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  1. Article ; Online: In vitro chemosensitivity testing of the feline large granular lymphocyte cell line (S87).

    Hartung, Svenja / Herden, Christiane / Sparenberg, Marion / Henrich, Manfred

    Veterinary medicine and science

    2024  Volume 10, Issue 2, Page(s) e1350

    Abstract: Background: Feline large granular lymphocyte (LGL) lymphoma is an aggressive neoplasia characterised by short survival and poor response to chemotherapy.: Objectives: In this study, the effect of different chemotherapeutic agents on the growth ... ...

    Abstract Background: Feline large granular lymphocyte (LGL) lymphoma is an aggressive neoplasia characterised by short survival and poor response to chemotherapy.
    Objectives: In this study, the effect of different chemotherapeutic agents on the growth kinetics of the feline cell line S87, a non-MHC-restricted feline LGL cell line, was investigated. Where possible, IC
    Methods: Cells were incubated with various concentrations of vincristine, doxorubicin, 4-hydroperoxycyclophosphamide, prednisolone, methotrexate and L-asparaginase for 24 and 48 h, respectively.
    Results: The IC
    Conclusion: Overall, the feline LGL cell line S87 proves to be relatively sensitive to doxorubicin and 4-hydroperoxycyclophosphamide and relatively resistant to treatment with vincristine, prednisolone, methotrexate and L-asparaginase. The results of this study can be used for further investigations on resistance mechanisms in feline LGL lymphoma. Doxorubicin and cyclophosphamide can be interpreted as promising candidates for the therapy of feline LGL lymphomas.
    MeSH term(s) Cats ; Animals ; Vincristine ; Asparaginase/therapeutic use ; Methotrexate/therapeutic use ; Lymphoma/drug therapy ; Lymphoma/veterinary ; Lymphoma/pathology ; Doxorubicin/pharmacology ; Cell Line ; Prednisolone/pharmacology ; Prednisolone/therapeutic use ; Lymphocytes/pathology ; Cat Diseases ; Cyclophosphamide/analogs & derivatives
    Chemical Substances Vincristine (5J49Q6B70F) ; Asparaginase (EC 3.5.1.1) ; perfosfamide (U880A4FUDA) ; Methotrexate (YL5FZ2Y5U1) ; Doxorubicin (80168379AG) ; Prednisolone (9PHQ9Y1OLM) ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2819409-3
    ISSN 2053-1095 ; 2053-1095
    ISSN (online) 2053-1095
    ISSN 2053-1095
    DOI 10.1002/vms3.1350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tumor Necrosis Factor-α Receptor 1 Mediates Borna Disease Virus 1-Induced Changes in Peroxisomal and Mitochondrial Dynamics in Neurons.

    Osei, Dominic / Baumgart-Vogt, Eveline / Ahlemeyer, Barbara / Herden, Christiane

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Borna disease virus 1 (BoDV1) causes a persistent infection in the mammalian brain. Peroxisomes and mitochondria play essential roles in the cellular antiviral immune response, but the effect of BoDV1 infection on peroxisomal and mitochondrial dynamics ... ...

