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Article ; Online: Bu-Fei Yi-Shen Granules Reduce Acute Exacerbations in Patients with GOLD 3-4 COPD: A Randomized Controlled Trial.

Yu, Xue-Qing / Di, Jia-Qi / Zhang, Wei / Wei, Geng-Shu / Ma, Zhan-Ping / Wu, Lei / Yu, Xue-Feng / Zhu, Hui-Zhi / Zhou, Miao / Feng, Cui-Ling / Feng, Ji-Hong / Fan, Ping / Li, Jian-Sheng / Yang, Jian-Ya

International journal of chronic obstructive pulmonary disease

2023 Volume 18, Page(s) 2439–2456

Abstract: ... of Bu-fei Yi-shen granules (BYGs) for COPD.: Patients and methods: We conducted a multicenter ...

Abstract	Purpose: Chronic obstructive pulmonary disease (COPD) is a disease characterized by frequent acute exacerbations (AEs), especially in severe and very severe cases. We aimed to evaluate the efficacy and safety of Bu-fei Yi-shen granules (BYGs) for COPD. Patients and methods: We conducted a multicenter, randomized, double-blinded, placebo-controlled trial of 348 COPD patients with GOLD 3-4 COPD. The patients were randomly assigned into experimental or control groups in a 1:1 ratio. Patients in the experimental group were prescribed BYG, while those in the control group were administered a placebo, orally, twice daily, with 5 days on and 2 days off per week for 52 weeks. The outcomes included AEs, pulmonary function, clinical signs and symptoms, dyspnea scores (mMRC), quality of life scores, and a 6-minute walk test (6MWT). Results: A total of 280 patients completed the trial, including 135 patients in the experimental group and 145 in the control group. Compared to the control group, significant differences were observed in frequencies of AEs (mean difference: -0.35; 95% CI: -0.61, -0.10; Conclusion: BYG, as compared to a placebo, could significantly reduce the frequencies of AEs and AE-related hospitalizations for GOLD 3-4 COPD patients. Clinical symptoms, treatment satisfaction, quality of life, and exercise capacity improved. There was no significant improvement in mortality and pulmonary function.
MeSH term(s)	Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Quality of Life ; Lung ; Dyspnea ; Walking
Language	English
Publishing date	2023-11-06
Publishing country	New Zealand
Document type	Randomized Controlled Trial ; Multicenter Study ; Case Reports ; Clinical Trial
ZDB-ID	2212419-6
ISSN	1178-2005 ; 1176-9106
ISSN (online)	1178-2005
ISSN	1176-9106
DOI	10.2147/COPD.S413754
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Corrigendum to "Fei-Yan-Qing-Hua decoction decreases hyperinflammation by inhibiting HMGB1/RAGE signaling and promotes bacterial phagocytosis in the treatment of sepsis" [J. Ethnopharmacol. (2024 Mar 1) 321:117553].

Zhang, Huan / Xu, Guihua / Wu, Xiao / Xu, Yanwu / Xu, Lirong / Zou, Yingxiang / Yang, Xiaodong / Pan, Lingyun / Lei, Biao / Mu, Jingwen / Huang, Qilin / Ma, Yuhe / Duan, Naifan / Zhang, Wei / Zheng, Yuejuan

Journal of ethnopharmacology

2024 Volume 326, Page(s) 117978

Language	English
Publishing date	2024-03-05
Publishing country	Ireland
Document type	Published Erratum
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117978
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Article ; Online: Fei-Yan-Qing-Hua decoction decreases hyperinflammation by inhibiting HMGB1/RAGE signaling and promotes bacterial phagocytosis in the treatment of sepsis.

Journal of ethnopharmacology

2023 Volume 321, Page(s) 117553

Abstract: Ethnopharmacological relevance: Fei-Yan-Qing-Hua decoction (FYQHD), derived from the renowned ... formula Ma Xing Shi Gan tang documented in Zhang Zhong Jing's "Treatise on Exogenous Febrile Disease ...

