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Article ; Online: The Important Role of Interleukin-2 in COVID-19.

Ghanbari Naeini, Leila / Abbasi, Laleh / Karimi, Farzaneh / Kokabian, Pajman / Abdi Abyaneh, Fahimeh / Naderi, Delaram

2023 Volume 2023, Page(s) 7097329

Abstract: There is controversial literature about the effects of the interleukin-2 (IL-2) cytokine family in COVID-19 pathogenesis and immunity. So we aimed to identify the potential in the role of the IL-2 family in COVID-19. A narrative review search was done ... ...

Abstract	There is controversial literature about the effects of the interleukin-2 (IL-2) cytokine family in COVID-19 pathogenesis and immunity. So we aimed to identify the potential in the role of the IL-2 family in COVID-19. A narrative review search was done through online databases, including PubMed, Scopus, and Web of Science. The search deadline was up to December 2022. We applied no time limits for the searching strategy. After retrieving articles from the databases, the authors summarized the data into two data extraction tables. The first data extraction table described the changes in the IL-2 cytokine family in COVID-19 and the second table described the therapeutic interventions targeting IL-2 family cytokines. The results of the literature on the role of the IL-2 cytokine family do not show a singular rule. IL-2 cytokine family can change during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Some studies suggest that IL-2 cytokine family rise during the infection and cause severe inflammatory response and cytokine storm. These cytokines are shown to be increased in immunocompromised patients and worsen their prognosis. In individuals without underlying disease, the upregulation of the IL-2 family shows the clinical outcome of the disease and rises with disease severity. However, some other studies show that these cytokines do not significantly change. IL-2 cytokine family is mostly upregulated in healthy individuals who had vaccination, but immunocompromised patients did not show significant changes after a single dose of vaccines, which shows that these patients need booster doses for efficient immunity. IL-2 cytokine family can also be used as immunotherapy agents in COVID-19.
MeSH term(s)	Humans ; COVID-19/immunology ; Cytokine Release Syndrome ; Cytokines ; Interleukin-2/immunology
Chemical Substances	Cytokines ; Interleukin-2
Language	English
Publishing date	2023-08-22
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-7156
ISSN (online)	2314-7156
ISSN	2314-7156
DOI	10.1155/2023/7097329
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Article ; Online: Targeting DNA repair pathways with B02 and Nocodazole small molecules to improve CRIS-PITCh mediated cassette integration in CHO-K1 cells.

Rahmani, Behnaz / Kheirandish, Mohammad Hassan / Ghanbari, Samaneh / Raz, Abbasali / Shamsi, Fahimeh / Davami, Fatemeh

Scientific reports

2023 Volume 13, Issue 1, Page(s) 3116

Abstract: CRISPR-mediated integration could be used to develop the recombinant CHO (rCHO) cells by knock-in into the hotspot loci. However, low HDR efficiency besides the complex donor design is the main barrier for achieving so. The recently introduced MMEJ- ... ...

Abstract	CRISPR-mediated integration could be used to develop the recombinant CHO (rCHO) cells by knock-in into the hotspot loci. However, low HDR efficiency besides the complex donor design is the main barrier for achieving so. The recently introduced MMEJ-mediated CRISPR system (CRIS-PITCh) uses a donor with short homology arms, being linearized in the cells via two sgRNAs. In this paper, a new approach to improve CRIS-PITCh knock-in efficiency by employing small molecules was investigated. Two small molecules, B02, a Rad51 inhibitor, and Nocodazole, a G2/M cell cycle synchronizer, were used to target the S100A hotspot site using a bxb1 recombinase comprised landing pad in CHO-K1 cells. Following transfection, the CHO-K1 cells were treated with the optimum concentration of one or combination of small molecules, being determined by the cell viability or flow cytometric cell cycle assay. Stable cell lines were generated and the single-cell clones were achieved by the clonal selection procedure. The finding showed that B02 improved the PITCh-mediated integration approximately twofold. In the case of Nocodazole treatment, the improvement was even more significant, up to 2.4-fold. However, the combinatorial effects of both molecules were not substantial. Moreover, according to the copy number and out-out PCR analyses, 5 and 6 of 20 clonal cells exhibited mono-allelic integration in Nocodazole and B02 groups, respectively. The results of the present study as the first attempt to enhance the CHO platform generation by exploiting two small molecules in the CRIS-PITCh system could be used in future researches to establish rCHO clones.
MeSH term(s)	Cricetinae ; Animals ; Nocodazole ; CRISPR-Cas Systems ; CHO Cells ; Cricetulus ; DNA Repair
Chemical Substances	Nocodazole (SH1WY3R615)
Language	English
Publishing date	2023-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-29863-8
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Article: Combined Effects of High-Intensity Aerobic Exercise Training and

Ghanbari-Niaki, Abbass / Hosseini, Fahimeh / Broom, David Robert / Tejenjari, Bahareh / Rahmati-Ahmadabad, Saleh

Frontiers in endocrinology

2022 Volume 13, Page(s) 845014

Abstract: Nesfatin-1 is involved in metabolic/feeding regulation and prevention of cardiovascular disease. Previous studies have shown that exercise and herb supplementation can influence nesfatin-1 concentration. The present study investigated the effects of high- ...

