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  1. Article: Tailored Nanoparticles With the Potential to Reduce Ruminant Methane Emissions.

    Altermann, Eric / Reilly, Kerri / Young, Wayne / Ronimus, Ron S / Muetzel, Stefan

    Frontiers in microbiology

    2022  Volume 13, Page(s) 816695

    Abstract: Agricultural methane produced by archaea in the forestomach of ruminants is a key contributor to rising levels of greenhouse gases leading to climate change. Functionalized biological polyhydroxybutyrate (PHB) nanoparticles offer a new concept for the ... ...

    Abstract Agricultural methane produced by archaea in the forestomach of ruminants is a key contributor to rising levels of greenhouse gases leading to climate change. Functionalized biological polyhydroxybutyrate (PHB) nanoparticles offer a new concept for the reduction of enteric methane emissions by inhibiting rumen methanogens. Nanoparticles were functionalized
    Language English
    Publishing date 2022-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.816695
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  2. Article ; Online: Complete genome sequence of

    Palevich, Nikola / Jeyanathan, Jeyamalar / Reilly, Kerri / Palevich, Faith P / Maclean, Paul H / Li, Dong / Altermann, Eric / Kelly, William J / Leahy, Sinead C / Attwood, Graeme T / Ronimus, Ron S / Henderson, Gemma / Janssen, Peter H

    Microbiology resource announcements

    2024  Volume 13, Issue 4, Page(s) e0004324

    Abstract: ... ...

    Abstract Methanosphaera
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00043-24
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  3. Article ; Online: Crystal Structures of Bacterial Pectin Methylesterases Pme8A and PmeC2 from Rumen

    Carbone, Vincenzo / Reilly, Kerri / Sang, Carrie / Schofield, Linley R / Ronimus, Ron S / Kelly, William J / Attwood, Graeme T / Palevich, Nikola

    International journal of molecular sciences

    2023  Volume 24, Issue 18

    Abstract: Pectin is a complex polysaccharide that forms a substantial proportion of the plant's middle lamella of forage ingested by grazing ruminants. Methanol in the rumen is derived mainly from methoxy groups released from pectin by the action of pectin ... ...

    Abstract Pectin is a complex polysaccharide that forms a substantial proportion of the plant's middle lamella of forage ingested by grazing ruminants. Methanol in the rumen is derived mainly from methoxy groups released from pectin by the action of pectin methylesterase (PME) and is subsequently used by rumen methylotrophic methanogens that reduce methanol to produce methane (CH
    MeSH term(s) Animals ; Methanol ; Rumen ; Butyrivibrio ; Carboxylesterase ; Bacteria ; Pectins
    Chemical Substances pectinesterase (EC 3.1.1.11) ; Methanol (Y4S76JWI15) ; Carboxylesterase (EC 3.1.1.1) ; Pectins (89NA02M4RX)
    Language English
    Publishing date 2023-09-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241813738
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  4. Article ; Online: Using genome comparisons of wild-type and resistant mutants of

    Long, Feng / Cheung, Chen-Yi / Whitman, William B / Cook, Gregory M / Ronimus, Ron S

    Access microbiology

    2021  Volume 3, Issue 7, Page(s) 244

    Abstract: Methane emissions from enteric fermentation in the ruminant digestive system generated by methanogenic archaea are a significant contributor to anthropogenic greenhouse gas emissions. Additionally, methane produced as an end-product of enteric ... ...

    Abstract Methane emissions from enteric fermentation in the ruminant digestive system generated by methanogenic archaea are a significant contributor to anthropogenic greenhouse gas emissions. Additionally, methane produced as an end-product of enteric fermentation is an energy loss from digested feed. To control the methane emissions from ruminants, extensive research in the last decades has been focused on developing viable enteric methane mitigation practices, particularly, using methanogen-specific inhibitors. We report here the utilization of two known inhibitors of methanogenic archaea, neomycin and chloroform, together with a recently identified inhibitor, echinomycin, to produce resistant mutants of
    Language English
    Publishing date 2021-07-21
    Publishing country England
    Document type Journal Article
    ISSN 2516-8290
    ISSN (online) 2516-8290
    DOI 10.1099/acmi.0.000244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Tailored Nanoparticles With the Potential to Reduce Ruminant Methane Emissions

    Eric Altermann / Kerri Reilly / Wayne Young / Ron S. Ronimus / Stefan Muetzel

    Frontiers in Microbiology, Vol

    2022  Volume 13

    Abstract: Agricultural methane produced by archaea in the forestomach of ruminants is a key contributor to rising levels of greenhouse gases leading to climate change. Functionalized biological polyhydroxybutyrate (PHB) nanoparticles offer a new concept for the ... ...

