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  1. Book ; Thesis: Randomisierte kontrollierte Studie zum Einlfuss von Prasugrel und Clopidogrel auf die Endothelfunktion, Thrombozyten-Leukozyten-Interaktionen und Inflammation bei Patienten mit instabiler Angina pectoris

    Fuchs, Alexander

    2018  

    Author's details vorgelegt von Alexander Fuchs
    Language German
    Size 90 Seiten, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2018
    HBZ-ID HT019785794
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 D 796 order for loan Magazin

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  2. Book ; Thesis: Etablierung einer ex-vivo Expansion und funktionellen Überprüfung von CD8+ T-Zellen zur Identifizierung tumorspezifischer Peptide auf disseminierten Tumorzellen

    Fuchs, Alexander Erich

    2019  

    Author's details vorgelegt von Alexander Erich Fuchs
    Language German
    Size 104 Blätter, Illustrationen, Diagramme, 21 cm
    Publishing place Regensburg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Regensburg, 2019
    HBZ-ID HT020333655
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 D 23 order for loan Magazin

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  3. Book ; Thesis: Optimierung der Techniken für die erfolgreiche Punktion des Plexus lumbalis zur Regionalanästhesie

    Fuchs, Alexander Reiner

    2009  

    Author's details vorgelegt von Alexander Reiner Fuchs
    Subject code 617.96
    Language German
    Size 86 Bl., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dresden, Techn. Univ., Diss., 2009
    HBZ-ID HT016307739
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 E 1691 order for loan Magazin

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  4. Article ; Online: To gel or not to gel - Tuning the sulfation pattern of carrageenans to expand their field of application.

    Fuchs, Alexander / Hupfeld, Enrico / Sieber, Volker

    Carbohydrate polymers

    2024  Volume 333, Page(s) 121930

    Abstract: Carrageenans represent a major cell wall component of red macro algae and, as established gelling and thickening agents, they contribute significantly to a broad variety of commercial applications in the food and cosmetic industry. As a highly sulfated ... ...

    Abstract Carrageenans represent a major cell wall component of red macro algae and, as established gelling and thickening agents, they contribute significantly to a broad variety of commercial applications in the food and cosmetic industry. As a highly sulfated class of linear polysaccharides, their functional properties are strongly related to the sulfation pattern of their carrabiose repeating units. Therefore, the biocatalytic fine-tuning of these polymers by generating tailored sulfation architectures harnessing the hydrolytic activity of sulfatases could be a powerful tool to produce novel polymer structures with tuned properties to expand applications of carrageenans beyond their current use. To contribute to this vision, we sought to identify novel carrageenan sulfatases by studying several putative carrageenolytic clusters in marine heterotrophic bacteria. This approach revealed two novel formylglycine-dependent sulfatases from Cellulophaga algicola DSM 14237 and Cellulophaga baltica DSM 24729 with promiscuous hydrolytic activity towards the sulfated galactose in the industrially established ι- and κ-carrageenan, converting them into α- and β-carrageenan, respectively, and enabling the production of a variety of novel pure and hybrid carrageenans. The rheological analysis of these enzymatically generated structures revealed significantly altered physicochemical properties that may open the gate to a variety of novel carrageenan-based applications.
    MeSH term(s) Carrageenan/chemistry ; Polysaccharides ; Gels ; Sulfates ; Sulfatases
    Chemical Substances Carrageenan (9000-07-1) ; Polysaccharides ; Gels ; Sulfates ; Sulfatases (EC 3.1.6.-)
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2024.121930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Biocatalytic Conversion of Carrageenans for the Production of 3,6-Anhydro-D-galactose.

    Fuchs, Alexander / Romeis, Dennis / Hupfeld, Enrico / Sieber, Volker

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 11, Page(s) 5816–5827

    Abstract: Marine biomass stands out as a sustainable resource for generating value-added chemicals. In particular, anhydrosugars derived from carrageenans exhibit a variety of biological functions, rendering them highly promising for utilization and cascading in ... ...

    Abstract Marine biomass stands out as a sustainable resource for generating value-added chemicals. In particular, anhydrosugars derived from carrageenans exhibit a variety of biological functions, rendering them highly promising for utilization and cascading in food, cosmetic, and biotechnological applications. However, the limitation of available sulfatases to break down the complex sulfation patterns of carrageenans poses a significant limitation for the sustainable production of valuable bioproducts from red algae. In this study, we screened several carrageenolytic polysaccharide utilization loci for novel sulfatase activities to assist the efficient conversion of a variety of sulfated galactans into the target product 3,6-anhydro-D-galactose. Inspired by the carrageenolytic pathways in marine heterotrophic bacteria, we systematically combined these novel sulfatases with other carrageenolytic enzymes, facilitating the development of the first enzymatic one-pot biotransformation of ι- and κ-carrageenan to 3,6-anhdyro-D-galactose. We further showed the applicability of this enzymatic bioconversion to a broad series of hybrid carrageenans, rendering this process a promising and sustainable approach for the production of value-added biomolecules from red-algal feedstocks.
    MeSH term(s) Carrageenan/chemistry ; Galactose ; Galactans/chemistry ; Polysaccharides ; Rhodophyta/chemistry ; Sulfatases
    Chemical Substances Carrageenan (9000-07-1) ; Galactose (X2RN3Q8DNE) ; Galactans ; Polysaccharides ; Sulfatases (EC 3.1.6.-)
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c08613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Book ; Thesis: Simultaneous laryngopharyngeal pH monitoring (Restech) and conventional esophageal pH monitoring

