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  1. Article ; Online: Response to: Correspondence on "Outcomes in patients with moderate and asymptomatic severe aortic stenosis followed up in heart valve clinics" by José Alberto San Román.

    Van Camp, Guy

    Heart (British Cardiac Society)

    2023  Volume 109, Issue 17, Page(s) 1338

    MeSH term(s) Humans ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/complications ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis Implantation ; Severity of Illness Index ; Asymptomatic Diseases
    Language English
    Publishing date 2023-08-11
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2023-322845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 112: Show issues

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  2. Article ; Online: A rare cause of syndromic mitral valve prolapse.

    Iturriagagoitia, Arthur / Heggermont, Ward / Van Camp, Guy

    European heart journal. Cardiovascular Imaging

    2024  

    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeae027
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    Zs.A 5614: Show issues Location:
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  3. Article ; Online: Malignancy-driven hypercoagulability: a fatal combination.

    Decommer, Birgit / Verbesselt, Matthias / Wouters, Erik / Spapen, Jerrold / Van Camp, Guy

    European heart journal. Cardiovascular Imaging

    2023  Volume 24, Issue 6, Page(s) e103

    MeSH term(s) Humans ; Neoplasms ; Thrombophilia
    Language English
    Publishing date 2023-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jead049
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  4. Article ; Online: Recurrent patch dehiscence of left ventricular aneurysm, an unexpected cause.

    Verbesselt, Matthias / Decommer, Birgit / Schelfaut, Dan / Casselman, Filip / Van Praet, Frank / Van Camp, Guy

    European heart journal. Cardiovascular Imaging

    2023  Volume 25, Issue 3, Page(s) e105

    MeSH term(s) Humans ; Heart Aneurysm/diagnostic imaging ; Heart Aneurysm/etiology ; Heart Aneurysm/surgery ; Cardiac Surgical Procedures/adverse effects ; Heart Ventricles/diagnostic imaging
    Language English
    Publishing date 2023-10-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jead271
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  5. Article ; Online: A peculiar mitral valve mass.

    Spapen, Jerrold / Deschepper, Céline / De Raeve, Hendrik / Van Camp, Guy

    The international journal of cardiovascular imaging

    2022  Volume 38, Issue 9, Page(s) 1987–1988

    MeSH term(s) Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Predictive Value of Tests
    Language English
    Publishing date 2022-06-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2055311-0
    ISSN 1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
    ISSN (online) 1875-8312 ; 1573-0743
    ISSN 1569-5794 ; 0167-9899
    DOI 10.1007/s10554-022-02634-8
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    Zs.A 2104: Show issues Location:
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  6. Article ; Online: Mitral valve annuloplasty ring dehiscence.

    Spapen, Jerrold / Paolisso, Pasquale / Van Camp, Guy

    The international journal of cardiovascular imaging

    2021  Volume 37, Issue 9, Page(s) 2747–2748

    MeSH term(s) Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Mitral Valve Annuloplasty/adverse effects ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/etiology ; Mitral Valve Insufficiency/surgery ; Predictive Value of Tests ; Prosthesis Design
    Language English
    Publishing date 2021-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2055311-0
    ISSN 1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
    ISSN (online) 1875-8312 ; 1573-0743
    ISSN 1569-5794 ; 0167-9899
    DOI 10.1007/s10554-021-02249-5
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  7. Article ; Online: CRISPR/Cas9-edited ROS1 + non-small cell lung cancer cell lines highlight differential drug sensitivity in 2D vs 3D cultures while reflecting established resistance profiles.

    Terrones, Marc / Deben, Christophe / Rodrigues-Fortes, Felicia / Schepers, Anne / de Beeck, Ken Op / Van Camp, Guy / Vandeweyer, Geert

    Journal of translational medicine

    2024  Volume 22, Issue 1, Page(s) 234

    Abstract: Introduction: The study of resistance-causing mutations in oncogene-driven tumors is fundamental to guide clinical decisions. Several point mutations affecting the ROS1 kinase domain have been identified in the clinical setting, but their impact ... ...