Abstract	Ethnopharmacological relevance: Fei-Yan-Qing-Hua decoction (FYQHD), derived from the renowned formula Ma Xing Shi Gan tang documented in Zhang Zhong Jing's "Treatise on Exogenous Febrile Disease" during the Han Dynasty, has demonstrated notable efficacy in the clinical treatment of pneumonia resulting from bacterial infection. However, its molecular mechanisms underlying the therapeutic effects remains elusive. Aim of the study: This study aimed to investigate the protective effects of FYQHD against lipopolysaccharide (LPS) and carbapenem-resistant Klebsiella pneumoniae (CRKP)-induced sepsis in mice and to elucidate its specific mechanism of action. Materials and methods: Sepsis models were established in mice through intraperitoneal injection of LPS or CRKP. FYQHD was administered via gavage at low and high doses. Serum cytokines, bacterial load, and pathological damage were assessed using enzyme-linked immunosorbent assay (ELISA), minimal inhibitory concentration (MIC) detection, and hematoxylin and eosin staining (H&E), respectively. In vitro, the immunoregulatory effects of FYQHD on macrophages were investigated through ELISA, MIC, quantitative real-time PCR (Q-PCR), immunofluorescence, Western blot, and a network pharmacological approach. Results: The application of FYQHD in the treatment of LPS or CRKP-induced septic mouse models revealed significant outcomes. FYQHD increased the survival rate of mice exposed to a lethal dose of LPS to 33.3%, prevented hypothermia (with a rise of 3.58 °C), reduced pro-inflammatory variables (including TNF-α, IL-6, and MCP-1), and mitigated tissue damage in LPS or CRKP-induced septic mice. Additionally, FYQHD decreased bacterial load in CRKP-infected mice. In vitro, FYQHD suppressed the expression of inflammatory cytokines in macrophages activated by LPS or HK-CRKP. Mechanistically, FYQHD inhibited the PI3K/AKT/mTOR/4E-BP1 signaling pathway, thereby suppressing the translational level of inflammatory cytokines. Furthermore, it reduced the expression of HMGB1/RAGE, a positive feedback loop in the inflammatory response. Moreover, FYQHD was found to enhance the phagocytic activity of macrophages by upregulating the expression of phagocytic receptors such as CD169 and SR-A1. Conclusion: FYQHD provides protection against bacterial sepsis by concurrently inhibiting the inflammatory response and augmenting the phagocytic ability of immune cells.
MeSH term(s)	Mice ; Animals ; Lipopolysaccharides/pharmacology ; HMGB1 Protein/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction ; Cytokines/metabolism ; Phagocytosis ; Sepsis/drug therapy
Chemical Substances	Lipopolysaccharides ; HMGB1 Protein ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Cytokines
Language	English
Publishing date	2023-12-06
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117553
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Article ; Online: Bu-Fei Yi-Shen Granules Reduce Acute Exacerbations in Patients with GOLD 3–4 COPD

Yu XQ / Di JQ / Zhang W / Wei GS / Ma ZP / Wu L / Yu XF / Zhu HZ / Zhou M / Feng CL / Feng JH / Fan P / Li JS / Yang JY

International Journal of COPD, Vol Volume 18, Pp 2439-

A Randomized Controlled Trial

2023 Volume 2456

Abstract: Xue-Qing Yu,1,2,* Jia-Qi Di,2,* Wei Zhang,3 Geng-Shu Wei,4 Zhan-Ping Ma,5 Lei Wu,6 Xue-Feng Yu,7 ...

