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Article ; Online: Diagnostic value of three-dimensional neuroretinal rim thickness for differentiation of superior segmental optic nerve hypoplasia.

Choe, Sooyeon / Jang, Mirinae / Kim, Young Kook / Park, Ki Ho / Jeoung, Jin Wook

2023 Volume 13, Issue 1, Page(s) 19877

Abstract: Little is known about the diagnostic utility of three-dimensional neuroretinal rim thickness (3D-NRRT) for differentiating patients with superior segmental optic nerve hypoplasia (SSOH) from normal-tension glaucoma (NTG). Since SSOH is defined by ... ...

Abstract	Little is known about the diagnostic utility of three-dimensional neuroretinal rim thickness (3D-NRRT) for differentiating patients with superior segmental optic nerve hypoplasia (SSOH) from normal-tension glaucoma (NTG). Since SSOH is defined by characteristic optic nerve head features, investigation of diagnostic usefulness of 3D-NRRT is necessary. In this cross-sectional study, 49 SSOH eyes, 52 NTG eyes, and 41 normal eyes were enrolled. Retinal nerve fiber layer thickness (RNFLT) and 3D-NRRT values, as obtained in the right-eye orientation by optical coherence tomography (OCT), were recorded. On RNFLT clock-hour comparison, the 11-3 clock-hour sectors were significantly thinner for SSOH than for NTG (all P < 0.01). As for 3D-NRRT, whereas the 1 and 2 sectors were significantly thinner for SSOH (P < 0.001, P = 0.004), the 6-11 sectors were significantly thinner for NTG (all P < 0.01). The area under receiver operating characteristic (AUROC) curves of the superior and nasal quadrants of RNFLT (0.838, 0.729) were significantly greater than those of 3D-NRRT (0.518, 0.588; P < 0.001, P = 0.043). However, the AUROCs of the inferior and temporal quadrants were significantly greater for 3D-NRRT (0.728, 0.760) than for RNFLT (0.527, 0.550; P = 0.008, P = 0.019). The appropriate use of 3D-NRRT can be useful in differentiating SSOH from NTG.
MeSH term(s)	Humans ; Optic Disk/diagnostic imaging ; Optic Disk/abnormalities ; Optic Nerve Hypoplasia ; Cross-Sectional Studies ; Tomography, Optical Coherence/methods ; Low Tension Glaucoma/diagnosis ; Intraocular Pressure
Language	English
Publishing date	2023-11-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-46545-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Analysis of Variation in Incidence of Optic Disc Hemorrhage According to Seasonal and Temperature Changes.

Jang, Mirinae / Kim, Young Kook / Jeoung, Jin Wook / Park, Ki Ho

American journal of ophthalmology

2022 Volume 239, Page(s) 84–89

Abstract: Purpose: To investigate seasonal variation in optic disc hemorrhage (DH) by review of fundus photographs representative of 2 calendar years (2019 and 2020).: Design: Retrospective, observational trend study.: Methods: Patients who visited the ... ...

Abstract	Purpose: To investigate seasonal variation in optic disc hemorrhage (DH) by review of fundus photographs representative of 2 calendar years (2019 and 2020). Design: Retrospective, observational trend study. Methods: Patients who visited the Glaucoma Clinic of Seoul National University Hospital and underwent fundus photography were included. All available stereo disc photographs and red-free retinal nerve fiber layer photographs taken between January 1, 2019 and December 31, 2020 were retrospectively reviewed. The monthly incidence rate of DH was determined by reference to the photographs. Seasonal temperature information and patients' intraocular pressure (IOP) information were obtained, organized, and analyzed. Results: Fundus images of 13,514 eyes were reviewed, and 454 eyes were confirmed to have DH. Poisson regression analyses revealed that as the temperature (T) increased by 1 °C, the DH risk ratio was reduced to 0.979 (95% confidence interval [CI] 0.969-0.989, P < .01). The DH incidence ratio was 1.53 (95% CI 1.23-1.91, P < .01) for the T <10 °C group relative to the T ≥20 °C group. The IOP of the patients with DH in winter was significantly higher than that measured in summer. Conclusion: DH is affected by temperature, and as such, shows seasonal variability. This variability is believed to be caused by temperature-related factors such as IOP or hematological factors. © 2022 Elsevier Inc. All rights reserved.
MeSH term(s)	Humans ; Incidence ; Intraocular Pressure ; Optic Disk ; Optic Nerve Diseases/diagnosis ; Optic Nerve Diseases/epidemiology ; Retinal Hemorrhage/diagnosis ; Retinal Hemorrhage/epidemiology ; Retrospective Studies ; Seasons ; Temperature
Language	English
Publishing date	2022-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	80030-2
ISSN	1879-1891 ; 0002-9394
ISSN (online)	1879-1891
ISSN	0002-9394
DOI	10.1016/j.ajo.2022.02.007
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Article ; Online: Comparative effectiveness of interventions for improving adherence to ocular hypotensive therapy in patients with glaucoma or ocular hypertension