    Abstract Borna disease virus 1 (BoDV1) causes a persistent infection in the mammalian brain. Peroxisomes and mitochondria play essential roles in the cellular antiviral immune response, but the effect of BoDV1 infection on peroxisomal and mitochondrial dynamics and their respective antioxidant capacities is still not clear. Using different mouse lines-i.e., tumor necrosis factor-α transgenic (TNFTg; to pro-inflammatory status), TNF receptor-1 knockout (TNFR1ko), and TNFR2ko mice in comparison to wild-type (Wt) mice-we analyzed the abundances of both organelles and their main antioxidant enzymes, catalase and superoxide dismutase 2 (SOD2), in neurons of the hippocampal, cerebral, and cerebellar cortices. In TNFTg mice, a strong increase in mitochondrial (6.9-fold) and SOD2 (12.1-fold) abundances was detected; meanwhile, peroxisomal abundance increased slightly (1.5-fold), but that of catalase decreased (2.9-fold). After BoDV1 infection, a strong decrease in mitochondrial (2.1-6.5-fold), SOD2 (2.7-9.1-fold), and catalase (2.7-10.3-fold) abundances, but a slight increase in peroxisomes (1.3-1.6-fold), were detected in Wt and TNFR2ko mice, whereas no changes occurred in TNFR1ko mice. Our data suggest that the TNF system plays a crucial role in the biogenesis of both subcellular organelles. Moreover, TNFR1 signaling mediated the changes in peroxisomal and mitochondrial dynamics after BoDV1 infection, highlighting new mechanisms by which BoDV1 may achieve immune evasion and viral persistence.
    MeSH term(s) Mice ; Animals ; Receptors, Tumor Necrosis Factor, Type I/genetics ; Tumor Necrosis Factor-alpha/physiology ; Catalase/genetics ; Borna disease virus ; Antioxidants ; Mitochondrial Dynamics ; Mice, Knockout ; Neurons ; Mice, Inbred C57BL ; Mammals
    Chemical Substances Receptors, Tumor Necrosis Factor, Type I ; Tumor Necrosis Factor-alpha ; Catalase (EC 1.11.1.6) ; Antioxidants
    Language English
    Publishing date 2024-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031849
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  3. Article ; Online: Borna disease in an adult free-ranging Eurasian beaver (Castor fiber albicus).

    Ellenberger, Christin / Heenemann, Kristin / Vahlenkamp, Thomas W / Grothmann, Pierre / Herden, Christiane / Heinrich, Anja

    Journal of comparative pathology

    2024  Volume 209, Page(s) 31–35

    Abstract: Borna disease (BD) associated with a peracute bacterial septicaemia with Escherichia coli was diagnosed in an adult female, naturally infected, free-ranging Eurasian beaver of the subspecies Castor fiber albicus, clinically characterized by weight loss, ... ...

    Abstract Borna disease (BD) associated with a peracute bacterial septicaemia with Escherichia coli was diagnosed in an adult female, naturally infected, free-ranging Eurasian beaver of the subspecies Castor fiber albicus, clinically characterized by weight loss, depression, weakness and gurgled peristaltic sounds. The beaver was euthanized humanely. Necropsy and light microscopy revealed a non-purulent meningoencephalitis with typical mononuclear perivascular cuffs and parenchymal infiltrates. The diagnosis of BD was confirmed by detection of viral antigen and RNA by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). The PCR product was sequenced and cluster analysis revealed a close relationship between endemic clusters in Saxony-Anhalt. This is the first report of naturally occurring BD in a free-ranging Eurasian beaver.
    MeSH term(s) Female ; Animals ; Borna Disease ; Antigens, Viral ; Autopsy/veterinary ; Meningoencephalitis/veterinary ; Sepsis/veterinary
    Chemical Substances Antigens, Viral
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 390920-7
    ISSN 1532-3129 ; 0021-9975
    ISSN (online) 1532-3129
    ISSN 0021-9975
    DOI 10.1016/j.jcpa.2024.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Book: Naturschutzfachliche Bewertungsmethoden von Freilandphotovoltaikanlagen

    Herden, Christoph / Gharadjedaghi, Bahram / Rassmus, Jörg

    Endbericht

    (BfN-Skripten ; 247)

    2009  

    Author's details Christoph Herden ; Bahram Gharadjedaghi ; Jörg Rassmus
    Series title BfN-Skripten ; 247
    BfN-Skripten / Bundesamt für Naturschutz
    Collection BfN-Skripten / Bundesamt für Naturschutz
    Language German
    Size VIII, 168, XIV S. : Ill., graph. Darst., Kt., 29 cm
    Edition Stand Januar 2006
    Publisher BfN
    Publishing place Bonn- Bad Godesberg
    Publishing country Germany
    Document type Book
    Note Literaturverz. S. 165 - 168 ; Zsfassung in engl. Sprache
    HBZ-ID HT015951785
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    094/153 available for loan (reading room) Freihandmagazin (U1)

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  5. Article ; Online: No evidence for European bats serving as reservoir for Borna disease virus 1 or other known mammalian orthobornaviruses.

    Nobach, Daniel / Herden, Christiane

    Virology journal

    2020  Volume 17, Issue 1, Page(s) 11

    Abstract: Background: The majority of emerging infectious diseases are zoonotic in nature and originate from wildlife reservoirs. Borna disease, caused by Borna disease virus 1 (BoDV-1), is an infectious disease affecting mammals, but recently it has also been ... ...

