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Article: Clinical symptoms, pathogenesis and postoperative course of non-specific constrictive pericarditis with dumbbell-shaped heart.

Sabzi, Feridoun / Faraji, Reza / Khoshnood, Saeed

2024 Volume 19, Page(s) Doc08

Abstract: Non-specific chronic constrictive pericarditis is a rare and debilitating chronic infection in developed countries and its rapid diagnosis and treatment has not affected its outcome and complication. A 15-year-old male, well nourished, negative HIV test, ...

Abstract	Non-specific chronic constrictive pericarditis is a rare and debilitating chronic infection in developed countries and its rapid diagnosis and treatment has not affected its outcome and complication. A 15-year-old male, well nourished, negative HIV test, and without a history of previous pulmonary tuberculosis, was admitted to our hospital for exertional dyspnea (New York Heart Association, NYHA, functional class II). Our patient had had no pulmonary tuberculosis during childhood, had received anti-tuberculosis treatment, and was referred to our center for further surgical pericardiectomy.
Language	English
Publishing date	2024-02-21
Publishing country	Germany
Document type	Case Reports
ZDB-ID	2717852-3
ISSN	2196-5226
ISSN	2196-5226
DOI	10.3205/dgkh000463
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Article ; Online: Clinical symptoms, pathogenesis and postoperative course of non-specific constrictive pericarditis with dumbbell-shaped heart

Sabzi, Feridoun / Faraji, Reza / Khoshnood, Saeed

GMS Hygiene and Infection Control

2024 Volume 19, Page(s) 8

Abstract: Die unspezifische konstriktive Perikarditis ist eine seltene und belastende chronische Infektion in Industrieländern. Ihre rasche Diagnose und Behandlung hat sich jedoch nicht auf ihre Folgen und Komplikationen ausgewirkt. Ein 15-jähriger Mann, gut ... ...

Title translation	Klinische Symptomatik, Pathogenese und unspezifische chronische konstriktive Perikarditis mit hantelförmigem Herz
Abstract	Die unspezifische konstriktive Perikarditis ist eine seltene und belastende chronische Infektion in Industrieländern. Ihre rasche Diagnose und Behandlung hat sich jedoch nicht auf ihre Folgen und Komplikationen ausgewirkt. Ein 15-jähriger Mann, gut ernährt, mit negativem HIV-Test und ohne Vorgeschichte einer Lungentuberkulose, wurde wegen Belastungsdyspnoe (New York Heart Association; NYHA, Funktionsklasse II) in unser Krankenhaus eingeliefert. Der Patient hatte in seiner Kindheit keine Lungentuberkulose, erhielt eine Anti-Tuberkulose-Behandlung und wurde zur weiteren chirurgischen Perikardektomie in unser Zentrum überwiesen. Non-specific chronic constrictive pericarditis is a rare and debilitating chronic infection in developed countries and its rapid diagnosis and treatment has not affected its outcome and complication. A 15-year-old male, well nourished, negative HIV test, and without a history of previous pulmonary tuberculosis, was admitted to our hospital for exertional dyspnea (New York Heart Association, NYHA, functional class II). Our patient had had no pulmonary tuberculosis during childhood, had received anti-tuberculosis treatment, and was referred to our center for further surgical pericardiectomy.
Keywords	Medizin, Gesundheit ; constrictive pericarditis ; tuberculosis ; konstriktive Perikarditis ; Tuberkulose
Publishing date	2024-02-21
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Article ; Online
ZDB-ID	2717852-3
ISSN	2196-5226 ; 2196-5226
ISSN (online)	2196-5226
ISSN	2196-5226
DOI	10.3205/dgkh000463
Database	German Medical Science

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Article: Evaluation of the Levels of Blood Cells, Vitamin D, and Inflammatory Factors in Children with PFAPA Syndrome.

