxic activities against A549, DU145, HCT116, and HT1080 cancer cell lines. Compounds 1‒5 showed strong cytotoxic activities against DU145, with IC
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 390800-8
    ISSN 1881-1469 ; 0021-8820 ; 0368-3532
    ISSN (online) 1881-1469
    ISSN 0021-8820 ; 0368-3532
    DOI 10.1038/s41429-024-00720-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Triterpenoidal Saponins from the Leaves of

    Kim, Ji-Young / Kim, Tai Young / Son, So-Ri / Kim, Suyeon Yellena / Kwon, Jaeyoung / Kwon, Hak Cheol / Lee, C Justin / Jang, Dae Sik

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: Triterpenoidal saponins have been reported to be able to restrain SARS-CoV-2 infection. To isolate antiviral compounds against SARS-CoV-2 from the leaves ... ...

    Abstract Triterpenoidal saponins have been reported to be able to restrain SARS-CoV-2 infection. To isolate antiviral compounds against SARS-CoV-2 from the leaves of
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13020303
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  7. Article ; Online: FoxO6-Mediated TXNIP Induces Lipid Accumulation in the Liver through NLRP3 Inflammasome Activation.

    Kim, Mi Eun / Lee, Jun Sik / Kim, Tae Won / Park, Min Hi / Kim, Dae Hyun

    Endocrinology and metabolism (Seoul, Korea)

    2024  Volume 39, Issue 1, Page(s) 127–139

    Abstract: Backgruound: Hepatic steatosis, which involves the excessive accumulation of lipid droplets in hepatocytes, presents a significant global health concern due to its association with obesity and metabolic disorders. Inflammation plays a crucial role in ... ...

    Abstract Backgruound: Hepatic steatosis, which involves the excessive accumulation of lipid droplets in hepatocytes, presents a significant global health concern due to its association with obesity and metabolic disorders. Inflammation plays a crucial role in the progression of hepatic steatosis; however, the precise molecular mechanisms responsible for this process remain unknown.
    Methods: This study investigated the involvement of the nucleotide-binding oligomerization domain-like receptor pyrin domain-containing-3 (NLRP3) inflammasome and the forkhead box O6 (FoxO6) transcription factor in the pathogenesis of hepatic steatosis. We monitored the NLRP3 inflammasome and lipogenesis in mice overexpressing the constitutively active (CA)-FoxO6 allele and FoxO6-null mice. In an in vitro study, we administered palmitate to liver cells overexpressing CA-FoxO6 and measured changes in lipid metabolism.
    Results: We administered palmitate treatment to clarify the mechanisms through which FoxO6 activates cytokine interleukin (IL)-1β through the NLRP3 inflammasome. The initial experiments revealed that dephosphorylation led to palmitate-induced FoxO6 transcriptional activity. Further palmitate experiments showed increased expression of IL-1β and the hepatic NLRP3 inflammasome complex, including adaptor protein apoptotic speck protein containing a caspase recruitment domain (ASC) and pro-caspase-1. Furthermore, thioredoxin-interacting protein (TXNIP), a key regulator of cellular redox conditions upstream of the NLRP3 inflammasome, was induced by FoxO6 in the liver and HepG2 cells.
    Conclusion: The findings of this study shed light on the molecular mechanisms underpinning the FoxO6-NLRP3 inflammasome axis in promoting inflammation and lipid accumulation in the liver.
    MeSH term(s) Animals ; Mice ; Inflammasomes/metabolism ; Inflammation/metabolism ; Liver/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Palmitates
    Chemical Substances Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Palmitates ; Foxo6 protein, mouse ; Txnip protein, mouse
    Language English
    Publishing date 2024-02-22
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2802452-7
    ISSN 2093-5978 ; 2093-5978
    ISSN (online) 2093-5978
    ISSN 2093-5978
    DOI 10.3803/EnM.2023.1826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Unlocking synergies: Harnessing the potential of biological methane sequestration through metabolic coupling between Methylomicrobium alcaliphilum 20Z and Chlorella sp. HS2.

    Yun, Jin-Ho / Lee, Hyewon / Nam, Jang-Won / Ko, Minji / Park, Jaehyun / Lee, Dae-Hee / Lee, Seung-Goo / Kim, Hee-Sik

    Bioresource technology

    2024  Volume 399, Page(s) 130607

    Abstract: A halotolerant consortium between microalgae and methanotrophic bacteria could effectively remediate in situ ... ...

    Abstract A halotolerant consortium between microalgae and methanotrophic bacteria could effectively remediate in situ CH
    MeSH term(s) Methane/metabolism ; Chlorella/metabolism ; Methylococcaceae/metabolism ; Bacteria/metabolism
    Chemical Substances Methane (OP0UW79H66)
    Language English
    Publishing date 2024-03-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1065195-0
    ISSN 1873-2976 ; 0960-8524
    ISSN (online) 1873-2976
    ISSN 0960-8524
    DOI 10.1016/j.biortech.2024.130607
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    In stock of ZB MED Bonn / Germany

    Z 3258: Show issues

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  9. Article ; Online: Intrusion Detection System CAN-Bus In-Vehicle Networks Based on the Statistical Characteristics of Attacks.

    Khan, Junaid / Lim, Dae-Woon / Kim, Young-Sik

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 7

    Abstract: For in-vehicle network communication, the controller area network (CAN) broadcasts to all connected nodes without address validation. Therefore, it is highly vulnerable to all sorts of attack scenarios. This research proposes a novel intrusion detection ... ...

    Abstract For in-vehicle network communication, the controller area network (CAN) broadcasts to all connected nodes without address validation. Therefore, it is highly vulnerable to all sorts of attack scenarios. This research proposes a novel intrusion detection system (IDS) for CAN to identify in-vehicle network anomalies. The statistical characteristics of attacks provide valuable information about the inherent intrusion patterns and behaviors. We employed two real-world attack scenarios from publicly available datasets to record a real-time response against intrusions with increased precision for in-vehicle network environments. Our proposed IDS can exploit malicious patterns by calculating thresholds and using the statistical properties of attacks, making attack detection more efficient. The optimized threshold value is calculated using brute-force optimization for various window sizes to minimize the total error. The reference values of normality require a few legitimate data frames for effective intrusion detection. The experimental findings validate that our suggested method can efficiently detect fuzzy, merge, and denial-of-service (DoS) attacks with low false-positive rates. It is also demonstrated that the total error decreases with an increasing attack rate for varying window sizes. The results indicate that our proposed IDS minimizes the misclassification rate and is hence better suited for in-vehicle networks.
    Language English
    Publishing date 2023-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23073554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Identification of Loliolide with Anti-Aging Properties from

    Cho, Dae-Hyun / Yun, Jin-Ho / Heo, Jina / Lee, In-Kyoung / Lee, Yong-Jae / Bae, Seunghee / Yun, Bong-Sik / Kim, Hee-Sik

    Journal of microbiology and biotechnology

    2023  Volume 33, Issue 9, Page(s) 1250–1256

    Abstract: Herein, different extracts ... ...

    Abstract Herein, different extracts of
    MeSH term(s) Humans ; Scenedesmus ; Acetates ; Aging ; Microalgae/chemistry
    Chemical Substances ethyl acetate (76845O8NMZ) ; loliolide (U3BB4IM281) ; Acetates
    Language English
    Publishing date 2023-06-02
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2412195-2
    ISSN 1738-8872 ; 1738-8872
    ISSN (online) 1738-8872
    ISSN 1738-8872
    DOI 10.4014/jmb.2304.04044
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