Abstract	Nesfatin-1 is involved in metabolic/feeding regulation and prevention of cardiovascular disease. Previous studies have shown that exercise and herb supplementation can influence nesfatin-1 concentration. The present study investigated the effects of high-intensity training (HIT) and Ziziphus jujuba (ZJ) extract on tissue nesfatin-1 in rats. Twenty-eight female rats were randomly assigned to one of four groups i.e. 1) Saline-Control (SC), 2) Saline-High Intensity Training (ST), 3) Ziziphus jujuba-Control (ZJC), and 4) Ziziphus jujuba-High Intensity Training (ZJT). Rats performed exercise on a treadmill and/or administered supplements intragastrically for 6 weeks, depending on group category. Seventy-two hours after the last training session, rats were anesthetized. Blood, hypothafi 2lamus tissue, heart and gastrocnemius muscles were sent to the laboratory for analyses. Significantly higher nesfatin-1 gene expression and concentration and ATP concentration were found in trained rat. HIT increased plasma High Density Lipoprotein (HDL) and insulin concentration and reduced plasma Triglyceride (TG) and cortisol. ZJ increased tissue nesftain-1 gene expression and concentration while only increasing heart ATP. The combination of exercise and ZJ showed an additive effect compared to each intervention alone on hypothalamus, heart and gastrocnemius NUCB2 gene expression, heart and gastrocnemius nesfatin-1 concentration, plasma HDL and cortisol concentration. The authors recommend both interventions as a means to improve cardiovascular health in rats with further work needed to confirm similar findings in homo sapiens.
MeSH term(s)	Adenosine Triphosphate ; Animals ; Dietary Supplements ; Female ; Hydrocortisone ; Plant Extracts/pharmacology ; Rats ; Ziziphus
Chemical Substances	Plant Extracts ; Adenosine Triphosphate (8L70Q75FXE) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2022-05-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.845014
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Article ; Online: How gallic acid regulates molecular signaling: role in cancer drug resistance.

Hassani, Samira / Ghanbari, Fahimeh / Lotfi, Marzieh / Alam, Waqas / Aschner, Michael / Popović-Djordjević, Jelena / Shahcheraghi, Seyed Hossein / Khan, Haroon

Medical oncology (Northwood, London, England)

2023 Volume 40, Issue 11, Page(s) 308

Abstract: Cancer is one of the deadliest and most heterogeneous diseases. Cancers often develop drug resistance, which can lead to treatment failure or recurrence. Accordingly, anticancer compounds are essential for chemotherapy-resistant cancer cells. Phenolic ... ...

Abstract	Cancer is one of the deadliest and most heterogeneous diseases. Cancers often develop drug resistance, which can lead to treatment failure or recurrence. Accordingly, anticancer compounds are essential for chemotherapy-resistant cancer cells. Phenolic compounds are of interest in the development of cancer drugs due to their medicinal properties and ability to target different molecular pathways. Gallic acid (GA), as one of the main components of phenol, which is abundantly present in plant compounds such as walnut, sumac, grapes, tea leaves, oak bark, and other plant compounds, has antitumor properties. GA can prevent cancer progression, cell invasion, and metastasis by targeting molecular pathways and is an effective complement to chemotherapy drugs and combating multidrug resistance (MDR). In this review, we discuss various mechanisms related to cancer, the therapeutic potential of GA, the antitumor properties of GA in various cancers, and the targeted delivery of GA with nanocarriers.
MeSH term(s)	Humans ; Gallic Acid/pharmacology ; Gallic Acid/therapeutic use ; Drug Resistance, Neoplasm ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Signal Transduction ; Neoplasms/drug therapy
Chemical Substances	Gallic Acid (632XD903SP) ; Antineoplastic Agents
Language	English
Publishing date	2023-09-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-023-02178-4
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Article ; Online: The brain functional connectivity alterations in traumatic patients with olfactory disorder after low-level laser therapy demonstrated by fMRI.

Hosseini, Seyedeh Fahimeh / Farhadi, Mohammad / Alizadeh, Rafieh / Ghanbari, Hadi / Maleki, Shayan / Zare-Sadeghi, Arash / Kamrava, Seyed Kamran

The neuroradiology journal

2023 Volume 36, Issue 6, Page(s) 716–727

Abstract: Background: Low-level laser therapy (LLLT) has been clinically accepted to accelerate the nerve regeneration process after a nerve injury or transection. We aimed to investigate the neuronal basis and the influence of LLLT on brain functional networks ... ...