Abbasi, Ehsan / Mamizadeh, Nahid / Seidkhani, Hossein / Khoshnood, Saeed / Mohamadi, Jasem

Clinical laboratory

2023 Volume 69, Issue 11

Abstract: Background: The syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA syndrome) is the most common type of recurrent fever in childhood. The aim of this study was evaluation of the levels of blood cells, vitamin D, ... ...

Abstract	Background: The syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA syndrome) is the most common type of recurrent fever in childhood. The aim of this study was evaluation of the levels of blood cells, vitamin D, and inflammatory factors in children with PFAPA syndrome. Methods: This retrospective descriptive study was conducted on the recorded information of children with PFAPA syndrome referred to the children's specialty clinic of Imam Khomeini Hospital in Ilam city from March 2021 to February 2022. Complete demographic information, presence of underlying disease, changes in blood cells, vitamin D level and inflammatory factors were obtained from the patients' records. Diagnosis of PFAPA syndrome was performed according to Thomas' criteria. Results: This study was conducted on 40 children with PFAPA syndrome. The majority of patients were male and in the age range of 3 - 4 years. The results show that the average percentage of neutrophil and lymphocyte cells in the blood of patients was 54.45% and 40.62%, respectively. Also, 6 (15%), 3 (7.5%), and 31 (77.5%) patients had normal neutrophil levels, neutropenia, and neutrophilia, respectively. Regarding lymphocyte cells, 26 (65%), 8 (20%), and 6 (15%) people had normal lymphocyte level, lymphocytosis and lymphopenia, respectively. ESR levels increased in all patients (average percentage: 16.72). CRP level was negative in 9 (22.5%) and +1 in 19 (47.5%) patients, respectively. The results showed that 33 (82.5%) patients were deficient in vitamin D level. Conclusions: The etiology and pathogenesis of PFAPA is still unknown; however, the rapid response to corticosteroid therapy is the indication of an immune deregulation. Treatment guidelines for PFAPA syndrome based on controlled studies are needed, as well as a better understanding of the disease itself.
MeSH term(s)	Child ; Humans ; Male ; Female ; Child, Preschool ; Vitamin D ; Retrospective Studies ; Stomatitis, Aphthous/diagnosis ; Pharyngitis/diagnosis ; Lymphadenitis/diagnosis ; Lymphadenopathy ; Vitamins ; Neutrophils
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2023-11-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2023.230518
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Article ; Online: Antibacterial and Immunoregulatory Effects of Metformin against

Valadbeigi, Hassan / Khoshnood, Saeed / Negahdari, Babak / Abdullah, Mohd Azmuddin / Haddadi, Mohammad Hossein

BioMed research international

2023 Volume 2023, Page(s) 5583286

Abstract: Introduction: Helicobacter pylori: Methods: Forty-five male Sprague-Dawley rats were divided into seven groups and infected with : Results: Metformin showed weak antibacterial activity against clinically isolated : Conclusions: The combination ... ...

Abstract	Introduction: Helicobacter pylori Methods: Forty-five male Sprague-Dawley rats were divided into seven groups and infected with Results: Metformin showed weak antibacterial activity against clinically isolated Conclusions: The combination of metformin with potential antibiotics such as AMX had a positive effect on the relief of
MeSH term(s)	Male ; Rats ; Animals ; Helicobacter Infections/drug therapy ; Helicobacter pylori ; Interleukin-8 ; Rats, Sprague-Dawley ; Anti-Bacterial Agents/pharmacology ; Amoxicillin/pharmacology ; Inflammation ; Transforming Growth Factor beta
Chemical Substances	Interleukin-8 ; Anti-Bacterial Agents ; Amoxicillin (804826J2HU) ; Transforming Growth Factor beta
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2023/5583286
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Article ; Online: Mixed oral biofilms are controlled by the interspecies interactions of Fusobacterium nucleatum.

Valadbeigi, Hassan / Khoshnood, Saeed / Negahdari, Babak / Maleki, Abbas / Mohammadinejat, Medya / Haddadi, Mohammad Hossein

Oral diseases

2023

Abstract: Background: Fusobacterium nucleatum (F. nucleatum) is an integral component of supra- and subgingival biofilms, especially more prevalent in subgingival areas during both periodontal health and disease.: Aims: In this review, we explore the physical, ...