Abstract	Xue-Qing Yu,1,2,* Jia-Qi Di,2,* Wei Zhang,3 Geng-Shu Wei,4 Zhan-Ping Ma,5 Lei Wu,6 Xue-Feng Yu,7 Hui-Zhi Zhu,8 Miao Zhou,9 Cui-Ling Feng,10 Ji-Hong Feng,11 Ping Fan,12 Jian-Sheng Li,1,2 Jian-Ya Yang1 1Department of Respiratory Disease, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan Province, 450000, People’s Republic of China; 2Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of China; 3Department of Respiratory Disease, Shanghai Shuguang Hospital, Shanghai University of Chinese Medicine, Shanghai, 200000, People’s Republic of China; 4Department of Respiratory Disease, the Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, 712000, People’s Republic of China; 5Department of Respiratory Disease, Shaanxi Province Hospital of Traditional Chinese Medicine, Xi’an, Shaanxi Province, 710000, People’s Republic of China; 6Department of Respiratory Disease, Hebei Province Hospital of Traditional Chinese Medicine, Shijiazhuang, Hebei, 050000, People’s Republic of China; 7Department of Respiratory Disease, the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, 110000, People’s Republic of China; 8Department of Respiratory Disease, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230000, People’s Republic of China; 9Department of Respiratory Disease, the Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan Province, 450000, People’s Republic of China; 10Department of Traditional Chinese Medicine, People’s Hospital Affiliated to Peking University, Beijing, 100000, People’s Republic of China; 11Department of Respiratory Disease, the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300000, People’s ...
Keywords	chronic obstructive pulmonary disease ; traditional chinese medicine ; efficacy ; safety ; rct ; Diseases of the respiratory system ; RC705-779
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Tiao-Bu-Fei-Shen Formula Improves Glucocorticoid Resistance of Chronic Obstructive Pulmonary Disease via Downregulating the PI3K-Akt Signaling Pathway and Promoting GR

Zhou, Pengcheng / Ma, Jianli / Yu, Wei / Chen, Keling / Zhang, Wensheng / Zhou, Jiang

Evidence-based complementary and alternative medicine : eCAM

2023 Volume 2023, Page(s) 4359616

Abstract: Objective: To predict and determine the mechanism through which Tiao-Bu-Fei-Shen (TBFS) formula ...

Abstract	Objective: To predict and determine the mechanism through which Tiao-Bu-Fei-Shen (TBFS) formula improves glucocorticoid resistance in chronic obstructive pulmonary disease (COPD), using network pharmacology, molecular docking technology, and Methods: The main active components and associated targets of TBFS were screened using the systems pharmacology database of traditional Chinese medicine database (TCMSP). The main COPD targets were retrieved from the Human Gene (GeneCards) and DrugBank databases. A protein-protein interaction (PPI) network was constructed using the protein interaction platform STRING and Cytoscape 3.6.1. Gene ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genome Pathway (KEGG) analyses were performed using the biological information annotation database Metascape. Molecular docking was performed using the AutoDock Vina software. THP-1 monocytes were treated with TBFS-containing serum and cigarette smoke extract (CSE) for 48 h, and cell proliferation in each group was determined using cell counting kit-8 (CCK-8). A COPD cell model was constructed by stimulating THP-1 monocytes with CSE for 12 h. A lentivirus vector for RNA interference of histone deacetylase 2 (HDAC2) gene was constructed and transfected into the THP-1 monocytes, and the transfection efficiency was verified using quantitative polymerase chain reaction (qPCR) and western blotting (WB). The expression of HDAC2 in each group of cells was detected using qPCR, and the expression of HDAC2, phosphoinositide-3 kinase (PI3K) p85 Results: A total of 344 TBFS active components, 249 related drug targets, 1,171 COPD target proteins, and 138 drug and disease intersection targets were obtained. Visual analysis of the PPI network map revealed that the core COPD targets of TBFS were AKT1, IL-6, TNF, TP53, and IL1- Conclusion: TBFS treatment improves glucocorticoid resistance observed in COPD through downregulation of the PI3K-Akt signaling pathway and promotion of GR
Language	English
Publishing date	2023-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2023/4359616
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Zs.A 5995: Show issues

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Article: Challenges encountered by Federation Equestre Internationale (FEI) veterinarians in gait evaluation during FEI endurance competitions: an international survey

de Mira, M.C / Santos, C / Lopes, M.A / Marlin, D.J

Comparative exercise physiology. 2019 Dec. 10, v. 15, no. 5

2019

Abstract: ... in international competitions by FEI veterinarians for lameness at any time. Elimination rates due to lameness are ... competitors. The aims of this study were: (1) to assess the opinion of FEI official endurance veterinarians ... friendly technology for objective gait evaluation to help detect, quantify and document lameness. All FEI ...