Abstract	Background: Low-level laser therapy (LLLT) has been clinically accepted to accelerate the nerve regeneration process after a nerve injury or transection. We aimed to investigate the neuronal basis and the influence of LLLT on brain functional networks in traumatic patients with olfactory dysfunction. Methods: Twenty-four Patients with traumatic anosmia/hyposmia were exposed to pleasant olfactory stimuli during a block-designed fMRI session. After a 10-week period, patients as control group and patients who had completed the sessions of LLLT were invited for follow-up testing using the same fMRI protocol. Two-sample t-tests were conducted to explore group differences in activation responding to odorants ( Results: Compared to controls, laser-treated patients showed increased activation in the cingulate, rectus gyrus, and some parts of the frontal gyrus. Shorter pathlength ( Conclusions: The results support that low-level laser induces neural reorganization process and make new connections in the olfactory structures. Furthermore, the connectivity parameters may serve as potential biomarkers for traumatic anosmia or hyposmia by revealing the underlying neural mechanisms of LLLT.
MeSH term(s)	Humans ; Magnetic Resonance Imaging/methods ; Anosmia ; Low-Level Light Therapy ; Olfaction Disorders/diagnostic imaging ; Olfaction Disorders/etiology ; Brain/diagnostic imaging
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2257770-1
ISSN	2385-1996 ; 1971-4009 ; 1120-9976
ISSN (online)	2385-1996
ISSN	1971-4009 ; 1120-9976
DOI	10.1177/19714009231188589
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Article ; Online: Effect of Microalgae Arthrospira on Biomarkers of Glycemic Control and Glucose Metabolism: A Systematic Review and Meta-analysis.

Ghanbari, Fahimeh / Amerizadeh, Atefeh / Behshood, Parisa / Moradi, Sajjad / Asgary, Sedigheh

Current problems in cardiology

2021 Volume 47, Issue 10, Page(s) 100942

Abstract: Diabetes mellitus and insulin resistance are associated with an increased risk of cardiovascular disease (CVD) incidence and a higher rate of CVD-related death. In this study, the effects of Arthrospira (Spirulina) a blue-green algae supplementation on ... ...

Abstract	Diabetes mellitus and insulin resistance are associated with an increased risk of cardiovascular disease (CVD) incidence and a higher rate of CVD-related death. In this study, the effects of Arthrospira (Spirulina) a blue-green algae supplementation on biomarkers of glycemic control and glucose metabolism has been evaluated. PubMed, Scopus, and ISI Web of Science were searched systematically of English human subjects and PubMed for pre-clinical animal studies (rats and mice) from January 2008 until November 2020. The pooled weighted mean difference (MD) and its 95% confidence interval (CI) were calculated and pooled using a random-effect model. Seven clinical and 27 preclinical studies were included. Pooled results of the clinical studies showed that Arthrospira supplementation significantly reduced the fasting blood sugar (FBS): (0.63- 2.90-) 1.77-, total cholesterol (TC): (0.46- ، 4.61-) 2.54-, triglycerides (TG): (0.89- ، 6.54-) 3.71- and increased the high-density lipoprotein cholesterol (HDL-C): (3.86 ، 0.67) 2.27; however, Arthrospira was not significantly effective in terms of reducing the glycated hemoglobin A1c (HbA1C): (1.04 ، 2.23-) 0.59- and low-density lipoprotein cholesterol (LDL-C). Pooled results of preclinical studies showed that Arthrospira supplementation reduced FBS [-10.31 (-12.49, -8.13)] and HbA1C [-5.12 (-8.06, -2.19)] significantly in diabetic animals. Sub-group analysis of clinical studies showed that intervention duration less than 2 months [-2.52 (-4.37, -0.67)] and the dose less than 2 gram [-3.22 (-5.67, -0.76)] showed significant improvement in terms of reducing the FBS in humans. It can be concluded that Arthrospira can be considered as an effective FBS, TG, TC, and HDL-C adjusting nutraceutical agent for diabetes mellitus. Due to the differences in the results of clinical and animal studies in terms of HbA1c, more studies are needed for a definitive conclusion.
MeSH term(s)	Animals ; Biomarkers ; Blood Glucose ; Cardiovascular Diseases ; Cholesterol, HDL ; Diabetes Mellitus ; Diabetes Mellitus, Type 2 ; Glycated Hemoglobin A ; Glycemic Control ; Humans ; Mice ; Microalgae ; Rats ; Spirulina ; Triglycerides
Chemical Substances	Biomarkers ; Blood Glucose ; Cholesterol, HDL ; Glycated Hemoglobin A ; Triglycerides
Language	English
Publishing date	2021-07-24
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	441230-8
ISSN	1535-6280 ; 0146-2806
ISSN (online)	1535-6280
ISSN	0146-2806
DOI	10.1016/j.cpcardiol.2021.100942
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Article ; Online: Isolation of Oxidase-Negative Pseudomonas aeruginosa from Various Specimens