Abstract	Background: Fusobacterium nucleatum (F. nucleatum) is an integral component of supra- and subgingival biofilms, especially more prevalent in subgingival areas during both periodontal health and disease. Aims: In this review, we explore the physical, metabolic, and genetic interactions that influence the role of F. nucleatum in the formation of mixed oral biofilms. The role of F. nucleatum in antibiotic resistance in oral biofilms was discussed and some therapeutic strategies were proposed. Methods: PubMed, Scopus, Google Scholar, and the Web of Science were extensively searched for English-language reports. Results: F. nucleatum-derived proteins such as RadD, Fap2, FomA, and CmpA are involved in direct interactions contributing to biofilm formation, while autoinducer-2 and putrescine are involved in metabolic interactions. Both groups are essential for the formation and persistence of oral biofilms. This study highlights the clinical relevance of targeted interactions of F. nucleatum in supra- and subgingival oral biofilms. Conclusions: By focusing on these interactions, researchers and clinicians can develop more effective strategies to prevent biofilm-related disease and reduce the spread of antibiotic resistance. Further research in this area is warranted to explore the potential therapeutic interventions that can be derived from understanding the interactions of F. nucleatum in oral biofilm dynamics.
Language	English
Publishing date	2023-11-27
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	1290529-x
ISSN	1601-0825 ; 1354-523X
ISSN (online)	1601-0825
ISSN	1354-523X
DOI	10.1111/odi.14822
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Article ; Online: Toxin-antitoxin Genes Expression in Multidrug-resistant

Khosravi, Azar Dokht / Savari, Mohammad / Khoshnood, Saeed / Shahi, Fatemeh / Farshadzadeh, Zahra

Infectious disorders drug targets

2023 Volume 23, Issue 7, Page(s) 66–72

Abstract: Introduction: Toxin-antitoxin systems (TAs) are highly conserved in Mycobacterium tuberculosis (Mtb). The TAs role in maintaining and disseminating drug resistance in bacterial populations has been indicated. So, we aimed to analyze the expression level ...

Abstract	Introduction: Toxin-antitoxin systems (TAs) are highly conserved in Mycobacterium tuberculosis (Mtb). The TAs role in maintaining and disseminating drug resistance in bacterial populations has been indicated. So, we aimed to analyze the expression level of mazEF-related genes in drugsusceptible and multidrug-resistant (MDR) Mtb isolates under isoniazid (INH) and rifampin (RIF) stress. Methods: We obtained 23 Mtb isolates, including 18 MDR and 5 susceptible isolates, from the Ahvaz Regional TB Laboratory collection. The expression levels of mazF3, mazF6, and mazF9 toxin genes, and mazE3, mazE6, and mazE9 antitoxin genes in MDR and susceptible isolates were evaluated by quantitative real-time PCR (qRT-PCR) after exposure to RIF and INH. Results: The mazF3, F6, and F9 toxin genes were overexpressed in at least two MDR isolates in the presence of RIF and INH, in contrast to mazE antitoxin genes. More MDR isolates were induced to overexpress mazF genes by RIF than INH (72.2% vs. 50%). Compared to the H37Rv strain and susceptible isolates, the expression levels of mazF3,6 by RIF and mazF3,6,9 by INH were significantly upregulated in MDR isolates (p<0.05), but no remarkable difference was detected in the expression level of mazF9 genes by INH between these groups. In susceptible isolates, the expression levels of mazE3,6 by RIF and mazE3,6,9 by INH were induced and enhanced significantly compared to MDR isolates, but there was no difference between MDR and H37Rv strain. Conclusion: Based on the results, we propose that mazF expression under RIF/INH stress may be associated with drug resistance in Mtb in addition to mutations, and the mazE antitoxins may be related to enhanced susceptibility of Mtb to INH and RIF. Further experiments are needed to investigate the exact mechanism underlying the TA system's role in drug resistance.
MeSH term(s)	Humans ; Mycobacterium tuberculosis ; Antitubercular Agents/pharmacology ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/microbiology ; Antitoxins/genetics ; Isoniazid/pharmacology ; Rifampin/pharmacology ; Mutation ; Microbial Sensitivity Tests
Chemical Substances	Antitubercular Agents ; Antitoxins ; Isoniazid (V83O1VOZ8L) ; Rifampin (VJT6J7R4TR)
Language	English
Publishing date	2023-05-24
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2234298-9
ISSN	2212-3989 ; 1871-5265
ISSN (online)	2212-3989
ISSN	1871-5265
DOI	10.2174/1871526523666230524144448
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Article: Amoxicillin-docosahexaenoic acid encapsulated chitosan-alginate nanoparticles as a delivery system with enhanced biocidal activities against