    Abstract Background: The majority of emerging infectious diseases are zoonotic in nature and originate from wildlife reservoirs. Borna disease, caused by Borna disease virus 1 (BoDV-1), is an infectious disease affecting mammals, but recently it has also been shown to cause fatal encephalitis in humans. The endemic character of Borna disease points towards a nature-bound reservoir, with only one shrew species identified as reservoir host to date. Bats have been identified as reservoirs of a variety of zoonotic infectious agents. Endogenous borna-like elements in the genome of certain bat species additionally point towards co-evolution of bats with bornaviruses and therefore raise the question whether bats could serve as a potential reservoir of orthobornaviruses.
    Methods: Frozen brain samples (n = 257) of bats of seven different genera from Germany were investigated by orthobornaviral RT-PCR. Additionally, tissue slides of formalin-fixed paraffin-embedded material of a subset of these bats (n = 140) were investigated for orthobornaviral phosphoprotein by immunohistochemistry.
    Results: The brain samples were tested by RT-PCR without any evidence of orthobornavirus specific amplicons. Immunohistochemistry revealed a faint immunoreaction in 3/140 bats but with an untypical staining pattern for viral antigen.
    Conclusions: RT-PCR-screening showed no evidence for orthobornaviral RNA in the investigated bats. However, immunohistochemistry results should be investigated further to elucidate whether the reaction might be associated with expressed endogenous bornaviral elements or other so far unknown bornaviruses.
    MeSH term(s) Animals ; Antigens, Viral/chemistry ; Antigens, Viral/immunology ; Borna Disease/epidemiology ; Borna Disease/virology ; Borna disease virus/chemistry ; Borna disease virus/genetics ; Brain/virology ; Chiroptera/virology ; Disease Reservoirs/veterinary ; Disease Reservoirs/virology ; Germany/epidemiology ; Immunohistochemistry ; Paraffin Embedding ; Phosphoproteins/immunology
    Chemical Substances Antigens, Viral ; Phosphoproteins
    Keywords covid19
    Language English
    Publishing date 2020-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2160640-7
    ISSN 1743-422X ; 1743-422X
    ISSN (online) 1743-422X
    ISSN 1743-422X
    DOI 10.1186/s12985-020-1289-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Pindborg Tumor-An Uncommon Odontogenic Tumor Detected by 68Ga-DOTATOC.

    Herden, Anna / Sabtan, Deema / Warnecke, Katja / Doll, Christian / Furth, Christian

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 2

    Abstract: A 62-year-old-woman with a suspected Tumor-induced-osteomalacia (TIO), a rare neoplastic syndrome that results in renal phosphate wasting with hypophosphatemia, ... ...

    Abstract A 62-year-old-woman with a suspected Tumor-induced-osteomalacia (TIO), a rare neoplastic syndrome that results in renal phosphate wasting with hypophosphatemia, underwent
    Language English
    Publishing date 2022-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12020389
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  7. Article ; Conference proceedings: Adenosquamöses Karzinom am Larynx einer Katze

    Lépine, M / Weyrich, A / Henrich, M / Herden, C

    Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere

    2022  Volume 50, Issue 03

    Event/congress 65. Jahrestagung der Fachgruppe Pathologie der Deutschen Veterinärmedizinischen Gesellschaft, Online-Tagung, 2022-03-05
    Language German
    Publishing date 2022-07-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ISSN 2567-5842 ; 1434-1239
    ISSN (online) 2567-5842
    ISSN 1434-1239
    DOI 10.1055/s-0042-1750000
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  8. Article: Histological and Immunohistochemical Characterization of Vascular Alterations in Meninges of Cats Infected with

    Hartung, Svenja / Weyrich, Angelika / Moroni, Manuel / Gómez, Marcelo / Herden, Christiane

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 1

    Abstract: ... Gurltia ... ...

    Abstract Gurltia paralysans
    Language English
    Publishing date 2022-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11010088
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  9. Article ; Online: Differential diagnosis for a mandibular mass - a rare case of an odontoameloblastoma in a red deer (Cervus elaphus elaphus).