Young Kook Kim / Ahnul Ha / Mirinae Jang / Sung Ryul Shim

BMJ Open, Vol 11, Iss

protocol for network meta-analysis

2021 Volume 8

Abstract: Introduction Poor medication adherence is an important issue in healthcare. Various types of interventions for improved adherence to ocular hypotensive therapy have been proposed, though evidence on the effectiveness of any isolated intervention remains ... ...

Abstract	Introduction Poor medication adherence is an important issue in healthcare. Various types of interventions for improved adherence to ocular hypotensive therapy have been proposed, though evidence on the effectiveness of any isolated intervention remains limited. The current protocol is an ongoing network meta-analysis (NMA) design that enables comparative investigation of any and all interventions for which there are available randomised controlled trials (RCTs). Our aim is the systematic comparison of the efficacy of different types of adherence interventions for patients suffering from glaucoma or ocular hypertension (OHT).Methods and analysis Studies of interest will assess the effects of any interventions on medication adherence in adults (age ≥18 years) with either glaucoma or OHT. Four electronic databases (Cochrane Central Register of Controlled Trials, Embase, MEDLINE and Scopus) will be searched for RCTs published in any language, without any time limitation. First, titles and abstracts, and then full-text papers, will be screened by two reviewers, who will extract the useful data. The primary outcome measure is an intervention’s impact on adherence. The two reviewers will also assess, using the relevant domain-based risk-of-bias assessment tool, the internal validity of the studies. The overall quality of the evidence will be assessed by the Confidence in Network Meta-Analysis approach, and will be summarised with network diagrams. To allow for assessment of both direct and indirect evidence, a contribution matrix will be used. For visualisation of the effects of all of the included interventions, forest plots will be constructed. Pairwise effect sizes will be calculated according to all of the evidence available in the network.Ethics and dissemination This work will synthesise evidence from already published studies and, as such, will not require an ethics review or approval. A manuscript presenting the findings will be submitted to a peer-reviewed scientific journal for publication.PROSPERO ...
Keywords	Medicine ; R
Subject code	306
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical Significance of Optic Disc Hemorrhage Size in Visual Field Progression in Glaucoma.

Jeong, Yoon / Bak, Eunoo / Jang, Mirinae / Ha, Ahnul / Shin, Young In / Huh, Min Gu / Kim, Young Kook / Jeoung, Jin Wook / Park, Ki Ho

American journal of ophthalmology

2024 Volume 263, Page(s) 109–116

Abstract: Purpose: To investigate the correlation between optic disc hemorrhage (DH) size and glaucoma progression.: Design: A retrospective observational cohort study METHODS:   SETTING: A single tertiary hospital in South Korea STUDY POPULATION: Two hundred ... ...