Khoshnood, Saeed / Negahdari, Babak / Kaviar, Vahab Hassan / Sadeghifard, Nourkhoda / Abdullah, Mohd Azmuddin / El-Shazly, Mohamed / Haddadi, Mohammad Hossein

Frontiers in microbiology

2023 Volume 14, Page(s) 1083330

Abstract: Encapsulation of amoxicillin (AMX) for drug delivery ... ...

Abstract	Encapsulation of amoxicillin (AMX) for drug delivery against
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1083330
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Article: Tuberculosis challenges: Resistance, co-infection, diagnosis, and treatment.

Heidary, Mohsen / Shirani, Maryam / Moradi, Melika / Goudarzi, Mehdi / Pouriran, Ramin / Rezaeian, Tayebe / Khoshnood, Saeed

European journal of microbiology & immunology

2022

Abstract: Early diagnosis of tuberculosis (TB), followed by effective treatment, is the cornerstone of global TB control efforts. An estimated 3 million cases of TB remain undetected each year. Early detection and effective management of TB can prevent severe ... ...

Abstract	Early diagnosis of tuberculosis (TB), followed by effective treatment, is the cornerstone of global TB control efforts. An estimated 3 million cases of TB remain undetected each year. Early detection and effective management of TB can prevent severe disease and reduce mortality and transmission. Intrinsic and acquired drug resistance of Mycobacterium tuberculosis (MTB) severely restricted the anti-TB therapeutic options, and public health policies are required to preserve the new medications to treat TB. In addition, TB and HIV frequently accelerate the progression of each other, and one disease can enhance the other effect. Overall, TB-HIV co-infections show an adverse bidirectional interaction. For HIV-infected patients, the risk of developing TB disease is approximately 22 times higher than for persons with a protective immune response. Analysis of the current TB challenges is critical to meet the goals of the end TB strategy and can go a long way in eradicating the disease. It provides opportunities for global TB control and demonstrates the efforts required to accelerate eliminating TB. This review will discuss the main challenges of the TB era, including resistance, co-infection, diagnosis, and treatment.
Language	English
Publishing date	2022-04-14
Publishing country	Hungary
Document type	Journal Article ; Review
ZDB-ID	2652327-9
ISSN	2062-8633 ; 2062-509X
ISSN (online)	2062-8633
ISSN	2062-509X
DOI	10.1556/1886.2021.00021
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Article: Potential Role of Lactobacillus and Bifidobacterium for Preventing Kidney Stones.

Masoleh, Aghdas M / Khoshnood, Saeed / Haddadi, Mohammad H / Rostamzad, Arman / Narki, Mahmoud / Hoshmandfar, Reza / Sadeghifard, Nourkhoda

Clinical laboratory

2023 Volume 69, Issue 5

Abstract: Background: A probiotic is a living microorganism that promotes host health when grown under appropriate conditions. Kidney stones are one of the universal agonizing diseases that have increased dramatically in recent years. One of the causes of this ... ...