    Abstract Agricultural methane produced by archaea in the forestomach of ruminants is a key contributor to rising levels of greenhouse gases leading to climate change. Functionalized biological polyhydroxybutyrate (PHB) nanoparticles offer a new concept for the reduction of enteric methane emissions by inhibiting rumen methanogens. Nanoparticles were functionalized in vivo with an archaeal virus lytic enzyme, PeiR, active against a range of rumen Methanobrevibacter species. The impact of functionalized nanoparticles against rumen methanogens was demonstrated in pure cultures, in rumen batch and continuous flow rumen models yielding methane reduction of up to 15% over 11 days in the most complex system. We further present evidence of biological nanoparticle fermentation in a rumen environment. Elevated levels of short-chain fatty acids essential to ruminant nutrition were recorded, giving rise to a promising new strategy combining methane mitigation with a possible increase in animal productivity.
    Keywords bionanoparticles ; methane mitigation ; biotechnology ; sustainable agriculture ; climate change ; methanogens ; Microbiology ; QR1-502
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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  6. Article ; Online: Structural characterisation of methanogen pseudomurein cell wall peptide ligases homologous to bacterial MurE/F murein peptide ligases.

    Subedi, Bishwa P / Schofield, Linley R / Carbone, Vincenzo / Wolf, Maximilian / Martin, William F / Ronimus, Ron S / Sutherland-Smith, Andrew J

    Microbiology (Reading, England)

    2022  Volume 168, Issue 9

    Abstract: Archaea have diverse cell wall types, yet none are identical to bacterial peptidoglycan (murein). ... ...

    Abstract Archaea have diverse cell wall types, yet none are identical to bacterial peptidoglycan (murein). Methanogens
    MeSH term(s) Adenosine Triphosphate/metabolism ; Amino Acids/metabolism ; Archaea/metabolism ; Bacteria/metabolism ; Cell Wall/metabolism ; Euryarchaeota/metabolism ; Ligases/metabolism ; Peptide Synthases/metabolism ; Peptidoglycan/metabolism ; Sugars/metabolism ; Uridine Diphosphate/analysis ; Uridine Diphosphate/metabolism
    Chemical Substances Amino Acids ; Peptidoglycan ; Sugars ; Uridine Diphosphate (58-98-0) ; Adenosine Triphosphate (8L70Q75FXE) ; Ligases (EC 6.-) ; Peptide Synthases (EC 6.3.2.-)
    Language English
    Publishing date 2022-09-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180712-x
    ISSN 1465-2080 ; 1350-0872
    ISSN (online) 1465-2080
    ISSN 1350-0872
    DOI 10.1099/mic.0.001235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Crystal Structures of Bacterial Pectin Methylesterases Pme8A and PmeC2 from Rumen Butyrivibrio

    Vincenzo Carbone / Kerri Reilly / Carrie Sang / Linley R. Schofield / Ron S. Ronimus / William J. Kelly / Graeme T. Attwood / Nikola Palevich

    International Journal of Molecular Sciences, Vol 24, Iss 13738, p

    2023  Volume 13738

    Abstract: Pectin is a complex polysaccharide that forms a substantial proportion of the plant’s middle ...

    Abstract Pectin is a complex polysaccharide that forms a substantial proportion of the plant’s middle lamella of forage ingested by grazing ruminants. Methanol in the rumen is derived mainly from methoxy groups released from pectin by the action of pectin methylesterase (PME) and is subsequently used by rumen methylotrophic methanogens that reduce methanol to produce methane (CH 4 ). Members of the genus Butyrivibrio are key pectin-degrading rumen bacteria that contribute to methanol formation and have important roles in fibre breakdown, protein digestion, and the biohydrogenation of fatty acids. Therefore, methanol release from pectin degradation in the rumen is a potential target for CH 4 mitigation technologies. Here, we present the crystal structures of PMEs belonging to the carbohydrate esterase family 8 (CE8) from Butyrivibrio proteoclasticus and Butyrivibrio fibrisolvens , determined to a resolution of 2.30 Å. These enzymes, like other PMEs, are right-handed β-helical proteins with a well-defined catalytic site and reaction mechanisms previously defined in insect, plant, and other bacterial pectin methylesterases. Potential substrate binding domains are also defined for the enzymes.
    Keywords pectin methylesterase ; Butyrivibrio ; rumen ; pectin ; methanol ; methane ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: A review on comparative mechanistic studies of antimicrobial peptides against archaea.

    Varnava, Kyriakos G / Ronimus, Ron S / Sarojini, Vijayalekshmi

    Biotechnology and bioengineering

    2017  Volume 114, Issue 11, Page(s) 2457–2473

    Abstract: Archaea was until recently considered as a third domain of life in addition to bacteria and eukarya but recent studies support the existence of only two superphyla (bacteria and archaea). The fundamental differences between archaeal, bacterial, and ... ...