Abstract	Purpose: To investigate the correlation between optic disc hemorrhage (DH) size and glaucoma progression. Design: A retrospective observational cohort study METHODS:   SETTING: A single tertiary hospital in South Korea STUDY POPULATION: Two hundred and fifty (250) open-angle glaucoma (OAG) patients with DH. Participants were followed for 5 years or longer, with a minimum of 5 visual field (VF) tests. Observation procedure: The DH area was calculated by comparing the pixel numbers of the DH area with the disc area based on optical coherence tomography (OCT). For recurrent DH cases, we calculated the average DH area. DH size was classified as large or small based on the median value. Rates of mean deviation (MD) loss were determined using guided progression analysis (GPA). Univariable and multivariable regression analyses were performed to identify significant predictors of MD loss. Main outcome measures: DH size and longitudinal VF progression RESULTS: The mean follow-up period was 11.1 ± 3.6 years. The group with large DH showed faster global MD loss relative to the group with small DH (-0.51±0.48 dB/y vs -0.36 ± 0.42 dB/y, P = .01). In the multivariable model, mean DH size, maximum DH size, and initial MD were all significantly associated with the overall rate of MD loss (all P < .05). Conclusions: DH size was associated with the rate of VF deterioration. Eyes with larger DH showed more pronounced VF progression.
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	80030-2
ISSN	1879-1891 ; 0002-9394
ISSN (online)	1879-1891
ISSN	0002-9394
DOI	10.1016/j.ajo.2024.02.019
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Article ; Online: Clinical usefulness of layer-by-layer deviation maps of Spectralis OCT: comparison with Cirrus OCT.

Choe, Sooyeon / Jang, Mirinae / Kim, Young Kook / Park, Ki Ho / Jeoung, Jin Wook

The British journal of ophthalmology

2022 Volume 107, Issue 11, Page(s) 1645–1651

Abstract: Background/aims: To compare the diagnostic abilities of Spectralis (Heidelberg Engineering, Heidelberg, Germany) and Cirrus (Carl Zeiss Meditec, Dublin, California, USA) spectral domain-optical coherence tomography (OCT) for retinal nerve fibre layer ( ... ...

Abstract	Background/aims: To compare the diagnostic abilities of Spectralis (Heidelberg Engineering, Heidelberg, Germany) and Cirrus (Carl Zeiss Meditec, Dublin, California, USA) spectral domain-optical coherence tomography (OCT) for retinal nerve fibre layer (RNFL) defect detection among patients with preperimetric glaucoma (PPG) and early glaucoma (EG). Methods: In this cross-sectional study, a total of 144 eyes (47 healthy, 43 PPG, 54 EG; MD≥-6 dB) of 144 participants underwent Spectralis and Cirrus OCT on the same day. The presence of RNFL defect on red-free RNFL photography and the respective deviation maps of Spectralis and Cirrus OCT was rated. Areas under the receiver operating characteristic curves (AUCs), sensitivities and specificities were analysed for each deviation layer to discriminate healthy eyes from PPG and EG eyes. Results: The RNFL, ganglion cell layer (GCL) and retinal layers of Spectralis OCT and the RNFL and macular ganglion cell-inner plexiform layer of Cirrus OCT showed high diagnostic performance (all AUCs >0.8) in discriminating PPG and EG eyes from healthy eyes. Among them, RNFL layer of Cirrus OCT had the largest AUC (0.840 for PPG, 0.959 for EG) but showed no statistical differences from RNFL and retinal layers of Spectralis OCT. The inner plexiform layer (IPL) of Spectralis OCT had the smallest AUC (0.563 for PPG, 0.799 for EG). Conclusions: The Spectralis and Cirrus OCT deviation maps showed good diagnostic abilities except for the IPL layer of Spectralis. In the clinical setting, both Spectralis and Cirrus OCT can be useful for detection of RNFL defects in PPG and EG eyes.
Language	English
Publishing date	2022-08-24
Publishing country	England
Document type	Journal Article
ZDB-ID	80078-8
ISSN	1468-2079 ; 0007-1161
ISSN (online)	1468-2079
ISSN	0007-1161
DOI	10.1136/bjo-2022-321054
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Article ; Online: Comparative effectiveness of interventions for improving adherence to ocular hypotensive therapy in patients with glaucoma or ocular hypertension: protocol for network meta-analysis.