Abstract	Background: A probiotic is a living microorganism that promotes host health when grown under appropriate conditions. Kidney stones are one of the universal agonizing diseases that have increased dramatically in recent years. One of the causes of this disease is hyperoxaluria (HOU), which is known to be an important factor in the formation of oxalate stones and is manifested by high levels of oxalate in the urine. In addition, about 80% of kidney stones contain oxalate, and decomposition of this material by microbes is one way to dispose of it. Methods: Therefore, we examined a bacterial mixture containing Lactobacillus plantarum, Lactobacillus casei, Lactobacillus acidophilus, and Bifidobacterium longum to prevent of oxalate production in Wistar rats with kidney stones. We divided the rats into 6 groups defined in the method. Results: The results of this study clearly show a decrease in urinary oxalate levels by exogenous means by L. plantarum, L. casei, L. acidophilus, and B. longum at the beginning of the experiment. Therefore, these bacteria can be used to control and prevent the formation of kidney stones. Conclusions: However, further studies should be conducted on the effects of these bacteria, and it is recommended to identify the gene responsible for the degradation of oxalate in order to develop a new probiotic.
MeSH term(s)	Rats ; Animals ; Lactobacillus/metabolism ; Bifidobacterium/metabolism ; Rats, Wistar ; Kidney Calculi/prevention & control ; Kidney Calculi/urine ; Oxalates/metabolism ; Bacteria
Chemical Substances	Oxalates
Language	English
Publishing date	2023-05-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2022.220645
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Article: Detection of qacΔE Efflux Pump Gene among the Clinical Isolates of Escherichia coli and its Correlation with Resistance to Disinfectants.

Amiri, Pouya / Khoshnood, Saeed / Mohammadinejat, Medya / Abdollahikahri, Neda / Heidari, Hamid / Koupaei, Maryam / Mohamadi, Jasem / Kazemian, Hossein

Clinical laboratory

2023 Volume 69, Issue 10

Abstract: Background: Disinfectants and antiseptics inhibit the dissemination of pathogenic organisms in hospitals but often cause disinfectant-resistant microorganisms, an important factor for nosocomial infection. This study aimed to evaluate the correlation ... ...

Abstract	Background: Disinfectants and antiseptics inhibit the dissemination of pathogenic organisms in hospitals but often cause disinfectant-resistant microorganisms, an important factor for nosocomial infection. This study aimed to evaluate the correlation between qacΔE efflux pump gene and its resistance to disinfectants among Escherichia coli clinical isolates. Methods: A total of 97 E. coli isolates were isolated from patients with urinary tract infections. The minimum inhibition concentration (MIC) value of chlorhexidine and benzalkonium chloride was determined using broth microdilution method. Effect of efflux pumps was assessed by MIC test in the presence of phenylalanine-arginine β-naphthylamide (PAβN), and then the qacΔE efflux pump gene was detected using polymerase chain reaction (PCR). Result: Of the isolates, 85.6% and 61.9% were resistant to chlorhexidine and benzalkonium chloride, respectively. Following the treatment of isolates with the efflux pump's inhibitor, PAβN, the MIC value of chlorhexidine and benzalkonium chloride decreased in 75.2% and 57.7% of the isolates, respectively. A significant correlation was found between PAβN treatment and the change in the resistant strains to susceptible strains (p = 0.021). The qacΔE gene was detected in 84.5% (n = 82) of the isolates, and the presence of the gene amongst disinfectant-resistant strains was also significant (p < 0.001). Conclusions: It is suggested to conduct other studies on other efflux pumps, as well as to periodically monitor the resistance to disinfectants. Substances inhibiting efflux pumps and neutral compounds are effective in the reduction of resistance to disinfectants. New disinfectants and drugs should be designed.
MeSH term(s)	Humans ; Disinfectants/pharmacology ; Chlorhexidine/pharmacology ; Escherichia coli/genetics ; Benzalkonium Compounds/pharmacology ; Cross Infection ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial/genetics
Chemical Substances	Disinfectants ; Chlorhexidine (R4KO0DY52L) ; Benzalkonium Compounds ; Anti-Bacterial Agents
Language	English
Publishing date	2023-10-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2023.230232
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