    Müller, Dolores Thea / Fuchs, Hans Friedrich / Töx, Ulrich / Gutschow, Christian Alexander

    correlation using a large patient cohort of more than 100 patients with suspected gastroesophageal reflux disease

    2020  

    Institution Universitätsklinikum Köln / Klinik und Poliklinik für Allgemein-, Viszeral- und Tumorchirurgie
    Author's details vorgelegt von Dolores Thea Müller ; 1. Gutachter: Privatdozent Dr. med. H. Fuchs, 2. Gutachter: Professor Dr. med. U. Töx, 3. Gutachter: Professor Dr. med. C. Gutschow ; aus dem Zentrum für Operative Medizin der Universität zu Köln, Klinik und Poliklinik für Allgemein-, Viszeral-, Tumor- und Transplantationschirurgie
    Subject code 610
    Language English
    Size 46 Seiten, Illustrationen
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2020
    Note Enthält Sonderabdruck aus Zeitschrift
    HBZ-ID HT020663451
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2020 D 889 order for loan Magazin

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  7. Article ; Online: Favourable neurological outcome following paediatric out-of-hospital cardiac arrest: authors' reply.

    Fuchs, Alexander / Albrecht, Roland / Greif, Robert / Mueller, Martin / Pietsch, Urs

    Scandinavian journal of trauma, resuscitation and emergency medicine

    2024  Volume 32, Issue 1, Page(s) 8

    MeSH term(s) Child ; Humans ; Out-of-Hospital Cardiac Arrest/therapy ; Retrospective Studies ; Cardiopulmonary Resuscitation
    Language English
    Publishing date 2024-01-26
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2455990-8
    ISSN 1757-7241 ; 1757-7241
    ISSN (online) 1757-7241
    ISSN 1757-7241
    DOI 10.1186/s13049-024-01176-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online ; Thesis: Die Rolle von NFAT2 und LCK in der Pathophysiologie der chronischen lymphatischen Leukämie

    Fuchs, Alexander [Verfasser]

    2021  

    Author's details Alexander Fuchs
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Universitätsbibliothek Tübingen
    Publishing place Tübingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Article ; Online: Innovations in GI-endoscopy.

    Meining, Alexander / Hann, Alexander / Fuchs, Karl Hermann

    Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

    2022  Volume 23, Issue 3, Page(s) 139–143

    Abstract: Gastrointestinal endoscopy covers both diagnosis and therapy. Due to its diagnostic accuracy and minimal invasiveness, several innovations have been made within the last years including artificial intelligence and endoscopic tumor resection. The present ... ...

    Abstract Gastrointestinal endoscopy covers both diagnosis and therapy. Due to its diagnostic accuracy and minimal invasiveness, several innovations have been made within the last years including artificial intelligence and endoscopic tumor resection. The present review highlights some of these innovation. In addition, a special focus is set on the experience made by our own research group trying to combine the expertise of endoscopists/ physicians as well as engineers and computer scientists.
    MeSH term(s) Artificial Intelligence ; Endoscopy, Gastrointestinal ; Humans
    Language English
    Publishing date 2022-06-21
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 2502114-X
    ISSN 2090-2387 ; 1687-1979
    ISSN (online) 2090-2387
    ISSN 1687-1979
    DOI 10.1016/j.ajg.2022.06.003
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  10. Article: New Concept of External and Independent Next-to-the-Scope Intraluminal Grasping Device (EINTS).

    Fuchs, Karl-Hermann / Sudarevic, Boban / Troya, Joel / Hann, Alexander / Meining, Alexander

    Chirurgia (Bucharest, Romania : 1990)

    2023  Volume 118, Issue 2, Page(s) 127–136

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Treatment Outcome ; Dissection/methods ; Equipment Design
    Language English
    Publishing date 2023-05-05
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 419244-8
    ISSN 1842-368X ; 1221-9118 ; 0009-4730 ; 0377-5003
    ISSN (online) 1842-368X
    ISSN 1221-9118 ; 0009-4730 ; 0377-5003
    DOI 10.21614/chirurgia.2813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1352: Show issues Location:
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    Zs.MO 620: Show issues

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