Jang, Mirinae / Shim, Sung Ryul / Ha, Ahnul / Kim, Young Kook

BMJ open

2021 Volume 11, Issue 8, Page(s) e054340

Abstract: Introduction: Poor medication adherence is an important issue in healthcare. Various types of interventions for improved adherence to ocular hypotensive therapy have been proposed, though evidence on the effectiveness of any isolated intervention ... ...

Abstract	Introduction: Poor medication adherence is an important issue in healthcare. Various types of interventions for improved adherence to ocular hypotensive therapy have been proposed, though evidence on the effectiveness of any isolated intervention remains limited. The current protocol is an ongoing network meta-analysis (NMA) design that enables comparative investigation of any and all interventions for which there are available randomised controlled trials (RCTs). Our aim is the systematic comparison of the efficacy of different types of adherence interventions for patients suffering from glaucoma or ocular hypertension (OHT). Methods and analysis: Studies of interest will assess the effects of any interventions on medication adherence in adults (age ≥18 years) with either glaucoma or OHT. Four electronic databases (Cochrane Central Register of Controlled Trials, Embase, MEDLINE and Scopus) will be searched for RCTs published in any language, without any time limitation. First, titles and abstracts, and then full-text papers, will be screened by two reviewers, who will extract the useful data. The primary outcome measure is an intervention's impact on adherence. The two reviewers will also assess, using the relevant domain-based risk-of-bias assessment tool, the internal validity of the studies. The overall quality of the evidence will be assessed by the Confidence in Network Meta-Analysis approach, and will be summarised with network diagrams. To allow for assessment of both direct and indirect evidence, a contribution matrix will be used. For visualisation of the effects of all of the included interventions, forest plots will be constructed. Pairwise effect sizes will be calculated according to all of the evidence available in the network. Ethics and dissemination: This work will synthesise evidence from already published studies and, as such, will not require an ethics review or approval. A manuscript presenting the findings will be submitted to a peer-reviewed scientific journal for publication. Prospero registration number: CRD42021253145.
MeSH term(s)	Adolescent ; Adult ; Glaucoma/drug therapy ; Humans ; Medication Adherence ; Meta-Analysis as Topic ; Network Meta-Analysis ; Ocular Hypertension/drug therapy
Language	English
Publishing date	2021-08-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-054340
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Article ; Online: Interventions for Glaucoma Medication Adherence Improvement: A Network Meta-analysis of Randomized Controlled Trials.

Ha, Ahnul / Jang, Mirinae / Shim, Sung Ryul / Kim, Chung Young / Chang, In Boem / Kim, Young Kook

Ophthalmology

2022 Volume 129, Issue 11, Page(s) 1294–1304

Abstract: Topic: Comparative effectiveness of interventions to improve glaucoma medication adherence.: Clinical relevance: High adherence to ocular hypotensive therapy is essential for prevention of visual impairment in glaucoma patients. Various types of ... ...