Ahmad FARAJZADEH SHEIKH / Fahimeh GHANBARI / Maryam AFZALI / Mojtaba SHAHIN

Iranian Journal of Public Health, Vol 49, Iss

2020 Volume 6

Abstract: ... No ... ...

Abstract	No Abstract
Keywords	Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
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Article: Relationship of personality characteristics and eating attitude with the success of bariatric surgery.

Tayefi, Ahmad / Pazouki, Abdolreza / Alavi, Kaveh / Salehian, Razieh / Soheilipour, Fahimeh / Ghanbari Jolfaei, Atefeh

Medical journal of the Islamic Republic of Iran

2020 Volume 34, Page(s) 89

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2020-07-31
Publishing country	Iran
Document type	Journal Article
ZDB-ID	1095990-7
ISSN	1016-1430
ISSN	1016-1430
DOI	10.34171/mjiri.34.89
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Article ; Online: Quantifying the Impact of Algae Supplement on Blood Pressure: Systematic Review and Meta-analysis of Randomized Controlled Trials.

Ayatollahi, Seyed Abdulmajid / Asgary, Sedigheh / Ghanbari, Fahimeh / Karimi, Raheleh / Kobarfard, Farzad / Sarfaraz, Sana / Nazim, Urooj / Mohammadi Pour, Pardis

Current problems in cardiology

2022 Volume 47, Issue 11, Page(s) 101336

Abstract: The impact of Algae supplements and its extract on blood pressure has not concluded yet. The aim of this systematic review meta-analysis is to evaluate the antihypertensive activity of this group marine organism on human. Alga was used in some studies as ...

Abstract	The impact of Algae supplements and its extract on blood pressure has not concluded yet. The aim of this systematic review meta-analysis is to evaluate the antihypertensive activity of this group marine organism on human. Alga was used in some studies as capsules (from 500-mg to 8-g) and the follow-up duration changed from 17 days to 9 months. The difference in standardized mean and its corresponding 95% confidence interval (CI) was applied as the effect size of algae supplementation on systolic and diastolic blood pressure. Based on the results, a meta-analysis of 10 studies with baseline effect control demonstrated that there was no difference in the mean systolic blood pressure in the 2 groups SMD (95%CI): -1.05 (-2.85,0.76), but a significant difference in the mean diastolic blood pressure was observed and showed that the mean diastolic blood pressure in the treatment group was lower than the control group SMD(95%CI): -2.23 (-4.35,-0.11). A meta-analysis of 4 studies with no baseline control effect did not show significant results on both blood pressure. The evidence to support this systematic review meta-analysis requires more investigation and future large scale RCT clinical trial to confirm the results.
MeSH term(s)	Antihypertensive Agents/therapeutic use ; Blood Pressure ; Dietary Supplements ; Humans ; Hypertension/drug therapy ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Randomized Controlled Trials as Topic
Chemical Substances	Antihypertensive Agents ; Plant Extracts
Language	English
Publishing date	2022-07-20
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	441230-8
ISSN	1535-6280 ; 0146-2806
ISSN (online)	1535-6280
ISSN	0146-2806
DOI	10.1016/j.cpcardiol.2022.101336
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Article: Emerge of NDM-1-Producing Multidrug-Resistant

Farajzadeh Sheikh, Ahmad / Shahin, Mojtaba / Shokoohizadeh, Leili / Ghanbari, Fahimeh / Solgi, Hamid / Shahcheraghi, Fereshteh

Iranian journal of public health

2020 Volume 49, Issue 5, Page(s) 959–967

Abstract: Background: New Delhi metallo: Methods: This present cross-sectional research was conducted on 369 : Results: From 236 carbapenem-resistant : Conclusion: The finding of this co-existence of multiple carbapenemase resistance genes is threating ... ...

Abstract	Background: New Delhi metallo Methods: This present cross-sectional research was conducted on 369 Results: From 236 carbapenem-resistant Conclusion: The finding of this co-existence of multiple carbapenemase resistance genes is threating for public health. Dipicolinic acid is a superior MBL inhibitor in DDPT antique than EDTA in DDST method for the detection of MBL-
Language	English
Publishing date	2020-08-27
Publishing country	Iran
Document type	Journal Article
ISSN	2251-6085
ISSN	2251-6085
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