Abstract	Equine endurance competitions are long races over 1-2 days and horses can be eliminated in international competitions by FEI veterinarians for lameness at any time. Elimination rates due to lameness are high, affect the outcome of the races and commonly elicit objections to the decision from endurance competitors. The aims of this study were: (1) to assess the opinion of FEI official endurance veterinarians (OEVs) about the challenges in assessing lameness; (2) the occurrence of confrontations with riders when horses are eliminated from races due to lameness; (3) to assess OEVs’ thoughts about the adoption of user-friendly technology for objective gait evaluation to help detect, quantify and document lameness. All FEI OEVs were asked to complete a questionnaire. There were 157 responses, being most of the respondents from Europe (56.1%) or the Middle East (16.6%). For the majority of respondents, detection of lameness was considered challenging, even for experienced and well-trained veterinarians (57.3%). OEVs also considered it was often hard to classify horses as lame or sound (65.8%). Handlers not trotting the horse appropriately during gait evaluations was considered the most common problem compromising the evaluation (94.3%). Most OEVs (98.2%) responded that they had been confronted at least once by a rider or associate about the decision to eliminate a horse due to lameness. Most OEVs (71.3%) would be interested in having the support of user-friendly technology for objective gait evaluation (33.3% for all evaluations; 38.0% only when horses have more subtle gait abnormalities). The findings of this survey suggest that technology to objectively detect and quantify gait abnormalities during endurance competitions would be beneficial to support decisions made by OEVs when evaluating and or eliminating horses for lameness.
Keywords	gait ; horses ; lameness ; questionnaires ; races ; surveys ; trotting ; veterinarians ; Europe ; Middle East
Language	English
Dates of publication	2019-1210
Size	p. 371-378.
Publishing place	Wageningen Academic Publishers
Document type	Article
ISSN	1755-2559
DOI	10.3920/CEP180058
Database	NAL-Catalogue (AGRICOLA)

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Article: Integrating Network Pharmacology, Transcriptome and Artificial Intelligence for Investigating Into the Effect and Mechanism of Ning Fei Ping Xue Decoction Against the Acute Respiratory Distress Syndrome.

Lu, Xiaoxiao / Ma, Wentao / Fan, Baofeng / Li, Peng / Gao, Jing / Liu, Qiuhong / Hu, Chunling / Li, Yong / Yao, Mengying / Ning, Hanbing / Xing, Lihua

Frontiers in pharmacology

2021 Volume 12, Page(s) 731377

Abstract: ... pharmacotherapy. A traditional Chinese medicine (TCM) formula, Ning Fei Ping Xue (NFPX) decoction, was ...

Abstract	Acute respiratory distress syndrome (ARDS) is a high-mortality disease and lacks effective pharmacotherapy. A traditional Chinese medicine (TCM) formula, Ning Fei Ping Xue (NFPX) decoction, was demonstrated to play a critical role in alleviating inflammatory responses of the lung. However, its therapeutic effectiveness in ARDS and active compounds, targets, and molecular mechanisms remain to be elucidated. The present study investigates the effects of NFPX decoction on ARDS mice induced by lipopolysaccharides (LPS). The results revealed that NFPX alleviated lung edema evaluated by lung ultrasound, decreased lung wet/Dry ratio, the total cell numbers of bronchoalveolar lavage fluid (BALF), and IL-1β, IL-6, and TNF-α levels in BALF and serum, and ameliorated lung pathology in a dose-dependent manner. Subsequently, UPLC-HRMS was performed to establish the compounds of NFPX. A total of 150 compounds in NFPX were characterized. Moreover, integrating network pharmacology approach and transcriptional profiling of lung tissues were performed to predict the underlying mechanism. 37 active components and 77 targets were screened out, and a herbs-compounds-targets network was constructed. Differentially expressed genes (DEGs) were identified from LPS-treated mice compared with LPS combined with NFPX mice. GO, KEGG, and artificial intelligence analysis indicated that NFPX might act on various drug targets. At last, potential targets, HRAS, SMAD4, and AMPK, were validated by qRT-PCR in ARDS murine model. In conclusion, we prove the efficacy of NFPX decoction in the treatment of ARDS. Furthermore, integrating network pharmacology, transcriptome, and artificial intelligence analysis contributes to illustrating the molecular mechanism of NFPX decoction on ARDS.
Language	English
Publishing date	2021-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.731377
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Book ; Audio / Video: Fei ying