Abstract	Topic: Comparative effectiveness of interventions to improve glaucoma medication adherence. Clinical relevance: High adherence to ocular hypotensive therapy is essential for prevention of visual impairment in glaucoma patients. Various types of intervention for adherence enhancement have been proposed, although there is still no firm evidence of their relative efficacies. Methods: We searched PubMed, EMBASE, Scopus, the Cochrane Central Register of Controlled Trials, the World Health Organization International Clinical Trials Registry Platform, and ClinicalTrials.gov on November 30, 2021. Randomized controlled trials (RCTs) entailing interventions for improved adherence to ocular hypotensive therapy were identified. A network meta-analysis (NMA) was performed, and the following 11 interventions (single category or combinations of categories) were compared: (1) standard of care ([SOC] control), (2) short message service, (3) telephone call, (4) device reminder, (5) motivational interview, (6) multimedia education, (7) physician education, (8) provision of own medical records, (9) incentives, (10) tailored care, and (11) enhanced SOC. The primary outcome was the postintervention mean adherence score. The standardized mean differences (SMDs) were analyzed, and the effectiveness was ranked by P-score (probability of being best treatment). We appraised trials using the Cochrane risk-of-bias tool for RCTs. Confidence of results was assessed by Confidence in Network Meta-analysis. Results: We obtained data for 19 RCTs (4981 participants). Tailored care, as inclusive of face-to-face needs assessment and a personalized care plan, was superior to SOC in improving adherence (SMD, 1.28; 95% confidence interval [CI], 0.08-2.48; P-score, 0.810). Multifaceted interventions that included tailored care showed further adherence improvement: tailored care + multimedia education (SMD, 1.44; 95% CI, 0.20-2.67; 0.850) and tailored care + multimedia education + device reminder (SMD, 1.61; 95% CI, 0.75-2.47; 0.914). The ranking of the remaining interventions by P-scores was as follows: incentives (0.606), short message service (0.535), enhanced SOC (0.458), multimedia education (0.430), device reminder (0.429), telephone call (0.401), provision of own medical records (0.391), physician education (0.281), SOC (0.230), and motivational interview (0.165). Conclusions: The NMA indicated that tailored care can improve adherence to glaucoma medication compared with SOC. A multifaceted approach might yield additional improvements.
MeSH term(s)	Humans ; Network Meta-Analysis ; Randomized Controlled Trials as Topic ; Medication Adherence ; Bias ; Glaucoma/drug therapy
Language	English
Publishing date	2022-08-23
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	392083-5
ISSN	1549-4713 ; 0161-6420
ISSN (online)	1549-4713
ISSN	0161-6420
DOI	10.1016/j.ophtha.2022.06.025
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Article ; Online: Rare case of sympathetic ophthalmia with severe annular choroidal detachment.

Jang, Mirinae / Lee, Hye Jin / Jeong, Jin Ho / Kim, Jin Young

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2018 Volume 54, Issue 1, Page(s) e6–e10

MeSH term(s)	Aged ; Choroid/diagnostic imaging ; Choroidal Effusions/diagnosis ; Choroidal Effusions/etiology ; Humans ; Male ; Ophthalmia, Sympathetic/complications ; Ophthalmia, Sympathetic/diagnosis ; Rare Diseases ; Severity of Illness Index ; Tomography, Optical Coherence ; Ultrasonography ; Visual Acuity
Language	English
Publishing date	2018-05-21
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2018.04.009
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Article ; Online: Demographics Prediction and Heatmap Generation From OCT Images of Anterior Segment of the Eye: A Vision Transformer Model Study.

Lee, Yun Jeong / Choe, Sooyeon / Wy, Seoyoung / Jang, Mirinae / Jeoung, Jin Wook / Choi, Hyuk Jin / Park, Ki Ho / Sun, Sukkyu / Kim, Young Kook

Translational vision science & technology

2022 Volume 11, Issue 11, Page(s) 7

Abstract: Purpose: To predict demographic characteristics from anterior segment optical coherence tomography (AS-OCT) images of eyes using a Vision Transformer (ViT) model.: Methods: A total of 2970 AS-OCT images were used to train, validate, and test a ViT to ...