    Abstract Introduction: The study of resistance-causing mutations in oncogene-driven tumors is fundamental to guide clinical decisions. Several point mutations affecting the ROS1 kinase domain have been identified in the clinical setting, but their impact requires further exploration, particularly in improved pre-clinical models. Given the scarcity of solid pre-clinical models to approach rare cancer subtypes like ROS1 + NSCLC, CRISPR/Cas9 technology allows the introduction of mutations in patient-derived cell lines for which resistant variants are difficult to obtain due to the low prevalence of cases within the clinical setting.
    Methods: In the SLC34A2-ROS1 rearranged NSCLC cell line HCC78, we knocked-in through CRISPR/Cas9 technology three ROS1 drug resistance-causing mutations: G2032R, L2026M and S1986Y. Such variants are located in different functional regions of the ROS1 kinase domain, thus conferring TKI resistance through distinct mechanisms. We then performed pharmacological assays in 2D and 3D to assess the cellular response of the mutant lines to crizotinib, entrectinib, lorlatinib, repotrectinib and ceritinib. In addition, immunoblotting assays were performed in 2D-treated cell lines to determine ROS1 phosphorylation and MAP kinase pathway activity. The area over the curve (AOC) defined by the normalized growth rate (NGR_fit) dose-response curves was the variable used to quantify the cellular response towards TKIs.
    Results: Spheroids derived from ROS1
    Conclusion: In this study we knock-in for the first time in a ROS1 + patient-derived cell line, three different known resistance-causing mutations using CRISPR/Cas9 in the endogenous translocated ROS1 alleles. Pharmacological assays performed in 2D and 3D cell culture revealed that spheroids are more sensitive to TKIs than cells cultured as a monolayer. This direct comparison between two culture systems could be done thanks to the implementation of normalized growth rates (NGR) to uniformly quantify drug response between 2D and 3D cell culture. Overall, this study presents the added value of using spheroids and positions lorlatinib and repotrectinib as the most effective TKIs against the studied ROS1 resistance point mutations.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung ; Protein-Tyrosine Kinases/genetics ; Crizotinib ; CRISPR-Cas Systems/genetics ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Proto-Oncogene Proteins ; Drug Resistance ; Pyrazoles ; Sulfones ; Benzamides ; Aminopyridines ; Indazoles ; Lactams ; Pyrimidines
    Chemical Substances entrectinib (L5ORF0AN1I) ; lorlatinib (OSP71S83EU) ; ceritinib (K418KG2GET) ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Crizotinib (53AH36668S) ; Proto-Oncogene Proteins ; ROS1 protein, human (EC 2.7.10.1) ; Pyrazoles ; Sulfones ; Benzamides ; Aminopyridines ; Indazoles ; Lactams ; Pyrimidines
    Language English
    Publishing date 2024-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-024-04988-0
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  8. Article ; Online: Pre-clinical modelling of ROS1+ non-small cell lung cancer.

    Terrones, Marc / de Beeck, Ken Op / Van Camp, Guy / Vandeweyer, Geert

    Lung cancer (Amsterdam, Netherlands)

    2023  Volume 180, Page(s) 107192

    Abstract: Non-small cell lung cancer (NSCLC) is a heterogeneous group of diseases which accounts for 80% of newly diagnosed lung cancers. In the previous decade, a new molecular subset of NSCLC patients (around 2%) harboring rearrangements of the c-ros oncogene 1 ... ...

    Abstract Non-small cell lung cancer (NSCLC) is a heterogeneous group of diseases which accounts for 80% of newly diagnosed lung cancers. In the previous decade, a new molecular subset of NSCLC patients (around 2%) harboring rearrangements of the c-ros oncogene 1 was defined. ROS1+ NSCLC is typically diagnosed in young, nonsmoker individuals presenting an adenocarcinoma histology. Patients can benefit from tyrosine kinase inhibitors (TKIs) such as crizotinib and entrectinib, compounds initially approved to treat ALK-, MET- or NTRK- rearranged malignancies respectively. Given the low prevalence of ROS1-rearranged tumors, the use of TKIs was authorized based on pre-clinical evidence using limited experimental models, followed by basket clinical trials. After initiating targeted therapy, disease relapse is reported in approximately 50% of cases as a result of the appearance of resistance mechanisms. The restricted availability of TKIs active against resistance events critically reduces the overall survival. In this review we discuss the pre-clinical ROS1+ NSCLC models developed up to date, highlighting their strengths and limitations with respect to the unmet clinical needs. By combining gene-editing tools and novel cell culture approaches, newly developed pre-clinical models will enhance the development of next-generation tyrosine kinase inhibitors that overcome resistant tumor cell subpopulations.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Protein-Tyrosine Kinases/genetics ; Anaplastic Lymphoma Kinase ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins/genetics ; Neoplasm Recurrence, Local/drug therapy ; Oncogenes ; Gene Rearrangement
    Chemical Substances Protein-Tyrosine Kinases (EC 2.7.10.1) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; Protein Kinase Inhibitors ; Proto-Oncogene Proteins ; ROS1 protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2023-04-11
    Publishing country Ireland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2023.107192
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    Zs.A 2135: Show issues Location:
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    Zs.MO 423: Show issues

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  9. Article: Transduction Efficiency and Immunogenicity of Viral Vectors for Cochlear Gene Therapy: A Systematic Review of Preclinical Animal Studies.

    Verdoodt, Dorien / Peeleman, Noa / Van Camp, Guy / Van Rompaey, Vincent / Ponsaerts, Peter

    Frontiers in cellular neuroscience

    2021  Volume 15, Page(s) 728610

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-08-30
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2021.728610
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  10. Article ; Online: Dyspnoea in a 36-year-old woman.

    Wens, Jeroen / Van Camp, Guy

    Heart (British Cardiac Society)

    2016  Volume 102, Issue 12, Page(s) e4

    Language English
    Publishing date 2016-06-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2015-308885
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    Zs.MO 112: Show issues

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