    Hartung, Svenja / Köhler, Kernt / Herden, Christiane / Henrich, Manfred

    BMC veterinary research

    2021  Volume 17, Issue 1, Page(s) 55

    Abstract: Background: Mandibular masses caused by inflammatory processes due to bacterial infections, most common with Actinomyces bovis, are well known in herbivors. This case represents a rare differential diagnosis to common inflammatory processes which cannot ...

    Abstract Background: Mandibular masses caused by inflammatory processes due to bacterial infections, most common with Actinomyces bovis, are well known in herbivors. This case represents a rare differential diagnosis to common inflammatory processes which cannot be distinguished from neoplasia without detailed histopathological examination.
    Case presentation: A large unilateral mandibular mass of a free-ranging female adult red deer (Cervus elaphus elaphus) was submitted for pathological examination. The animal had been shot due to its poor body condition. Grossly, the mandibular mass showed gingival ulceration and necrosis. Histologically, irregular strands and islands of odontogenic epithelial cells and a matrix of dentin and osteoid-like material were found, leading to the diagnosis of an odontogenic tumor. Considering the animal's age the tumor was classified as odontoameloblastoma with secondary chronic purulent osteomyelitis.
    Conclusions: Odontogenic tumors are rare in domestic and wildlife species and so far have not been reported in red deer. In addition to the more common inflammatory processes of the mandibula and other neoplastic diseases of the oral cavity, odontogenic tumors represent a rare differential diagnosis that must be kept in mind especially when masked by inflammatory lesions.
    MeSH term(s) Animals ; Animals, Wild ; Deer ; Diagnosis, Differential ; Female ; Mandible/pathology ; Mandibular Neoplasms/diagnosis ; Mandibular Neoplasms/pathology ; Mandibular Neoplasms/veterinary ; Odontogenic Tumors/diagnosis ; Odontogenic Tumors/pathology ; Odontogenic Tumors/veterinary
    Language English
    Publishing date 2021-01-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1746-6148
    ISSN (online) 1746-6148
    DOI 10.1186/s12917-021-02759-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Occupational Safety in Chemosensitivity Tests: A Method to Minimize the Risk of Contamination While Maximizing the Safety for the Examiner.

    Henrich, Manfred / Hartung, Svenja / Herden, Christiane

    Chemotherapy

    2021  Volume 66, Issue 4, Page(s) 156–160

    Abstract: In vitro chemosensitivity tests are a widely used and established method in research. In laboratory environments, work safety is particularly important when working with carcinogenic, mutagenic, or reprotoxic (CMR) substances. When working with cell ... ...

    Abstract In vitro chemosensitivity tests are a widely used and established method in research. In laboratory environments, work safety is particularly important when working with carcinogenic, mutagenic, or reprotoxic (CMR) substances. When working with cell cultures, minimizing the risk of contamination with CMR substances and protecting the experimenter must be in the foreground of the experimental setup since risk minimization and occupational safety when handling CMR substances are mandatory. To minimize any personnel risk, studies with solid CMR substances should be carried out in a closed system. However, publications on occupational health and safety in laboratory environments in which CMR substances are tested in cell cultures are rare. Therefore, this article presents an easily applicable and safe method for improving work safety for in vitro chemosensitivity tests when working with CMR substances while also taking cell culture hygiene into account. For this purpose, a risk assessment of the test design was carried out, and the steps that were decisive for safety were highlighted. Some user-friendly and easily reproducible elements are presented, which increase the occupational safety of in vitro chemosensitivity assays, especially by reducing the risk of personnel contamination.
    MeSH term(s) Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Dogs ; Doxorubicin/chemistry ; Doxorubicin/pharmacology ; Drug Residues/analysis ; Equipment Contamination ; Hazardous Substances/analysis ; Hazardous Substances/toxicity ; Humans ; Laboratories ; Methotrexate/chemistry ; Methotrexate/pharmacology ; Occupational Health ; Risk
    Chemical Substances Antineoplastic Agents ; Hazardous Substances ; Doxorubicin (80168379AG) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2021-09-08
    Publishing country Switzerland
    Document type News
    ZDB-ID 6708-8
    ISSN 1421-9794 ; 0009-3157
    ISSN (online) 1421-9794
    ISSN 0009-3157
    DOI 10.1159/000518552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.174: Show issues Location:
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