Abstract	Purpose: To predict demographic characteristics from anterior segment optical coherence tomography (AS-OCT) images of eyes using a Vision Transformer (ViT) model. Methods: A total of 2970 AS-OCT images were used to train, validate, and test a ViT to predict age and sex, and 2616 images were used for height, weight, and body mass index (BMI). The main outcome measure was the area under the receiver operating characteristic curve (AUC) of the ViT. Results: The ViT achieved the largest AUC (0.910) for differentiating age ≤75 versus >75 years, followed by age ≤60 versus 60-75 versus >75 years (AUC, 0.844), and for discriminating sex (AUC, 0.665). The prediction abilities for the other demographic characteristics were lower: an AUC of 0.521 for classifying height ≤170 versus >170 cm in males and ≤155 versus >155 cm in females; 0.522 for weight <70 versus ≥70 kg in males and 0.503 for <55 versus ≥55 kg in females, and 0.517 for BMI <23 versus 23-25 versus ≥25 kg/m2. Heatmaps highlighted the area of the iridocorneal angle for its contribution to the prediction of age ≤75 versus >75 years. Conclusions: Although the ViT demonstrated a good ability to classify age from AS-OCT images, it performed poorly for sex, height, weight, and BMI. The heatmap obtained of the prediction will provide clues to understanding the age-related anterior segment changes in eyes. Translational relevance: The ViT can determine age-related anterior segment structural changes using AS-OCT images, which will aid clinicians in the management of ocular diseases.
MeSH term(s)	Male ; Female ; Humans ; Aged ; Anterior Eye Segment/diagnostic imaging ; Tomography, Optical Coherence/methods ; ROC Curve ; Face ; Demography
Language	English
Publishing date	2022-11-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2674602-5
ISSN	2164-2591 ; 2164-2591
ISSN (online)	2164-2591
ISSN	2164-2591
DOI	10.1167/tvst.11.11.7
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Article ; Online: Decision Tree Algorithm-Based Prediction of Vulnerability to Depressive and Anxiety Symptoms in Caregivers of Children With Glaucoma.

Wy, Seoyoung / Choe, Sooyeon / Lee, Yun Jeong / Bak, Eunoo / Jang, Mirinae / Lee, Seung Chan / Ha, Ahnul / Jeoung, Jin Wook / Park, Ki Ho / Kim, Young Kook

American journal of ophthalmology

2022 Volume 239, Page(s) 90–97

Abstract: Purpose: Development and validation of a decision tree model (DTM) for prediction of mental health status in Korean caregivers of children with glaucoma.: Design: Cross-sectional study.: Methods: Caregivers of children younger than 18 years with ... ...

Abstract	Purpose: Development and validation of a decision tree model (DTM) for prediction of mental health status in Korean caregivers of children with glaucoma. Design: Cross-sectional study. Methods: Caregivers of children younger than 18 years with diagnosed primary childhood glaucoma (n = 42), secondary childhood glaucoma (n = 51), and glaucoma suspect (GS; n = 36) were prospectively enrolled at Seoul National University Children's Hospital, Seoul, Korea. The participants completed 2 questionnaires, the 9-item Patient Health Questionnaire (PHQ-9) and the 7-item Generalized Anxiety Disorder (GAD-7) Assessment. A DTM analysis for discrimination of those with moderate-to-severe depressive (PHQ-9 score ≥10) and anxiety (GAD-7 score ≥11) symptoms was performed with recursive partitioning algorithms based on the obtained clinical, demographic, and socioeconomic data. Results: The mean PHQ-9 and GAD-7 scores did not significantly differ among the 3 groups (P = .823 for PHQ-9 score; P = .730 for GAD-7 score). The DTM's balanced accuracies were 0.875 (95% CI = 0.778-0.972) for the PHQ-9 score and 0.880 (95% CI = 0.800-0.960) for theGAD-7 score. The DTM of the PHQ-9 revealed that in caregivers of children with glaucoma, depressive symptoms should be strongly suspected when (1) the child has undergone more than 2 glaucoma surgeries; or (2) the visual acuity (VA, converted to logarithm of minimum angle of resolution [logMAR]) in the better eye is worse than 0.4 if the child has had only 1 or no surgery. Conclusions: Evaluation of the number of glaucoma surgeries and VA in the better eye can be a useful decision support tool in predicting mental illness in caregivers of children with glaucoma.
MeSH term(s)	Algorithms ; Anxiety ; Caregivers/psychology ; Child ; Cross-Sectional Studies ; Decision Trees ; Depression/diagnosis ; Depression/etiology ; Glaucoma ; Humans ; Surveys and Questionnaires
Language	English
Publishing date	2022-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	80030-2
ISSN	1879-1891 ; 0002-9394
ISSN (online)	1879-1891
ISSN	0002-9394
DOI	10.1016/j.ajo.2022.01.025
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