    Abstract Archaea was until recently considered as a third domain of life in addition to bacteria and eukarya but recent studies support the existence of only two superphyla (bacteria and archaea). The fundamental differences between archaeal, bacterial, and eukaryal cells are probably the main reasons for the comparatively lower susceptibility of archaeal strains to current antimicrobial agents. The possible emerging pathogenicity of archaea and the role of archaeal methanogens in methane emissions, a potent greenhouse gas, has led many researchers to examine the sensitivity patterns of archaea and make attempts to find agents that have significant anti-archaeal activity. Even though antimicrobial peptides (AMPs) are well known with several published reviews concerning their mode of action against bacteria and eukarya, to our knowledge, to date no reviews are available that focus on the action of these peptides against archaea. Herein, we present a review on all the peptides that have been tested against archaea. In addition, in an attempt to shed more light on possible future work that needs to be performed we have included a brief overview of the chemical characteristics, spectrum of activity, and the known mechanism of action of each of these peptides against bacteria and/or fungi. We also discuss the nature of and key physiological differences between Archaea, Bacteria, and Eukarya that are relevant to the development of anti-archaeal peptides. Despite our relatively limited knowledge about archaea, available data suggest that AMPs have an even broader spectrum of activity than currently recognized.
    MeSH term(s) Antimicrobial Cationic Peptides/administration & dosage ; Apoptosis/drug effects ; Apoptosis/physiology ; Archaea/cytology ; Archaea/drug effects ; Archaea/physiology ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests/methods ; Species Specificity
    Chemical Substances Antimicrobial Cationic Peptides
    Language English
    Publishing date 2017-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 280318-5
    ISSN 1097-0290 ; 0006-3592
    ISSN (online) 1097-0290
    ISSN 0006-3592
    DOI 10.1002/bit.26387
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  9. Article: Inhibition of Rumen Methanogens by a Novel Archaeal Lytic Enzyme Displayed on Tailored Bionanoparticles.

    Altermann, Eric / Schofield, Linley R / Ronimus, Ron S / Beatty, Amy K / Reilly, Kerri

    Frontiers in microbiology

    2018  Volume 9, Page(s) 2378

    Abstract: Methane is a potent greenhouse gas, 25 times more efficient at trapping heat than carbon dioxide. Ruminant methane emissions contribute almost 30% to anthropogenic sources of global atmospheric methane levels and a reduction in methane emissions would ... ...

    Abstract Methane is a potent greenhouse gas, 25 times more efficient at trapping heat than carbon dioxide. Ruminant methane emissions contribute almost 30% to anthropogenic sources of global atmospheric methane levels and a reduction in methane emissions would significantly contribute to slowing global temperature rises. Here we demonstrate the use of a lytic enyzme, PeiR, from a methanogen virus that infects
    Language English
    Publishing date 2018-10-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2018.02378
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  10. Article ; Online: Structural determination of archaeal UDP-N-acetylglucosamine 4-epimerase from Methanobrevibacter ruminantium M1 in complex with the bacterial cell wall intermediate UDP-N-acetylmuramic acid.

    Carbone, Vincenzo / Schofield, Linley R / Sang, Carrie / Sutherland-Smith, Andrew J / Ronimus, Ron S

    Proteins

    2018  Volume 86, Issue 12, Page(s) 1306–1312

    Abstract: The crystal structure of UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase; WbpP; EC 5.1.3.7), from the archaeal methanogen Methanobrevibacter ruminantium strain M1, was determined to a resolution of 1.65 Å. The structure, with a single monomer ...

    Abstract The crystal structure of UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase; WbpP; EC 5.1.3.7), from the archaeal methanogen Methanobrevibacter ruminantium strain M1, was determined to a resolution of 1.65 Å. The structure, with a single monomer in the crystallographic asymmetric unit, contained a conserved N-terminal Rossmann-fold for nucleotide binding and an active site positioned in the C-terminus. UDP-GlcNAc 4-epimerase is a member of the short-chain dehydrogenases/reductases superfamily, sharing sequence motifs and structural elements characteristic of this family of oxidoreductases and bacterial 4-epimerases. The protein was co-crystallized with coenzyme NADH and UDP-N-acetylmuramic acid, the latter an unintended inclusion and well known product of the bacterial enzyme MurB and a critical intermediate for bacterial cell wall synthesis. This is a non-native UDP sugar amongst archaea and was most likely incorporated from the E. coli expression host during purification of the recombinant enzyme.
    MeSH term(s) Archaeal Proteins/chemistry ; Archaeal Proteins/genetics ; Carbohydrate Epimerases/chemistry ; Carbohydrate Epimerases/genetics ; Catalytic Domain ; Crystallography, X-Ray ; Escherichia coli/metabolism ; Methanobrevibacter/enzymology ; Models, Molecular ; NAD/chemistry ; Protein Conformation ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Uridine Diphosphate N-Acetylmuramic Acid/chemistry
    Chemical Substances Archaeal Proteins ; Recombinant Proteins ; Uridine Diphosphate N-Acetylmuramic Acid ; NAD (0U46U6E8UK) ; Carbohydrate Epimerases (EC 5.1.3.-) ; UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.14)
    Language English
    Publishing date 2018-10-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 806683-8
    ISSN 1097-0134 ; 0887-3585
    ISSN (online) 1097-0134
    ISSN 0887-3585
    DOI 10.1002/prot.25606
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    Zs.A 2291: Show issues Location:
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