Ma, Chucheng

Silver hawk

2004

Author's details	[Regie: Ma Chucheng]
Language	Chinese
Size	1 DVD (Region 1-8), 99 Min
Publishing place	Hongkong
Document type	Book ; Audio / Video
Note	Audiosprachen: Chinesisch, Kantonesisch ; Untertitel: Chinesisch (Lang- und Kurzzeichen), Englisch
Database	Former special subject collection: coastal and deep sea fishing

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Book: Shanghai fei wu zhi wen hua yi chan chuan tong yi yao xiang mu feng cai

Ma, Junjian

2014

Author's details	Ma Junjian zhu bian
MeSH term(s)	Medicine, Chinese Traditional ; Materia Medica
Keywords	China
Language	Chinese
Size	130 p. :, ill., ports.
Edition	Di 1 ban.
Publisher	Shanghai ke xue ji shu chu ban she
Publishing place	Shanghai
Document type	Book
ISBN	9787547821503 ; 7547821502
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: Effect of auxin treatments, cuttings' collection date and initial characteristics on Paeonia 'Yang Fei Chu Yu' cutting propagation

Guo, XianFeng / Fu, XiLing / Zang, DeKui / Ma, Yan

Scientia horticulturae. 2009 Jan. 6, v. 119, no. 2

2009

Abstract: Paeonia 'Yang Fei Chu Yu' is one of the most popular and commercially valuable cultivars ...

Abstract	Paeonia 'Yang Fei Chu Yu' is one of the most popular and commercially valuable cultivars of herbaceous peony. The study was performed to explore propagation techniques by cuttings for the nursery industry. Results showed that the stem cuttings pretreated with 2000mgL⁻¹ indole-3-butyric acid (IBA) in quick-dip method got the best rooting traits (rooting percentage is 86.7%, root number is 23.1 and root length per rooted cutting is 6.4cm). Therefore pre-treatment with 2000mgL⁻¹ IBA is recommended. To establish the optimum cuttings' collection date and interpret better the relation between the rooting ability and the cutting material's initial physiological characteristics, three collection periods were designed after florescence and the stem cuttings' endogenous factors (nutrient reserves and hormones) were examined. The results showed stem cuttings collected at the 70th day after florescence rooted best, and then cuttings collected at the 40th day, while those taken at the 10th day worst. Among the three collection dates, the soluble carbohydrate level had no statistically significant difference, but its increasing concentration was positively related to the cuttings' rooting potential. The nitrogen level decreased with the delaying of cuttings' collection and the difference was significant. This tendency implicated the negative relation between the nitrogen level and the cuttings' rooting potential. Among the four determined endogenous plant hormones, both gibberellic acid (GA₃) and abscisic acid (ABA) content had no significant seasonal difference, while indole-3-acetic acid (IAA) and zeatin riboside (ZR) content significantly varied with collection date. IAA content was the highest at the 10th day after florescence and subsequently significantly decreased with the delaying of cuttings' collection date, whereas ZR content exhibited the contrary tendency.
Keywords	Paeonia ; ornamental plants ; nursery crops ; plant cuttings ; temporal variation ; vegetative propagation ; auxins ; plant growth substances ; indole butyric acid ; rooting ; length ; flowering ; phenology ; nitrogen content ; carbohydrate content ; seasonal variation ; abscisic acid ; gibberellic acid ; zeatin ; indole acetic acid
Language	English
Dates of publication	2009-0106
Size	p. 177-181.
Publishing place	[Amsterdam; New York, NY]: Elsevier Science
Document type	Article
ZDB-ID	185557-8
ISSN	0304-4238
ISSN	0304-4238
DOI	10.1016/j.scienta.2008.07.022
Database	NAL-Catalogue (AGRICOLA)

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